Dr. Vujković is trained in Computer Science, Clinical Epidemiology, and Population Genetics. Her NIH-funded research program aims to advance the understanding of genetics underlying obesity-induced diseases to enable personalized disease risk assessment and intervention. Her lab is focused on identifying and quantifying the role of actionable clinical factors in moderating the genetic risk for non-alcoholic fatty liver disease and subsequent progression to cirrhosis and liver cancer. Her team has developed a scalable genomics-informed pharmaco-epidemiologic research program to accelerate drug-discovery efforts, focusing on the repurposing of existing medications for novel indications.
Marijana obtained her BSc in Computer Science, MSc and PhD doctorate in Epidemiology at Erasmus University Rotterdam in the Netherlands. She moved to the United States for a post-doctoral fellowship in Precision Oncology at the Children’s Hospital of Philadelphia prior to becoming a faculty member at the University of Pennsylvania.
Dr. Vujković is an investigator in in the Million Veteran Program at the US Department of Veteran Affairs, where in 2019 she received the Million Veteran Program Early Career Investigator Award. Her research productivity is evidenced by 70+ peer-reviewed publications, which includes two first-author publications in ’Nature Genetics’, and a shared senior authorship in ’Nature’ as part of the T2D Global Genomics Initiative.
Selected Publications
Vujkovic M.: Assessing Long-Term Liver Safety of Statins and PCSK9 Inhibitors Using Human Genetics. Cell Mol Gastroenterol Hepatol 17(1): 173-174, Jan 2024.
Suzuki K, Hatzikotoulas K, Southam L, Taylor HJ, Yin X, Lorenz KM, Mandla R, Huerta-Chagoya A, Melloni GEM, Kanoni S, Rayner NW, Bocher O, Arruda AL, Sonehara K, Namba S, Lee SSK, Preuss MH, Petty LE, Schroeder P, Vanderwerff B, Kals M, Bragg F, Lin K, Guo X, Zhang W, Yao J, Kim YJ, Graff M, Takeuchi F, Nano J, Lamri A, Nakatochi M, Moon S, Scott RA, Cook JP, Lee JJ, Pan I, Taliun D, Parra EJ, Chai JF, Bielak LF, Tabara Y, Hai Y, Thorleifsson G, Grarup N, Sofer T, Wuttke M, Sarnowski C, Gieger C, Nousome D, Trompet S, Kwak SH, Long J, Sun M, Tong L, Chen WM, Nongmaithem SS, Noordam R, Lim VJY, Tam CHT, Joo YY, Chen CH, Raffield LM, Prins BP, Nicolas A, Yanek LR, Chen G, Brody JA, Kabagambe E, An P, Xiang AH, Choi HS, Cade BE, Tan J, Broadaway KA, Williamson A, Kamali Z, Cui J, Thangam M, Adair LS, Adeyemo A, Aguilar-Salinas CA, Ahluwalia TS, Anand SS, Bertoni A, Bork-Jensen J, Brandslund I, Buchanan TA, Burant CF, Butterworth AS, Canouil M, Chan JCN, Chang LC, Chee ML, Chen J, Chen SH, Chen YT, Chen Z, Chuang LM, Cushman M, Danesh J, Das SK, de Silva HJ, Dedoussis G, Dimitrov L, Doumatey AP, Du S, Duan Q, Eckardt KU, Emery LS, Evans DS, Evans MK, Fischer K, Floyd JS, Ford I, Franco OH, Frayling TM, Freedman BI, Genter P, Gerstein HC, Giedraitis V, González-Villalpando C, González-Villalpando ME, Gordon-Larsen P, Gross M, Guare LA, Hackinger S, Hakaste L, Han S, Hattersley AT, Herder C, Horikoshi M, Howard AG, Hsueh W, Huang M, Huang W, Hung YJ, Hwang MY, Hwu CM, Ichihara S, Ikram MA, Ingelsson M, Islam MT, Isono M, Jang HM, Jasmine F, Jiang G, Jonas JB, Jørgensen T, Kamanu FK, Kandeel FR, Kasturiratne A, Katsuya T, Kaur V, Kawaguchi T, Keaton JM, Kho AN, Khor CC, Kibriya MG, Kim DH, Kronenberg F, Kuusisto J, Läll K, Lange LA, Lee KM, Lee MS, Lee NR, Leong A, Li L, Li Y, Li-Gao R, Ligthart S, Lindgren CM, Linneberg A, Liu CT, Liu J, Locke AE, Louie T, Luan J, Luk AO, Luo X, Lv J, Lynch JA, Lyssenko V, Maeda S, Mamakou V, Mansuri SR, Matsuda K, Meitinger T, Melander O, Metspalu A, Mo H, Morris AD, Moura FA, Nadler JL, Nalls MA, Nayak U, Ntalla I, Okada Y, Orozco L, Patel SR, Patil S, Pei P, Pereira MA, Peters A, Pirie FJ, Polikowsky HG, Porneala B, Prasad G, Rasmussen-Torvik LJ, Reiner AP, Roden M, Rohde R, Roll K, Sabanayagam C, Sandow K, Sankareswaran A, Sattar N, Schönherr S, Shahriar M, Shen B, Shi J, Shin DM, Shojima N, Smith JA, So WY, Stančáková A, Steinthorsdottir V, Stilp AM, Strauch K, Taylor KD, Thorand B, Thorsteinsdottir U, Tomlinson B, Tran TC, Tsai FJ, Tuomilehto J, Tusie-Luna T, Udler MS, Valladares-Salgado A, van Dam RM, van Klinken JB, Varma R, Wacher-Rodarte N, Wheeler E, Wickremasinghe AR, van Dijk KW, Witte DR, Yajnik CS, Yamamoto K, Yamamoto K, Yoon K, Yu C, Yuan JM, Yusuf S, Zawistowski M, Zhang L, Zheng W; VA Million Veteran Program; Raffel LJ, Igase M, Ipp E, Redline S, Cho YS, Lind L, Province MA, Fornage M, Hanis CL, Ingelsson E, Zonderman AB, Psaty BM, Wang YX, Rotimi CN, Becker DM, Matsuda F, Liu Y, Yokota M, Kardia SLR, Peyser PA, Pankow JS, Engert JC, Bonnefond A, Froguel P, Wilson JG, Sheu WHH, Wu JY, Hayes MG, Ma RCW, Wong TY, Mook-Kanamori DO, Tuomi T, Chandak GR, Collins FS, Bharadwaj D, Paré G, Sale MM, Ahsan H, Motala AA, Shu XO, Park KS, Jukema JW, Cruz M, Chen YI, Rich SS, McKean-Cowdin R, Grallert H, Cheng CY, Ghanbari M, Tai ES, Dupuis J, Kato N, Laakso M, Köttgen A, Koh WP, Bowden DW, Palmer CNA, Kooner JS, Kooperberg C, Liu S, North KE, Saleheen D, Hansen T, Pedersen O, Wareham NJ, Lee J, Kim BJ, Millwood IY, Walters RG, Stefansson K, Ahlqvist E, Goodarzi MO, Mohlke KL, Langenberg C, Haiman CA, Loos RJF, Florez JC, Rader DJ, Ritchie MD, Zöllner S, Mägi R, Marston NA, Ruff CT, van Heel DA, Finer S, Denny JC, Yamauchi T, Kadowaki T, Chambers JC, Ng MCY, Sim X, Below JE, Tsao PS, Chang KM, McCarthy MI, Meigs JB, Mahajan A, Spracklen CN, Mercader JM, Boehnke M, Rotter JI, Vujkovic M, Voight BF, Morris AP, Zeggini E.: Genetic drivers of heterogeneity in type 2 diabetes pathophysiology. Nature 627(8003): 347-357, Mar 2024.
Ghouse J, Sveinbjörnsson G, Vujkovic M, Seidelin AS, Gellert-Kristensen H, Ahlberg G, Tragante V, Rand SA, Brancale J, Vilarinho S, Lundegaard PR, Sørensen E, Erikstrup C, Bruun MT, Jensen BA, Brunak S, Banasik K, Ullum H; DBDS Genomic Consortium; Verweij N, Lotta L, Baras A; Regeneron Genetics Center; Mirshahi T, Carey DJ; Geisinger-Regeneron DiscovEHR Collaboration; VA Million Veteran Program; Kaplan DE, Lynch J, Morgan T, Schwantes-An TH, Dochtermann DR, Pyarajan S, Tsao PS; Estonian Biobank Research Team; Laisk T, Mägi R, Kozlitina J, Tybjærg-Hansen A, Jones D, Knowlton KU, Nadauld L, Ferkingstad E, Björnsson ES, Ulfarsson MO, Sturluson Á, Sulem P, Pedersen OB, Ostrowski SR, Gudbjartsson DF, Stefansson K, Olesen MS, Chang KM, Holm H, Bundgaard H, Stender S. : Integrative common and rare variant analyses provide insights into the genetic architecture of liver cirrhosis. Nature Genetics Apr 2024 Notes: Online ahead of print.
Vujkovic M*, Ramdas S*, Lorenz KM, Guo X, Darlay R, Cordell HJ, He J, Gindin Y, Chung C, Meyers RP, Schneider CV, Park J, Lee KM, Serper M, Carr RM, Kaplan DE, Haas ME, MacLean MT, Witschey WR, Zhu X, Tcheandjieu CI, Kember RL, Kranzler HR, Verma A, Giri A, Klarin DM, Sun YV, Huang J, Huffman J, Townsend Creasy K, Hand NJ, Liu CT, Long MT, Yao J, Budoff M, Tan J, Li X, Lin HH, Yii-Der Chen I, Taylor KD, Chang RK, Krauss RM, Vilarinho S, Brancale J, Nielsen JB, Locke AE, Jones MB, Verweij N, Baras A, Reddy KR, Neuschwander-Tetri BA, Schwimmer JB, Sanyal AJ, Chalasan N, Ryan KA, Mitchell BD, Gill D, Wells AD, Manduchi E, Saiman Y, Mahmud N, Miller DR, Reaven PD, Phillips LS, Muralidhar S, DuVall SL, Lee JS, Assimes TL, Pyarajan S, Cho K, Edwards TL, Damrauer SM, Wilson PW, Gaziano JM, O’Donnell CJ, Khera AV, Grant SF, Brown CD, Tsao PS, Saleheen D, Lotta LA, Bastarache L, Anstee QM, Daly AK, Meigs JB, Rotter JI, Lynch JA, Regeneron Genetics Center, DiscovEHR Collaboration, EPoS Consortium Investigators, VA Million Veteran Program, Rader DJ*, Voight BF*, Chang KM*: A multi-ancestry genome-wide association study of unexplained chronic ALT elevation as a proxy for nonalcoholic fatty liver disease with histological and radiological validation. Nature Genetics 54(6): 761-771, Jun 2022.
Vujkovic M*, Keaton J*, Miller DR, Lynch JA, Zhou J, Tcheandjieu C, Huffman J, Assimes TL, Judy RL, Huang J, Lee KM, Klarin D, Pyarajan S, Danesh J, Mellander O, Rasheed A, Qamar N, Sheikh SS, Hameed S, Qureshi IH, Afzal MN, Jahazaib U, Jalal A, Abbas S, Sheng X, Gao L, Kaestner KH, Susztak K, Sun YV, Duvall SL, Cho K, Lee JS, Gaziano JM, Philips LS, Meigs JB, Reaven PD, Wilson PW, Edwards TL, Rader DJ, Damrauer SM, O'Donnell CJ, Tsao PS, HPAP Consortium, Regeneron Genetics Center, VA Million Veteran Program, Chang KM, Voight BF, Saleheen D: Discovery of 318 novel loci for type-2 diabetes and related micro- and macrovascular outcomes among 1.4 million participants in a multi-ethnic meta-analysis. Nature Genetics 52(7): 680-691, Jul 2020.
Pazoki R*, Vujkovic M*, Elliott JS, Evangelou E, Gill D, Ghanbari M, van der Most P, Climaco Pinto R, Wielscher M, Farlik M, Zuber V, de Knegt R, Snieder H, Uitterlinden A, Lifelines Study, Million Veteran Program, Lynch JA, Jiang X, Said S, Kaplan DE, Lee KM, Serper M, Carr R, Tsao PS, Atkinson S, Dehghan A, Tzoulaki I, Ikram MA, Herzig KH, Jarvelin MR, Alizadeh BZ, O'Donnell CJ, Saleheen D, Voight BF, Chang KM, Thursz M, Elliot P: Genetic analysis in European ancestry individuals identifies 517 loci associated with liver enzymes. Nature Communications 12(1): 2579, May 2021.
Shuey MM, Lee KM, Keaton J, Khankari NK, Breeyear JH, Walker VM, Miller DR, Heberer KR, Reaven PD, Clarke SL, Lee J, Lynch JA, Vujkovic M, Edwards TL.: A genetically supported drug repurposing pipeline for diabetes treatment using electronic health records. EBioMedicine 94: 104674, Aug 2023.
Khankari NK, Keaton JM, Walker VM, Lee KM, Shuey MM, Clarke SL, Heberer KR, Miller DR, Reaven PD, Lynch JA, Vujkovic M, Edwards TL.: Using Mendelian randomisation to identify opportunities for type 2 diabetes prevention by repurposing medications used for lipid management. EBioMedicine 80: 104038, Apr 2022.
Kamiza A, Toure S, Vujkovic M, Machipisa T, Soremekun O, Kintu C, Corpas M, Pirie F, Young E, Gill D, Sandhu M, Kaleebu P, Nyirenda M, Motala A, Chikowore, Fatumo S.: Transferability of genetic risk scores in African populations. Nature Medicine 28(6): 1163-1166, Jun 2022.
Gaziano L, Giambartolomei C, Pereira AC, Gaulton A, Posner DC, Swanson SA, Ho YL, Iyengar S, Kosik N, Vujkovic M, Gagnon D, Bento AP, Beltrao P, Barrio-Hernandez I, Rönnblom L, Hagberg N, Langenberg C, Pietzner M, Valentine D, Allara E, Surendran P, Burgess S, Zhao JH, Danesh J, Devineni P, Shi Y, Lynch K, DuVall S, Garcon H, Thomann LO, Zhou JJ, Gorman BR, Huffman J, O'Donnell C, Tsao P, Beckham JC, Pyarajan S, Muralidhar S, Huang GD, Ramoni R, Hung AM, Chang KM, Sun YV, Joseph J, Leach A, Edwards TL, Cho K, Gaziano JM, Butterworth A, Lundtoft C, Prins B, Peters J, Gustincich S, Gaetano Tartaglia J, Di Angelantonio E, Casas JP: Actionable druggable genome-wide Mendelian randomization identifies repurposing opportunities for COVID-19. Nature Medicine 27(4): 668-676, Apr 2021.
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Last updated: 04/24/2024
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