Penn Cardiovascular Institute

Penn Cardiovascular Institute Research Directory

faculty photo

Mark L. Kahn, M.D., B.A.

Professor of Medicine
Department: Medicine
Graduate Group Affiliations

Contact information
11-123 Smilow Center for Translational Research
3400 Civic Center Boulevard, Bldg. 421
Philadelphia, PA 19104-5159
Office: (215) 898-9007
Fax: (215) 573-2094
Education:
B.A. (Science)
Brown University, 1984.
M.D. (Internal Medicine)
Brown University School of Medicine, 1987.
Permanent link
 
> Perelman School of Medicine   > Faculty   > Details

Description of CVI Expertise

CVI Program Unit(s):
Cardiovascular Development / Congenital Heart Disease
Thrombosis / Hemostasis

CVI Research Description:
The Kahn Lab investigates signaling pathways in platelets that mediate thrombosis and signaling pathways in vascular endothelial cells of the blood and lymphatic system utilized during cardiovascular development.

Selected Publications

Herzog BH, Fu J, Wilson SJ, Hess PR, Sen A, McDaniel JM, Pan Y, Sheng M, Yago T, Silasi-Mansat R, McGee S, May F, Nieswandt B, Morris AJ, Lupu F, Coughlin SR, McEver RP, Chen H, Kahn ML, Xia L: Podoplanin maintains high endothelial venule integrity by interacting with platelet CLEC-2. Nature Sept 2013 Notes: Epub ahead of print.

Rawnsley DR, Xiao J, Lee J, Liu X, Mericko-Ishizuka P, Kumar V, He J, Basu A, Lu M, Lynn FC, Pack M, Gasa R, Kahn ML: The transcription factor Atonal homolog 8 regulates Gata4 and Friend of Gata-2 during vertebrate development. Journal of Biology and Chemistry Jul 2013 Notes: Epub ahead of print.

Stanger BZ, Kahn ML: Platelets and tumor cells: a new form of border control. Cancer Cell 8(24): 9-11, Jul 2013.

Kahn ML, Rader DJ: Lymphatics as a new player in cholesterol transport. Cell Metabolism 17(5): 627-8, May 2013.

Zou Z, Enis D, Bui H, Khandros E, Kumar V, Jakus Z, Thom C, Yang Y, Dhillon V, Chen M, Lu M, Weiss MJ, Kahn ML: The secreted lymphangiogenic factor CCBE1 is essential for fetal liver erythopoiesis. Blood Apr 2013 Notes: Epub ahead of print.

Zou Z, Enis D, Bui H, Khandros E, Kumar V, Jakus Z, Thom C, Yang Y, Dhillon V, Chen M, Lu M, Weiss MJ, Kahn ML: The secreted lymphangiogenic factor CCBE1 is essential for fetal liver erythropoiesis. Blood Feb 2013.

Boulaftali Y, Hess PR, Getz TM, Cholka A, Stolla M, Mackman N, Owens AP 3rd, Ware,J Kahn ML, Bergmeier W.: Platelet ITAM signaling is critical for vascular integrity in inflammation. Journal of Clinical Investigation Jan 2013 Notes: [Epub ahead of print]

Hess PR, Rawnsley DR, Jakus Z, Yang Y, Sweet DT, Fu J, Herzog B, Lu MM, Nieswandt B, Oliver G, Makinen T, Xia L, Kahn ML: Platelets mediate lympho-venous hemostasis to maintain blood-lymphatic separation throughout life. Journal of Clinical Investigation 2013 Notes: in press.

Acton SE, Astarita JL, Malhotra D, Lukacs-Kornek V, Franz B, Hess PR, Jakus Z, Kuligowski M, Fletcher AL, Elpek KG, Bellemare-Pelletier A, Sceats L, Reynoso ED, Gonzalez SF, Graham DB, Chang J, Peters A, Woodruff M, Kim YA, Swat W, Morita T, Kuchroo V, Carroll MC, Kahn ML, Wucherpfennig KW, Turley SJ.: Podoplanin-rich stromal networks induce dendritic cell motility via activation of the C-type ectin receptor CLEC-2. Immunity 37(2): 276-89, Aug 2012.

Zheng X, Xu C, Smith AO, Stratman AN, Zou Z, Kleaveland B, Yuan L, Didiku C, Sen A, Liu X, Skuli N, Zaslavasky A, Chen M, Cheng L, Davis GE, Kahn ML. : Dynamic regulation of the cerebral cavernous malformation pathway controls vascular stability and growth. Developmental Cell 23(2): 342-55, Aug 2012.

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Last updated: 12/06/2013
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