Dr. Weissman's laboratory focuses on the study of RNA and innate immune system biology and the application of these findings to vaccine research and gene therapy. There are three main projects in his laboratory. The first project began through the use of mRNA encoding antigen as a delivery system to load dendritic cells to promote broad immune responses as part of a vaccine. This project has expanded to include basic studies of RNA immunogenicity and translation and the development of applications for gene therapy. The second project develops new HIV envelope immunogens that can induce broad responses and cross-reactive neutralizing antibodies. The third project continues previous studies that identified a protein found on DC, macrophages, and epithelial cells that binds HIV envelope with high affinity. The main focus of this project is testing whether this and related molecules function in vivo to promote HIV genital tract infection.
Weissman D, Karikó K: mRNA: Fulfilling the Promise of Gene Therapy. Molecular therapy : the journal of the American Society of Gene Therapy 23(9): 1416-7, Sep 2015.
Castellano Laura M, Hammond Rebecca M, Holmes Veronica M, Weissman Drew, Shorter James: Epigallocatechin-3-gallate rapidly remodels PAP85-120, SEM1(45-107), and SEM2(49-107) seminal amyloid fibrils. Biology open 4(9): 1206-12, Aug 2015.
Castellano Laura M, Bart Stephen M, Holmes Veronica M, Weissman Drew, Shorter James: Repurposing Hsp104 to Antagonize Seminal Amyloid and Counter HIV Infection. Chemistry & biology 22(8): 1074-86, Aug 2015.
Pardi Norbert, Tuyishime Steven, Muramatsu Hiromi, Kariko Katalin, Mui Barbara L, Tam Ying K, Madden Thomas D, Hope Michael J, Weissman Drew: Expression kinetics of nucleoside-modified mRNA delivered in lipid nanoparticles to mice by various routes. Journal of controlled release : official journal of the Controlled Release Society Aug 2015.
Ravimohan Shruthi, Tamuhla Neo, Steenhoff Andrew P, Letlhogile Rona, Nfanyana Kebatshabile, Bellamy Scarlett L, MacGregor Rob Roy, Gross Robert, Weissman Drew, Bisson Gregory P: Immunological profiling of tuberculosis-associated immune reconstitution inflammatory syndrome and non-immune reconstitution inflammatory syndrome death in HIV-infected adults with pulmonary tuberculosis starting antiretroviral therapy: a prospective observational cohort study. The Lancet. Infectious diseases 15(4): 429-38, Apr 2015.
Knudsen Christelle, Combes Sylvie, Briens Christophe, Duperray Joël, Rebours Gwenaël, Salaun Jean-Marc, Travel Angélique, Weissman Delphine, Gidenne Thierry, Oswald Isabelle P: Quantitative feed restriction rather than caloric restriction modulates the immune response of growing rabbits. The Journal of nutrition 145(3): 483-9, Mar 2015.
Lump Edina, Castellano Laura M, Meier Christoph, Seeliger Janine, Erwin Nelli, Sperlich Benjamin, Stürzel Christina M, Usmani Shariq, Hammond Rebecca M, von Einem Jens, Gerold Gisa, Kreppel Florian, Bravo-Rodriguez Kenny, Pietschmann Thomas, Holmes Veronica M, Palesch David, Zirafi Onofrio, Weissman Drew, Sowislok Andrea, Wettig Burkhard, Heid Christian, Kirchhoff Frank, Weil Tanja, Klärner Frank-Gerrit, Schrader Thomas, Bitan Gal, Sanchez-Garcia Elsa, Winter Roland, Shorter James, Münch Jan: A molecular tweezer antagonizes seminal amyloids and HIV infection. eLife 4, 2015.
Li Minghong, Holmes Veronica, Ni Houping, Sanzari Jenine K, Romero-Weaver Ana L, Lin Liyong, Carabe-Fernandez Alejandro, Diffenderfer Eric S, Kennedy Ann R, Weissman Drew: Broad-spectrum antibiotic or G-CSF as potential countermeasures for impaired control of bacterial infection associated with an SPE exposure during spaceflight. PloS one 10(3): e0120126, 2015.
Boros Gábor, Miko Edit, Muramatsu Hiromi, Weissman Drew, Emri Eszter, van der Horst Gijsbertus T J, Szegedi Andrea, Horkay Irén, Emri Gabriella, Karikó Katalin, Remenyik Éva: Identification of Cyclobutane Pyrimidine Dimer-Responsive Genes Using UVB-Irradiated Human Keratinocytes Transfected with In Vitro-Synthesized Photolyase mRNA. PloS one 10(6): e0131141, 2015.
Patyka Mariia, Malamud Daniel, Weissman Drew, Abrams William R, Kurago Zoya: Periluminal Distribution of HIV-Binding Target Cells and Gp340 in the Oral, Cervical and Sigmoid/Rectal Mucosae: A Mapping Study. PloS one 10(7): e0132942, 2015.
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Last updated: 10/31/2016
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