Anil K. Rustgi, M.D.
T. Grier Miller Professorship of Medicine
Chief
Director
Co-Director
Department: Medicine
Graduate Group Affiliations
Contact information
415 Curie Boulevard
600 CRB
Philadelphia, PA 19104
600 CRB
Philadelphia, PA 19104
Office: 215-898-0154
Fax: 215-573-5412
Fax: 215-573-5412
Email:
anil2@mail.med.upenn.edu
anil2@mail.med.upenn.edu
Publications
Links
Search PubMed for articles
Gastroenterology Website
Center for Molecular Studies in Digestive and Liver Diseases
Digestive and Liver Center
Search PubMed for articles
Gastroenterology Website
Center for Molecular Studies in Digestive and Liver Diseases
Digestive and Liver Center
Education
B.S. (Molecular Biochemistry & Biophysics)
Yale University, New Haven, CT, 1980.
M.D. (Medicine)
Duke University, Durham, NC, 1984.
(Medical Internship)
Medical Internship, Beth Israel Hospital/Harvard Medical School, 1985.
(Medical Resident)
Beth Israel Hospital/Harvard Medical School, 1987.
(Chief Medical Resident)
Beth Israel Hospital/Brockton VA, Harvard Medical School , 1987.
(Clinical and Research Fellow in Gastroenterology)
Massachusetts General Hospital, Harvard Medical School, 1990.
Permanent linkB.S. (Molecular Biochemistry & Biophysics)
Yale University, New Haven, CT, 1980.
M.D. (Medicine)
Duke University, Durham, NC, 1984.
(Medical Internship)
Medical Internship, Beth Israel Hospital/Harvard Medical School, 1985.
(Medical Resident)
Beth Israel Hospital/Harvard Medical School, 1987.
(Chief Medical Resident)
Beth Israel Hospital/Brockton VA, Harvard Medical School , 1987.
(Clinical and Research Fellow in Gastroenterology)
Massachusetts General Hospital, Harvard Medical School, 1990.
Description of Research Expertise
Research InterestsOncogenes, tumor suppressor genes, molecular genetics of GI cancers (colon, pancreatic, upper GI)
Key words: Cancers: esophageal, pancreatic, colon Oncogenes: EGFR, cyclin D1, Ki-Ras Organotypic culture
Description of Research
Our laboratory has had long-standing thematic interests in the cell-type and tissue-type specific actions of certain oncogenes (cyclin D1, Ki-Ras, EGFR) and tumor suppressor genes (p53, p16INK4a) in modulating the initiation, progression and invasion of gastrointestinal cancers, especially upper GI, pancreatic and colon. To that end, we employ novel three-dimensional cell culture systems (mouse and human origins) and geneticaly-engineered mouse models to investigate molecular mechanisms. These projects are translated into the objectives of improving molecular diagnostics and experimental therapeutics in patients.
Our research is funded through an NCI program project entitled "Mechanisms of Esophageal Carcinogenesis", NIH R01 grant on pancreatic cancer, and NIH R01 grant on colon cancer. Students and postdoctoral fellows are supported in didactic venues and conferences, present at national meetings, and have obtained national grant fellowships when applicable.
Rotation Projects for 2007-2008
1. To understand the role of oncogenes (EGFR, cyclin D1, Ras) and tumor suppressor genes (p53, p120catenin) in the tumor microenvironment as they relate to tumor cell migration and invasion in GI cancers, using organotypic culture and mouse models.
2. To define mechanisms underlying cell lineage during pancreatic development and cancer
3. To functionally characterize novel suppressor genes in colon and breast cancers.
4. To functionally characterize stem cells in the upper GI tract.
Lab personnel:
Claudia Andl, PhD, Research Associate(recipient of NIH K01 grant and AGA Research Scholar Award)
Cameron Johnstone, PhD, Research Investigator (recipient of American Association for Cancer Research fellowship and Department of Defense grant)
James Lee, BA, Research Specialist
Jiri Kalabis, MD, Postdoctoral fellow
Carmen Z. Michaylira, PhD, Postdoctoral fellow (recipient of NIH NRSA fellowship)
Perry Mongroo, PhD, Posdoctoral fellow
Hiroshi Nakagawa, MD, PhD, Research Assistant Professor (recipient of NIH K01 grant and AGA Research Scholar Award)
Ben Rhoades, M.B., Research specialist and lab manager
Doug Stairs, PhD, Postdoctoral fellow (recipient of NIH NRSA fellowship)
Johannes von Burstin, MD, Postdoctoral fellow
Melanie P. Wescott, PhD, Postdoctoral fellow (recipient of National Pancreas Foundation fellowship)
Daniel Abravanel, University of Pennsylvania, Rotating MD, PhD Student
Charles Miller, University of Pennsylvania, Undergraduate student
Anna-Sophie Rich, University of Pennsylvania, Medical Student
Selected Publications
Okawa, T., Michaylira, C.Z., Kalabis, J., Stair, D., Nakagawa, H., Andl, C., Claudia, D., Johnstone, C.N., Andres, J., Klein-Szanto, A.J., El-Deiry, W.S., Cukierman, E., Herlyn, M., Rustgi, A.K.: The functional interplay between EGFR overexpression, hTERT activation and p53 mutation in esophageal epithelial cells with activation of stromal fibroblasts induce tumor development, invasion and differentiation. Genes & Development (in Press), 2007.Deramaudt TB, Takaoka M, Upadhyay R, Bowser MJ, Porter J, Lee A, Rhoades B, Johnstone CN, Weissleder R, Hingorani SR, Mahmood U, Rustgi AK: N-cadherin and keratinocyte growth factor receptor mediate the functional interplay between Ki-RASG12V and p53V143A in promoting pancreatic cell migration, invasion, and tissue architecture disruption. Mol Cell Biol 26(11): 4185-4200, June 2006.
Andl CD., Mizushima T., Nakagawa H., Oyama K., Harada H., Chruma K., Herlyn M., Rustgi AK.: Epidermal growth factor receptor mediates increased cell proliferation, migration, and aggregation in esophageal keratinocytes in vitro and in vivo. Journal of Biological Chemistry 278(3): 1824-30, Jan 17 2003.
Opitz O.G., Harada H., Suliman Y., Rhoades B., Sharpless N.E., Kent R., Kopelovich L., Nakagawa H., Rustgi A.K.: A mouse genetic model of human oral-esophageal cancer. Journal of Clinical Investigation 110: 761-769, 2002.
