Morris J. Birnbaum, M.D., Ph.D.
Professor of Medicine
Department: Medicine
Graduate Group Affiliations
Contact information
322 Clinical Research Building
415 Curie Blvd
Philadelphia, PA 19104
415 Curie Blvd
Philadelphia, PA 19104
Office: (215) 898-5001
Fax: (215) 573-9138
Fax: (215) 573-9138
Email:
birnbaum@mail.med.upenn.edu
birnbaum@mail.med.upenn.edu
Publications
Education:
A.B.
Brown University, 1973.
Ph.D. (Physiological Chemistry)
Brown University, 1977.
M.D.
Brown University, 1978.
Permanent linkA.B.
Brown University, 1973.
Ph.D. (Physiological Chemistry)
Brown University, 1977.
M.D.
Brown University, 1978.
Description of CVI Expertise
CVI Program Unit(s):Lipid / Atherosclerosis / CAD / ACS / Prevention
Myocyte Biology / Heart Failure
CVI Research Description:
We work on the signal transduction pathways that govern cardiac growth, both developmental and during hypertrophy. We are also interested in signaling pathways controlling cardiac metabolism. Lastly, there is work underway trying to understand the regulation of lipid metabolism and how this becomes disrupted in insulin-resitanrt states.
Selected Publications
Li, Xinghai. Monks, Bobby. Ge, Qingyuan. Birnbaum, Morris J.: Akt/PKB regulates hepatic metabolism by directly inhibiting PGC-1alpha transcription coactivator. Nature 447(7147): 1012-6, Jun 21 2007.Gleason, Catherine E. Lu, Danhong. Witters, Lee A. Newgard, Christopher B. Birnbaum, Morris J.: The role of AMPK and mTOR in nutrient sensing in pancreatic beta-cells. Journal of Biological Chemistry 282(14): 10341-51, Apr 2007.
O'Neill, Brian T. Kim, Jaetaek. Wende, Adam R. Theobald, Heather A. Tuinei, Joseph. Buchanan, Jonathan. Guo, Aili. Zaha, Vlad G. Davis, Don K. Schell, John C. Boudina, Sihem. Wayment, Benjamin. Litwin, Sheldon E. Shioi, Tetsuo. Izumo, Seigo. Birnbaum, Morris J. Abel, E Dale.: A conserved role for phosphatidylinositol 3-kinase but not Akt signaling in mitochondrial adaptations that accompany physiological cardiac hypertrophy. Cell Metabolism 6(4): 294-306, Oct 2007.
Holland, William L. Brozinick, Joseph T. Wang, Li-Ping. Hawkins, Eric D. Sargent, Katherine M. Liu, Yanqi. Narra, Krishna. Hoehn, Kyle L. Knotts, Trina A. Siesky, Angela. Nelson, Don H. Karathanasis, Sotirios K. Fontenot, Greg K. Birnbaum, Morris J. Summers, Scott A.: Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance.[see comment]. Cell Metabolism 5(3): 167-79, Mar 2007.
Easton, R. M., Cho, H., Roovers, K., Shineman, D. W., Mizrahi, M., Forman, M. S., Lee, V. M., Szabolcs, M., de Jong, R., Oltersdorf, T., Ludwig, T., Efstratiadis, A., Birnbaum, M. J.: Role for Akt3/protein kinase Bgamma in attainment of normal brain size. Mol Cell Biol 25: 1869-78, 2005.
Jones, R. G., Plas, D. R., Kubek, S, Buzzai, M., Mu, J., Xu, Y., Birnbaum, M. J., Thompson, C. B.: AMP-activated protein kinase induces a p53-dependent metabolic checkpoint. Mol Cell 18: 283-93, 2005.
Emamian, E .S., Hall, D., Birnbaum, M. J., Karayiorgou, M., Gogos, J. A: Convergent Evidence for Impaired AKT1/GSK3b Signaling in Schizophrenia. Nature Genetics 36: 131-7, 2004.
Mu, J., Brozinick, J.T., Valladares, O., Bucan, M., and Birnbaum, M.J.: A Role for AMP-activated Protein Kinase in Contraction and Hypoxia Regulated Glucose Transport in Skeletal Muscle. Molecular Cell 7: 1085-1094, 2001.
Cho, H., Mu, J., Kim, J. K., Thorvaldson, J. L., Chu, Q., Crenshaw, E. B., Kaestner, K. H., Bartolomei, M. S., Shulman, G. I., Birnbaum, M. J.: Insulin Resistance and Diabetes Mellitus in Mice Lacking Akt2/PKB. Science 292: 1728-31, 2001.
Tuttle, R.L., Gill, N. S, Pugh, W., Lee, J.-P., Koeberlein, B., Furth, E. E., Polonsky, K. S., Naji, A., and Birnbaum, M.J.: Regulation of Pancreatic Beta Cell Size and Survival by the Serine/Threonine Protein Kinase Akt/PKB. Nature Medicine 7(10): 1133-7, 2001.
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