HIV care, general infectious disease care
We study the basic mechanisms of transmission, pathogenesis and persistence in HIV and other chronic viral infections.
Current projects include:
1. The HIV transmission bottleneck and virus phenotype in injection drug users
2. The viral dynamics of rebound viremia upon cART interruption, both in the presence and absence of treatment and curative strategies
3. The neutralization properties of SIV challenge swarms and their transmitted/founder viruses
4. The genetic signatures of Herpes Simplex Virus immune escape from vaccine pressure
Benjamin Scheinfeld, technician
D. Brenda Salantes, graduate student
Bar KJ, Sneller MC, Harrison LJ, Justement SJ, Overton ET, Petrone ME, Salantes BD, Seamon CA, Scheinfeld B, Kwan RW, Learn GH, Proschan MA, Kreider EF, Bazkova J, Bardsley M, Refsland EW, Messer M, Clarridge KE, Tustin NB, Madden PJ, Oden KS, O'Dell SJ, Jarocki B, Shiakolas AR, Tressler RL, Doria-Rose NA, Bailer RT, Ledgerwood JE, Capparelli EV, Lynch RM, Graham BS, Moir S, Koup RA, Mascola JR, Hoxie JA, Fauci AS, Tebas P, Chun T-W: Effect of HIV Antibody VRC01 on Viral Rebound after Treatment Interruption. NEJM 375(21): 2037-2050, November 24 2016.
Lopker MJ, Del Prete GQ, Estes JD, Li H, Reid C, Newman L, Lipkey L, Camus C, Easlick JL, Wang S, Decker JM, Bar KJ, Learn G, Pal R, Weiss DE, Hahn BH, Lifson JD, Shaw GM, Keele BF: Derivation and Characterization of Pathogenic Transmitted/Founder Molecular Clones from Simian Immunodeficiency Virus SIVsmE660 and SIVmac251 following Mucosal Infection. Journal of virology 90(19): 8435-53, Oct 2016.
Salazar-Gonzalez JF, Salazar MG, Tully DC, Ogilvie CB, Learn GH, Allen TM, Heath SL, Goepfert P, Bar KJ: Use of dried blood spots to elucidate full-length transmitted/founder HIV-1 genomes. Pathogens and Immunity 1(1): 129-153, July 2016.
Jiao Y, Zhang X, Wang C, Li L, Liu J, Bar KJ, Wei H, Hu Y, Huang P, Zeng Z, Jiang S, Du J, Shao Y, Metzger D, Li S, Ma L: Hepatitis C Virus Subtype and Evolution Characteristic Among Drug Users, Men Who Have Sex With Men, and the General Population in Beijing, China. Medicine 95(6): e2688, Feb 2016.
Lee FH, Mason R, Welles H, Learn GH, Keele BF, Roederer M, Bar KJ: Breakthrough virus neutralization resistance as a correlate of protection in a nonhuman primate heterologous SIV vaccine challenge study. J Virol 89(24): 12388-400, Dec 2015.
Sterret S, Edlefsen PT, Learn GH, Haynes BF, Hahn BH, Shaw GM and Bar KJ: Low multiplicity of HIV-1 infection and no vaccine enhancement in VAX003 injection drug users. Open Forum Infect Dis 1(2): ofu056, Sept 2014.
Li H, Blair L, Chen Y, Learn G, Pfafferott K, John M, Bhattacharya T, Hahn BH, Mallal S, Shaw GM, Bar KJ: Molecular mechanisms of HIV-1 prophylaxis failure revealed by single genome sequencing. J Inf Dis 208(10): 1598-1603, November 2013.
Lopker M, Easlick J, Sterrett S, Decker JM, Barbian, Learn G, Keele BF, Robinson JE, Li H, Hahn BH, Shaw GM and Bar KJ : Heterogeneity in neutralization sensitivity of viruses comprising the simian immunodeficiency virus SIVsmE660 isolate and vaccine challenge stock. J Virol 87(10): 5477-92, May 2013.
Song H, Pavlicek JW, Cai F, Bhattacharya T, Li H, Iyer SS, Bar KJ, Decker JM, Goonetilleke N, Liu MK, Berg A, Hora B, Drinker MS, Eudailey J, Pickeral J, Moody MA, Ferrari G, McMichael A, Perelson AS, Shaw GM, Hahn BH, Haynes BF, Gao F: Impact of immune escape mutations on HIV-1 fitness in the context of the cognate transmitted founder/genome. Retrovirology 9(89): 1742-4690, Oct 2012.
Bar KJ, Tsao C, Iyer SS, Decker JM, Yang Y, Bonsignori M, Chen X, Hwang K, Montefiori DC, Liao H, Hraber P, Fischer W, Li H, Wang S, Sterett S, Keele BF, Ganusov VV, Perelson AS, Korber BT, Georgiev I, McLellan JS, Pavlicek JW, Gao F, Haynes BF, Hahn BH, Kwong PD, and Shaw GM: Early Low-Titer Neutralizing Antibodies Impede HIV-1 Replication and Select for Virus Escape. PLoS Pathogens 8(5): e1002721, May 2012.
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Last updated: 01/12/2017
The Trustees of the University of Pennsylvania