HIV care, general infectious disease care
We study the basic mechanisms of transmission, pathogenesis and persistence in HIV and other chronic viral infections.
Current projects include:
1. The HIV transmission bottleneck and virus phenotype in injection drug users
2. The viral dynamics of rebound viremia upon cART interruption, both in the presence and absence of treatment and curative strategies
3. The neutralization properties of SIV challenge swarms and their transmitted/founder viruses
4. The genetic signatures of Herpes Simplex Virus immune escape from vaccine pressure
Benjamin Scheinfeld, technician
D. Brenda Salantes, graduate student
Lee FH, Mason R, Welles H, Learn GH, Keele BF, Roederer M, Bar KJ: Breakthrough virus neutralization resistance as a correlate of protection in a nonhuman primate heterologous SIV vaccine challenge study. Journal of Virology 2015.
Sterret S, Edlefsen PT, Learn GH, Haynes BF, Hahn BH, Shaw GM and Bar KJ: Low multiplicity of HIV-1 infection and no vaccine enhancement in VAX003 injection drug users. Open Forum Infect Dis 1(2), 2014.
Li H, Blair L, Chen Y, Learn G, Pfafferott K, John M, Bhattacharya T, Hahn BH, Mallal S, Shaw GM and Bar KJ: Molecular mechanisms of HIV-1 prophylaxis failure revealed by single genome sequencing. J Inf Dis 208(10): 1598-1603, November 2013.
Lopker M, Easlick J, Sterrett S, Decker JM, Barbian, Learn G, Keele BF, Robinson JE, Li H, Hahn BH, Shaw GM and Bar KJ : Heterogeneity in neutralization sensitivity of viruses comprising the simian immunodeficiency virus SIVsmE660 isolate and vaccine challenge stock. J Virol 87(10): 5477-92, May 2013.
Song H, Pavlicek JW, Cai F, Bhattacharya T, Li H, Iyer SS, Bar KJ, Decker JM, Goonetilleke N, Liu MK, Berg A, Hora B, Drinker MS, Eudailey J, Pickeral J, Moody MA, Ferrari G, McMichael A, Perelson AS, Shaw GM, Hahn BH, Haynes BF, Gao F: Impact of immune escape mutations on HIV-1 fitness in the context of the cognate transmitted founder/genome. Retrovirology 9(89): 1742-4690, Oct 2012.
Bar KJ, Tsao C, Iyer SS, Decker JM, Yang Y, Bonsignori M, Chen X, Hwang K, Montefiori DC, Liao H, Hraber P, Fischer W, Li H, Wang S, Sterett S, Keele BF, Ganusov VV, Perelson AS, Korber BT, Georgiev I, McLellan JS, Pavlicek JW, Gao F, Haynes BF, Hahn BH, Kwong PD, and Shaw GM: Early Low-Titer Neutralizing Antibodies Impede HIV-1 Replication and Select for Virus Escape. PLoS Pathogens 8(5): e1002721, May 2012.
Liao H, Chen X, Munshaw S, Zhang R, Marshall DJ, Vandergrift N, Whitesides JF, Lu X, Yu J, Hwang K, Gao F, Markowitz M, Heath SL, Bar KJ, Goepfert P, Montefiori D, Shaw GM, Alam M, Margolis D, Denny TN, Boyd SD, Marshal E, Egholm M, Simen B, Hanczaruk B, Fire AZ, Voss G, Kelsoe G, Tomaras G, Moody MA, Kepler TB, and Haynes BF: Initial Antibodies to Transmitted HIV-1 gp41 Env are Polyreactive and Have Characteristics of Origin from Mutated Memory B Cells. J Exp Med 208(11): 2237-49, October 2011.
Bar KJ, Li H, Chamberland A, Tremblay C, Routy JP, Grayson T, Sun C, Learn GH, Morgan CJ, Schumacher JE, Haynes BF, Keele BF, Hahn BH and Shaw GM: Wide Variation in the Multiplicity of HIV-1 Infection Among Injection Drug Users. J Virol 84(12): 6421-6427, June 2010.
Li H, Bar KJ, Wang S, Decker JM, Chen Y, Sun C, Salazar-Gonzales JF, Salazar MG, Learn GH, Morgan CJ, Schumacher JE, Hraber P, Giorgi EE, Bhattacharya T, Korber BT,Perelson AS, Eron J, Cohen MS, Hicks CB, Haynes BF, Markowitz M, Keele BF, Hahn BH and Shaw GM : High Multiplicity Infection by HIV-1 in Men Who Have Sex with Men. PLoS Pathogens 6(5): e10000890, May 2010.
Salazar-Gonzalez JF, Salazar MG, Keele BF, Learn GH, Giorgi EE, Li H,Decker JD, Wang S, Baalwa J, Kraus M, Parrish N, Shaw K, Guffey MB, Bar KJ, Davis K, Ochsenbauer-Jambor C, Kappes J, Saag M, Cohen M, Mulenga J, Derdeyn C, Allen S, Hunter E, Markowitz M, Hraber P, Perelson A, Bhattacharya T, Haynes B, Korber B, Hahn BH and Shaw GM: Genetic Identity, Biologic Phenotype and Evolutionary Pathways of Transmitted/Founder Viruses and Their Progeny in Acute and Early HIV-1 Infection. J Exp Med 206: 1273-1289, June 2009.
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Last updated: 10/28/2015
The Trustees of the University of Pennsylvania