Mark L. Kahn, M.D., B.A.
Professor of Medicine
Department: Medicine
Graduate Group Affiliations
Contact information
11-123 Smilow Center for Translational Research
3400 Civic Center Boulevard, Bldg. 421
Philadelphia, PA 19104-5159
3400 Civic Center Boulevard, Bldg. 421
Philadelphia, PA 19104-5159
Office: (215) 898-9007
Fax: (215) 573-2094
Fax: (215) 573-2094
Email:
markkahn@mail.med.upenn.edu
markkahn@mail.med.upenn.edu
Publications
Links
Search PubMed for articles
Kahn Lab (CVI)
Cardiovascular Division Faculty
Cell and Molecular Biology Graduate Group
Cardiovascular Institute
Pharmacological Sciences Graduate Group
Search PubMed for articles
Kahn Lab (CVI)
Cardiovascular Division Faculty
Cell and Molecular Biology Graduate Group
Cardiovascular Institute
Pharmacological Sciences Graduate Group
Education:
B.A. (Science)
Brown University, 1984.
M.D. (Internal Medicine)
Brown University School of Medicine, 1987.
Permanent linkB.A. (Science)
Brown University, 1984.
M.D. (Internal Medicine)
Brown University School of Medicine, 1987.
Description of CVI Expertise
CVI Program Unit(s):Cardiovascular Development / Congenital Heart Disease
Thrombosis / Hemostasis
CVI Research Description:
The Kahn Lab investigates signaling pathways in platelets that mediate thrombosis and signaling pathways in vascular endothelial cells of the blood and lymphatic system utilized during cardiovascular development.
Selected Publications
Zou Z, Enis D, Bui H, Khandros E, Kumar V, Jakus Z, Thom C, Yang Y, Dhillon V, Chen M, Lu M, Weiss MJ, Kahn ML: The secreted lymphangiogenic factor CCBE1 is essential for fetal liver erythopoiesis. Blood Feb 2013 Notes: Epub ahead of print.Zou Z, Enis D, Bui H, Khandros E, Kumar V, Jakus Z, Thom C, Yang Y, Dhillon V, Chen M, Lu M, Weiss MJ, Kahn ML: The secreted lymphangiogenic factor CCBE1 is essential for fetal liver erythropoiesis. Blood Feb 2013.
Boulaftali Y, Hess PR, Getz TM, Cholka A, Stolla M, Mackman N, Owens AP 3rd, Ware,J Kahn ML, Bergmeier W.: Platelet ITAM signaling is critical for vascular integrity in inflammation. Journal of Clinical Investigation Jan 2013 Notes: [Epub ahead of print]
Acton SE, Astarita JL, Malhotra D, Lukacs-Kornek V, Franz B, Hess PR, Jakus Z, Kuligowski M, Fletcher AL, Elpek KG, Bellemare-Pelletier A, Sceats L, Reynoso ED, Gonzalez SF, Graham DB, Chang J, Peters A, Woodruff M, Kim YA, Swat W, Morita T, Kuchroo V, Carroll MC, Kahn ML, Wucherpfennig KW, Turley SJ.: Podoplanin-rich stromal networks induce dendritic cell motility via activation of the C-type ectin receptor CLEC-2. Immunity 37(2): 276-89, Aug 2012.
Zheng X, Xu C, Smith AO, Stratman AN, Zou Z, Kleaveland B, Yuan L, Didiku C, Sen A, Liu X, Skuli N, Zaslavasky A, Chen M, Cheng L, Davis GE, Kahn ML. : Dynamic regulation of the cerebral cavernous malformation pathway controls vascular stability and growth. Developmental Cell 23(2): 342-55, Aug 2012.
Chen CY, Bertozzi C, Zou Z, Yuan L, Lee JS, Lu MM, Stachelek SJ, Srinivasan S, Guo L, Vincente A, Mericko P, Levy RJ, Makinen T, Oliver G, Kahn ML: Blood flow reprograms lymphatic vessels to blood vessels. Journal of Clinical Investigation 122(6): 2006-17, June 2012.
Schmaier AA, Stalker TJ, Runger JJ, Lee D, Nagaswami C, Mericko P, Chen M, Cliché S, Gariepy C, Brass LF, Hammer DA, Weisel J, Rosenthal K, Kahn ML. : Occusive thrombi arise in mammals but not birds in response to arterial injury: evolutionary insight into human cardiovascular disease. Blood 118(13): 3661, Sept. 2011.
Yuan LJ, Wang T, Kahn ML, Ferrari VA: High-resolution echocardiographic assessment of infarct size and cardiac function in mice with myocardial infarction. Journal of the American Society of Echocardiography Page: 219-26, Feb 2011.
Rubio-Garcia J, Coppel Y, Lecante P, Mingotaud C, Chaudret B, Gauffre F, Kahn ML. : One-step synthesis of metallic and metal oxide nanoparticles using amino-PEG oligomers as multi-purpose ligands: size and shape control, and quasi-universal solvent dispersibility. Chemistry Communications (Cambridge England) Page: 988-90, Jan 2011.
Winkelmann R, Sandrock L, Porstner M, Roth E, Mathews M, Hobeika E, Reth M, Kahn ML, Schuh W, Jäck HM.: B cell homeostasis and plasma cell homing controlled by Kruppel-like factor 2. Proceedings of the National Academy of Sciences of the United States of America 108(2): 710-5, Jan 2011 Notes: [Epub 2010, Dec. 27.