faculty photo

Mortimer Poncz

Professor of Pediatrics
Department: Pediatrics

Contact information
317 Abramson Research Center
The Children’s Hospital of Philadelphia
3615 Civic Center Blvd
Philadelphia, PA 19104-4318
Office: (215) 590-3574
Fax: (215) 590-4834
Education
B.S.
Columbia University, 1972.
M.D.
University of Pennsylvania, 1976.
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Description of CVI Expertise

CVI Program Unit Administrator:
Thrombosis / Hemostasis

CVI Program Unit(s):
Thrombosis / Hemostasis

CVI Research Description:
Interested in thrombosis and hemostasis, vascular biology, the development of atherosclerosis, and megakaryopoiesis. My studies are mostly on platelets, platelet chemokines, platelet integrins and gene regulation in megakaryopoiesis. I am a pediatric hematologist by training.

Selected Publications

Nassar T, Sachais BS, Akkawi S, Kowalska MA, Bdeir K, Leitersdorf E, Hiss E, Ziporen L, Aviram M, Cines D, Poncz M, Higazi AA-R. : Platelet Factor 4 enhances the binding of oxidized-low density lipoprotein to vascular wall cells. J Biol Chem 278: 6187-93, 2003.

Rozmyslowicz T, Majka M, Kijowski J, Murphy SL, Conover DO, Poncz M, Ratajczak J, Gaulton GN, Ratajczak MZ. : Platelet- and megakaryocyte-derived microparticles transfer CXCR4 receptor to CXCR4-null cells and make them susceptible to infection by X4-HIV. AIDS 17: 33-42, 2003.

Kufrin D, Eslin DE, Bdeir K, Murciano J-C, Kuo A, Kowalska MA, Degen JL, Sachais BS, Cines DB, Poncz M. : Anti-thrombotic thrombocytes: Ectopic expression of urokinase-type plasminogen activator in platelets. Blood 102: 926-33, 2003.

Sachais BS, Kuo A, Morgan J, Kariko K, Poncz M, Williams KJ, Feldman M, Shah N, Jarett L, Cines DB, Higazi AA-R. : Platelet factor 4 binds to the low density lipoprotein receptor and inhibits receptor-dependent binding, endocytosis and degradation of low density lipoprotein. Blood 99: 3613-22, 2002.

Li ZQ, Liu W, Park KS, Sachais BS, Arepally GM, Cines DB, Poncz M: Defining a second epitope for Heparin-Induced Thrombocytopenia/Thrombosis (HIT/T) antibodies using KKO, a Murine HIT-like monoclonal antibody. Blood 99: 1230-1236, 2002.

Sachais BS, Kuo A, Nassar T, Morgan J, Kariko K, Williams KJ, Feldman M, Aviram M, Shah N, Jarett L, Poncz M, Cines DB, Higazi AA-R. : Platelet factor 4 binds to low-density lipoprotein receptors and disrupts the endocytic itinerary, resulting in retention of low-density lipoprotein. Blood 99: 3613-22, 2002.

Fang J, Hsu BY, MacMullen CM, Poncz M, Smith TJ, Stanley CA. : Expression, purification and characterization of human glutamate dehydrogenase (GDH) allosteric regulatory mutations. Biochemical J 363: 81-87, 2002.

Thornton MA, Zhang C, Cheng J-F, Kowalska MA, Poncz M: Distal regulatory regions 5¡¦ and 3¡¦ to the human ƒÑIIb gene confer copy number-dependent and enhanced expression, respectively, in transgenic animals. Blood 100: 3588-96, 2002.

Wang X, Crispino JD, Orkin SH, Poncz M , Blobel G: Cooperativity between GATA-1, FOG-1 and FLI1 during activation of a megakaryocyte-specific gene ĄIIb in vivo. EMBO J 21: 5225-34, 2002.

Basani RB, D¡¦Andrea G, Mitra N, Vilaire G, Richberg M, Kowalska MA, Bennett JS, Poncz M. : Arg-Gly-Asp (RGD)-containing Peptides inhibit fibrinogen binding to platelet ƒÑIIb/ƒÒ3 by inducing an allosteric change in the amino-terminal portion of ƒÑIIb. J Biol Chem 276: 13975-81, 2001.

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Last updated: 07/09/2007
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