Carla R Scanzello, MD, PhD
Assistant Professor of Medicine at the Hospital of the University of Pennsylvania
Member, Penn Center for Musculoskeletal Disorders
Member, Penn Institute for Immunology
Member, Penn Institute for Translational Medicine and Therapeutics
Staff Physician, Philadelphia VA Medical Center
Department: Medicine
Contact information
Division of Rheumatology
University of Pennsylvania, School of Medicine
8th Floor Penn Tower
3400 Spruce Street
Philadelphia, PA 19104
University of Pennsylvania, School of Medicine
8th Floor Penn Tower
3400 Spruce Street
Philadelphia, PA 19104
Education:
B.S. (Biochemistry)
University of Delaware, Newark, DE, 1991.
Ph.D (Immunology & Microbiology)
Temple University, School of Medicine, Philadelphia, PA, 2001.
M.D.
Temple University, School of Medicine, Philadelphia, PA, 2001.
B.S. (Biochemistry)
University of Delaware, Newark, DE, 1991.
Ph.D (Immunology & Microbiology)
Temple University, School of Medicine, Philadelphia, PA, 2001.
M.D.
Temple University, School of Medicine, Philadelphia, PA, 2001.
Post-Graduate Training
Resident in Medicine, New York Presbyterian Hospital/ Weill-Cornell Medical Center, New York, NY, 2002-2004.
Fellow, Hospital for Special Surgery, New York, NY, 2004-2008.
Resident in Medicine, New York Presbyterian Hospital/ Weill-Cornell Medical Center, New York, NY, 2002-2004.
Fellow, Hospital for Special Surgery, New York, NY, 2004-2008.
Certifications
American Board of Internal Medicine, 2005.
American Board of Internal Medicine / Rheumatology, 2007.
Permanent linkAmerican Board of Internal Medicine, 2005.
American Board of Internal Medicine / Rheumatology, 2007.
Selected Publications
M Jolly, S Francis, R Aggarwal, R Mikolaitis, T Niewold, S Chubinskaya, J Block, C Scanzello, W Sequeira. : Serum free light chains, interferon-alpha, and interleukins in systemic lupus erythematosus. Lupus 23: 881-888, 2014.N Ruel, DZ Markova, SL Adams, C Scanzello, G Cs-Szabo, D Gerard, P Shi, DG Anderson, M Zack, HS An, D Chen, Y Zhang. : Fibronectin Fragments and the Cleaving Enzyme ADAM-8 in the Degenerative Human Intervertebral Disc. Spine 39: 1274-9, 2014.
J Kurkó, A Vida, TT Glant, CR Scanzello, RS Katz, A Nair, Z Szekanecz, K Mikecz: Identification of myeloid-derived suppressor cells in the synovial fluid of patients with rheumatoid arthritis: a pilot study. BMC Musculoskelet Disord 15: 281, 2014.
S Ritter, R Subbaiaih, G Bebek, J Crish, CR Scanzello, B Krastins, A Garces, D Sarracino, M Lopez, MK Crow, T Aigner, MB Goldring, SR Goldring, DM Lee, R Gobezie, AO Aliprantis: Proteomic analysis of synovial fluid from the osteoarthritic knee: comparison with transcriptome analyses of joint tissues. Arthritis & Rheumatism 65: 981-92, 2013.
CR Scanzello, AS Albert, E DiCarlo, KB Rajan, V Kanda, EU Asomugha, BH Swaim, JN Katz, SR Goldring, JC Richmond, B McKeon. : The influence of synovial inflammation and hyperplasia on symptomatic outcomes up to two-years post-operatively in patients undergoing partial meniscectomy. Osteoarthritis Cartilage 21: 1392-9, 2013.
A Nair, V Kanda, C Bush-Joseph, N Verma, S Chubinskaya, K Mikecz, TT Glant, A-M Malfait, MK Crow, GT Spear, A Finnegan, CR Scanzello: "Synovial fluid from patients with early osteoarthritis modulates fibroblast-like synoviocyte responses to TLR-4 and TLR-2 ligands via soluble CD14" Arthritis & Rheumatism 64: 2268-77, 2012.
CR Scanzello, B McKeon, BH Swaim, E DiCarlo, EU Asomugha, V Kanda, A Nair, DM Lee, JC Richmond, JN Katz, MK Crow, SR Goldring. : "Synovial inflammation in patients undergoing arthroscopic meniscectomy: molecular characterization and relationship with symptoms" Arthritis & Rheumatism 63: 391-400, 2011.
Q Wang, AL Rozelle, CM Lepus, CR Scanzello, JJ Song, DM Larsen, JF Crish, G Bebek, SY Ritter, TM Lindstrom, I Hwang, HH Wong, L Punzi, A Encarnacion, M Shamloo, SB Goodman, T Wyss-Coray, SR Goldring, R Gobezie, MK Crow, VM Holers DM Lee, WH Robinson: "Identification of a central role for complement in osteoarthritis" Nature Medicine 17: 1674-9, 2011.
CR Scanzello, Umoh EM, Pessler F, Diaz-Torne C, Miles T, DiCarlo EF, Potter HG, Mandl LA, Marx R, Rodeo S, Goldring SR, Crow MK: "Local cytokine profiles in knee osteoarthritis: Elevated synovial fluid interleukin-15 differentiates early from end-stage disease" OA and Cartilage 17: 1040-8, 2009.
F Pessler, L Dai, C Diaz-Torne, C Gomez-Vaquero, , ME Paessler, DH Zheng, E Einhorn, U Range, C Scanzello, HR Schumacher: "The synovitis of "non-inflammatory" orthopedic arthropathies: a quantitative histologic and immunohistochemical analysis. " Ann Rheum Dis 67: 1184-1187, 2008.