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Mortimer Poncz, MD

Professor of Pediatrics
Department: Pediatrics
Graduate Group Affiliations

Contact information
3615 Civic Center Blvd.
Division of Hematology
The Children's Hospital of Philadelphia
Abramson Research Bdg. Rm. 317
Philadelphia, PA 19104-4318
Office: (215) 590-3574
Fax: (267) 426-5476
Education:
B.S.
Columbia University, 1972.
M.D.
University of Pennsylvania, 1976.
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Description of CVI Expertise

CVI Program Unit Administrator:
Thrombosis / Hemostasis

CVI Program Unit(s):
Thrombosis / Hemostasis

CVI Research Description:
Interested in thrombosis and hemostasis, vascular biology, the development of atherosclerosis, and megakaryopoiesis. My studies are mostly on platelets, platelet chemokines, platelet integrins and gene regulation in megakaryopoiesis. I am a pediatric hematologist by training.

Selected Publications

Johnston Ian, Hayes Vincent, Poncz Mortimer: Threading an elephant through the eye of a needle: Where are platelets made? Cell research May 2017.

Sim Xiuli, Jarocha Danuta, Hayes Vincent, Hanby Hayley A, Marks Michael S, Camire Rodney M, French Deborah L, Poncz Mortimer, Gadue Paul: Identifying and enriching the platelet-producing human stem cell-derived megakaryocytes using factor V uptake. Blood Apr 2017.

Vo Karen K, Jarocha Danuta J, Lyde Randolph B, Hayes Vincent, Thom Christopher S, Sullivan Spencer K, French Deborah L, Poncz Mortimer: FLI1 level during megakaryopoiesis affects thrombopoiesis and platelet biology. Blood Apr 2017.

Hayes Vincent, Johnston Ian, Arepally Gowthami M, McKenzie Steven E, Cines Douglas B, Rauova Lubica, Poncz Mortimer: Endothelial antigen assembly leads to thrombotic complications in heparin-induced thrombocytopenia. The Journal of clinical investigation 127(3): 1090-1098, Mar 2017.

Madeeva Daria, Cines Douglas B, Poncz Mortimer, Rauova Lubica: Role of monocytes and endothelial cells in heparin-induced thrombocytopenia. Thrombosis and haemostasis 116(5): 806-812, Oct 2016.

Bdeir Khalil, Gollomp Kandace, Stasiak Marta, Mei Junjie, Papiewska-Pajak Izabela, Zhao Guohua, Worthen G Scott, Cines Douglas B, Poncz Mortimer, Kowalska M Anna: Platelet-specific Chemokines Contribute to the Pathogenesis of Acute Lung Injury. American journal of respiratory cell and molecular biology 56(2): 261-270, Oct 2016.

Wang Qi, You Tao, Fan Hongqiong, Wang Yinyan, Chu Tinatian, Poncz Mortimer, Zhu Li: Rapamycin and bafilomycin A1 alter autophagy and megakaryopoiesis. Platelets 28(1): 1-8, Aug 2016.

Khandelwal Sanjay, Lee Grace M, Hester C Garren, Poncz Mortimer, McKenzie Steven, Sachais Bruce S, Rauova Lubica, Kelsoe Garnett, Cines Douglas B, Frank Michael, Arepally Gowthami M: The antigenic complex in HIT binds to B-cells via complement and complement receptor 2 (CD21). Blood Jul 2016.

Ostertag Eric M, Bdeir Khalil, Kacir Stephen, Thiboutot Michelle, Gulendran Gayathri, Yunk Lenka, Hayes Vincent M, Motto David G, Poncz Mortimer, Zheng X Long, Cines Douglas B, Siegel Don L: ADAMTS13 autoantibodies cloned from patients with acquired thrombotic thrombocytopenic purpura: 2. Pathogenicity in an animal model. Transfusion 56(7): 1775-85, Jul 2016.

Greineder Colin F, Hood Elizabeth D, Yao Anning, Khoshnejad Makan, Brenner Jake S, Johnston Ian H, Poncz Mortimer, Gottstein Claudia, Muzykantov Vladimir R: Molecular engineering of high affinity single-chain antibody fragment for endothelial targeting of proteins and nanocarriers in rodents and humans. Journal of controlled release : official journal of the Controlled Release Society 226: 229-237, Feb 2016.

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Last updated: 05/18/2017
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