Morris J. Birnbaum
Professor of Medicine
Department: Medicine
Graduate Group Affiliations
Contact information
322 Clinical Research Building
422 Curie Blvd
Philadelphia, PA 19104
422 Curie Blvd
Philadelphia, PA 19104
Office: (215) 898-5001
Fax: (215) 573-9138
Fax: (215) 573-9138
Email:
birnbaum@mail.med.upenn.edu
birnbaum@mail.med.upenn.edu
Publications
Education
A.B.
Brown University, 1973.
Ph.D. (Physiological Chemistry)
Brown University, 1977.
M.D.
Brown University, 1978.
Permanent linkA.B.
Brown University, 1973.
Ph.D. (Physiological Chemistry)
Brown University, 1977.
M.D.
Brown University, 1978.
Description of CVI Expertise
CVI Program Unit(s):Lipid / Atherosclerosis / CAD / ACS / Prevention
Myocyte Biology / Heart Failure
CVI Research Description:
We work on the signal transduction pathways that govern cardiac growth, both developmental and during hypertrophy. We are also interested in signaling pathways controlling cardiac metabolism. Lastly, there is work underway trying to understand the regulation of lipid metabolism and how this becomes disrupted in insulin-resitanrt states.
Selected Publications
Whiteman, E. L., Cho, H., and Birnbaum, M. J. : Role of Akt/Protein Kinase B in Metabolism. Trends Endocrin. Metab 13: 444-51, 2002.Mu, J., Brozinick, J.T., Valladares, O., Bucan, M., and Birnbaum, M.J.: A Role for AMP-activated Protein Kinase in Contraction and Hypoxia Regulated Glucose Transport in Skeletal Muscle. Molecular Cell 7: 1085-1094, 2001.
Cho, H., Mu, J., Kim, J. K., Thorvaldson, J. L., Chu, Q., Crenshaw, E. B., Kaestner, K. H., Bartolomei, M. S., Shulman, G. I., Birnbaum, M. J.: Insulin Resistance and Diabetes Mellitus in Mice Lacking Akt2/PKB. Science 292: 1728-31, 2001.
Tuttle, R.L., Gill, N. S, Pugh, W., Lee, J.-P., Koeberlein, B., Furth, E. E., Polonsky, K. S., Naji, A., and Birnbaum, M.J.: Regulation of Pancreatic Beta Cell Size and Survival by the Serine/Threonine Protein Kinase Akt/PKB. Nature Medicine 7(10): 1133-7, 2001.
Miron, M., Verdu, J., Lachance, P. E. D., Birnbaum, M. J., Lasko, P. F. and Sonenberg, N: The Translational Inhibitor 4E-BP is an Effector of PI3K/Akt Signaling in Drosophila, and Regulates Cell Growth. Nature Cell Biol 3: 596-601, 2001.
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