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Sissel Lund-Katz, Ph.D

Adjunct Professor of Medicine
Department: Medicine

Contact information
Division of Translational Medicine and Human Genetics
Perelman School of Medicine at the University of Pennsylvania
3400 Civic Center Boulevard
Philadelphia, PA 19104-4318
Fax: 215-573-8606
Education:
BS (Chemical Technology)
Oslo Institute of Technology, Oslo, Norway, 1964.
BS (Chemical Engineering)
Gothenburg Technical Institute, Gothenburg, Sweden, 1967.
Ph.D. ( Organic and Biophysical Chemistry)
Bryn Mawr College, Bryn Mawr, PA, 1979.
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Description of CVI Expertise

CVI Program Unit(s):
Lipid / Atherosclerosis / CAD / ACS / Prevention

CVI Research Description:
I am a biophysicist with a particular interest in relating the structure of serum lipoproteins to their function in lipid and cholesterol transport and to the development of atherosclerosis. My area of investigation focuses on the role of one of the structural proteins,apolipoprotein (apo) E, which is involved in the metabolism of cholesterol and triglycerides. This protein is a major risk factor for both type III hyperlipoproteinemia and Alzheimer's disease.

In my laboratory I am seeking to discover how the apo E molecule is organized in lipoprotein particles so that the domains involved in lipid-binding, interaction with the LDL receptor and binding to heparin are in the appropriate conformation. This requires knowledge at high resolution of the organization and properties of the functional regions of the protein. A range of physical-biochemical methods are used to monitor these factors such as Surface Plasmon Resonance and calorimetric and NMR spectroscopy. In addition, protein biochemistry, molecular biology techniques and protein mutagenesis are employed. In this manner I am seeking to define the structural defects of apo E which result in the development of atherosclerosis and Alzheimer's disease.

Selected Publications

Glickson JD, Lund-Katz S, Zhou R, Choi H, Chen IW, Li H, Corbin I, Popov AV, Cao W, Song L, Qi C, Marotta D, Nelson DS, Chen J, Chance B, Zheng G: Lipoprotein nanoplatform for targeted delivery of diagnostic and therapeutic agents. Mol Imaging 7(2): 101-10, March-April 2008.

Sakamoto T, Tanaka M, Vedhachalam C, Nickel M, Nguyen D, Dhanasekaran P, Phillips MC, Lund-Katz S, Saito H: Contributions of the carboxyl-terminal helical segment to the self-association and lipoprotein preferences of human apolipoprotein E3 and E4 isoforms. Biochemistry 47(9): 2968-77, March 2008.

Corbin IR, Li H, Chen J, Lund-Katz S, Zhou R, Glickson JD, Zheng G.: Low-density lipoprotein nanoparticles as magnetic resonance imaging contrast agents Neoplasia 8(6): 488-498, June 2006.

Tanaka M, Vedhachalam C, Sakamoto T, Dhanasekaran P, Phillips MC, Lund-Katz S, Saito H.: Effect of carboxyl-terminal truncation on structure and lipid interaction of human apolipoprotein E4 Biochemistry 45(13): 4240-4247, April 2006.

Futamura M, Dhanasekaran P, Handa T, Phillips MC, Lund-Katz S, Saito H.: Two-step mechanism of binding of apolipoprotein E to heparin: implications for the kinetics of apolipoprotein E-heparan sulfate proteoglycan complex formation on cell surfaces. J Biol Chem 280(7): 5414-5422, 2005.

Li H, Gray BD, Corbin I, Lebherz C, Choi H, Lund-Katz S, Wilson JM, Glickson JD, Zhou R.: MR and fluorescent imaging of low-density lipoprotein receptors. Acad Radiol 11: 1251-1259, 2004.

Narayanaswami V, Maiorano JN, Dhanasekaran P, Ryan RO, Phillips MC, Lund-Katz S, Davidson WS.: Helix orientation of the functional domains in apolipoprotein e in discoidal high density lipoprotein particles. J Biol Chem 279(14): 14273-14279, 2004.

Saito H, Dhanasekaran P, Baldwin F, Weisgraber KH, Phillips MC, Lund-Katz S.: Effects of polymorphism on the lipid interaction of human apolipoprotein E. J Biol Chem 278(42): 40723-40729, 2003.

H. Saito, P. Dhanasekaran, D. Nguyen, F. Baldwin, K.H. Weisgraber, S. Wehrli, M.C. Phillips, S. Lund-Katz: Characterization of the Heparin Binding Sites in Human Apolipoprotein E. J. Biol. Chem 278(17): 14782-14787, 2003.

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Last updated: 01/12/2017
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