Morris J. Birnbaum, M.D., Ph.D.
Willard and Rhoda Ware Professor of Diabetes and Metabolic Diseases
Department: Medicine
Graduate Group Affiliations
Contact information
Room 12-123 TRC
3400 Civic Center Blvd., Bldng. 421
Philadelphia, PA 19104
3400 Civic Center Blvd., Bldng. 421
Philadelphia, PA 19104
Office: 215-898-5001
Fax: 215-573-3178
Lab: 215-898-9929
Fax: 215-573-3178
Lab: 215-898-9929
Email:
birnbaum@mail.med.upenn.edu
birnbaum@mail.med.upenn.edu
Publications
Education:
A.B.
Brown University, 1973.
Ph.D. (Physiological Chemistry)
Brown University, 1977.
M.D.
Brown University, 1978.
Permanent linkA.B.
Brown University, 1973.
Ph.D. (Physiological Chemistry)
Brown University, 1977.
M.D.
Brown University, 1978.
Description of CVI Expertise
CVI Program Unit(s):Lipid / Atherosclerosis / CAD / ACS / Prevention
Myocyte Biology / Heart Failure
CVI Research Description:
We work on the signal transduction pathways that govern cardiac growth, both developmental and during hypertrophy. We are also interested in signaling pathways controlling cardiac metabolism. Lastly, there is work underway trying to understand the regulation of lipid metabolism and how this becomes disrupted in insulin-resitanrt states.
Selected Publications
Sun Zheng, Miller Russell A, Patel Rajesh T, Chen Jie, Dhir Ravindra, Wang Hong, Zhang Dongyan, Graham Mark J, Unterman Terry G, Shulman Gerald I, Sztalryd Carole, Bennett Michael J, Ahima Rexford S, Birnbaum Morris J, Lazar Mitchell A: Hepatic Hdac3 promotes gluconeogenesis by repressing lipid synthesis and sequestration. Nature medicine May 2012.Lu Mingjian, Wan Min, Leavens Karla F, Chu Qingwei, Monks Bobby R, Fernandez Sully, Ahima Rexford S, Ueki Kohjiro, Kahn C Ronald, Birnbaum Morris J: Insulin regulates liver metabolism in vivo in the absence of hepatic Akt and Foxo1. Nature medicine 18(3): 388-95, Mar 2012.
Bauerfeld Christian P, Rastogi Ruchi, Pirockinaite Gaila, Lee Icksoo, Hüttemann Maik, Monks Bobby, Birnbaum Morris J, Franchi Luigi, Nuñez Gabriel, Samavati Lobelia: TLR4-mediated AKT activation is MyD88/TRIF dependent and critical for induction of oxidative phosphorylation and mitochondrial transcription factor A in murine macrophages. Journal of immunology (Baltimore, Md. : 1950) 188(6): 2847-57, Mar 2012.
Balu Darrick T, Carlson Gregory C, Talbot Konrad, Kazi Hala, Hill-Smith Tiffany E, Easton Rachel M, Birnbaum Morris J, Lucki Irwin: Akt1 deficiency in schizophrenia and impairment of hippocampal plasticity and function. Hippocampus 22(2): 230-40, Feb 2012.
Panasyuk Ganna, Espeillac Catherine, Chauvin Céline, Pradelli Ludivine A, Horie Yasuo, Suzuki Akira, Annicotte Jean-Sebastien, Fajas Lluis, Foretz Marc, Verdeguer Francisco, Pontoglio Marco, Ferré Pascal, Scoazec Jean-Yves, Birnbaum Morris J, Ricci Jean-Ehrland, Pende Mario: PPARγ contributes to PKM2 and HK2 expression in fatty liver. Nature communications 3: 672, Feb 2012.
Wan Min, Easton Rachael M, Gleason Catherine E, Monks Bobby R, Ueki Kohjiro, Kahn C Ronald, Birnbaum Morris J: Loss of Akt1 in mice increases energy expenditure and protects against diet-induced obesity. Molecular and cellular biology 32(1): 96-106, Jan 2012.
Chatterjee Shampa, Browning Elizabeth A, Hong Nankang, Debolt Kris, Sorokina Elena M, Liu Weidong, Birnbaum Morris J, Fisher Aron B: Membrane depolarization is the trigger for PI3K/Akt activation and leads to the generation of ROS. American journal of physiology. Heart and circulatory physiology 302(1): H105-14, Jan 2012.
Yao Li-Jun, McCormick James A, Wang Jian, Yang Katherine Y, Kidwai Atif, Colussi Gian Luca, Boini Krishna M, Birnbaum Morris J, Lang Florian, German Michael S, Pearce David: Novel role for SGK3 in glucose homeostasis revealed in SGK3/Akt2 double-null mice. Molecular endocrinology (Baltimore, Md.) 25(12): 2106-18, Dec 2011.
Wan Min, Leavens Karla F, Saleh Danish, Easton Rachael M, Guertin David A, Peterson Timothy R, Kaestner Klaus H, Sabatini David M, Birnbaum Morris J: Postprandial hepatic lipid metabolism requires signaling through Akt2 independent of the transcription factors FoxA2, FoxO1, and SREBP1c. Cell metabolism 14(4): 516-27, Oct 2011.
Miller Russell A, Chu Qingwei, Le Lay John, Scherer Philipp E, Ahima Rexford S, Kaestner Klaus H, Foretz Marc, Viollet Benoit, Birnbaum Morris J: Adiponectin suppresses gluconeogenic gene expression in mouse hepatocytes independent of LKB1-AMPK signaling. The Journal of clinical investigation 121(6): 2518-28, Jun 2011.