David E. Kaplan, M.D. M.Sc.
Assistant Professor of Medicine at the Veteran's Administration Medical Center
Attending Gastroenterologist / Hepatologist , Philadelphia VA Medical Center
Department: Medicine
Contact information
Division of Gastroenterology
600 CRB, 415 Curie Blvd.
Philadelphia, PA 19104
600 CRB, 415 Curie Blvd.
Philadelphia, PA 19104
Office: 215-823-5800 x 6729
Fax: 215-823-4289
Fax: 215-823-4289
Email:
dakaplan@mail.med.upenn.edu
dakaplan@mail.med.upenn.edu
Publications
Education:
B.A. (Political Science)
University of California, San Diego, 1992.
M.D.
University of Texas Southwestern Medical School, 1997.
M.Sc. (Patient-Oriented Research)
University of Pennsylvania, 2007.
B.A. (Political Science)
University of California, San Diego, 1992.
M.D.
University of Texas Southwestern Medical School, 1997.
M.Sc. (Patient-Oriented Research)
University of Pennsylvania, 2007.
Post-Graduate Training
Intern in Medicine, Osler Medical Service, Johns Hopkins School of Medicine, 1997-1998.
Resident in Medicine, Osler Medical Service, Johns Hopkins School of Medicine, 1998-2000.
Fellow in Gastroenterology and Hepatology, University of Pennsylvania, 2001-2004.
Post-doctoral Research Fellow, University of Pennsylvania, 2002-2004.
AASLD / Schering Advanced Hepatology Fellow, University of Pennsylvania, 2004-2005.
Permanent linkIntern in Medicine, Osler Medical Service, Johns Hopkins School of Medicine, 1997-1998.
Resident in Medicine, Osler Medical Service, Johns Hopkins School of Medicine, 1998-2000.
Fellow in Gastroenterology and Hepatology, University of Pennsylvania, 2001-2004.
Post-doctoral Research Fellow, University of Pennsylvania, 2002-2004.
AASLD / Schering Advanced Hepatology Fellow, University of Pennsylvania, 2004-2005.
Description of Research Expertise
Hepatitis C and hepatocellular carcinoma immunopathogenesisDescription of Clinical Expertise
Hepatology, viral and non-viral chronic liver disease and cirrhosis, hepatocellular carcinoma, end-stage liver diseaseSelected Publications
Doi H, Iyer TK, Carpenter EL, Li H, Chang KM, Vonderheide RH, Kaplan DE.: Dysfunctional B-cell activation in cirrhosis due to hepatitis C infection associated with disappearance of CD27+ B-cell population. Hepatology September 2011 (epub ahead of print).Lo Re III V, Teal V, Localio AR, Amorosa VK, Kaplan DE, Gross R.: Adherence to Hepatitis C Virus Therapy: Relationship with Virologic Outcomes, Change in Adherence Over Time, and Risk Factors for Non-Adherence. Annals of Internal Medicine 155(6): 353-360, September 2011.
Xu Y, Li H, Gao RL, Adeyemo O, Itkin M, Kaplan DE.: Expansion of interferon-gamma-producing multifunctional CD4+ T-cells and dysfunctional CD8+ T-cells by glypican-3 peptide library in hepatocellular carcinoma patients. Clinical Immunology 139(3): 302-313, June 2011 Notes: doi:10.1016/j.clim.2011.02.014.
Rech A, Mick R, Kaplan D, Chang K-M, Domchek SM, Vonderheide RH.: Homeostasis of peripheral FoxP3+ CD4+ regulatory T cells in patients with early and late stage breast cancer. Cancer Immunol Immunother 59(4): 599-607, April 2010.
Forde KA, Law C, O'Flynn R, Kaplan DE.: Do statins reduce hepatitis C RNA titers during routine clinical use? World J Gastroenterology 15(40): 5020-7, October 2009.
Stiffler JD, Nguyen M, Sohn JA, Liu C, Kaplan DE, Seeger C.: Focal distribution of hepatitis C virus RNA in infected livers. PloS one 4(8): e6661, August 2009.
Andrea L. Cox, Kimberly Page, Julie Bruneau, Naglaa H. Shoukry, Georg M. Lauer, Arthur Y. Kim, Hugo R. Rosen, Hank Radziewicz, Arash Grakoui, Daniel S. Fierer, Andrea D. Branch, David E. Kaplan, Kyong-Mi Chang : Rare Birds in North America: Acute Hepatitis C Cohorts. Gastroenterology 136(1): 26-31, Jan 2009.
Carpenter EL, Mick R, Rech AJ, Beatty GL, Colligon TA, Rosenfeld MR, Kaplan DE, Chang KM, Domchek SM, Kanetsky PA, Fecher LA, Flaherty KT, Schuchter LM, Vonderheide RH.: Collapse of the CD27+ B-cell compartment associated with systemic plasmacytosis in patients with advanced melanoma and other cancers. Clinical cancer research : an official journal of the American Association for Cancer Research 15(13): 4277-87, July 2009.
Harris RA, Sugimoto K, Kaplan DE, Ikeda F, Kamoun M, Chang KM.: Human leukocyte antigen class II associations with hepatitis C virus clearance and virus-specific CD4 T cell response among Caucasians and African Americans. Hepatology 48(1): 70-9, July 2008.
Kaplan DE, Ikeda F, Li Y, Nakamoto N, Ganesan S, Valiga ME, Nunes FA, Reddy KR, Chang KM.: Peripheral virus-specific T-cell interleukin-10 responses develop early in acute hepatitis C infection and become dominant in chronic hepatitis. J Hepatol 48(6): 903-913, June 2008.
Nakamoto N, Kaplan DE, Coleclough J, Li Y, Valiga ME, Kaminski M, Shaked A, Olthoff K, Gostick E, Price DA, Freeman GJ, Wherry EJ, Chang KM: Functional restoration of HCV-specific CD8 T cells by PD-1 blockade is defined by PD-1 expression and compartmentalization. Gastroenterology 134(7): 1927-37, 1937.e1-2, June 2008.
Kaplan, DE: Propagation of hepatitis C virus infection: Elucidating targets for therapeutic intervention. Drug Discovery Today: Disease Mechanisms 3(4): 471-477, Winter 2006.
Kaplan DE., Reddy KR.: Rising incidence of hepatocellular carcinoma: the role of hepatitis B and C; the impact on transplantation and outcomes. [Review] [331 refs] Clinics in Liver Disease 7(3): 683-714, Aug 2003.
