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Mark L. Kahn, M.D.

Edward S. Cooper, M.D./Norman Roosevelt and Elizabeth Meriwether McLure Professor
Department: Medicine
Graduate Group Affiliations

Contact information
11-123 Smilow Center for Translational Research
3400 Civic Center Boulevard, Bldg. 421
Philadelphia, PA 19104-5159
Office: (215) 898-9007
Fax: (215) 573-2094
Education:
B.A. (Science)
Brown University, 1984.
M.D. (Internal Medicine)
Brown University School of Medicine, 1987.
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Description of CVI Expertise

CVI Program Unit(s):
Cardiovascular Development / Congenital Heart Disease
Thrombosis / Hemostasis

CVI Research Description:
The Kahn Lab investigates signaling pathways in platelets that mediate thrombosis and signaling pathways in vascular endothelial cells of the blood and lymphatic system utilized during cardiovascular development.

Selected Publications

Tang Alan T, Choi Jaesung P, Kotzin Jonathan J, Yang Yiqing, Hong Courtney C, Hobson Nicholas, Girard Romuald, Zeineddine Hussein A, Lightle Rhonda, Moore Thomas, Cao Ying, Shenkar Robert, Chen Mei, Mericko Patricia, Yang Jisheng, Li Li, Tanes Ceylan, Kobuley Dmytro, Võsa Urmo, Whitehead Kevin J, Li Dean Y, Franke Lude, Hart Blaine, Schwaninger Markus, Henao-Mejia Jorge, Morrison Leslie, Kim Helen, Awad Issam A, Zheng Xiangjian, Kahn Mark L: Endothelial TLR4 and the microbiome drive cerebral cavernous malformations. Nature 545(7654): 305-310, May 2017 Notes: Covered in the NYT: https://www.nytimes.com/2017/05/10/health/brain-defect-gut-bacteria-microbiome.html.

Welsh John D, Kahn Mark L, Sweet Daniel T: Lymphovenous hemostasis and the role of platelets in regulating lymphatic flow and lymphatic vessel maturation. Blood 128(9): 1169-73, Sep 2016.

Girard Romuald, Zeineddine Hussein A, Orsbon Courtney, Tan Huan, Moore Thomas, Hobson Nick, Shenkar Robert, Lightle Rhonda, Shi Changbin, Fam Maged D, Cao Ying, Shen Le, Neander April I, Rorrer Autumn, Gallione Carol, Tang Alan T, Kahn Mark L, Marchuk Douglas A, Luo Zhe-Xi, Awad Issam A: Micro-computed tomography in murine models of cerebral cavernous malformations as a paradigm for brain disease. Journal of neuroscience methods 271: 14-24, Sep 2016.

Cha Boksik, Geng Xin, Mahamud Md Riaj, Fu Jianxin, Mukherjee Anish, Kim Yeunhee, Jho Eek-Hoon, Kim Tae Hoon, Kahn Mark L, Xia Lijun, Dixon J Brandon, Chen Hong, Srinivasan R Sathish: Mechanotransduction activates canonical Wnt/β-catenin signaling to promote lymphatic vascular patterning and the development of lymphatic and lymphovenous valves. Genes & development 30(12): 1454-69, Jun 2016.

Bui Hung M, Enis David, Robciuc Marius R, Nurmi Harri J, Cohen Jennifer, Chen Mei, Yang Yiqing, Dhillon Veerpal, Johnson Kathy, Zhang Hong, Kirkpatrick Robert, Traxler Elizabeth, Anisimov Andrey, Alitalo Kari, Kahn Mark L: Proteolytic activation defines distinct lymphangiogenic mechanisms for VEGFC and VEGFD. The Journal of Clinical Investigation 126(6): 2167-80, May 2016.

Zhou Z, Tang AT, Wong WY, Bamezai S, Goddard LM, Shenkar R, Zhou S, Yang J, Wright AC, Foley M, Arthur JS, Whitehead KJ, Awad IA, Li DY, Zheng X, Kahn ML: Cerebral cavernous malformations arise from endothelial gain of MEKK3-KLF2/4 signaling. Nature 532(7597): 122-6, April 2016.

Maltzman Jonathan S, Reed Hasina Outtz, Kahn Mark L: HA-ving lymphatics improves lung transplantation. The Journal of clinical investigation 125(11): 3999-4001, Nov 2015.

Sweet DT, Jiménez JM, Chang J, Hess PR, Mericko-Ishizuka P, Fu J, Xia L, Davies PF, Kahn ML: Lymph flow regulates collecting lymphatic vessel maturation in vivo. Journal of Clinical Investigation 125(8): 2995-3007, Aug 2015.

Kahn Mark L: Vascular development for climate control. Developmental cell 33(3): 241-2, May 2015.

Yang Yiqing, Enis David, Zheng Hui, Chia Stephanie, Yang Jisheng, Chen Mei, Dhillon Veerpal, Papayannapoulou Thalia, Kahn Mark L: Cell adhesion mediated by VCAM-ITGa9 interactions enables lymphatic development. Arteriosclerosis, Thrombosis, and Vascular Biology 35(5): 1175-89, Mar 2015.

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Last updated: 06/09/2017
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