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Joel S. BennettProfessor of Medicine
Department: Medicine
Contact information
914 BRB II/III
421 Curie Drive/6160 Philadelphia, PA 19104
Office: (215) 573-3280
Fax: (215) 573-7039 Email: BENNETTS@MAIL.MED.UPENN.EDU
Graduate Group Affiliations
Publications
Education:
University of Michigan , 1963. M.D. (Medicine) University of Michigan, 1967.
Post-Graduate Training
Intern in Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA , 1967-1968. Resident in Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, 1968-1970. Fellow in Hematology, Hospital of the University of Pennsylvania, Philadelphia, PA, 1970-1971. Fellow in Hematology , Hospital of the University of Pennsylvania, Philadelphia, PA, 1973-1975.
Certifications
Permanent linkAmerican Board of Internal Medicine, 1974. American Board of Internal Medicine (Hematology), 1974. Description of Research ExpertiseIntegrin function is essential for normal platelet adhesion and aggregation and participates i n the formation of the arterial thrombi that are responsible for heart attacks and strokes. The activation state of platelet integrins is regulated by platelet agonists, but the structural basis for this regulation is not known. Our studies indicate that helix-helix interactions involving the transmembrane and membrane-proximal cytoplasmic domain segments play an essential role in regulating the function of both beta 1 and beta 3 integrins. The current focus of the laboratory is to use biophysical and molecular biologic techniques to characterize these interactions in detail and to use this information to design potential anti-thrombotic agents.Selected PublicationsLi, R., Hoess, R.H., Bennett, J.S., and DeGrado, W.F. : Use of phage display to probe the evolution of binding specificity and affinity in integrins. Protein Engineering 16: 65-72, 2003.Paul, B.Z.S., Vilaire, G., Kunapuli, S.P., and Bennett, J.S. : Concurrent signaling from Galphaq- and Galphai-coupled pathways is essential for agonist-induced alphavbeta3 activation on human platelets. J. Haemost. Thromb. 1: 814-820, 2003. Li, R., Mitra, N., Gratkowski, H., Vilaire, G., Litvinov, R.I., Nagaswami, C., Weisel, J.W., Lear, J.D., DeGrado, W.F., and Bennett, J.S. : Activation of integrin alphaIIbbeta3 by modulation of transmembrane helix associations. Science 300: 795-798, 2003. Litvinov, R.I., Vilaire, G., Shuman, H., Bennett, J.S., and Weisel, J.W. : Quantitative analysis of platelet alphavbeta3 binding to osteopontin using laser tweezers. J. Biol. Chem. 278: 51285-51290, 2003. Litvinov, R.I., Shuman, H., Bennett, J.S., and Weisel, J.W. : Intermolecular forces between fibrinogen-integrin pairs measured by laser tweezers Proc. Natl. Acad. Sci., USA 99: 7426-7431 2002. Li, R., Babu, C.R., Valentine, K., Lear, J.D., Wand, A.J., Bennett, J.S., and DeGrado, W.F. : Characterization of the monomeric form of the transmembrane and cytoplasmic domains of the integrin beta3 subunit by NMR spectroscopy. Biochemistry 41: 15618-15624, 2002. Bennett, J.S., Catella-Lawson, F., Rut, A.R., Vilaire, G., Qi, W.. Kapoor, S.C., Murphy, S., and FitzGerald, G. : The PlA2 alloantigen does not alter the function of beta3 integrins in platelets. Blood 97: 3093-3099, 2001. Basani, R., D¡¦Andrea, G., Mitra, N., Vilaire, G., Richberg, M., Kowalska, M.A., Bennett, J.S., and Poncz, M.: RGD-containing peptides inhibit fibrinogen binding to platelet alphaIIbbeta3 by inducing an allosteric change in the amino terminal portion of alphaIIb, J. Biol. Chem. 276 : 13975-13981, 2001. Li, R., Babu, C.R., Lear, J.D., Wand, A.J., Bennett, J.S., and DeGrado, W.F. : Oligomerization of the integrin alphaIIb beta3: Roles of the transmembrane and cytoplasmic domains Proc. Natl. Acad. Sci., USA 98: 12462-12467, 2001. Shattil, S.J., Abrams, C.S. and Bennett, J.S. : Acquired disorder of platelet function. Hematology Beutler, E., Lichtman, M.A., Coller, B.S., and Kipps, T.J. (eds.). Sixth Edition, McGraw-Hill Book Co., New York Page: 1583-1602, 2001.
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