Metabolic bone and calcium disorders including osteoporosis, Paget's disease, hypo- and hyper-parathyroidism as well as bone diseases related to transplant, medications (example aromatase inhibitors and glucocorticoids) and iron overload.
Rare bone disease including Fibrodysplasia Ossificans Progressiva and hypophosphatasia.
Clinical research in Fibrodysplasia Ossificans Progressiva.
Evaluation of osteoporosis and the effects of treatment/diseases on "bone quality" using high resolution imaging of bone (uMRI).
Selected Publications
Pignolo RJ, Al Mukaddam M, Baujat G, Brown MA, De Cunto C, Hsiao EC, Keen R, Le Quan Sang KH, Grogan DR, Marino R, Strahs AR, Kaplan FS.: Study methodology and insights from the palovarotene clinical development program in fibrodysplasia ossificans progressiva. BMC Med Res Methodol Nov 2023.
Pignolo RJ, Al Mukaddam M, Baujat G, Brown MA, De Cunto C, Hsiao EC, Keen R, Le Quan Sang KH, Grogan DR, Marino R, Strahs AR, Kaplan FS.:
Study methodology and insights from the palovarotene clinical development program in fibrodysplasia ossificans progressiva.
BMC Med Res Methodol Nov 2023.
Robert J Pignolo, Mona Al Mukaddam, Geneviève Baujat, Angela M Cheung, Carmen De Cunto, Edward C Hsiao, Richard Keen, Rose Marino, Andrew Strahs, Frederick S Kaplan: Health Assessments of Normotopic Bone in Individuals with Fibrodysplasia Ossificans Progressiva
Poster Presentation at the Annual ASBMR meeting October 2023.
Kathryn M. Dahir, Jennifer McGinniss, Eduardo Forleo-Neto, Scott Mellis, Robert J. Sanchez, Maja Di Rocco, Richard Keen, Philippe Orcel, Christian Roux, Jacek Tabarkiewicz, Javier Bachiller-Corral, Angela M. Cheung, Mona Al Mukaddam, Kusha Mohammadi, Dushyanth Srinivasan, Andrew J. Rankin, Aris N. Economides, Dinko Gonzalez Trotter, Frederick S. Kaplan, E. Marelise W. Eekhoff, Robert J. Pignolo: Flare-Ups in Patients with Fibrodysplasia Ossificans Progressiva Reduced by Garetosmab Treatment: LUMINA-1 Data
Poster Presentation at the Annual ASBMR meeting October 2023.
Edward C. Hsiao, Robert J. Pignolo, Mona Al Mukaddam, Geneviève Baujat,
Staffan K. Berglund, Angela M. Cheung, Carmen De Cunto, Patricia Delai,
Peter Kannu, Richard Keen, Edna E. Mancilla, Rose Marino, Andrew Strahs, Frederick S. Kaplan
: Long-Term Impact of Palovarotene Treatment on Heterotopic Ossification in Patients with Fibrodysplasia Ossificans Progressiva: Data from the Phase III MOVE Trial. Poster Presentation at ASBMR annual meeting October 2023.
Bassam AlHamer, Ajit Singh, Carmen Patrascu, Mona Al Mukaddam
: How an underappreciated electrolyte abnormality led to a rare diagnosis
Poster Presentation at ACP meeting (awarded second best poster prize) October 2023.
Richard Keen, Jennifer McGinniss, Eduardo Forleo-Neto, Scott Mellis, Kathryn M. Dahir, Maja Di Rocco, Jacek Tabarkiewicz, Javier Bachiller-Corral, Angela M. Cheung, Mona Al Mukaddam, Jing Gu, Aris N. Economides, Dushyanth Srinivasan, Dinko Gonzalez Trotter, Frederick S. Kaplan, Marelise W. Eekhoff, Robert J. Pignolo: The Relationship of Flare-Ups and Heterotopic Ossification in Patients with Fibrodysplasia Ossificans Progressiva: LUMINA-1 Data. Plenary Poster Presentation at Annual ASBMR meeting October 2023.
Edward C. Hsiao, Robert J. Pignolo, Mona Al Mukaddam, Geneviève Baujat,
Staffan K. Berglund, Angela M. Cheung, Carmen De Cunto, Patricia Delai,
Peter Kannu, Richard Keen, Edna E. Mancilla, Rose Marino, Andrew Strahs, Frederick S. Kaplan : Efficacy of Palovarotene for the Reduction of New Heterotopic Ossification in Patients with Fibrodysplasia Ossificans Progressiva: Sensitivity Analyses from the Phase III MOVE Trial Poster Presentation at Annual ASBMR meeting October 2023.
Di Rocco M, Forleo-Neto E, Pignolo RJ, Keen R, Orcel P, Funck-Brentano T, Roux C, Kolta S, Madeo A, Bubbear JS, Tabarkiewicz J, Szczepanek M, Bachiller-Corral J, Cheung AM, Dahir KM, Botman E, Raijmakers PG, Al Mukaddam M, Tile L, Portal-Celhay C, Sarkar N, Hou P, Musser BJ, Boyapati A, Mohammadi K, Mellis SJ, Rankin AJ, Economides AN, Trotter DG, Herman GA, O'Meara SJ, DelGizzi R, Weinreich DM, Yancopoulos GD, Eekhoff EMW, Kaplan FS. : Garetosmab in fibrodysplasia ossificans progressiva: a randomized, double-blind, placebo-controlled phase 2 trial.
Nature Medicine Oct 2023.
Kathryn M. Dahir, Jennifer McGinniss, Eduardo Forleo-Neto, Scott Mellis, Robert J. Sanchez, Maja Di Rocco, Richard Keen, Philippe Orcel, Christian Roux, Jacek Tabarkiewicz, Javier Bachiller-Corral, Angela M. Cheung, Mona Al Mukaddam, Kusha Mohammadi, Dushyanth Srinivasan, Andrew J. Rankin, Aris N. Economides, Dinko Gonzalez Trotter, Frederick S. Kaplan, Marelise W. Eekhoff, Robert J. Pignolo
: Garetosmab Reduces Flare-Ups in Patients with Fibrodysplasia Ossificans Progressiva: Long-Term Efficacy Data. Oral Presentation at Annual Endocrine Society Meeting June 2023.
back to top
Last updated: 12/01/2023
The Trustees of the University of Pennsylvania