David E. Kaplan, M.D. M.Sc.
Assistant Professor of Medicine at the Hospital of the University of Pennsylvania and the Veteran's Administration Medical Center
Attending Gastroenterologist / Hepatologist, Philadelphia VA Medical Center
Department: Medicine
Contact information
Division of Gastroenterology
600 CRB, 415 Curie Blvd.
Philadelphia, PA 19104
600 CRB, 415 Curie Blvd.
Philadelphia, PA 19104
Office: 215-823-5800 x 6729
Fax: 215-823-4289
Fax: 215-823-4289
Email:
dakaplan@mail.med.upenn.edu
dakaplan@mail.med.upenn.edu
Publications
Education
B.A. (Political Science)
University of California, San Diego, 1992.
M.D.
University of Texas Southwestern Medical School, 1997.
MSc (Patient-Oriented Research)
University of Pennsylvania, 2007.
B.A. (Political Science)
University of California, San Diego, 1992.
M.D.
University of Texas Southwestern Medical School, 1997.
MSc (Patient-Oriented Research)
University of Pennsylvania, 2007.
Post-Graduate Training
Intern in Medicine, Osler Medical Service, Johns Hopkins School of Medicine, 1997-1998.
AASLD / Schering Advanced Hepatology Fellow, University of Pennsylvania, 2004-2005.
Post-doctoral Research Fellow, University of Pennsylvania, 2002-2004.
Fellow in Gastroenterology and Hepatology, University of Pennsylvania, 2001-2004.
Resident in Medicine, Osler Medical Service, Johns Hopkins School of Medicine, 1998-2000.
Permanent linkIntern in Medicine, Osler Medical Service, Johns Hopkins School of Medicine, 1997-1998.
AASLD / Schering Advanced Hepatology Fellow, University of Pennsylvania, 2004-2005.
Post-doctoral Research Fellow, University of Pennsylvania, 2002-2004.
Fellow in Gastroenterology and Hepatology, University of Pennsylvania, 2001-2004.
Resident in Medicine, Osler Medical Service, Johns Hopkins School of Medicine, 1998-2000.
Description of Research Expertise
Hepatitis C and hepatocellular carcinoma immunopathogenesisDescription of Clinical Expertise
Hepatology, viral and non-viral chronic liver disease and cirrhosis, hepatocellular carcinoma, end-stage liver diseaseSelected Publications
Kaplan, D.E., F. Ikeda, Y. Li, N. Nakamoto, S. Ganesan, M. E. Valiga, F. A. Nunes, K. R. Reddy and K.M. Chang.: Peripheral virus-specific T-cell interleukin-10 responses develop early in acute hepatitis C infection and become dominant in chronic hepatitis. J Hepatol 48(6): 903-913, June 2008.Nakamoto, N, D.E., Kaplan, J. Coleclough, Y. Li, M. Kaminski, A. Shaked, K. Olthoff, E. Gostick, D.A. Price, G.J. Freeman, E.J. Wherry and K.M. Chang: Functional restoration of HCV-specific CD8 T-cells by PD1 blockade is defined by their PD1 expression and compartmentalization. Gastroenterology 134(7): 1927-1937, June 2008.
Harris, R.A., K. Sugimoto, D.E. Kaplan, F. Ikeda, M. Kamoun and K.M. Chang: HLA class II associations with HCV clearance and virus-specific CD4 T cell response among Caucasian and African Americans. Hepatology 48(1): 70-79, 2008.
Kaplan DE, Sugimoto K, Valiga M, Newton K, Ikeda F, Aytaman A, Nunes FA, Lucey MR, Vance BA, Vonderheide RH, Reddy KR, McKeating JA, Chang KM. : Virus-specific CD4 T-cell response relative to CD8 T-cell and neutralizing antibody responses in the outcome of acute hepatitis C. Gastroenterology 132(2): 654-666, February 2007.
Kaplan DE., Sugimoto K., Ikeda F., Stadanlick J., Valiga M., Shetty K., Reddy KR., Chang KM.: T-cell response relative to genotype and ethnicity during antiviral therapy for chronic hepatitis C. Hepatology 41(6): 1365-75, Jun 2005.
Sugimoto K., Kaplan DE., Ikeda F., Ding J., Schwartz J., Nunes FA., Alter HJ., Chang KM.: Strain-specific T-cell suppression and protective immunity in patients with chronic hepatitis C virus infection. Journal of Virology 79(11): 6976-83, Jun 2005.
