faculty photo

Douglas C Wallace

Professor of Pathology and Laboratory Medicine
Department: Pathology and Laboratory Medicine

Contact information
The Children's Hospital of Philadelphia
Colket Translational Research Building, Rm 6060
3501 Civic Center Blvd
Philadelphia, PA 19104-4302
Office: 267-425-3034
Fax: 267-303-3615
Education:
B.S. (Genetics, Developmental Biology)
Cornell University, Ithaca, NY, 1968.
M. Phil. (Microbiology and Human Genetics)
Yale University, New Haven CT, 1972.
PhD (Microbiology and Human Genetics)
Yale University, New Haven CT, 1975.
Post-Graduate Training
Predoctoral Research, Department of Microbiology, Yale University, 1971-1975.
Predoctoral Research, Woods Hole Marine Biological Laboratory, 1971-1971.
NIH Postdoctoral Fellowship, Department of Human Genetics, Yale University, 1975-1976.
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Selected Publications

Golomb BA, Erickson LC, Scott-Van Zeeland AA, Koperski S, Haas RH, Wallace DC, Naviaux RK, Lincoln AJ, Reiner GE, Hamilton G: Assessing Bioenergetic Compromise in Autism Spectrum Disorder with 31P Magnetic Resonance Spectroscopy: Preliminary Report. J Child Neurol [Epub ahead of print], Oct 2013.

Picard M, Gentil BJ, McManus MJ, White K, St. Louis K, Gartside SE, Wallace DC, Turnbull DM: Acute exercise remodels mitochondrial membrane interactions in mouse skeletal muscle. J Appl Physiol 115: 1562-1571, Aug 2013 Notes: doi:10.1152/japplphysiol.00819.2013.

Wallace DC: Bioenergetics in human evolution and disease: implications for the origins of biological complexity and the missing genetic variation of commone disease. PHil Trans R Soc B 368(1622): 1-10, June 2013.

Yang JY, Deng W, Chen Y, Fan W, Baldwin KM, Jope RS, Wallace DC, Wang PH: Impaired translocation and activation of mitochondrial Akt1 mitigated mitochondrial oxidative phosphorylation Complex V activity in diabetic myocardium J Mol Cell Cardiol 59: 167-175, Jun 2013.

Douglas C Wallace: A mitochondrial bioenergetic etiology of disease. Journal of Clinical Investigation 123(4): 1405-1412, Apr 2013.

Chen, P L. Chen, C F. Chen, Y. Guo, X E. Huang, C K. Shew, J Y. Reddick, R L. Wallace, D C. Lee, W H.: Mitochondrial genome instability resulting from SUV3 haploinsufficiency leads to tumorigenesis and shortened lifespan. Oncogene 32(9): 1193-1201, Feb 2013 Notes: doi: 10.1038/onc.2012.120.

Strauss KA, DuBiner L, Simon M, Zaragoza M, Sengupta PP, Li P, Narula N, Dreike S, Platt J, Procaccio V, Ortiz-González XR, Puffenberger EG, Kelley RI, Morton DH, Narula J, Wallace DC : Severity of cardiomyopathy associated with adenine nucleotide translocator-1 deficiency correlates with mtDNA haplogroup. Proceedings of the National Academy of Sciences of the USA 110(9): 3453-3458, Feb 2013.

Kenney MC, Chwa M, Atilano SR, Pavlis JM, Falatoonzadeh P, Ramirez C, Malik D, Hsu T, Woo G, Soe Kyaw, Nesburn AB, Boyer DS, Kuppermann BD, Jazwinski SM, Miceli MV, Wallace DC, Udar N: Mitochondrial DNA Variants Mediate Energy Production and Expression Levels for CFH, C3 and EFEMP1 Genes: Implications for Age-Related Macular Degeneration. Plos One 8(1): 1-9, Jan 2013 Notes: doi: 10.1371/journal.pone.0054339.

Zand K, Pham T, Davila Jr A, Wallace DC, Burke, PJ: Nanofluidic Platform for Single Mitochondria Analysis Using Fluorescence Microscopy. Analytical Chemistry 85(12): 6018-6025, 2013 Notes: doi:10.1021/ac4010088.

Wallace D C.: Bioenergetics and the Mitochondrial Genome. Encyclopedia of Biological Chemistry 1: 210-216, 2013.

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Last updated: 01/09/2014
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