Elena A Goncharova, Ph.D.
Research Assistant Professor of Medicine
Department: Medicine
Contact information
Airways Biology Initiative
Pulmonary, Allergy, and Critical Care Division
University of Pennsylvania School of Medicine
TRL, Room 1214,
125 South 31st Street
Philadelphia, PA 19104
Pulmonary, Allergy, and Critical Care Division
University of Pennsylvania School of Medicine
TRL, Room 1214,
125 South 31st Street
Philadelphia, PA 19104
Office: (215)746-3593
Fax: (215)746-1224
Fax: (215)746-1224
Email:
goncharo@mail.med.upenn.edu
goncharo@mail.med.upenn.edu
Education:
M.S.
Moscow Lomonosov State University, Moscow, Russia, 1993.
Ph.D.
Cardiology Research Center, Russian Academy of Sciences, 2000.
Permanent linkM.S.
Moscow Lomonosov State University, Moscow, Russia, 1993.
Ph.D.
Cardiology Research Center, Russian Academy of Sciences, 2000.
Selected Publications
Goncharova, E.A.: mTOR and vascular remodeling in lung diseases: current challenges and therapeutic prospects. The FASEB Journal accepted, 2013.Goncharova, E.A., Goncharov, D.A., Fehrenbach, M., Khavin, I., Ducka, B., Hino, O., Colby, T.V., Merrilees, M.J., Haczku, A., Albelda, S.M., and Krymskaya, V.P. : Prevention of Alveolar Destruction and Airspace Enlargement in a Mouse Model of Pulmonary Lymphangioleiomyomatosis (LAM) Science Translational Medicine 4(154): 154ra134, Oct 2012.
Krymskaya, V.P., Snow, J., Cesarone, G., Khavin, I., Goncharov, D.A., Lim, P.N., Veasey, S.C., Ihida-Stansbury, K., Jones, P.L., Goncharova, E.A.: mTOR is Required for Pulmonary Arterial Vascular Smooth Muscle Cell Proliferation Under Chronic Hypoxia. The FASEB Journal 25(6): 1922-1933, June 2011.
Goncharova, E.A., Goncharov, D.A., Li, H., Pimtong, W., Lu, S., Khavin, I., Krymskaya, V.P.: mTORC2 is Required for Proliferation and Survival of TSC2-Null Cells. Molecular and Cellular Biology 31(12): 2484-2498, June 2011.
Goncharova, E.A., Lim, P.N., Chisolm, A., Fogle H.W. III, Taylor, J.H., Goncharov, D.A., Eszterhas, A., Panettieri, R.A., Jr., Krymskaya, V.P. : Interferons Modulate Mitogen-Induced Protein Synthesis in Airway Smooth Muscle (ASM) American Journal of Physiology - Lung Cellular and Molecular Physiology 299: L25-L35, 2010.
Goncharova, E.A., Goncharov, D.A., Damera G., Tliba, O., Amrani, Y., Panettieri, R.A., Krymskaya, V.P.: STAT3 is required for abnormal proliferation and survival of TSC2-deficient cells: relevance to pulmonary LAM. Molecular Pharmacology 76(4): 766-777, 2009.
Goncharova EA, Goncharov DA, Lim PN, Noonan D, Krymskaya VP.: Modulation of cell migration and invasiveness by tumor suppressor TSC2 in lymphangioleiomyomatosis. American Journal of Respiratory Cell and Molecular Biology 34(4): 473-80, Apr 2006.
Goncharova E, Goncharov D, Noonan D, Krymskaya VP.: TSC2 modulates actin cytoskeleton and focal adhesion through TSC1-binding domain and the Rac1 GTPase. Journal of Cell Biology 167(6): 1171-82, Dec 20 2004.
Goncharova EA, Ammit AJ, Irani C, Carroll RG, Eszterhas AJ, Panettieri RA, Krymskaya VP.: PI3K is required for proliferation and migration of human pulmonary vascular smooth muscle cells. American Journal of Physiology - Lung Cellular and Molecular Physiology 283(2): L354-63, Aug 2002.
Goncharova EA, Goncharov DA, Eszterhas A, Hunter DS, Glassberg MK, Yeung RS, Walker CL, Noonan D, Kwiatkowski DJ, Chou MM, Panettieri RA Jr, Krymskaya VP.: Tuberin regulates p70 S6 kinase activation and ribosomal protein S6 phosphorylation. A role for the TSC2 tumor suppressor gene in pulmonary lymphangioleiomyomatosis (LAM). Journal of Biological Chemistry 277(34): 30958-67, Aug 23 2002.