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Mortimer Poncz, MD

Professor of Pediatrics
Department: Pediatrics
Graduate Group Affiliations

Contact information
3615 Civic Center Blvd.
Division of Hematology
The Children's Hospital of Philadelphia
Abramson Research Bdg. Rm. 317
Philadelphia, PA 19104-4318
Office: (215) 590-3574
Fax: (267) 426-5476
Columbia University, 1972.
University of Pennsylvania, 1976.
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Description of CVI Expertise

CVI Program Unit Administrator:
Thrombosis / Hemostasis

CVI Program Unit(s):
Thrombosis / Hemostasis

CVI Research Description:
Interested in thrombosis and hemostasis, vascular biology, the development of atherosclerosis, and megakaryopoiesis. My studies are mostly on platelets, platelet chemokines, platelet integrins and gene regulation in megakaryopoiesis. I am a pediatric hematologist by training.

Selected Publications

Greineder Colin F, Hood Elizabeth D, Yao Anning, Khoshnejad Makan, Brenner Jake S, Johnston Ian H, Poncz Mortimer, Gottstein Claudia, Muzykantov Vladimir R: Molecular engineering of high affinity single-chain antibody fragment for endothelial targeting of proteins and nanocarriers in rodents and humans. Journal of controlled release : official journal of the Controlled Release Society 226: 229-237, Feb 2016.

Zhang Nanyan, Zhi Huiying, Curtis Brian R, Rao Sridhar, Jobaliya Chintan, Poncz Mortimer, French Deborah L, Newman Peter J: CRISPR/Cas9-mediated conversion of human platelet alloantigen allotypes. Blood 127(6): 675-80, Feb 2016.

Parker Zahra Folasade, Rux Ann H, Riblett Amber M, Lee Fang-Hua, Rauova Lubica, Cines Douglas B, Poncz Mortimer, Sachais Bruce S, Doms Robert W: Platelet-Factor 4 (PF4) inhibits and enhances HIV-1 infection in a concentration-dependent manner by modulating viral attachment. AIDS research and human retroviruses 32(7): 705-17, Feb 2016.

Sim Xiuli, Poncz Mortimer, Gadue Paul, French Deborah L: Understanding platelet generation from megakaryocytes: implications for in vitro-derived platelets. Blood 127(10): 1227-33, Jan 2016.

Tutwiler Valerie, Madeeva Daria, Ahn Hyun Sook, Andrianova Izabella, Hayes Vincent, Zheng X Long, Cines Douglas B, McKenzie Steven E, Poncz Mortimer, Rauova Lubica: Platelet transactivation by monocytes promotes thrombosis in heparin-induced thrombocytopenia. Blood 127(4): 464-72, Jan 2016.

Fuentes Rudy E, Zaitsev Sergei, Ahn Hyun Sook, Hayes Vincent, Kowalska M Anna, Lambert Michele P, Wang Yuhuan, Siegel Donald L, Bougie Daniel W, Aster Richard H, Myers Daniel D, Stepanova Victoria, Cines Douglas B, Muzykantov Vladimir R, Poncz Mortimer: A chimeric platelet-targeted urokinase prodrug selectively blocks new thrombus formation. The Journal of clinical investigation 126(2): 483-94, Dec 2015.

Zhou Junsong, Wu Yi, Wang Lu, Rauova Lubica, Hayes Vincent M, Poncz Mortimer, Essex David W: The C-terminal CGHC motif of protein disulfide isomerase supports thrombosis. The Journal of clinical investigation 125(12): 4391-406, Dec 2015.

Lambert M P, Meng R, Xiao L, Harper D C, Marks M S, Kowalska M A, Poncz M: Intramedullary megakaryocytes internalize released platelet factor 4 and store it in alpha granules. Journal of thrombosis and haemostasis : JTH 13(10): 1888-99, Oct 2015.

Cai Zheng, Yarovoi Serge V, Zhu Zhiqiang, Rauova Lubica, Hayes Vincent, Lebedeva Tatiana, Liu Qun, Poncz Mortimer, Arepally Gowthami, Cines Douglas B, Greene Mark I: Atomic description of the immune complex involved in heparin-induced thrombocytopenia. Nature communications 6: 8277, Sep 2015.

Chacko Ann-Marie, Han Jingyan, Greineder Colin F, Zern Blaine J, Mikitsh John L, Nayak Madhura, Menon Divya, Johnston Ian H, Poncz Mortimer, Eckmann David M, Davies Peter F, Muzykantov Vladimir R: Collaborative Enhancement of Endothelial Targeting of Nanocarriers by Modulating Platelet-Endothelial Cell Adhesion Molecule-1/CD31 Epitope Engagement. ACS nano 9(7): 6785-93, Jul 2015.

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Last updated: 12/22/2016
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