Mortimer Poncz, MD
Professor of Pediatrics
Department: Pediatrics
Graduate Group Affiliations
Contact information
3615 Civic Center Blvd.
Division of Hematology
The Children's Hospital of Philadelphia
Abramson Research Bdg. Rm. 317
Philadelphia, PA 19104-4318
Division of Hematology
The Children's Hospital of Philadelphia
Abramson Research Bdg. Rm. 317
Philadelphia, PA 19104-4318
Office: (215) 590-3574
Fax: (267) 426-5476
Fax: (267) 426-5476
Email:
poncz@email.chop.edu
poncz@email.chop.edu
Publications
Links
Search PubMed for articles
Cell and Molecular Biology Graduate Group
Joseph Stokes Jr. Research Institute Profile
Pharmacological Sciences Graduate Group
Search PubMed for articles
Cell and Molecular Biology Graduate Group
Joseph Stokes Jr. Research Institute Profile
Pharmacological Sciences Graduate Group
Education:
B.S.
Columbia University, 1972.
M.D.
University of Pennsylvania, 1976.
Permanent linkB.S.
Columbia University, 1972.
M.D.
University of Pennsylvania, 1976.
Description of CVI Expertise
CVI Program Unit Administrator:Thrombosis / Hemostasis
CVI Program Unit(s):
Thrombosis / Hemostasis
CVI Research Description:
Interested in thrombosis and hemostasis, vascular biology, the development of atherosclerosis, and megakaryopoiesis. My studies are mostly on platelets, platelet chemokines, platelet integrins and gene regulation in megakaryopoiesis. I am a pediatric hematologist by training.
Selected Publications
Meng R, Wang Y, Yao Y, Zhang Z, Harper DC, Heijnen HF, Sitaram A, Li W, Raposo G, Weiss MJ, Poncz M, Marks MS.: SLC35D3 delivery from megakaryocyte early endosomes is required for platelet dense granule biogenesis and is differentially defective in Hermansky-Pudlak syndrome models. Blood 120: 404-14, 2012.Lambert MP, Reznikov A, Grubbs A, Nguyen Y, Xiao L, Aplenc R, Rauova L, Poncz M. : Platelet factor 4 platelet levels are inversely correlated with steady-state platelet counts and with platelet transfusion needs in pediatric leukemia patients. J Thromb Haemost 10: 1442-6, 2012.
Zaitsev S, Kowalska MA, Neyman M, Carnemolla R, Tliba S, Ding BS, Stonestrom A, Spitzer D, Atkinson JP, Poncz M, Cines DB, Esmon CT, Muzykantov VR. : Targeting recombinant thrombomodulin fusion protein to red blood cells provides multifaceted thromboprophylaxis. Blood 119: 4779-85, 2012.
Sachais BS, Litvinov RI, Yarovoi SV, Rauova L, Hinds JL, Rux AH, Arepally GM, Poncz M, Cuker A, Weisel JW, Cines DB. : Dynamic antibody binding properties in the pathogenesis of HIT. Blood 2012.
Wang Yuhuan, Meng Ronghua, Hayes Vincent, Fuentes Rudy, Yu Xiang, Abrams Charles S, Heijnen Harry F G, Blobel Gerd A, Marks Michael S, Poncz Mortimer: Pleiotropic platelet defects in mice with disrupted FOG1-NuRD interaction. Blood 118(23): 6183-91, Dec 2011.
Ahmad F, Boulaftali Y, Greene T K, Ouellette T D, Poncz M, Feske S, Bergmeier W: Relative contributions of stromal interaction molecule 1 and CalDAG-GEFI to calcium-dependent platelet activation and thrombosis. Journal of thrombosis and haemostasis : JTH 9(10): 2077-86, Oct 2011.
Kowalska M Anna, Krishnaswamy Sriram, Rauova Lubica, Zhai Li, Hayes Vincent, Amirikian Karine, Esko Jeffrey D, Bougie Daniel W, Aster Richard H, Cines Douglas B, Poncz Mortimer: Antibodies associated with heparin-induced thrombocytopenia (HIT) inhibit activated protein C generation: new insights into the prothrombotic nature of HIT. Blood 118(10): 2882-8, Sep 2011.
Lambert Michele P, Xiao Liqing, Nguyen Yvonne, Kowalska M Anna, Poncz Mortimer: The role of platelet factor 4 in radiation-induced thrombocytopenia. International journal of radiation oncology, biology, physics 80(5): 1533-40, Aug 2011.
DiCarlo Andrea L, Poncz Mortimer, Cassatt David R, Shah Jui R, Czarniecki Christine W, Maidment Bert W: Medical countermeasures for platelet regeneration after radiation exposure. Report of a workshop and guided discussion sponsored by the National Institute of Allergy and Infectious Diseases, Bethesda, MD, March 22–23, 2010. Radiation research 176(1): e0001-15, Jul 2011.
DiCarlo Andrea L, Poncz Mortimer, Cassatt David R, Shah Jui R, Czarniecki Christine W, Maidment Bert W: Development and licensure of medical countermeasures for platelet regeneration after radiation exposure. Radiation research 176(1): 134-7, Jul 2011.