X. Long Zheng, M.D, Ph.D
Associate Professor of Pathology and Laboratory Medicine
Department: Pathology and Laboratory Medicine
Graduate Group Affiliations
Contact information
Abramson Research Center 816G
The Children's Hospital of Philadelphia
The 34th Street & Civic Center Blvd,
Philadelphia, PA 19104
The Children's Hospital of Philadelphia
The 34th Street & Civic Center Blvd,
Philadelphia, PA 19104
Office: (215) 590-3565
Fax: 267-426-5165
Fax: 267-426-5165
Email:
zheng@email.chop.edu
zheng@email.chop.edu
Publications
Links
Search PubMed for articles
Biochemistry and Molecular Biophysics Graduate Program
All Publications and Impact Factors
Cell and Molecular Biology Graduate Program
Penn Medicine
Children's Hospital of Philadelphia Research Institute
Department of Pathology and Laboratory Medicine
Search PubMed for articles
Biochemistry and Molecular Biophysics Graduate Program
All Publications and Impact Factors
Cell and Molecular Biology Graduate Program
Penn Medicine
Children's Hospital of Philadelphia Research Institute
Department of Pathology and Laboratory Medicine
Education:
M.D. (Medicine)
Nanchang University Medical College, Nanchang, China, 1984.
Ph.D. (Molecular and Cell Biology)
Medical University of Vienna, Vienna, Austria, 1994.
Residency (Clinical Pathology)
Washington University School of Medicine, St. Louis, MO, 2002.
Fellowship (Transfusion Medicine)
Washington University School of Medicine, St. Louis, MO, 2003.
Permanent linkM.D. (Medicine)
Nanchang University Medical College, Nanchang, China, 1984.
Ph.D. (Molecular and Cell Biology)
Medical University of Vienna, Vienna, Austria, 1994.
Residency (Clinical Pathology)
Washington University School of Medicine, St. Louis, MO, 2002.
Fellowship (Transfusion Medicine)
Washington University School of Medicine, St. Louis, MO, 2003.
Selected Publications
Jin S.Y., Xiao J., Bao J., Zhou S.Z., Wright J.F., and Zheng X.L.: AAV-mediated expression of an ADAMTS13 variant prevents shigatoxin-induced thrombotic thrombocytopenic purpura. Blood In Press: doi:10.1182/blood-2013-02-486779, March 2013.Zheng X.L.: Structure-function and cofactor-dependent regulation of ADAMTS13 protease. J. Thromb. Haemost. In Press: doi:10.1111/jth.12221, June 2013.
Cao W.J., Sabatino D.E, Altynova E., Lange A.M., Casina V.C., Camire R.M. and Zheng X.L.: Light Chain of Factor VIII Is Sufficient for Accelerating Cleavage of von Willebrand Factor by ADAMTS13 Metalloprotease. J. Biol. Chem. 287(39): 32459–32466. August 2012.
Jian C., Xiao J., Gong L., Skipwith C.G., Jin S-Y, Kwaan H-C, and Zheng X.L.: Gain-of-function ADAMTS13 variants that are resistant to inhibition by autoantibodies in patients with acquired idiopathic thrombotic thrombocytopenic purpura. Blood 119(16): 3836-43. April 2012.
Jin S-Y., Tohyama J., Bauer R.C., Cao N.N, Rader D.J., and Zheng X.L.: Genetic ablation of Adamts13 gene dramatically accelerates the early atherosclerosis in a murine model. Arteriscler. Thromb. Vasc. Biol. (ATVB) 32: 1817-1823, August 2012.
Zheng X.L. : ADAMTS13 Meets MR, then What? Blood 119(16): 2652-54. April 2012.
Xiao J., Jin S-Y., Xue J., Sorvillo N., Voorberg J., and Zheng X.L.: Essential Domains of ADAMTS13 Metalloprotease Required for Modulation of Arterial Thrombosis. Arterioscler. Thromb. Vasc. Biol. (ATVB). 31: 2261-2269, October 2011
Li D., Xiao J., Paessler M., and Zheng X.L.: Novel Recombinant Glycosylphosphatidylinositol (GPI)-Anchored ADAMTS13 and Variants for Assessment of Anti-ADAMTS13 Autoantibodies in Patients with Thrombotic Thrombocytopenic Purpura. Thromb. Haemost. 106 (5): 947-58. November 2011.
Skipwith C., Cao W., and Zheng X.L.: Factor VIII and platelets synergistically accelerate cleavage of von Willebrand factor by ADAMTS13 under fluid shear stress. J. Biol. Chem. 285(37): 28596-603. September 2010.
Jin S.Y., Skipwith C.G., and Zheng X.L.: Amino acid residues Arg659, Arg660 and Tyr661 in the spacer domain of ADAMTS13 are critical for cleavage of von Willebrand factor Blood 115(11): 2300-10. March 2010.