faculty photo

Thomas P. Cappola

Herbert C. Rorer Associate Professor in Medical Sciences
Department: Medicine
Graduate Group Affiliations

Contact information
Division of Cardiovascular Medicine
9035 West Gates
3400 Spruce Street
Philadelphia, PA 19104
Office: 215-662-3140
Fax: 215-349-8017
Lab: 215-573-4717
Education:
A.B. (Chemistry)
Princeton University, 1991.
M.D. (Medicine)
Harvard Medical School, 1995.
Sc.M. (Clinical Investigation )
Johns Hopkins Bloomberg School of Public Health, 2004.
Post-Graduate Training
Intern and Resident, Internal Medicine, Brigham and Women’s Hospital, 1995-1998.
Clinical and Research Fellow, Cardiovascular Disease, Johns Hopkins Hospital, 1998-2002.
Heart Failure and Transplantation Fellow, Johns Hopkins Hospital, 2000-2001.
Research Fellow, National Heart, Lung, and Blood Institute Program in Genomic Applications, Johns Hopkins Medical Institutions, 2001-2002.
Honorary Senior Visiting Fellow, University of Cambridge, UK, 2013-2014.
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Description of Research Expertise

My laboratory uses clinical investigation and applied genomics to reveal mechanisms of human heart failure. This has included establishing a multicenter cohort study of advanced heart failure (Penn Heart Failure Study; PHFS) and a multicenter consortium for human myocardial transcriptomics and eQTL mapping (Myocardial Applied Genomics Network; MAGNet). Notable discoveries include the first demonstration that peripheral blood gene expression provides a clinical biomarker to track cardiac allograft rejection, identification of abnormalities in forkhead signaling and neuregulin signaling in common forms of human heart failure, and discovery of the 1p36 HSPB7/CLCNKA locus as the first bonafide genetic risk factor for non-familial heart failure. In my clinical role I treat patients with advanced heart failure on the inpatient and outpatient heart failure/transplant service.

Description of Clinical Expertise

My clinical focus is evaluation and treatment of advance heart failure including medical therapy, device therapy, investigational therapy, and cardiac transplantation

Selected Publications

Margulies KB, Hernandez A, Redfield M, Givertz M, Oliveira G, Cole R, Mann D, Whellan D, Kiernan M, Felker GM, McNulty S, Anstrom K, Shah S, Eugene Braunwald E, Cappola TP: Effects of liraglutide on clinical stability in advanced heart failure with reduced ejection fraction: a randomized clinical trial. JAMA 316(5): 500-508, Aug 2016.

AbouEzzeddine OF, French B, Mirzoyev SA, Jaffe AS, Levy WC, Fang JC, Sweitzer NK, Cappola TP, Redfield MM: From statistical significance to clinical relevance: A simple algorithm to integrate brain natriuretic peptide and the Seattle Heart Failure Model for risk stratification in heart failure. J Heart Lung Transplant 35(6): 714-21, Jun 2016 Notes: Epub 2016 Jan 15.

Smith JG, Felix J, Morrison AC, Kalogeropoulos A, Trompet S, Wilk JB, Gidlöf O, Wang X, Morley M, Mendelson M, Joehanes R, Ligthart S, Shan X, Bis JC, Wang YA, Sjögren M, Ngwa J, Brandimarto J, Stott D, Aguilar D, Rice KM, Sesso HD, Demissie S, Buckley BM, Taylor KD, Ford I, Yao C, Liu C, Sotoodehnia N, van der Harst P, Stricker BHC, Kritchevsky SB, Liu Y, Gaziano JM, Hofman A, Moravec CS, Uitterlinden AG, Kellis M, van Meurs JB, Margulies KB, Dehghan A, Levy D, Olde B, Psaty BM, Cupples LA, Jukema J, Djousse L, Franco OH, Boerwinkle E, Boyer LA, Newton-Cheh C, Butler J, Vasan R, Cappola TP, Smith NL: Discovery of genetic variation on chromosome 5q22 associated with mortality in heart failure. PLoS Genet 12(5): e1006034, May 2016.

French B, Wang L, Ky B, Brandimarto J, Basuray A, Fang JC, Sweitzer NK, Cappola TP: Prognostic value of galectin-3 for adverse outcomes in chronic heart failure. J Card Fail 22(4): 256-62, Apr 2016.

de Denus S, Rouleau JL, Mann DL, Huggins GL, Cappola TP, Shah S, Keleti J, Zada YF, Provost S, Bardhadi A, Phillips MS, Normand V, Mongrain I, Dube MP: A pharmacogenetic investigation of intravenous furosemide in decompensated heart failure: a meta-analysis of 3 clinical trials Pharmacogenomics J March 1 2016 Notes: Epub ahead of print.

French B, Saha-Chaudhuri P, Ky B, Cappola TP, Heagerty PJ: Development and evaluation of multi-marker risk scores for clinical prognosis. Stat Methods Med Res 25(1): 255-271, Feb 2016.

Keenan T, Zhao W, Rasheed A, Ho WK, Malik R, Felix JF, Young R, Shah N, Samuel M, Sheikh N, Mucksavage ML, Shah O, Li J, Morley M, Laser A, Mallick NH, Zaman KS, Ishaq M, Rasheed SZ, Memon FU, Ahmed F, Hanif B, Lakhani MS, Fahim M, Ishaq M, Shardha NK, Ahmed N, Mahmood K, Iqbal W, Akhtar S, Raheel R, O'Donnell CJ, Hengstenberg C, März W, Kathiresan S, Samani N, Goel A, Hopewell JC, Chambers J, Cheng YC, Sharma P, Yang Q, Rosand J, Boncoraglio GB, Kazmi SU, Hakonarson H, Köttgen A, Kalogeropoulos A, Frossard P, Kamal A, Dichgans M, Cappola T, Reilly MP, Danesh J, Rader DJ, Voight BF, Saleheen D: Causal assessment of serum rrate levels in cardiometabolic diseases through a Mendelian randomization study. J Am Coll Cardiol 2(67): 407-16, Feb 2016.

Ware JS, Li J, Mazaika E, Yasso CM, DeSouza T, Cappola TP, Tsai EJ, Hilfiker-Kleiner D, Kamiya CA, Mazzarotto F, Cook SA, Halder I, Prasad SK, Pisarcik J, Hanley-Yanez K, Alharethi R, Damp J, Hsich E, Elkayam U, Sheppard R, Kealey A, Alexis J, Ramani G, Safirstein J, Boehmer J, Pauly DF, Wittstein IS, Thohan V, Zucker MJ, Liu P, Gorcsan J 3rd, McNamara DM, Seidman CE, Seidman JG, Arany Z: Shared genetic predisposition in peripartum and dilated cardiomyopathies. N Engl J Med 374(3): 233-41, Jan 2016.

Perez MV, Pavlovic A, Shang C, Wheeler MT, Miller CL, Liu J, Dewey FE, Pan S, Thanaporn PK, Absher D, Brandimarto J, Salisbury H, Chan K, Mukherjee R, Konadhode RP, Myers RM, Sedehi D, Scammell TE, Quertermous T, Cappola T, Ashley EA: Systems genomics identifies a key role for hypocretin/orexin receptor-2 in human heart failure. J Am Coll Cardiol 66(22): 2522-33, Dec 2015.

Das A, Morley M, Moravec CS, Tang WH, Hakonarson H; MAGNet Consortium, Margulies KB, Cappola TP, Jensen S, Hannenhalli S: Bayesian integration of genetics and epigenetics detects causal regulatory SNPs underlying expression variability. Nat Commun 6: 8555, Oct 2015.

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Last updated: 09/19/2016
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