Penn Cardiovascular Institute

Penn Cardiovascular Institute Research Directory

faculty photo

Richard K. Assoian, Ph.D.

Professor of Pharmacology
Department: Pharmacology
Graduate Group Affiliations

Contact information
Department of Systems Pharmacology and Translational Therapeutics
421 Curie Blvd.
Rm 805(office)/833 (lab)
Philadelphia, PA 19104-6160
Office: (215) 898-7157
Fax: (215) 573-5656
Lab: (215) 898-7265
B.A. (Natural Science)
Johns Hopkins University, 1975.
Ph.D. (Biochemistry)
University of Chicago, 1981.
Permanent link
> Perelman School of Medicine   > Faculty   > Details

Selected Publications

Mui, KM., Bae, YH, Gao, L., Liu, S-L. Xu, T., Radice, GL., Chen, CS, and Assoian, RK: N-cadherin induction by ECM stiffness and FAK overrides the spreading requirement for proliferation of vascular smooth muscle cells. Cell Reports 10: 1477-1486, 2015.

Liu SL, Bae YH, Yu C, Monslow J, Hawthorne EA, Castagnino P, Branchetti E, Ferrari G, Damrauer SM, Puré E, Assoian RK: Matrix metalloproteinase-12 is an essential mediator of acute and chronic arterial stiffening. Scientific Reports 5: 17189, 2015.

Bae YH, Mui KL, Hsu BY, Liu SL, Cretu A, Razinia Z, Xu T, Puré E, Assoian RK. : A FAK-Cas-Rac-Lamellipodin Signaling Module Transduces Extracellular Matrix Stiffness into Mechanosensitive Cell Cycling. Science Signaling 7: ra57, 2014.

Castagnino, P.*, Kothapalli, D.*, Hawthorne, E.A., Liu, S-L., Xu, T., Rao, S., Yung, Y., and Assoian, R.K. : miR-221/222 compensates for Skp2-mediated p27 degradation and is a primary target of cell cycle regulation by prostacyclin and cAMP. PLoS One, 8: e56140, 2013.

Kothapalli, D.*, Liu, S.L.*, Bae, Y.H., Monslow, J., Xu, T., Hawthorne, E.A., Castagnino, P., Byfield, F.J., Rao, S., Rader, D.J., Pure, E., Phillips, M.C., Lund-Katz, S., Janmey, P.A., Assoian, R.K.: Cardiovascular protection by apoE and apoE-HDL linked to suppression of ECM gene expression and arterial stiffening. Cell Reports 2: 1259-1271, 2012.

Klein, E.A., Yin, L., Kothapalli, D., Castagnino, P., Byfield, F.J., Xu, T., Levantal, I., Hawthorne, E., Janmey, P.A., and Assoian, R.K.: Cell cycle control by physiological matrix elasticity and in vivo tissue stiffening. Current Biology 19: 1511-8, 2009.

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Last updated: 11/30/2015
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