Department of Sleep Medicine

Sleep Faculty
faculty photo

Allan I. Pack, M.B.Ch.B., Ph.D., FRCP

John Miclot Professor
Fellow, Institute on Aging, University of Pennsylvania, Philadelphia, PA
Member, Institute for Neurological Sciences, University of Pennsylvania, Philadelphia, PA
Director, Penn Sleep Center, University of Pennsylvania, Philadelphia, PA
Director, Center for Sleep and Circadian Neurobiology, University of Pennsylvania, Philadelphia, PA
Member, Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA
Chief, Division of Sleep Medicine, Department of Medicine, University of Pennsylvania, Philadelphia, PA
Member, Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania, Philadelphia, PA
Assistant Dean and Director of Global Sleep Programs, Perelman School of Medicine, University of Pennsylvaia
Department: Medicine

Contact information
Center for Sleep and Circadian Neurobiology
Translational Research Laboratories
125 South 31st Street, Suite 2100
Philadelphia, PA 19104-3403
Office: 215-746-4806
Fax: 215-746-4814
Graduate Group Affiliations
Education:
M.B.Ch.B
University of Glasgow, Scotland, 1967.
Ph.D. (Mathematical models of lung function)
University of Glasgow, Scotland, 1976.
Post-Graduate Training
Junior House Officer in Medicine, Department of Medicine, Glasgow Royal Infirmary, Scotland [Equivalent to Internship], 1967-1968.
Senior House Officer in Medicine, Department of Medical Cardiology, Glasgow Royal Infirmary, Scotland, 1968-1969.
Junior House Officer in Surgery, Glasgow Royal Infirmary, Scotland [Equivalent to Internship; February to July], 1968-1968.
Registrar in Internal/Pulmonary Medicine, Glasgow Royal Infirmary, Scotland [Equivalent to Residency, Fellowship], 1970-1973.
Wellcome Research Fellow, Centre for Respiratory Investigation, Glasgow Royal Infirmary, Scotland, 1973-1976.
Honorary Senior Registrar, Respiratory Medicine, Centre for Respiratory Investigation, Glasgow Royal Infirmary, Scotland, 1974-1976.
Senior Registrar, Pulmonary Medicine, Glasgow Royal Infirmary (further training in Pulmonary Medicine) [February to August], 1976-1976.
Certifications
MRCP (UK) (postgraduate examination - equivalent to Boards of Internal Medicine), 1970.
Permanent link
 
> Perelman School of Medicine   > Faculty   > Details

Description of Research Expertise

Dr. Pack is pursuing research on genetics/genomics of sleep and its disorders. His laboratory is conducting studies in Drosophila and mice and translating these findings to humans. A particular focus of Dr. Pack’s work is to evaluate the genetic determinants of sleep homeostasis. Studies are ongoing to evaluate molecular mechanisms of sleepiness and sleep promotion using both hypothesis-driven and discovery science. The latter involves analysis of the changes in the transcription with sleep/wake and sleep deprivation in identified neuronal populations. Techniques being used include behavioral/sleep studies in Drosophila and mice, RT-PCR, Western analysis of protein, expression profiling, laser microcapture dissection, RNA seq and immunohistochemistry. Dr. Pack is committed to research training and directs two training grants from the National Institutes of Health.

Description of Clinical Expertise

Dr. Pack's clinical expertise is in sleep disorders with a particular focus on diagnosis and management of obstructive sleep apnea. He is internationally recognized for his expertise in this area and has been listed in the Best Doctor's in the United States and in the Philadelphia region (Philadelphia Magazine).

Selected Publications

Lim, D.C., Brady, D.C., Soans, R., Kim, E.Y., Valverde, L., Keenan, B.T., Guo, X., Kim, W.Y., Park, M.J., Galante, R.J., Shackleford, J.A. and Pack, A.I.: Different cyclical intermittent hypoxia severities have different effects on hippocampal microvasculature. Journal of Applied Physiology (1985) 121(1): 78-88, Jul 2016.

Prasad, B., Usmani, S., Steffen, A.D., Van Dongen, H., Pack, F.M., Strakovsky, I., Staley, B., Dinges, D., Maislin, G., Pack, A.I. and Weaver, T.E.: Short-term variability in apnea-hypopnea index during extended home portable monitoring. Journal of Clinical Sleep Medicine 12(6): 855-863, Jun 2016.

Benotti, P., Wood, G.C., Argyropoulos, G., Pack, A., Keenan, B.T., Gao, X., Gerhard, G. and Still, C.: The impact of obstructive sleep apnea on nonalcoholic fatty liver disease in patients with severe obesity. Obesity 24(4): 871-877, Apr 2016.

Mullington, J.M., Abbott, .SM., Carroll, J.E., Dijk, D.J., Dinges, D.F., Gehrman, P.R., Ginsburg, G.S., Gozal, D., Haack, M., Lim, D.C., Macrea, M., Pack, A.I., Plante, D.T., Teske, J.A. and Zee, P.C.: Developing biomarker arrays predicting sleep and circadian-coupled risks to health. Sleep 39(4): 727-736, Apr 2016.

Magalang, U.J., Arnardottir, E.S., Chen, N.H., Cistulli, P.A., Gislason, T., Lim, D., Penzel, T., Schwab, R., Tufik, S. and Pack, A.I.: Agreement in the scoring of respiratory events among international sleep centers for home sleep testing. Journal of Clinical Sleep Medicine 12(1): 71-77, Jan 2016.

Bjornsdottir, E., Benediktsdottir, B., Pack, A.I., Arnardottir, E.S., Kuna, S.T., Gislason, T., Keenan, B.T., Maislin, G. and Sigurdsson, J.F.: The prevalence of depression among untreated obstructive sleep apnea patients using a standardized psychiatric interview. Journal of Clinical Sleep Medicine 12(1): 105-112, Jan 2016.

Lyons, M.M., Bhatt, N.Y., Kneeland-Szanto, E., Keenan, B.T., Pechar, J., Stearns, B., Elkassabany, N.M., Memtsoudis, S.G., Pack, A.I. and Gurubhagavatula, I.: Sleep apnea in total joint arthroplasty patients and the role for cardiac biomarkers for risk stratification: an exploration of feasibility. Biomarkers in Medicine 10(3): 265-300, 2016.

Soans, R.E., Lim, D.C., Keenan, B.T., Pack, A.I. and Shackleford, J.A.: Automated protein localization of blood brain barrier vasculature in brightfield IHC images. PLoS One 11(2): e0148411, 2016.

Parthasarathy, S., Carskadon, M.A., Jean-Louis, G., Owens, J., Bramoweth, A., Combs, D., Hale, L., Harrison, E., Hart, C.N., Hasler, B.P., Honaker, S.M. Hertenstein, E., Kuna, S., Kushida, C., Levenson, J.C., Murray, C., Pack, A.I., Pillai, V., Pruiksma, K., Seixas, A., Strollo, P. Thosar, S.S., Williams, N. and Buysse, D.: Implementation of sleep and circadian science: recommendation from the Sleep Research Society and National Institutes of Health workshop. Sleep 2016 Notes: Oct 10. pii: sp-00553-16.

Watson, N.F., Buchwald, D., Delrow, J.J., Altemeier, W.A., Vitiello, M.V., Pack, A.I., Bamshad, M., Noonan, C. and Gharib, S.: Transcriptional signatures of sleep duration discordance in monozygotic twins. Sleep 2016 Notes: Sep 9. pii: sp-00268-16. [Epub ahead of print]

back to top
Last updated: 10/20/2016
The Trustees of the University of Pennsylvania