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Mortimer Poncz, MD

Professor of Pediatrics
Department: Pediatrics
Graduate Group Affiliations

Contact information
3615 Civic Center Blvd.
Division of Hematology
The Children's Hospital of Philadelphia
Abramson Research Bdg. Rm. 317
Philadelphia, PA 19104-4318
Office: (215) 590-3574
Fax: (267) 426-5476
Columbia University, 1972.
University of Pennsylvania, 1976.
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Description of CVI Expertise

CVI Program Unit Administrator:
Thrombosis / Hemostasis

CVI Program Unit(s):
Thrombosis / Hemostasis

CVI Research Description:
Interested in thrombosis and hemostasis, vascular biology, the development of atherosclerosis, and megakaryopoiesis. My studies are mostly on platelets, platelet chemokines, platelet integrins and gene regulation in megakaryopoiesis. I am a pediatric hematologist by training.

Selected Publications

Tkaczynski Elizabeth, Arulselvan Abinaya, Tkaczynski John, Avery Stephen, Xiao Liqing, Torok-Storb Beverly, Abrams Kraig, Rao Narayanam V, Johnson Gregory, Kennedy Thomas P, Poncz Mortimer, Lambert Michele P: 2-O, 3-O desulfated heparin mitigates murine chemotherapy- and radiation-induced thrombocytopenia. Blood advances 2(7): 754-761, Apr 2018.

Jarocha Danuta, Vo Karen K, Lyde Randolph B, Hayes Vincent, Camire Rodney M, Poncz Mortimer: Enhancing functional platelet release in vivo from in vitro-grown megakaryocytes using small molecule inhibitors. Blood advances 2(6): 597-606, Mar 2018.

Villa Carlos H, Pan Daniel C, Johnston Ian H, Greineder Colin F, Walsh Landis R, Hood Elizabeth D, Cines Douglas B, Poncz Mortimer, Siegel Don L, Muzykantov Vladimir R: Biocompatible coupling of therapeutic fusion proteins to human erythrocytes. Blood advances 2(3): 165-176, Feb 2018.

Sim Xiuli, Jarocha Danuta, Hayes Vincent, Hanby Hayley A, Marks Michael S, Camire Rodney M, French Deborah L, Poncz Mortimer, Gadue Paul: Identifying and enriching the platelet-producing human stem cell-derived megakaryocytes using factor V uptake. Blood 130(2): 192-204, Apr 2017.

Vo Karen K, Jarocha Danuta J, Lyde Randolph B, Hayes Vincent, Thom Christopher S, Sullivan Spencer K, French Deborah L, Poncz Mortimer: FLI1 level during megakaryopoiesis affects thrombopoiesis and platelet biology. Blood 129(26): 3486-3494, Apr 2017.

Hayes Vincent, Johnston Ian, Arepally Gowthami M, McKenzie Steven E, Cines Douglas B, Rauova Lubica, Poncz Mortimer: Endothelial antigen assembly leads to thrombotic complications in heparin-induced thrombocytopenia. The Journal of clinical investigation 127(3): 1090-1098, Mar 2017.

Bdeir Khalil, Gollomp Kandace, Stasiak Marta, Mei Junjie, Papiewska-Pajak Izabela, Zhao Guohua, Worthen G Scott, Cines Douglas B, Poncz Mortimer, Kowalska M Anna: Platelet-specific Chemokines Contribute to the Pathogenesis of Acute Lung Injury. American journal of respiratory cell and molecular biology 56(2): 261-270, Oct 2016.

Wang Qi, You Tao, Fan Hongqiong, Wang Yinyan, Chu Tinatian, Poncz Mortimer, Zhu Li: Rapamycin and bafilomycin A1 alter autophagy and megakaryopoiesis. Platelets 28(1): 1-8, Aug 2016.

Khandelwal Sanjay, Lee Grace M, Hester C Garren, Poncz Mortimer, McKenzie Steven, Sachais Bruce S, Rauova Lubica, Kelsoe Garnett, Cines Douglas B, Frank Michael, Arepally Gowthami M: The antigenic complex in HIT binds to B-cells via complement and complement receptor 2 (CD21). Blood 128(14): 1789-1799, Jul 2016.

Ostertag Eric M, Bdeir Khalil, Kacir Stephen, Thiboutot Michelle, Gulendran Gayathri, Yunk Lenka, Hayes Vincent M, Motto David G, Poncz Mortimer, Zheng X Long, Cines Douglas B, Siegel Don L: ADAMTS13 autoantibodies cloned from patients with acquired thrombotic thrombocytopenic purpura: 2. Pathogenicity in an animal model. Transfusion 56(7): 1775-85, Jul 2016.

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Last updated: 08/23/2018
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