Hiroshi Nakagawa, M.D., Ph.D.
Research Associate Professor of Medicine
Department: Medicine
Contact information
Division of Gastroenterology,
638B Clinical Research Building,
415 Curie Boulevard
Philadelphia, PA 19104
638B Clinical Research Building,
415 Curie Boulevard
Philadelphia, PA 19104
Office: 215-573-1867
Fax: 215-573-2024
Fax: 215-573-2024
Email:
nakagawh@mail.med.upenn.edu
nakagawh@mail.med.upenn.edu
Publications
Education:
MD
Okayama University, Okayama, Japan, 1989.
Ph.D.
Okayama University (Medical Science) Okayama, Japan, 1993.
MD
Okayama University, Okayama, Japan, 1989.
Ph.D.
Okayama University (Medical Science) Okayama, Japan, 1993.
Post-Graduate Training
Resident in Medicine , Okayama University Hospital, Okayama, Japan, 1989-1990.
Clinical Fellow in Gastroenterology and Hepatology, The First Department of Internal Medicine, Okayama University Medical School, Okayama, Japan, 1990-1993.
Postdoctoral Research Fellow, Massachusetts General Hospital, Gastrointestinal Unit, Harvard Medical School, Boston, Mass, 1993-1996.
Postdoctoral Research Fellow, The First Department of Internal Medicine, Okayama University Medical School, Okayama, Japan, 1997-1998.
Permanent linkResident in Medicine , Okayama University Hospital, Okayama, Japan, 1989-1990.
Clinical Fellow in Gastroenterology and Hepatology, The First Department of Internal Medicine, Okayama University Medical School, Okayama, Japan, 1990-1993.
Postdoctoral Research Fellow, Massachusetts General Hospital, Gastrointestinal Unit, Harvard Medical School, Boston, Mass, 1993-1996.
Postdoctoral Research Fellow, The First Department of Internal Medicine, Okayama University Medical School, Okayama, Japan, 1997-1998.
Selected Publications
Noma K, Smalley KS, Lioni M, Naomoto Y, Tanaka N, El-Diery W, King AJ, Nakagawa H, and Herlyn M: The Essential Role of Fibroblasts in Esophageal Squamous Cell Carcinoma-Induced Angiogenesis. Gastroenterology March 2008.Okawa T, Michaylira CZ, Nakagawa H, Andl CD, Stairs DB, Johnstone CN, Klein-Szanto AJP, El-Deiry WS, Cukierman E, Herlyn M, and Rustgi AK: The functional interplay between EGFR overexpression, hTERT activation and p53 mutation in esophageal epithelial cells with activation of stromal fibroblasts induce tumor development, invasion and differentiation. Genes & Development 21(21): 2788-803, Nov 2007.
Yang Y, Goldstein BG., Nakagawa H, and Katz JP: Krüppel-like factor 5 activates MEK/ERK signaling via EGFR in primary squamous epithelial cells. FASEB J 21: 543-550, 2007.
Takaoka M, Kim SH, Okawa T, Michaylira CZ, Stairs DB, Johnstone CN, Andl CD, Rhoades B, Lee JJ, Klein-Szanto AJP, El-Deiry WS, and Nakagawa H: IGFBP-3 regulates esophageal tumor growth through IGF-dependent and independent mechanisms. Cancer Biol Ther 6: 534-540, 2007.
Oyama K, Okawa T, Nakagawa H, Takaoka M, Andl CD, Kim S-H, Klein-Szanto A, Dihel JA, Herlyn M, El-Deiry W, and Rustgi AK: AKT induces senescence in primary esophageal epithelial cells but is permissive for differentiation as revealed in organotypic culture. Oncogene 26: 2353-2364, 2007.
Kim S-H, Nakagawa H, Navaraj A, Naomoto Y, Klein-Szanto AJP, Rustgi AK, and El-Deiry WS: Tumorigenic conversion of primary human esophageal epithelial cells using oncogene combinations in the absence of exogenous Ras. Cancer Research 66: 10415-10424, 2006.
Kobayashi M, Naomoto Y, Nobuhisa T, Okawa T, Takaoka M, Shirakawa Y, Yamatsuji T, Matsuoka J, Mizushima T, Matsuura H, Nakajima M, Nakagawa H, Rustgi AK, Tanaka N: Heparanase regulates esophageal keratinocyte differentiation through nuclear translocation and heparan sulfate cleavage. Differentiation 74: 235-243, 2006.
Takaoka M, Smith CE, Mashiba MK, Okawa T, Andl CD, El-Deiry WS, and Nakagawa H: EGF-mediated regulation of insulin-like growth factor binding protein (IGFBP)-3 determines esophageal epithelial cellular response to IGF-I. Journal of Physiology - Gastrointestinal and Liver Physiology 290: G404-G416, 2006.
Andl CD, Fargnoli BB, Okawa T, Bowser M, Takaoka M, Nakagawa H, Klein-Szanto A, Hua X, Herlyn M and Rustgi AK: Coordinated functions of E-cadherin and TGF receptor II in vitro and in vivo. Cancer Research 66: 9878-9885, 2006.
Bartkova J, Rezaei N, Liontos M, Karakaidos P, Kletsas D, Issaeva N, Vassiliou L-VF Kolettas E, Niforou K, Zoumpourlis VC, Takaoka M, Nakagawa H, Tort F, Fugger K, Johansson F, Sehested M, Andersen CL, Dyrskjot L, Orntoft T, Lukas J, Kittas C, Helleday T, Halazonetis TD, Bartek J, and Gorgoulis VG: Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints. Nature 444: 633-637, 2006.
