Penn Cardiovascular Institute

Penn Cardiovascular Institute Research Directory

faculty photo

X. Long Zheng, M.D, Ph.D

Associate Professor of Pathology and Laboratory Medicine
Department: Pathology and Laboratory Medicine

Contact information
Abramson Research Center 816G
The Children's Hospital of Philadelphia
The 34th Street & Civic Center Blvd,
Philadelphia, PA 19104
Office: (215) 590-3565
Fax: 267-426-5165
Education:
M.D. (Medicine)
Nanchang University Medical College, Nanchang, China, 1984.
Ph.D. (Molecular and Cell Biology)
Medical University of Vienna, Vienna, Austria, 1994.
Residency (Clinical Pathology)
Washington University School of Medicine, St. Louis, MO, 2002.
Fellowship (Transfusion Medicine)
Washington University School of Medicine, St. Louis, MO, 2003.
Permanent link
 
> Perelman School of Medicine   > Faculty   > Details

Selected Publications

Bao J., Xiao J., Mao J., and Zheng X.L.: Carboxyl-terminus of ADAMTS13 directly inhibits platelet aggregation and ultra large VWF string formation under flow in a free thiol-dependent manner. Arteroscler. Thromb. Vascul. Biol. (ATVB) 34: 397-407, January 2014.

Jin S.Y., Xiao J., Bao J., Zhou S.Z., Wright J.F., and Zheng X.L.: AAV-mediated expression of an ADAMTS13 variant prevents shigatoxin-induced thrombotic thrombocytopenic purpura. Blood 121(19): 3825-3829, May 2013.

Zheng X.L.: Structure-function and cofactor-dependent regulation of ADAMTS13 protease. J. Thromb. Haemost. 11(Suppl. 1): 11-23, June 2013.

Cao W.J., Sabatino D.E, Altynova E., Lange A.M., Casina V.C., Camire R.M. and Zheng X.L.: Light Chain of Factor VIII Is Sufficient for Accelerating Cleavage of von Willebrand Factor by ADAMTS13 Metalloprotease. J. Biol. Chem. 287(39): 32459–32466. August 2012.

Jian C., Xiao J., Gong L., Skipwith C.G., Jin S-Y, Kwaan H-C, and Zheng X.L.: Gain-of-function ADAMTS13 variants that are resistant to inhibition by autoantibodies in patients with acquired idiopathic thrombotic thrombocytopenic purpura. Blood 119(16): 3836-43. April 2012.

Jin S-Y., Tohyama J., Bauer R.C., Cao N.N, Rader D.J., and Zheng X.L.: Genetic ablation of Adamts13 gene dramatically accelerates the early atherosclerosis in a murine model. Arteriscler. Thromb. Vasc. Biol. (ATVB) 32: 1817-1823, August 2012.

Zheng X.L. : ADAMTS13 Meets MR, then What? Blood 119(16): 2652-54. April 2012.

Xiao J., Jin S-Y., Xue J., Sorvillo N., Voorberg J., and Zheng X.L.: Essential Domains of ADAMTS13 Metalloprotease Required for Modulation of Arterial Thrombosis. Arterioscler. Thromb. Vasc. Biol. (ATVB). 31: 2261-2269, October 2011

Skipwith C., Cao W., and Zheng X.L.: Factor VIII and platelets synergistically accelerate cleavage of von Willebrand factor by ADAMTS13 under fluid shear stress. J. Biol. Chem. 285(37): 28596-603. September 2010.

Jin S.Y., Skipwith C.G., and Zheng X.L.: Amino acid residues Arg659, Arg660 and Tyr661 in the spacer domain of ADAMTS13 are critical for cleavage of von Willebrand factor Blood 115(11): 2300-10. March 2010.

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Last updated: 10/09/2014
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