Selected Publications

Jian C, Xiao J, Gong L, Skipwith C, Jin S-Y, Kwaan H-C, and Zheng X. : Gain-of-function ADAMTS13 variants that are resistant to inhibition by autoantibodies in patients with acquired idiopathic thrombotic thrombocytopenic purpura. Blood (in press) Page: doi:10.1182/blood-2011-12-399501, January 2012.

Xiao J., Jin S-Y., Xue J., Sorvillo N., Voorberg J., and Zheng X.L.: Essential Domains of ADAMTS13 Metalloprotease Required for Modulation of Arterial Thrombosis. Arterioscler. Thromb. Vasc. Biol. 31: 2261-2269, October 2011

Li D., Xiao J., Paessler M., and Zheng X.L.: Novel Recombinant Glycosylphosphatidylinositol (GPI)-Anchored ADAMTS13 and Variants for Assessment of Anti-ADAMTS13 Autoantibodies in Patients with Thrombotic Thrombocytopenic Purpura. Thromb Haemost 106 (5): 947-58. November 2011.

Skipwith C., Cao W., and Zheng X.L.: Factor VIII and platelets synergistically accelerate cleavage of von Willebrand factor by ADAMTS13 under fluid shear stress. J Biol Chem 285(37): 28596-603, September 2010.

Zheng X.L., Wu H.M., Shang D., Falls E., Skipwith C.G., Cataland S.R., Bennett C.L., and Kwaan H.C.: Multiple domains of ADAMTS13 are targeted by autoantibodies against ADAMTS13 in patients with acquired idiopathic thrombotic thrombocytopenic purpura. Haematologica 95(9): 1555-62, September 2010.

Jin S.Y., Skipwith C.G., and Zheng X.L.: Amino acid residues Arg659, Arg660 and Tyr661 in the spacer domain of ADAMTS13 are critical for cleavage of von Willebrand factor Blood 115(11): 2300-2310, March 2010.

Raife T.J., Cao W.J., Atkinson B.S., Bedell B., Montgomery R.R., Lentz S.R., Johnson G.F., and Zheng X.L.: Leukocyte proteases cleave von Willebrand factor near or at the ADAMTS13 cleavage site. Blood 114(8): 1666-74, August 2009.

Laje P., Shang D., Cao W., Niiya M., Endo M., Radu A., DeRagotis N., Scheiflinger F., Zoltick P.W., Flake A.W., and Zheng X.L.: Correction of murine ADAMTS13 deficiency by hematopoietic progenitor cell-mediated gene therapy Blood 113(10): 2172-2180, March 2009.

Niiya M., Endo M., Shang D., Zoltick P.W., Muvarak N.E., Cao W.J., Jin S-Y., Skipwith C.G., Motto,D.G., Flake A.W. and Zheng X.L.: Correction of ADAMTS13 deficiency by in utero gene transfer of lentiviral vector encoding ADAMTS13 genes. Mol Ther 17(1): 34-41, January 2009.

Cao W.J., Krishnaswamy S., Camire R.M., Lenting P.J., and Zheng X.L.: Factor VIII accelerates proteolytic cleavage of von Willebrand factor by ADAMTS13. Proc Natl Acad Sci USA 105(21): 7416-7421, May 2008.