1254 BRB II/III
421 Curie Boulevard
Philadelphia, PA 19104-6160
Fax: (215) 746-8941
Ocean University of China, Qingdao, P.R. China, 1983.
(Certificate in English)
Shanghai Foreign Language Institute, Shanghai, P.R. China, 1984.
School of Biological Sciences, University of Wales, U.K, 1989.
Description of Research ExpertiseRESEARCH INTERESTS
Pathogenesis and experimental therapeutics of complement-mediated inflammatory, autoimmune and thrombotic microangipathic diseases
complement, gene targeting, mouse model, innate immunity, inflammation, autoimmunity, C3 glomerulonephritis (C3GN), hemolytic uremic syndrome (HUS), dense deposit disease (DDD), age-related macular degeneration (AMD).
My research is focused on complement-mediated inflammatory, autoimmune and thrombotic microagiopathic disorders. By creating gene targeted mice, we establish mouse models of human diseases to understand disease pathogenesis and to test novel anti-complement therapies. We are also interested in the interaction of complement with other innate immune pathways such as the Toll-like receptors and with the adaptive immune system. Our long term goal is to advance basic complement immunology and to help develop new therapies for complement-mediated human diseases.
ROTATION PROJECTS (Please inquire).
Selected PublicationsDunkelberger, J.R. and Song, W.-C.: Complement and its role in innate and adaptive immune responses Cell Res. 20: 34-50, 2010.
Kimura, Y., Zhou, L., Miwa, T. and Song, W.-C. : Genetic and therapeutic targeting of properdin prevents complement-mediated tissue injury. J. Clin Invest. 120(10): 3545-3554, 2010.
Fang, C., Miwa, T. and Song, W.-C. : Decay-accelerating factor regulates T cell immunity in the context of inflammation by influencing co-stimulatory molecule expression on antigen-presenting cells. Blood. 118(4): 1008-1014, 2011.
Dunkelberger, J., Zhou, L., Miwa, T. and Song, W.-C. : C5aR expression in a novel GFP reporter gene knock-in mouse: implications for the mechanism of action of C5aR signaling in T cell immunity. J. Immunol 188(8): 4032-4042, 2012.
Miwa, T., Zhou, L., Maldonado, M. A., Eisenberg, R. A. and Song, W.-C. : Absence of CD59 exacerbates systemic autoimmunity in MRL/lpr mice. J. Immunol 189(11): 5434-5441, 2012.
Lesher, A. M., Zhou, L., Kimura, Y., Sato,S., Gullipalli, D., Ruseva, M. M., Pickering, M.C., Herbert, A. P., Barlow, P., Skerka, C., Zipfel, P., Miwa, T., Tung, K. S. and Song, W.-C.: Lethal C3 glomerulonephritis resembling human dense deposit disease caused by combined fH C-terminal mutation and properdin deficiency in mice. J. Am. Soc. Nephrol. 24(1): 53-65, 2013.
Ruseva, M. M., Vernon, K. A., Lesher, A. M., Schwaeble, W. J., Ali, Y. M., Botto, M., Cook, H. T., Song, W.-C., Stover, C. and Pickering, M. C. : Properdin deficiency exacerbates C3 glomerulopathy in factor H-deficient mice. J. Am. Soc. Nephrol. 24(1): 43-52, 2013.
Barata, L., Miwa, T., Sato, S., Kim, D. D., Mohammed, I. and Song, W.-C. : Deletion of Crry and DAF on murine platelets stimulates thrombopoiesis and increases fH-dependent resistance of peripheral platelets to complement attack. J. Immunol 190(6): 2886-2895, 2013.
Miwa, T., Sato, S., Gullipalli, D., Nangaku, M and Song, W.-C. : Blocking properdin, the alternative pathway complement and anaphylatoxin receptors ameliorates renal ischemia reperfusion injury in decay-accelerating factor and CD59 double knockout mice. J. Immunol 190(7): 3552-3559, 2013.
Lesher, A. M., Nilsson, B. and Song, W.-C.: Properdin in Complement Activation and Tissue Injury. Mol Immunol. [Epub ahead of print], June 2013.