Penn Cardiovascular Institute

Penn Cardiovascular Institute Research Directory

faculty photo

Mortimer Poncz, MD

Professor of Pediatrics
Department: Pediatrics
Graduate Group Affiliations

Contact information
3615 Civic Center Blvd.
Division of Hematology
The Children's Hospital of Philadelphia
Abramson Research Bdg. Rm. 317
Philadelphia, PA 19104-4318
Office: (215) 590-3574
Fax: (267) 426-5476
Education:
B.S.
Columbia University, 1972.
M.D.
University of Pennsylvania, 1976.
Permanent link
 
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Description of CVI Expertise

CVI Program Unit Administrator:
Thrombosis / Hemostasis

CVI Program Unit(s):
Thrombosis / Hemostasis

CVI Research Description:
Interested in thrombosis and hemostasis, vascular biology, the development of atherosclerosis, and megakaryopoiesis. My studies are mostly on platelets, platelet chemokines, platelet integrins and gene regulation in megakaryopoiesis. I am a pediatric hematologist by training.

Selected Publications

Lambert M P, Poncz M: They're not your daddy's inherited platelet disorders anymore. Journal of thrombosis and haemostasis : JTH 11(11): 2037-8, Nov 2013.

Kowalska M Anna, Zhao Guohua, Zhai Li, David George, Marcus Stephen, Krishnaswamy Sriram, Poncz Mortimer: Modulation of Protein C Activation by Histones, Platelet Factor 4, and Heparinoids: New Insights Into Activated Protein C Formation. Arteriosclerosis, thrombosis, and vascular biology Oct 2013.

Suzuki Aae, Shin Jae-Won, Wang Yuhuan, Min Sang H, Poncz Morty, Choi John K, Discher Dennis E, Carpenter Chris L, Lian Lurong, Zhao Liang, Wang Yangfeng, Abrams Charles S: RhoA Is Essential for Maintaining Normal Megakaryocyte Ploidy and Platelet Generation. PloS one 8(7): e69315, July 2013.

Siner Joshua I, Iacobelli Nicholas P, Sabatino Denise E, Ivanciu Lacramiora, Zhou Shangzhen, Poncz Mortimer, Camire Rodney M, Arruda Valder R: Minimal modification in the factor VIII B-domain sequence ameliorates the murine hemophilia A phenotype. Blood 121(21): 4396-403, May 2013.

Lambert Michele P, Sullivan Spencer K, Fuentes Rudy, French Deborah L, Poncz Mortimer: Challenges and promises for the development of donor-independent platelet transfusions. Blood 121(17): 3319-24, Apr 2013.

Zhi Huiying, Rauova Lubica, Hayes Vincent, Gao Cunji, Boylan Brian, Newman Debra K, McKenzie Steven E, Cooley Brian C, Poncz Mortimer, Newman Peter J: Cooperative integrin/ITAM signaling in platelets enhances thrombus formation in vitro and in vivo. Blood 121(10): 1858-67, Mar 2013.

Love Melissa S, Millholland Melanie G, Mishra Satish, Kulkarni Swapnil, Freeman Katie B, Pan Wenxi, Kavash Robert W, Costanzo Michael J, Jo Hyunil, Daly Thomas M, Williams Dewight R, Kowalska M Anna, Bergman Lawrence W, Poncz Mortimer, DeGrado William F, Sinnis Photini, Scott Richard W, Greenbaum Doron C: Platelet factor 4 activity against P. falciparum and its translation to nonpeptidic mimics as antimalarials. Cell host & microbe 12(6): 815-23, Dec 2012.

Ono Yukako, Wang Yuhuan, Suzuki Hidenori, Okamoto Shinichiro, Ikeda Yasuo, Murata Mitsuru, Poncz Mortimer, Matsubara Yumiko: Induction of functional platelets from mouse and human fibroblasts by p45NF-E2/Maf. Blood 120(18): 3812-21, Nov 2012.

Sachais Bruce S, Litvinov Rustem I, Yarovoi Serge V, Rauova Lubica, Hinds Jillian L, Rux Ann H, Arepally Gowthami M, Poncz Mortimer, Cuker Adam, Weisel John W, Cines Douglas B: Dynamic antibody-binding properties in the pathogenesis of HIT. Blood 120(5): 1137-42, Aug 2012.

Lambert M P, Reznikov A, Grubbs A, Nguyen Y, Xiao L, Aplenc R, Rauova L, Poncz M: Platelet factor 4 platelet levels are inversely correlated with steady-state platelet counts and with platelet transfusion needs in pediatric leukemia patients. Journal of thrombosis and haemostasis : JTH 10(7): 1442-6, Jul 2012.

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Last updated: 11/19/2013
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