Faculty & Staff
Reed E. Pyeritz, MD, PhD
Professor of Medicine
Chief, Division of Medical Genetics, University of Pennsylvania School of Medicine
Vice-Chair for Academic Affairs, Department of Medicine, Hospital of the University of Pennsylvania
Senior Felow, Leonard David Institute for Health Economics, University of Pennsylvania School of Medicine
Senior Fellow, Center for Bioethics, University of Pennsylvania
Department: Medicine
Contact information
3400 Spruce Street
11 Penn Tower, Suite 1115
Philadelphia, PA 19104
11 Penn Tower, Suite 1115
Philadelphia, PA 19104
Office: 215-662-4740
Fax: 215-614-0298
Fax: 215-614-0298
Email:
reed.pyeritz@uphs.upenn.edu
reed.pyeritz@uphs.upenn.edu
Publications
Education:
S.B. (Chemistry)
University of Delaware, 1968.
A.M, Ph.D. (Biological Chemistry)
Harvard University, 1972.
M.D.
Harvard Medical School, 1975.
S.B. (Chemistry)
University of Delaware, 1968.
A.M, Ph.D. (Biological Chemistry)
Harvard University, 1972.
M.D.
Harvard Medical School, 1975.
Links
Search PubMed for articles
Chief, Division of Medical Genetics
Penn Center for the Integration of Genetic Healthcare Technologies (CIGHT)
Search PubMed for articles
Chief, Division of Medical Genetics
Penn Center for the Integration of Genetic Healthcare Technologies (CIGHT)
Post-Graduate Training
Intern in Medicine, Peter Bent Brigham Hospital, Boston, MA, 1975-1976.
Assistant Resident Physician, Peter Bent Brigham Hospital, 1976-1977.
Clinial Fellow in Medicine, Harvard Medical School, 1976-1977.
Fellow in Medicine, Johns Hopkins University School of Medicine, 1977-1978.
Resident in Medicine, Johns Hopkins Hospital, 1977-1978.
Intern in Medicine, Peter Bent Brigham Hospital, Boston, MA, 1975-1976.
Assistant Resident Physician, Peter Bent Brigham Hospital, 1976-1977.
Clinial Fellow in Medicine, Harvard Medical School, 1976-1977.
Fellow in Medicine, Johns Hopkins University School of Medicine, 1977-1978.
Resident in Medicine, Johns Hopkins Hospital, 1977-1978.
Certifications
American Board of Internal Medicine, 1978.
American Board of Medical Genetics (Clinical Genetics), 1981.
Permanent linkAmerican Board of Internal Medicine, 1978.
American Board of Medical Genetics (Clinical Genetics), 1981.
Description of Research Expertise
Dr. Pyeritz focuses his research in two areas: Mendelian disorders of the cardiovascular system, especially those involving defects of connective tissue; and, ethical, legal and social implications of the human genetics. He is continuing his studies, begun over 20 years ago, of Marfan syndrome and related conditions, diseases in which the aorta and occasionally major arterial branches, gradually enlarge and dissect, leading to early demise if untreated. Current efforts include a multicenter trial of angiotensin receptor blockade in Marfan syndrome, the identification of additional genes that predispose to arteriopathy, and improving methods for diagnosing and treating arterio-venous malformations, especially in hereditary hemorrhagic telangiectasia (HHT).Dr. Pyeritz directs Penn CIGHT, the Center for the Integration of Genetic Healthcare Technologies. Supported by the ELSI Branch of the National Human Genome Research Institute, this center conducts research in the broad area of ‘uncertainty’ as related to the introduction of evolving approaches to assaying a patient’s genotype. Penn CIGHT also provides pilot grants to faculty and postdoctoral fellowships. Dr. Pyeritz is specifically addressing how molecular genetic testing for HHT impacts the acceptance and costs of screening relatives who are at-risk.
Selected Publications
Bernhardt Barbara A, Zayac Cara, Pyeritz Reed E: Why is genetic screening for autosomal dominant disorders underused in families? The case of hereditary hemorrhagic telangiectasia. Genetics in medicine : official journal of the American College of Medical Genetics 13(9): 812-20, Sep 2011.Mendoza Dorinna D, Kochar Minisha, Devereux Richard B, Basson Craig T, Min James K, Holmes Kathryn, Dietz Harry C, Milewicz Dianna M, Lemaire Scott A, Pyeritz Reed E, Bavaria Joseph E, Maslen Cheryl L, Song Howard, Kroner Barbara L, Eagle Kim A, Weinsaft Jonathan W, : Impact of Image Analysis Methodology on Diagnostic and Surgical Classification of Patients With Thoracic Aortic Aneurysms. The Annals of thoracic surgery Jul 2011.
Gollust S E, Gordon E S, Zayac C, Griffin G, Christman M F, Pyeritz R E, Wawak L, Bernhardt B A: Motivations and Perceptions of Early Adopters of Personalized Genomics: Perspectives from Research Participants. Public health genomics Jun 2011.
McDonald Jamie, Bayrak-Toydemir Pinar, Pyeritz Reed E: Hereditary hemorrhagic telangiectasia: An overview of diagnosis, management, and pathogenesis. Genetics in medicine : official journal of the American College of Medical Genetics May 2011.
Trimarchi Santi, Jonker Frederik H W, Hutchison Stuart, Isselbacher Eric M, Pape Linda A, Patel Himanshu J, Froehlich James B, Muhs Bart E, Rampoldi Vincenzo, Grassi Viviana, Evangelista Arturo, Meinhardt Gabriel, Beckman Joshua, Myrmel Truls, Pyeritz Reed E, Hirsch Alan T, Sundt Iii Thoralf M, Nienaber Christoph A, Eagle Kim A: Descending aortic diameter of 5.5 cm or greater is not an accurate predictor of acute type B aortic dissection. The Journal of thoracic and cardiovascular surgery May 2011.
Ramanath Vijay S, Eagle Kim A, Nienaber Christoph A, Isselbacher Eric M, Froehlich James B, Montgomery Daniel G, Cooper Jeanna V, Gu Xiaokui, Evangelista Arturo, Voehringer Matthias, Beckman Joshua, Myrmel Truls, Pape Linda, Pyeritz Reed E, Hirsch Alan T, Gilon Dan, Bossone Eduardo: The role of preoperative coronary angiography in the setting of type A acute aortic dissection: Insights from the International Registry of Acute Aortic Dissection. American heart journal 161(4): 790-796.e1, Apr 2011.
Jackson Laird, Pyeritz Reed E: Molecular technologies open new clinical genetic vistas. Science translational medicine 3(65): 65ps2, Jan 2011.
Booher Anna M, Isselbacher Eric M, Nienaber Christoph A, Froehlich James B, Trimarchi Santi, Cooper Jeanna V, Demertzis Stefanos, Ramanath Vijay S, Januzzi James L, Harris Kevin M, O'Gara Patrick T, Sundt Thoralf M, Pyeritz Reed E, Eagle Kim A, : Ascending thoracic aorta dimension and outcomes in acute type B dissection (from the International Registry of Acute Aortic Dissection [IRAD]). The American journal of cardiology 107(2): 315-20, Jan 2011.
Gollust SE, Gordon ES, Zayac C, Griffin G, Christman MF, Pyeritz RE, Wawak L, Bernhardt BA: Motivations and Perceptions of Early Adopters of Personalized Genomics: Perspectives from Research Participants. Public Health Genomics In Press 2011.
Messner Donna A, Pyeritz Reed E, Bernhardt Barbara A: Comment on the impact of gene patents and licensing practices on access to genetic testing: Lessons from hereditary hemorrhagic telangiectasia. Genetics in medicine : official journal of the American College of Medical Genetics 12(11): 746-8, Nov 2010.