faculty photo

Douglas C Wallace

Professor of Pathology and Laboratory Medicine
Department: Pathology and Laboratory Medicine
Graduate Group Affiliations

Contact information
The Children's Hospital of Philadelphia
Colket Translational Research Building, Rm 6060
3501 Civic Center Blvd
Philadelphia, PA 19104-4302
Office: 267-425-3034
Fax: 267-303-3615
Education:
B.S. (Genetics, Developmental Biology)
Cornell University, Ithaca, NY, 1968.
M. Phil. (Microbiology and Human Genetics)
Yale University, New Haven CT, 1972.
PhD (Microbiology and Human Genetics)
Yale University, New Haven CT, 1975.
Post-Graduate Training
Predoctoral Research, Woods Hole Marine Biological Laboratory, 1971-1971.
Predoctoral Research, Department of Microbiology, Yale University, 1971-1975.
NIH Postdoctoral Fellowship, Department of Human Genetics, Yale University, 1975-1976.
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Selected Publications

Picard, M. Zhang, J. Hancock, S. Derbeneva, O. Golhar, P. Golik, P. O'Hearn, S. Levy, S. Potluri, P. Lvova, M. Davila, A. Lin, CS. Perin, JC. Rappaport, EF. Hakonarson, H. Trounce, IA. Procaccio, V. Wallace, DC.: Progressive Increase in mtDNA 3243A>G Heteroplasmy Causes Abrupt Transcriptional Reprogramming. Proc Natl Acad Sci USA 111(38): E4033--E4042, Sep 2014.

Cristina Kenney M, Chwa M, Atilano SR, Falatoonzadeh P, Ramirez C, Malik D, Tarek M, Cáceres-del-Carpio J, Nesburn AB, Boyer DS, Kuppermann BD, Vawter M, Jazwinski SM, Miceli M, Wallace DC, Udar N: Inherited mitochondrial DNA variants can affect complement, inflammation and apoptosis pathways: insights into mitochondrial-nuclear interactions. Hum Mol Genet 23(13): 3537-51, Jul 2014 Notes: doi: 10.1093/hmg/ddu065. Epub 2014 Feb 28.

Malik D, Hsu T, Falatoonzadeh P, Cáceres-del-Carpio J, Tarek M, Chwa M, Atilano SR, Ramirez C, Nesburn AB, Boyer DS, Kuppermann BD, Jazwinski SM, Miceli MV, Wallace DC, Udar N, Kenney MC : Human retinal transmitochondrial cybrids with J or H mtDNA haplogroups respond differently to ultraviolet radiation: implications for retinal diseases. PLoS One 11(9): e99003, Jun 2014 Notes: doi: 10.1371/journal.pone.0099003. eCollection 2014.

Lin, R. Angelin, A. Da Settimo, F. Martini, C. Taliani, S. Zhu, S. Wallace, D C.: Genetic analysis of dTSPO, an outer mitochondrial membrane protein, reveals its functions in apoptosis, longevity, and Aβ42-induced neurodegeneration. Aging Cell 13(3): 507-518, Jun 2014.

Golomb, B A. Erickson, L C. Scott-Van Zeeland, A A. Koperski, S. Haas, R H. Wallace, D C. Naviaux, R K. Lincoln, A J. Reiner, G E. Hamilton, G.: Assessing Bioenergetic Compromise in Autism Spectrum Disorder With P-31 Magnetic Resonance Spectroscopy: Preliminary Report Journal of Child Neurology 29(2): 187-193, Feb 2014 Notes: published online October 18, 2013. doi: 10.1177/0883073813498466.

Kenney, M C. Chwa, M. Atilano, S R. Falatoonzadeh, P. Ramirez, C. Malik, D. Tarek, M. Del Carpio, J C. Nesburn, A B. Boyer, D S. Kuppermann, B D. Vawter, M P. Jazwinski, S M. Miceli, M V. Wallace, D C. Udar, N.: Molecular and bioenergetic differences between cells with African versus European inherited mitochondrial DNA haplogroups: Implications for population susceptibility to diseases Biochimica Et Biophysica Acta-Molecular Basis of Disease 1842(2): 208-219, Feb 2014.

Lampe, J W. Da, T. Selak, M A. McManus, M J. Wallace, D C. Becker, L B. : Critical Role For Intra-mitochondrial NADPH Generation For Survival After Cardiac Arrest: Studies In The Nicotinamide Nucleotide Transhydrogenase Deficit Mouse Circulation 128(22), Nov 2013.

Ortiz-Gonzaley, X R. Mills, J A. Wallace, D C.: Modeling mitochondrial cardiomyopathy using human ANT1 deficient iPSC-derived cardiomyocytes Mitochondrion 13(6): 941-942, Nov 2013.

Xu, S Q. Vu, N H T. Chao, E. Simon, M. Zoleikhaeian, M. Kimonis, V. Huang, T S. Mozaffar, T. Wallace, D C.: Summary of the mitochondrial findings in a series of 300 cases. Mitochondrion 13(6): 936-937, Nov 2013.

Wallace, D C. Chalkia, D.: Mitochondrial DNA Genetics and the Heteroplasmy Conundrum in Evolution and Disease Cold Spring Harbor Perspectives in Biology 5(11), Nov 2013.

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Last updated: 10/17/2014
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