Penn Cardiovascular Institute

Penn Cardiovascular Institute Research Directory

faculty photo

Mitchell A. Lazar, MD, PhD

Sylvan H. Eisman Professor of Medicine
Department: Medicine

Contact information
12-102 Smilow Center for Translational Research
3400 Civic Center Boulevard / 5160
Philadelphia, PA 19104-5160
Office: (215) 898-0198
Fax: (215) 898-5408
Education:
S.B. (Chemistry)
Massachusetts Institute of Technology, 1976.
Ph.D. (Neuroscience)
Stanford Univerity, 1981.
M.D.
Stanford Univerity, 1982.
Permanent link
 
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Description of CVI Expertise

CVI Program Unit(s):
Lipid / Atherosclerosis / CAD / ACS / Prevention

CVI Research Description:
We are interested in the transcriptional regulation of metabolism by nuclear receptors, particularly in the context of obesity, insulin resistance, and diabetes. We are studying how nuclear receptor signaling and adipocytokines contribute to atherosclerotic cardiovascular disease, which is the leading cause of death in diabetes.

I am the director of the Institute for Diabetes, Obesity and Metabolism (IDOM).

Selected Publications

Lim HW, Uhlenhaut NH, Rauch A, Weiner J, Hübner S, Hübner N, Won KJ, Lazar MA, Tuckermann J, Steger DJ.: Genomic redistribution of GR monomers and dimers mediates transcriptional response to exogenous glucocorticoid in vivo. Genome Res. 25(6): 836-44, Jun 2015 Notes: doi: 10.1101/gr.188581.114. Epub 2015 May 8.

Yuxiang Zhang, Bin Fang, Matthew J. Emmett, Manashree Damle, Zheng Sun, Dan Feng, Sean M. Armour, Jarrett R. Remsberg, Jennifer Jager, Raymond E. Soccio, David J. Steger, Mitchell A. Lazar : Discrete functions of nuclear receptor Rev-erbα couple metabolism to the clock. Science Page: DOI: 10.1126/science.aab3021 Jun 2015.

Gerhart-Hines Z, Lazar MA.: Circadian metabolism in the light of evolution. Endocr Rev. 36(3): 289-304, Jun 2015 Notes: doi: 10.1210/er.2015-1007. Epub 2015 Apr 30.

Harms MJ, Lim HW, Ho Y, Shapira SN, Ishibashi J, Rajakumari S, Steger DJ, Lazar MA, Won KJ, Seale P.: PRDM16 binds MED1 and controls chromatin architecture to determine a brown fat transcriptional program. Genes Dev. 29(3): 298-307, Feb 2015.

Jang JC, Chen G, Wang SH, Barnes MA, Chung JI, Camberis M, Le Gros G, Cooper PJ, Steel C, Nutman TB, Lazar MA, Nair MG.: Macrophage-derived human resistin is induced in multiple helminth infections and promotes inflammatory monocytes and increased parasite burden. PLoS Pathog. 11(1:e1004579), Jan 2015 Notes: doi: 10.1371/journal.ppat.1004579. eCollection 2015 Jan.

Lee JM, Wagner M, Xiao R, Kim KH, Feng D, Lazar MA, Moore DD. : Nutrient sensing nuclear receptors coordinate autophagy. Nature 516(7529): 112-5, Dec 2014.

Fang B, Everett LJ (co-first author), Jager J (co-first author), Briggs E, Armour S, Feng D, Roy A, Gerhart-Hines Z, Sun Z, Lazar MA. : Circadian enhancers coordinate multiple phases of rhythmic gene expression in vivo. Cell 159(5): 1140-52, Nov 2014.

Gardini A, Baillat D, Cesaroni M, Hu D, Marinis JM, Wagner EJ, Lazar MA, Shilatifard A, Shiekhattar R.: Integrator regulates transcriptional initiation and pause release following activation. Mol Cell. 56(1): 128-39, Oct 2014.

Gardini A, Baillat D, Cesaroni M, Hu D, Marinis JM, Wagner EJ, Lazar MA, Shilatifard A, Shiekhattar R. : Integrator regulates activator-dependent transcriptional elongation by recruiting super elongation complex. Molecular Cell 56(1): 128-139, Oct 2014.

Soccio RE, Chen ER, Lazar MA.: Thiazolidinediones and the promise of insulin sensitization in type 2 diabetes. Cell Metabolism 20(4): 573-591, Oct 2014.

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Last updated: 06/05/2015
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