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Mitchell A. Lazar, MD, PhD

Willard and Rhoda Ware Professor in Diabetes and Metabolic Diseases
Department: Medicine

Contact information
12-102 Smilow Center for Translational Research
3400 Civic Center Boulevard / 5160
Philadelphia, PA 19104-5160
Office: (215) 898-0198
Fax: (215) 898-5408
Education:
S.B. (Chemistry)
Massachusetts Institute of Technology, 1976.
Ph.D. (Neuroscience)
Stanford Univerity, 1981.
M.D.
Stanford Univerity, 1982.
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Description of CVI Expertise

CVI Program Unit(s):
Lipid / Atherosclerosis / CAD / ACS / Prevention

CVI Research Description:
We are interested in the transcriptional regulation of metabolism by nuclear receptors, particularly in the context of obesity, insulin resistance, and diabetes. We are studying how nuclear receptor signaling and adipocytokines contribute to atherosclerotic cardiovascular disease, which is the leading cause of death in diabetes.

I am the director of the Institute for Diabetes, Obesity and Metabolism (IDOM).

Selected Publications

Papazyan R, Sun Z, Kim YH, Titchenell PM, Hill DA, Lu W, Damle M, Wan M, Zhang Y, Briggs ER, Rabinowitz JD, Lazar MA.: Physiological Suppression of Lipotoxic Liver Damage by Complementary Actions of HDAC3 and SCAP/SREBP. Cell Metab. Nov 2016 Notes: pii: S1550-4131(16)30543-5. doi: 10.1016/j.cmet.2016.10.012. [Epub ahead of print]

Bass J, Lazar MA.: Circadian time signatures of fitness and disease. Science 354(6315): 994-999, Nov 2016.

Teng X, Emmett MJ, Lazar MA, Goldberg E, Rabinowitz JD.: Lactate Dehydrogenase C Produces S-2-Hydroxyglutarate in Mouse Testis. ACS Chem Biol. 11(9): 2420-7, Sep 2016.

Ferrannini G, Namwanje M, Fang B, Damle D, Li D, Liu Q, Lazar MA, Qiang L. : Genetic background determine brown remodeling of white fat in rodents. Molecular Metabolism 5(10): 948-958, Aug 2016.

Zhang Y, Fang B, Damle M, Guan D, Li Z, Kim YH, Gannon M, Lazar MA.: HNF6 and Rev-erbα integrate hepatic lipid metabolism by overlapping and distinct transcriptional mechanisms. Genes Dev. 30(14): 1636-44, July 2016 Notes: doi: 10.1101/gad.281972.116.

Zhang L, He X, Liu L, Jiang M, Zhao C, Wang H, He D, Zheng T, Zhou X, Hassan A, Ma Z, Xin M, Sun Z, Lazar MA, Goldman SA, Olson EN, Richard Lu Q.: Hdac3 Interaction with p300 Histone Acetyltransferase Regulates the Oligodendrocyte and Astrocyte Lineage Fate Switch. Dev Cell. 37(6): doi: 10.1016/j.devcel.2016.06.004. June 2016.

Jager J, Wang F, Fang B, Lim HW, Peed LC, Steger DJ, Won KJ, Kharitonenkov A, Adams AC, Lazar MA.: The Nuclear Receptor Rev-erbα Regulates Adipose Tissue-Specific Fibroblast Growth Factor 21 (FGF21) Signaling. J Biol Chem. 291(20): 10867-75, May 2016 Notes: pii: jbc.M116.719120. [Epub ahead of print]

Wang Y, Frank DB, Morley MP, Zhou S, Wang X, Lu MM, Lazar MA, Morrisey EE.: HDAC3-Dependent Epigenetic Pathway Controls Lung Alveolar Epithelial Cell Remodeling and Spreading via miR-17-92 and TGF-β Signaling Regulation. Dev Cell 36(3): 303-15, Feb 2016.

Zhang L, He X, Liu L, Jiang M, Zhao C, Wang H, He D, Zheng T, Zhou X, Hassan A, Ma Z, Xin M, Sun Z, Lazar MA, Goldman SA, Olson EN, Lu QR.: Hdac3 Interaction with p300 Histone Acetyltransferase Regulates the Oligodendrocyte and Astrocyte Lineage Fate Switch. Dev Cell 36(3): 316-30, Feb 2016.

Hong S, Zhou W, Fang B, Lu W, Loro E, Damle M, Ding, Jager J, Zhang S, Zhang Y, Feng D, Chu Q, Dill BD, Khurana TS, Rabinowitz JD, Lazar MA (co-corresponding), Sun Z. : Dissociation of muscle insulin sensitivity from exercise endurance in mice by HDAC3. Nature Medicine In Press, 2016.

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Last updated: 11/29/2016
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