Mark L. Kahn, M.D., B.A.
Professor of Medicine
Department: Medicine
Graduate Group Affiliations
Contact information
BRB II/III Room 952
421 Curie Boulevard
University of Pennsylvania
Philadelphia, PA 19104
421 Curie Boulevard
University of Pennsylvania
Philadelphia, PA 19104
Office: (215) 898-9007
Fax: (215) 573-2094
Fax: (215) 573-2094
Email:
markkahn@mail.med.upenn.edu
markkahn@mail.med.upenn.edu
Publications
Links
Search PubMed for articles
Kahn Lab (MCRC)
Cell and Molecular Biology Graduate Group
Pharmacological Sciences Graduate Group
Molecular Cardiology Research Center
Cardiovascular Institute
Cardiovascular Division Faculty
Search PubMed for articles
Kahn Lab (MCRC)
Cell and Molecular Biology Graduate Group
Pharmacological Sciences Graduate Group
Molecular Cardiology Research Center
Cardiovascular Institute
Cardiovascular Division Faculty
Education:
B.A. (Science)
Brown University, 1984.
M.D. (Internal Medicine)
Brown University School of Medicine, 1987.
Permanent linkB.A. (Science)
Brown University, 1984.
M.D. (Internal Medicine)
Brown University School of Medicine, 1987.
Description of CVI Expertise
CVI Program Unit(s):Cardiovascular Development / Congenital Heart Disease
Thrombosis / Hemostasis
CVI Research Description:
The Kahn Lab investigates signaling pathways in platelets that mediate thrombosis and signaling pathways in vascular endothelial cells of the blood and lymphatic system utilized during cardiovascular development.
Selected Publications
Sarratt K, Chen H, Kahn M.L., Hammer D.A. : Platelet receptor, glycoprotein VI-mediated adhesion to type I collagen under hydrodynamic flow. Annals of Biomedical Engineering 32(7): 970-976, July 2004.Boylan B, Chen H, Rathore V, Paddock C, Salacz M, Friedman KD, Curtis BR, Stapleton M, Newman DK, Kahn ML, Newman PJ. : Anti-GPVI-associated ITP: An acquired platelet disorder caused by autoantibody-mediated clearance of the GPVI/FcR{gamma}-chain complex from the human platelet surface. Blood 104(5): 1350-5, Sept 1 2004.
Brass LE, Mollino M, O'Brien PJ, Kahn ML: Platelet receptors for Thrombin. Platelets in Thrombotic and Non-Thrombotic Disorders: Pathophysiology, Pharmacology and Therapeutics. Paolo Gresele, Clive Page and Valentin Fuster. (eds.). Cambridge University Press 1 edition(Ch. 8): 113-126, Jun 15 2002.
Kahn, ML: Collagen-Platelet Interactions. Seminars in Thrombosis and Hemostasis 30(4): 419-425, Aug 2004.
Gardiner, E.E., Arthur, J.F., Kahn, M.L., Berndt, M.C., Andres, R.K.: Regulation of Platelet Membrane Levels of Glycoprotein VI by a Platelet-Derived Metaloproteinase. Blood 104(12): 3611-7, Dec 1 2004.
Abtahian F, Guerriero A, Sebzda E, Lu MM, Zhou R, Mocsia A, Myers EE, Huang B, Jackson DG, Ferrari VA, Tybulewicz V, Lowell CA, Lepore JJ, Koretzky GA, Kahn ML: Regulation of blood lymphatic vascular separation by signaling proteins SLP-76 and Syk. Science 299(5604): 247-251, Jan 10 2003.
Larson MK, Chen H, Kahn ML, Taylor AM, Fabre JE, Mortensen RM, Conley PB, Parise LV: Identification of P2Y12-dependent and –independent mechanisms of glycoprotein V1-mediated Rap1 activation in platelets. Blood 101(4): 1409-1415, Feb 15 2003.
Locke D, Liu C, Peng X, Chen H, Kahn ML. : Fc Rgamma -independent Signaling by the Platelet Collagen Receptor Glycoprotein VI. Journal of Biological Chemistry 278(17): 15441-15448, Apr 25 2003.
Chen,H and Kahn, M.L.: Reciprocal signaling by integrin and non-integrin receptors during collagen activation of platelets. Molecular and Cellular Biology 23(14): 4764-4777, July 2003.
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