John Chang, M.D.
Instructor A of Medicine
Instructor of Medicine
Department: Medicine
Contact information
663 Clinical Research Building
415 Curie Blvd.
Philadelphia, PA 19104
415 Curie Blvd.
Philadelphia, PA 19104
Office: 215-746-5543
Email:
john.chang@uphs.upenn.edu
john.chang@uphs.upenn.edu
Education
B.S (Biological Sciences)
Stanford University , 1995.
M.D.
Temple University School of Medicine, 2001.
B.S (Biological Sciences)
Stanford University , 1995.
M.D.
Temple University School of Medicine, 2001.
Post-Graduate Training
Fellow in Gastroenterology, Hospital of the University of Pennsylvania, 2004-2007.
Postdoctoral Fellow, Steven Rainer, MD, Abramson Family Cancer Research Institute, University of Pennsylvania, 2005-.
Intern and Resident , Hospital of the University of Pennsylvania, 2001-2004.
Permanent linkFellow in Gastroenterology, Hospital of the University of Pennsylvania, 2004-2007.
Postdoctoral Fellow, Steven Rainer, MD, Abramson Family Cancer Research Institute, University of Pennsylvania, 2005-.
Intern and Resident , Hospital of the University of Pennsylvania, 2001-2004.
Selected Publications
Chang, J.T. and Reiner, S.L.: Diversifying Helper T Cell Fates During Immunity. Journal of Pediatric Gastroenterology and Nutrition 46 Suppl: E19-E20, 2008.Chang, J.T., Palanivel, V.R., Kinjyo, I., Schambach, F., Intlekofer, A.M., Banerjee, A., Longworth, S., Vinup, V.E., Mrass P., Oliaro J., Killeen, N., Orange J., Russell S.M., Weninger, W., and Reiner, S.L.: Asymmetric T Lymphocyte Division in the Initiation of Adaptive Immune Responses. Science 315: 1687-1691, March 2007.
Chang, J.T. and Reiner, S.L.: Protection One Cell Thick. Immunity 27: 832-834, 2007.
Chang, J.T. and Lichtenstein, G.R. : Drug Insight: Antagonists of Tumor Necrosis Factor-alpha in the Treatment of Inflammatory Bowel Disease. Nature Clinical Practice Gastroenterology and Hepatology 3: 220-228, 2006.
Chang, J.T. and Katzka, D.A. : Gastroesophageal reflux disease, Barrett’s esophagus and esophageal adenocarcinoma: a review. Archives of Internal Medicine 164: 1482-1488, 2004.
B.M. Segal, Chang, J.T., and Shevach, E.M. : CpG Oligonucleotides are Potent Adjuvants for the Activation of Autoreactive Encephalitogenic T cells in Vivo. Journal of Immunology 164: 5683-5688, 2000.
Chang, J.T., B.M. Segal, B.M. Segal, Nakanishi, K., Okamura, H., and Shevach, E.M. : The Costimulatory Effect of IL-18 on the Induction of Antigen-specific Interferon Production by Resting T cells is IL-12 Dependent and is Mediated by Upregulation of the IL-12 Receptor b2 Subunit. European Journal of Immunology 30(4): 1113-1119, 2000.
Chang, J.T., Shevach, E.M., and Segal, B.M. : Role of Costimulation in the Induction of the IL-12/IL-12 Receptor Pathway and the Development of Autoimmunity. Journal of Immunology 164: 100-106, 2000.
Gurunathan, S., Stobie, L., Prussin, C., Sacks, D.L., Glaichenhaus, N., Fowell, D.J., Locksley, R.M., Chang, J.T., Wu, C., and Seder, R.A.: Requirements for the maintenance of Th1 immunity in vivo following DNA vaccination: A potential immunoregulatory role for CD8+ T cells. Journal of Immunology 165: 915-924, 2000.
Chang, J.T., Shevach, E.M., and Segal, B.M. : Regulation of IL-12 Receptor b2 Subunit Expression by Endogenous IL-12: A Critical Step in the Differentiation of Pathogenic Autoreactive T Cells Journal of Experimental Medicine 189: 969-978, 1999.
