Division of Hematology/Oncology

Faculty

faculty photo

Charles S. Abrams, M.D.

Professor of Medicine
Associate Chief, Hematology-Oncology, University of Pennsylvania School of Medicine
Director, Blood Center at PENN/CHOP
Department: Medicine

Contact information
912 BRB II/III
421 Curie Blvd.
Philadelphia, PA 19104
Office: (215) 573-3288
Education:
B.E.S. (Bioengineering)
The Johns Hopkins University, 1980.
M.D. (Medicine)
Yale University School of Medicine, 1984.
Post-Graduate Training
Intern in Medicine, Temple University Hospital, Philadelphia, 1984-1985.
Resident in Medicine, Hospital of the University of Pennsylvania, PA, 1985-1987.
Fellowship, Hematology-Oncology, Hospital of the University of Pennsylvania, PA , 1987-1991.
Certifications
American Board of Internal Medicine, 1987.
American Board of Internal Medicine, Oncology Subspecialty, 1989.
American Board of Internal Medicine, Hematology Subspecialty, 1990.
American Board of Internal Medicine, Recertification in Hematology Subspecialty , 2005.
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Description of Research Expertise

Research Interests

Phospholipid signaling in platelet and T-cells.

Key words: Pleckstrin, PH domains, cytoskeleton.

Description of Research

Inappropriate platelet activation contributes to vascular diseases including stroke and myocardial ischemia. Our laboratory is focused on phospholipid signaling in platelets and its contribution to inappropriate platelet activation. Ongoing projects are directed at understanding the roles of pleckstrin and lipid kinases in platelets. Pleckstrin (p47) was once solely known as an early marker of platelet activation; more recently it has been noted to contain the prototypic Pleckstrin Homology motif. Over the past half dozen years, work derived from our laboratory has demonstrated that pleckstrin plays a dominant role in the reorganization of the platelet, and lymphocyte, cytoskeleton. Furthermore, our laboratory has established these effects are regulated by pleckstrin phosphorylation, require critical lipid-binding residues contained with the amino-terminal Pleckstrin Homology domain, and have implicated an effector for this process to be the small GTP-binding protein, Rac. Additional work from our laboratory has helped define the role of phospholipid kinases in the pathway that is initiated by G-protein coupled receptors and ultimately leads to actin reorganization. Our studies use molecular and cellular biologic techniques to examine blood cell biology, and involve expression mutagenesis, single cell microinjection, genetic library screening, and murine homologous gene targeting ("gene knock-out").

Rotation projects

pleckstrin2 and actin assembly
PIP5K Ig and focal adhesions

Lab personnel:
Andrew Louden - Postdoctoral Fellow
Feng Wang - Postdoctoral Fellow
Seun-Ah Yang - Postdoctoral Fellow
Tami Bach - Postdoctoral Fellow
Michael Hu - Technician
Lurong Lian - Technician
Qing Chen - Undergraduate Student

Selected Publications

Wang, Y., Chen, X., Lian, L., Bach, T.L., Golden, J., Morrisey, E.M., Abrams, C.S.: PIP5Kγ is required for cardiovascular and neuronal development. Proceedings of the National Academy of Science (U.S.A.) 104(28): 11748-53, 2007 Notes: Track II.

Trivedi, C.M., Luo, Y., Yin, Z., Zhang, M., Floss, T., Goettlicher, M., Ruiz, P., Wurst, W., Ferrari, V., Abrams, C.S., Gruber, P., Epstein, J.A.: HDAC2 regulates the cardiac hypertrophic response by modulating GSK3β activity. Nature Medicine 13: 324-331, 2007.

Wang, Y., Chen, X., Lian, L., Tang, T., Stalker, T.J., Sasaki, T., Brass, L.F., Choi, J.K., Hartwig, J.H., Abrams, C.S.: Loss of PIP5KIβ demonstrates that rapid PIP2 synthesis is required for IP3 formation. Proceedings of the National Academy of Science (U.S.A.) 105: 14064-14069, 2008 Notes: Track II.

Pan, W., Choi, S.-C., Wang, H., Qin, Y., Volpicelli-Daley, L., Swan, L., Lucast, L., Khooo, C., Zhang, X., Li, L., Abrams, C.S., Sokol, S.Y., Wu, D.: Wnt3a-mediated formation of phosphatidylinositol 4,5-bisphosphate regulates LRP6 phosphorylation. Science 321: 1350-1353, 2008.

Wang, Y., Litvinov, R.I., Chen, X., Lian, L., Bach, T.L., Petrich, B., Monkley, S., Critchley, D., Birnbaum, M.J., Weisel, J.W., Hartwig, J.H., Abrams, C.S.: Loss of PIP5Kγ, but not PIP5Kβ, impairs the integrity of the membrane cytoskeleton. J. Clinical Investigation 118(2): 812-819, 2008.

Mao, Y.S., Yamaga, M., Zhu, X., Wei, M., Sun, H.-Q., Wang, J., Yun, M., Wang, Y., Di Paolo, G., Bennett, M., Mellman, I.S., Abrams, C.S., De Camilli, P.V., Lu, C.Y., and Yin, H.L.: Essential and unique roles of PIP5Kγ and α in Fcγ receptor-mediated phagocytosis J. Cell Biology Journal of Cell Biology 184: 281-296, 2009.

Lian, L., Wang, W., Flick, M., Choi, J., Scott, E., Degen, J., Lemmon, M.A., Abrams, C.S.: Loss of pleckstrin defines a novel pathway for PKC-mediated exocytosis. Blood In press, 2009.

Min, S.H., Abrams, C.S.: Why do phosphatidylinositol kinases have so many isoforms? Biochemical J 423(1): 99-108, 2009.

Volpicelli-Daley, L.A., Lucast, L., Gong, L.-W., Liu, L., Sasaki, J., Sasaki, T., Abrams, C.S., Kanaho, Y., De Camilli, P.: Phosphatidylinositol 4-phosphate 5-kinases (PIPKIs) and phosphatidylinositol 4,5 bisphosphate [PI(4,5)P2] synthesis in the brain. J. Biologic Chemistry Page: 28708-14, 2010.

Mitsios, J.V., Prévost, N., Kasirer-Friede, A., Gutierrez, E., Groisman, A., Abrams, C.S., Litvinov, R.I., Zemljic-Harpf, A., Ross, R.S., Shattil, S., J.: What is vinculin needed for in platelets? J. Thrombosis & Haemostasis Page: 2294-2304, 2010.

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Last updated: 12/29/2013
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