Penn Cardiovascular Institute

Penn Cardiovascular Institute Research Directory

faculty photo

Morris J. Birnbaum, M.D., Ph.D.

Willard and Rhoda Ware Professor of Diabetes and Metabolic Diseases
Department: Medicine

Contact information
Room 12-123 TRC
3400 Civic Center Blvd., Bldng. 421
Philadelphia, PA 19104
Office: 215-898-5001
Fax: 215-573-3178
Lab: 215-898-9929
Education:
A.B.
Brown University, 1973.
Ph.D. (Physiological Chemistry)
Brown University, 1977.
M.D.
Brown University, 1978.
Permanent link
 
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Description of CVI Expertise

CVI Program Unit(s):
Lipid / Atherosclerosis / CAD / ACS / Prevention
Myocyte Biology / Heart Failure

CVI Research Description:
We work on the signal transduction pathways that govern cardiac growth, both developmental and during hypertrophy. We are also interested in signaling pathways controlling cardiac metabolism. Lastly, there is work underway trying to understand the regulation of lipid metabolism and how this becomes disrupted in insulin-resitanrt states.

Selected Publications

Rastogi Ruchi, Jiang Zhongliang, Ahmad Nisar, Rosati Rita, Liu Yusen, Beuret Laurent, Monks Robert, Charron Jean, Birnbaum Morris J, Samavati Lobelia: Rapamycin Induces Mitogen-activated Protein (MAP) Kinase Phosphatase-1 (MKP-1) Expression through Activation of Protein Kinase B and Mitogen-activated Protein Kinase Kinase Pathways. The Journal of biological chemistry 288(47): 33966-77, Nov 2013.

Wan Min, Leavens Karla F, Hunter Roger W, Koren Shlomit, von Wilamowitz-Moellendorff Alexander, Lu Mingjian, Satapati Santhosh, Chu Qingwei, Sakamoto Kei, Burgess Shawn C, Birnbaum Morris J: A noncanonical, GSK3-independent pathway controls postprandial hepatic glycogen deposition. Cell metabolism 18(1): 99-105, Jul 2013.

Kim Jiyeon S, Sklarz Tammarah, Banks Lauren B, Gohil Mercy, Waickman Adam T, Skuli Nicolas, Krock Bryan L, Luo Chong T, Hu Weihong, Pollizzi Kristin N, Li Ming O, Rathmell Jeffrey C, Birnbaum Morris J, Powell Jonathan D, Jordan Martha S, Koretzky Gary A: Natural and inducible TH17 cells are regulated differently by Akt and mTOR pathways. Nature immunology 14(6): 611-8, Jun 2013.

Miller Russell A, Chu Qingwei, Xie Jianxin, Foretz Marc, Viollet Benoit, Birnbaum Morris J: Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP. Nature 494(7436): 256-60, Feb 2013.

Newman Robert H, Hu Jianfei, Rho Hee-Sool, Xie Zhi, Woodard Crystal, Neiswinger John, Cooper Christopher, Shirley Matthew, Clark Hillary M, Hu Shaohui, Hwang Woochang, Jeong Jun Seop, Wu George, Lin Jimmy, Gao Xinxin, Ni Qiang, Goel Renu, Xia Shuli, Ji Hongkai, Dalby Kevin N, Birnbaum Morris J, Cole Philip A, Knapp Stefan, Ryazanov Alexey G, Zack Donald J, Blackshaw Seth, Pawson Tony, Gingras Anne-Claude, Desiderio Stephen, Pandey Akhilesh, Turk Benjamin E, Zhang Jin, Zhu Heng, Qian Jiang: Construction of human activity-based phosphorylation networks. Molecular systems biology 9: 655, 2013.

Mallilankaraman Karthik, Doonan Patrick, Cárdenas César, Chandramoorthy Harish C, Müller Marioly, Miller Russell, Hoffman Nicholas E, Gandhirajan Rajesh Kumar, Molgó Jordi, Birnbaum Morris J, Rothberg Brad S, Mak Don-On Daniel, Foskett J Kevin, Madesh Muniswamy: MICU1 is an essential gatekeeper for MCU-mediated mitochondrial Ca(2+) uptake that regulates cell survival. Cell 151(3): 630-44, Oct 2012.

Quinn William J, Birnbaum Morris J: Distinct mTORC1 pathways for transcription and cleavage of SREBP-1c. Proceedings of the National Academy of Sciences of the United States of America 109(40): 15974-5, Oct 2012.

Sassu Eric D, McDermott Jacqueline E, Keys Brendan J, Esmaeili Melody, Keene Alex C, Birnbaum Morris J, DiAngelo Justin R: Mio/dChREBP coordinately increases fat mass by regulating lipid synthesis and feeding behavior in Drosophila. Biochemical and biophysical research communications 426(1): 43-8, Sep 2012.

Treins Caroline, Alliouachene Samira, Hassouna Rim, Xie Yun, Birnbaum Morris J, Pende Mario: The combined deletion of S6K1 and Akt2 deteriorates glycaemic control in high fat diet. Molecular and cellular biology 32(19): 4001-11, Jul 2012.

Sun Zheng, Miller Russell A, Patel Rajesh T, Chen Jie, Dhir Ravindra, Wang Hong, Zhang Dongyan, Graham Mark J, Unterman Terry G, Shulman Gerald I, Sztalryd Carole, Bennett Michael J, Ahima Rexford S, Birnbaum Morris J, Lazar Mitchell A: Hepatic Hdac3 promotes gluconeogenesis by repressing lipid synthesis and sequestration. Nature medicine May 2012.

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Last updated: 01/02/2014
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