Department of Sleep Medicine

Sleep Faculty
faculty photo

Allan I. Pack, M.B.Ch.B., Ph.D., FRCP

John Miclot Professor
Fellow, Institute on Aging, University of Pennsylvania, Philadelphia, PA
Member, Institute for Neurological Sciences, University of Pennsylvania, Philadelphia, PA
Director, Penn Sleep Center, University of Pennsylvania, Philadelphia, PA
Director, Center for Sleep and Circadian Neurobiology, University of Pennsylvania, Philadelphia, PA
Chief, Division of Sleep Medicine, Department of Medicine, University of Pennsylvania, Philadelphia, PA
Member, Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania, Philadelphia, PA
Assistant Dean and Director of Global Sleep Programs, Perelman School of Medicine, University of Pennsylvaia
Department: Medicine

Contact information
Center for Sleep and Circadian Neurobiology
Translational Research Laboratories
125 South 31st Street, Suite 2100
Philadelphia, PA 19104-3403
Office: 215-746-4806
Fax: 215-746-4814
Graduate Group Affiliations
Education:
M.B.Ch.B
University of Glasgow, Scotland, 1967.
Ph.D. (Mathematical models of lung function)
University of Glasgow, Scotland, 1976.
Post-Graduate Training
Junior House Officer in Medicine, Department of Medicine, Glasgow Royal Infirmary, Scotland [Equivalent to Internship], 1967-1968.
Senior House Officer in Medicine, Department of Medical Cardiology, Glasgow Royal Infirmary, Scotland, 1968-1969.
Junior House Officer in Surgery, Glasgow Royal Infirmary, Scotland [Equivalent to Internship; February to July], 1968-1968.
Registrar in Internal/Pulmonary Medicine, Glasgow Royal Infirmary, Scotland [Equivalent to Residency, Fellowship], 1970-1973.
Wellcome Research Fellow, Centre for Respiratory Investigation, Glasgow Royal Infirmary, Scotland, 1973-1976.
Honorary Senior Registrar, Respiratory Medicine, Centre for Respiratory Investigation, Glasgow Royal Infirmary, Scotland, 1974-1976.
Senior Registrar, Pulmonary Medicine, Glasgow Royal Infirmary (further training in Pulmonary Medicine) [February to August], 1976-1976.
Certifications
MRCP (UK) (postgraduate examination - equivalent to Boards of Internal Medicine), 1970.
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Description of Research Expertise

Dr. Pack is pursuing research on genetics/genomics of sleep and its disorders. His laboratory is conducting studies in Drosophila and mice and translating these findings to humans. A particular focus of Dr. Pack’s work is to evaluate the genetic determinants of sleep homeostasis. Studies are ongoing to evaluate molecular mechanisms of sleepiness and sleep promotion using both hypothesis-driven and discovery science. The latter involves analysis of the changes in the transcription with sleep/wake and sleep deprivation in identified neuronal populations. Techniques being used include behavioral/sleep studies in Drosophila and mice, RT-PCR, Western analysis of protein, expression profiling, laser microcapture dissection, RNA seq and immunohistochemistry. Dr. Pack is committed to research training and directs two training grants from the National Institutes of Health.

Description of Clinical Expertise

Dr. Pack's clinical expertise is in sleep disorders with a particular focus on diagnosis and management of obstructive sleep apnea. He is internationally recognized for his expertise in this area and has been listed in the Best Doctor's in the United States and in the Philadelphia region (Philadelphia Magazine).

Selected Publications

Li, Q.Y., Berry, R.B., Goetting, M.G., Staley, B., Soto-Calderon, H., Tsai, S.C., Jasko, J.G., Pack, A.I. and Kuna, S.T.: Detection of upper airway status and respiratory events by a current generation positive airway pressure device. Sleep 38(4): 597-605, Apr 2015.

Arnardottir, E.S., Lim, D.C., Keenan, B.T., Maislin, G., Benediktsdottir, B., Juliusson, S., Pack, A.I. and Gislason, T.: Effects of obesity on the association between long-term sleep apnea treatment and changes in interleukin-6 levels: the Icelandic Sleep Apnea Cohort. Journal of Sleep Research 24(2): 148-159, 2015.

Azarbarzin, A., Ostrowski, M., Younes, M., Keenan, B.T., Pack, A.I., Staley, B. and Kuna, S.T.: Arousal responses during overnight polysomnography and their reproducibility in healthy young adults. Sleep 2015 Notes: Jan 12. pii: sp-00438-14. [Epub ahead of print]

Lim, D.C., Brady, D.C., Po, P., Chuang, L.P., Marcondes, L., Kim, E.Y., Keenan, B.T., Guo, X., Maislin, G., Galante, R.J. and Pack. A.I.: Simulating obstructive sleep apnea patients’ oxygenation characteristics into a mouse model of cyclical intermittent hypoxia. Journal of Applied Physiology 118(5): 544-557, 2015.

Iftikhar, I.H., Valentine, C.W., Bittencourt, L.R., Cohen, D.L., Fedson, A.C., Gíslason, T., Penzel, T., Phillips, C.L., Yu-sheng, L., Pack, A.I. and Magalang, U.J.: Effects of continuous positive airway pressure on blood pressure in patients with resistant hypertension and obstructive sleep apnea: a meta-analysis. Journal of Hypertension 32(12): 2341-2350, Dec 2014.

Ye, L., Pien, G.W., Ratcliffe, S.J., Rjornsdottir, E., Arnardottir, E.S., Pack, A.I., Benediktsdottir, B. and Gislason, T.: The different clinical faces of obstructive sleep apnoea: a cluster analysis. European Respiratory Journal 44(6): 1600-1607, Dec 2014.

Arnardottir, E.S., Nikonova, E.V., Shockley, K.R., Podtelezhnikov, A.A., Anafi, R., Tanis, K.Q., Maislin, G., Stone, D.J., Renger, J.J., Winrow, C.J. and Pack, A.I.: Blood-gene expression reveals reduced circadian rhythmicity in individuals resistant to sleep deprivation. Sleep 37(10): 1589-1600, Oct 2014.

Chi, L., Comyn F-L., Keenan, B.T., Cater, J., Maislin, G., Pack, A.I. and Schwab, R.J.: Heritability of craniofacial structures in normal subjects and patients with sleep apnea. Sleep 37(10): 1689-1698, Oct 2014.

Kim, A.M., Keenan, B.T., Jackson, N., Chan, E.L., Staley, B., Poptani, H., Torigian, D.A., Pack, A.I. and Schwab, R.J.: Tongue fat and its relationship to obstructive sleep apnea. Sleep 37(10): 1639-1648, Oct 2014.

Pellegrino, R., Kavakli, I.H., Goel, N., Cardinale, C.J., Dinges, D.F., Kuna, S.T., Maislin, G., Van Dongen, H.P.A., Tufik, S., Hogenesch, J.B., Hakonarson, H. and Pack, A.I.: A novel BHLHE41 variant is associated with short sleep and resistance to sleep deprivation in humans. Sleep 37(8): 1327-1336, Aug 2014.

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Last updated: 05/18/2015
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