Richard K. Assoian, Ph.D.
Professor of Pharmacology
Department: Pharmacology
Graduate Group Affiliations
Contact information
Department of Pharmacology
167 Johnson Pavilion
3620 Hamilton Walk
Philadelphia, PA 19104-6084
167 Johnson Pavilion
3620 Hamilton Walk
Philadelphia, PA 19104-6084
Office: (215) 898-7157
Fax: (215) 573-5656
Fax: (215) 573-5656
Email:
assoian@mail.med.upenn.edu
assoian@mail.med.upenn.edu
Publications
Education:
B.A. (Natural Science)
Johns Hopkins University, 1975.
Ph.D. (Biochemistry)
University of Chicago, 1981.
Permanent linkB.A. (Natural Science)
Johns Hopkins University, 1975.
Ph.D. (Biochemistry)
University of Chicago, 1981.
Description of CVI Expertise
CVI Program Unit(s):Lipid / Atherosclerosis / CAD / ACS / Prevention
CVI Research Description:
We study molecular mechanisms that regulate the proliferation of vascular smooth muscle cells in injury and atherosclerosis. We identify cell cycle regulatory mechanisms using primary smooth muscle cells in culture and then assess the biological importance of these mechanisms in wild-type and genetically engineered mice, after vascular injury and during atherogenesis.
Selected Publications
Klein, E.A., Yin, L., Kothapalli, D., Castagnino, P., Byfield, F.J., Xu, T., Levantal, I., Hawthorne, E., Janmey, P.A., and Assoian, R.K.: Cell cycle control by phsyiological matrix elasticity and in vivo tissue stiffening. Current Biology 19: 1511-8, 2009.Assoian, R.K. and Klein, E.A.: Growth control by intracellular tension and extracellular stiffness. Trends in Cell Biology 18(7): 347-52, 2008.
Assoian RK and Yung Y: A reciprocal relationship between Rb and Skp2: Implications for restriction point control, signal transduction to the cell cycle and cancer [Review] Cell Cycle 7: 24-27, 2008.
Klein, E.A., Campbell, L.E., Kothapalli, D., Fournier, A.K., and Assoian, R.K.: Joint requirement for Rac and ERK activities underlies the mid-G1 phase induction of cyclin D1 and S phase entry in both epithelial and mesenchymal cells. The Journal of Biological Chemistry 283: 30911-8, 2008.
Yin L, Castagnino P, Assoian RK: ABCG2 expression and side population abundance regulated by a transforming growth factor beta-directed epithelial-mesenchymal transition. Cancer Res 68: 800-817, 2008.
Yung Y, Walker JL, Roberts JM, Assoian RK: A Skp2 autoinduction loop and restriction point control. J Cell Biol 178: 741-747, 2007.
Kothapalli D, Zhao L, Hawthorne EA, Cheng Y, Lee E, Pure E, Assoian RK: Hyaluronan and CD44 antagonize mitogen-dependent cyclin D1 expression in mesenchymal cells. J Cell Biol 176: 535-544, 2007.
Kothapalli D, Fuki I, Ali K, Stewart SA, Zhao L, Yahil R, Kwiatkowski D, Hawthorne EA, FitzGerald GA, Phillips MC, Lund-Katz S, Pure E, Rader DJ, Assoian RK: Antimitogenic effects of HDL and APOE mediated by Cox-2-dependent IP activation. J Clin Invest 113: 609-618, 2004.
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