Penn Cardiovascular Institute

Penn Cardiovascular Institute Research Directory

faculty photo

Dennis E. Discher

Professor of Chemical & Biomolecular Engineering
Department: Chemical & Biomolecular Engineering
Graduate Group Affiliations

Contact information
129 Towne Bldg
220 S. 33rd St.
Philadelphia, PA 19104
Office: (215) 898-4809
Education:
B.S.
UC Davis, 1986.
Ph.D. (Bioengineering)
Berkeley & UC San Francisco, 1993.
Permanent link
 
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Description of CVI Expertise

CVI Program Unit(s):
Myocyte Biology / Heart Failure
Biotechnology / Nanomedicine / Imaging

CVI Research Description:

1) Stem Cell and Cardiomyocyte contractility and mechanics in relation to fibrosis. See references below.

2) Nano-carrier delivery of oiligos and anti-thrombotics.

REFERENCES
A. Engler, S. Sen, H.L. Sweeney, and D.E. Discher. Matrix elasticity directs stem cell lineage specification. Cell 126: 677-689 (2006). 320 citations

D.E. Discher, P. Janmey, Y-L. Wang. Tissue cells feel and respond to the stiffness of their substrate. Science 310: 1139-1143 (2005). 313 citations

A. Engler, M. Sheehan, S. Sen, C. Bonnemann, H.L. Sweeney, and D.E. Discher. Myotubes Differentiate Optimally on Substrates with Tissue-like Stiffness: Pathological Implications of Stiff or Soft Microenvironments. Journal of Cell Biology 166(6): 877-887 (2004). 155 citations

C.P. Johnson, H-Y. Tang, C. Carag, D.W. Speicher, and D.E. Discher. Forced unfolding of proteins within cells. Science 317: 663-666 (2007).

Y. Geng, P. Dalhaimer, S. Cai, R. Tsai, M. Tewari, T. Minko, and D.E. Discher. Shape effects of filaments versus spherical particles in flow and drug delivery. Nature Nanotechnology 2: 249-255 (2007).

R. Tsai and D.E. Discher. Inhibition of ‘Self’ Engulfment through deactivation of Myosin-II at the Phagocytic Synapse between Human Cells Journal of Cell Biology 180: 989-1003 (2008).

A. Engler, C. Carag, C. Johnson, D. Speicher, J. Sanger, J. Sanger, and D.E. Discher. Embryonic Cardiomyocytes beat best on elastic matrices that mimic normal heart – Beating stops on mechanical mimics of fibrotic scars. Journal of Cell Science 121: 3794-3802 (2008).

Selected Publications

A.E.X. Brown, R. Litvinov, D.E. Discher, P. Purohit, J. Weisel. : Multiscale mechanics of fibrin polymer: Gel stretching with protein unfolding and loss of water. Science 325: 741-744, 2009.

R. Tsai and D.E. Discher. : Inhibition of ‘Self’ Engulfment through deactivation of Myosin-II at the Phagocytic Synapse between Human Cells Journal of Cell Biology 180 : 989-1003, 2008.

C.P. Johnson, H-Y. Tang, C. Carag, D.W. Speicher, and D.E. Discher. : Forced unfolding of proteins within cells. Science 317 : 663-666 2007.

A. Engler, S. Sen, H.L. Sweeney, and D.E. Discher. : Matrix elasticity directs stem cell lineage specification. Cell 126: 677-689, 2006.

D.E. Discher*, P. Janmey, Y-L. Wang: Tissue cells feel and respond to the stiffness of their substrate. Science 310: 1139-1143 2005.

K.N. Dahl, S.M. Kahn, K.L. Wilson, and D.E. Discher: The nuclear envelope lamina network has elasticity and a compressibility limit suggestive of a molecular shock absorber. Journal of Cell Science 117: 4779-4786 2004 Notes: With accompanying Editor's Highlight. And Highlight in Nature

A. Engler, M. Sheehan, S. Sen, C. Bonnemann, H.L. Sweeney, and D.E. Discher: Myotubes Differentiate Optimally on Substrates with Tissue-like Stiffness: Pathological Implications of Stiff or Soft Microenvironments. Journal of Cell Biology 166(6): 877-887 2004 Notes: With accompanying Editor's Highlight. And Highlight in Nature.

D.E. Discher* and A. Eisenberg: Polymer Vesicles. Science 297: 967-73, 2002 Notes: (*corresponding author).

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Last updated: 03/18/2013
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