Penn Cardiovascular Institute

Penn Cardiovascular Institute Research Directory

faculty photo

Mortimer Poncz, MD

Professor of Pediatrics
Department: Pediatrics
Graduate Group Affiliations

Contact information
3615 Civic Center Blvd.
Division of Hematology
The Children's Hospital of Philadelphia
Abramson Research Bdg. Rm. 317
Philadelphia, PA 19104-4318
Office: (215) 590-3574
Fax: (267) 426-5476
Education:
B.S.
Columbia University, 1972.
M.D.
University of Pennsylvania, 1976.
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Description of CVI Expertise

CVI Program Unit Administrator:
Thrombosis / Hemostasis

CVI Program Unit(s):
Thrombosis / Hemostasis

CVI Research Description:
Interested in thrombosis and hemostasis, vascular biology, the development of atherosclerosis, and megakaryopoiesis. My studies are mostly on platelets, platelet chemokines, platelet integrins and gene regulation in megakaryopoiesis. I am a pediatric hematologist by training.

Selected Publications

Skewis Lynell R, Lebedeva Tatiana, Papkov Vyacheslav, Thayer Edward C, Massefski Walter, Cuker Adam, Nagaswami Chandrasekaran, Litvinov Rustem I, Kowalska M Anna, Rauova Lubica, Poncz Mortimer, Weisel John W, Lowery Thomas J, Cines Douglas B: T2 Magnetic Resonance: A Diagnostic Platform for Studying Integrated Hemostasis in Whole Blood-Proof of Concept. Clinical chemistry Jun 2014.

Lian Lurong, Suzuki Aae, Hayes Vincent, Saha Sougata, Han Xuemei, Xu Tao, Yates John R, Poncz Mortimer, Kashina Anna, Abrams Charles S: Loss of ATE1-mediated arginylation leads to impaired platelet myosin phosphorylation, clot retraction, and in vivo thrombosis formation. Haematologica 99(3): 554-60, Mar 2014.

Shi Guanfang, Field David J, Ko Kyung-ae, Ture Sara, Srivastava Kalyan, Levy Scott, Kowalska M Anna, Poncz Mortimer, Fowell Deborah J, Morrell Craig N: Platelet factor 4 limits Th17 differentiation and cardiac allograft rejection. The Journal of clinical investigation 124(2): 543-52, Feb 2014.

Sullivan Spencer K, Mills Jason A, Koukouritaki Sevasti B, Vo Karen K, Lyde Randolph B, Paluru Prasuna, Zhao Guoha, Zhai Li, Sullivan Lisa M, Wang Yuhuan, Kishore Siddharth, Gharaibeh Eyad Z, Lambert Michele P, Wilcox David A, French Deborah L, Poncz Mortimer, Gadue Paul: High-level transgene expression in induced pluripotent stem cell-derived megakaryocytes: correction of Glanzmann thrombasthenia. Blood 123(5): 753-7, Jan 2014.

Kowalska M Anna, Zhao Guohua, Zhai Li, David George, Marcus Stephen, Krishnaswamy Sriram, Poncz Mortimer: Modulation of Protein C Activation by Histones, Platelet Factor 4, and Heparinoids: New Insights Into Activated Protein C Formation. Arteriosclerosis, thrombosis, and vascular biology 34(1): 120-6, Oct 2013.

Suzuki Aae, Shin Jae-Won, Wang Yuhuan, Min Sang H, Poncz Morty, Choi John K, Discher Dennis E, Carpenter Chris L, Lian Lurong, Zhao Liang, Wang Yangfeng, Abrams Charles S: RhoA Is Essential for Maintaining Normal Megakaryocyte Ploidy and Platelet Generation. PloS one 8(7): e69315, July 2013.

Siner Joshua I, Iacobelli Nicholas P, Sabatino Denise E, Ivanciu Lacramiora, Zhou Shangzhen, Poncz Mortimer, Camire Rodney M, Arruda Valder R: Minimal modification in the factor VIII B-domain sequence ameliorates the murine hemophilia A phenotype. Blood 121(21): 4396-403, May 2013.

Lambert Michele P, Sullivan Spencer K, Fuentes Rudy, French Deborah L, Poncz Mortimer: Challenges and promises for the development of donor-independent platelet transfusions. Blood 121(17): 3319-24, Apr 2013.

Zhi Huiying, Rauova Lubica, Hayes Vincent, Gao Cunji, Boylan Brian, Newman Debra K, McKenzie Steven E, Cooley Brian C, Poncz Mortimer, Newman Peter J: Cooperative integrin/ITAM signaling in platelets enhances thrombus formation in vitro and in vivo. Blood 121(10): 1858-67, Mar 2013.

Love Melissa S, Millholland Melanie G, Mishra Satish, Kulkarni Swapnil, Freeman Katie B, Pan Wenxi, Kavash Robert W, Costanzo Michael J, Jo Hyunil, Daly Thomas M, Williams Dewight R, Kowalska M Anna, Bergman Lawrence W, Poncz Mortimer, DeGrado William F, Sinnis Photini, Scott Richard W, Greenbaum Doron C: Platelet factor 4 activity against P. falciparum and its translation to nonpeptidic mimics as antimalarials. Cell host & microbe 12(6): 815-23, Dec 2012.

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Last updated: 07/01/2014
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