Penn Cardiovascular Institute

Penn Cardiovascular Institute Research Directory

faculty photo

Mortimer Poncz, MD

Professor of Pediatrics
Department: Pediatrics
Graduate Group Affiliations

Contact information
3615 Civic Center Blvd.
Division of Hematology
The Children's Hospital of Philadelphia
Abramson Research Bdg. Rm. 317
Philadelphia, PA 19104-4318
Office: (215) 590-3574
Fax: (267) 426-5476
Education:
B.S.
Columbia University, 1972.
M.D.
University of Pennsylvania, 1976.
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Description of CVI Expertise

CVI Program Unit Administrator:
Thrombosis / Hemostasis

CVI Program Unit(s):
Thrombosis / Hemostasis

CVI Research Description:
Interested in thrombosis and hemostasis, vascular biology, the development of atherosclerosis, and megakaryopoiesis. My studies are mostly on platelets, platelet chemokines, platelet integrins and gene regulation in megakaryopoiesis. I am a pediatric hematologist by training.

Selected Publications

Meng R, Wang Y, Yao Y, Zhang Z, Harper DC, Heijnen HF, Sitaram A, Li W, Raposo G, Weiss MJ, Poncz M, Marks MS.: SLC35D3 delivery from megakaryocyte early endosomes is required for platelet dense granule biogenesis and is differentially defective in Hermansky-Pudlak syndrome models. Blood 120: 404-14, 2012.

Lambert MP, Reznikov A, Grubbs A, Nguyen Y, Xiao L, Aplenc R, Rauova L, Poncz M. : Platelet factor 4 platelet levels are inversely correlated with steady-state platelet counts and with platelet transfusion needs in pediatric leukemia patients. J Thromb Haemost 10: 1442-6, 2012.

Zaitsev S, Kowalska MA, Neyman M, Carnemolla R, Tliba S, Ding BS, Stonestrom A, Spitzer D, Atkinson JP, Poncz M, Cines DB, Esmon CT, Muzykantov VR. : Targeting recombinant thrombomodulin fusion protein to red blood cells provides multifaceted thromboprophylaxis. Blood 119: 4779-85, 2012.

Sachais BS, Litvinov RI, Yarovoi SV, Rauova L, Hinds JL, Rux AH, Arepally GM, Poncz M, Cuker A, Weisel JW, Cines DB. : Dynamic antibody binding properties in the pathogenesis of HIT. Blood 2012.

Wang Yuhuan, Meng Ronghua, Hayes Vincent, Fuentes Rudy, Yu Xiang, Abrams Charles S, Heijnen Harry F G, Blobel Gerd A, Marks Michael S, Poncz Mortimer: Pleiotropic platelet defects in mice with disrupted FOG1-NuRD interaction. Blood 118(23): 6183-91, Dec 2011.

Ahmad F, Boulaftali Y, Greene T K, Ouellette T D, Poncz M, Feske S, Bergmeier W: Relative contributions of stromal interaction molecule 1 and CalDAG-GEFI to calcium-dependent platelet activation and thrombosis. Journal of thrombosis and haemostasis : JTH 9(10): 2077-86, Oct 2011.

Kowalska M Anna, Krishnaswamy Sriram, Rauova Lubica, Zhai Li, Hayes Vincent, Amirikian Karine, Esko Jeffrey D, Bougie Daniel W, Aster Richard H, Cines Douglas B, Poncz Mortimer: Antibodies associated with heparin-induced thrombocytopenia (HIT) inhibit activated protein C generation: new insights into the prothrombotic nature of HIT. Blood 118(10): 2882-8, Sep 2011.

Lambert Michele P, Xiao Liqing, Nguyen Yvonne, Kowalska M Anna, Poncz Mortimer: The role of platelet factor 4 in radiation-induced thrombocytopenia. International journal of radiation oncology, biology, physics 80(5): 1533-40, Aug 2011.

DiCarlo Andrea L, Poncz Mortimer, Cassatt David R, Shah Jui R, Czarniecki Christine W, Maidment Bert W: Medical countermeasures for platelet regeneration after radiation exposure. Report of a workshop and guided discussion sponsored by the National Institute of Allergy and Infectious Diseases, Bethesda, MD, March 22–23, 2010. Radiation research 176(1): e0001-15, Jul 2011.

DiCarlo Andrea L, Poncz Mortimer, Cassatt David R, Shah Jui R, Czarniecki Christine W, Maidment Bert W: Development and licensure of medical countermeasures for platelet regeneration after radiation exposure. Radiation research 176(1): 134-7, Jul 2011.

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Last updated: 01/04/2013
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