Jonathan P. Katz, M.D.
Assistant Professor of Medicine
Director, Undergraduate Student Scholars Program, Gastroenterology Division
Director, Morphology Core, NIH Center for Molecular Studies in Digestive and Liver Diseases
Associate Director, Gastroenterology Fellowship Program
Member, Abramson Cancer Center
Department: Medicine
Graduate Group Affiliations
Contact information
600 Clinical Research Building
415 Curie Blvd.
Philadelphia, PA 19104-6140
415 Curie Blvd.
Philadelphia, PA 19104-6140
Office: 215-746-7780
Fax: 215-573-2024
Fax: 215-573-2024
Email:
jpkatz@mail.med.upenn.edu
jpkatz@mail.med.upenn.edu
Publications
Links
Search PubMed for articles
CAMB Faculty Page
Center for Molecular Studies in Digestive and Liver Diseases
Search PubMed for articles
CAMB Faculty Page
Center for Molecular Studies in Digestive and Liver Diseases
Education:
A.B. (Chemistry)
Columbia University, Columbia College , 1988.
M.D.
University of Chicago, Pritzker School of Medicine, 1993.
A.B. (Chemistry)
Columbia University, Columbia College , 1988.
M.D.
University of Chicago, Pritzker School of Medicine, 1993.
Post-Graduate Training
Internship, Internal Medicine , Hospital of the University of Pennsylvania, 1993-1994.
Residency, Internal Medicine , Hospital of the University of Pennsylvania, 1994-1995.
Fellowship, Gastroenterology , Hospital of the University of Pennsylvania, 1995-1999.
Permanent linkInternship, Internal Medicine , Hospital of the University of Pennsylvania, 1993-1994.
Residency, Internal Medicine , Hospital of the University of Pennsylvania, 1994-1995.
Fellowship, Gastroenterology , Hospital of the University of Pennsylvania, 1995-1999.
Description of Research Expertise
Research InterestsFunctional analysis of gastrointestinal development, proliferation, and differentiation.
Key words: Klf4, Klf5, esophagus, intestine, gastrointestinal, epithelia, proliferation, differentiation.
Description of Research
My research focuses on the functional analysis of gastrointestinal development, proliferation, and differentiation. Recently, my laboratory has concentrated on Klf4 and Klf5, two related Krüppel-like factor (KLF) family members expressed in the gastrointestinal epithelia. Klf4 and Klf5 are important regulators of cellular proliferation and differentiation both in vitro and in vivo. Expression patterns and biochemical evidence suggest that Klf4 and Klf5 have complementary roles in regulating gastrointestinal morphogenesis, proliferation, and differentiation, by binding to identical cis-regulatory elements. While Klf4 negatively regulates proliferation and promotes cellular differentiation, Klf5 has been implicated as a positive regulator of cell proliferation with transforming properties in vitro.
Using tissue-specific gene ablation and transgenic approaches, we have generated a number of mouse models to investigate the function of Klf4 and Klf5 in development and gastrointestinal epithelial homeostasis in vivo. These mouse models are complemented by novel in vitro model systems, using primary esophageal cells in two-dimensional culture and three-dimensional organotypic culture. These experiments allow us to dissect the molecular mechanisms regulating gastrointestinal epithelial homeostasis, including the role of epithelial-mesenchymal interactions. Using these new in vitro and in vivo models, we are examining the specific factors which control the balance between proliferation and differentiation in gastrointestinal epithelia and the elements which disrupt this balance during mucosal injury and carcinogenesis
Rotation Projects
Rotation projects are available and generally focus on the regulation of epithelial proliferation, differentiation, and tumorigenesis by KLF4 and KLF5 using both mouse and cell culture models. Other projects may be available as well. Please feel free to contact me to find out all current research opportunities available in my laboratory.
Laboratory Personnel
Yizeng Yang, Senior Research Investigator;
Marie-Pier Tetreault, Postdoctoral Fellow;
Junsuke Maki, Gastroenterology Fellow;
Jenna Travis, Research Specialist;
Cassie Xu, Research Specialist
Selected Publications
Katz, J.P., Perreault, N., Goldstein, B.G., Lee, C.S., Labosky, P.A., Yang, V.W., Kaestner, K.H. : The zinc-finger transcription factor Klf4 is required for terminal differentiation of goblet cells in the colon. Development 129: 2619-2628, 2002.14. Katz, J.P., Perreault, N., Goldstein, B.G., McNally, S.R., Silberg, D.G., Furth, E.E., Kaestner, K.H. : Loss of Klf4 in mice causes altered proliferation and differentiation and precancerous changes in the adult stomach. Gastroenterology 128: 935-45, 2005.
Yang, Y., Goldstein, B.G., Chao, H., Katz, J.P.: KLF4 and KLF5 regulate proliferation, apoptosis, and invasion in esophageal cancer cells. Cancer Biology and Therapy 4: 1216-21, 2005.
Goldstein BG, Chao H, Yang Y, Yermolina Y, Tobia JW, Katz JP: Overexpression of Krüppel-like factor 5 in esophageal epithelia in vivo leads to increased proliferation in basal but not suprabasal cells. Am J Physiol Gastrointest Liver Physiol 292: G1784-92, 2007.
Yang Y, Goldstein BG, Nakagawa H, Katz JP: Krüppel-like factor 5 activates MEK/ERK signaling via EGFR in primary squamous epithelial cells. FASEB Journal 21: 543-50, 2007.
Yang, Y., Tetreault, M.P., Yermolina, Y., Goldstein, B.G., Katz, J.P.: Krüppel-like factor 5 controls keratinocyte migration via the integrin-linked kinase. J Biol Chem 283: 18812-20, 2008.
