Penn Cardiovascular Institute

Penn Cardiovascular Institute Research Directory

faculty photo

Mitchell A. Lazar, MD, PhD

Sylvan H. Eisman Professor of Medicine
Department: Medicine

Contact information
12-102 Smilow Center for Translational Research
3400 Civic Center Boulevard / 5160
Philadelphia, PA 19104-5160
Office: (215) 898-0198
Fax: (215) 898-5408
Education:
S.B. (Chemistry)
Massachusetts Institute of Technology, 1976.
Ph.D. (Neuroscience)
Stanford Univerity, 1981.
M.D.
Stanford Univerity, 1982.
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Description of CVI Expertise

CVI Program Unit(s):
Lipid / Atherosclerosis / CAD / ACS / Prevention

CVI Research Description:
We are interested in the transcriptional regulation of metabolism by nuclear receptors, particularly in the context of obesity, insulin resistance, and diabetes. We are studying how nuclear receptor signaling and adipocytokines contribute to atherosclerotic cardiovascular disease, which is the leading cause of death in diabetes.

I am the director of the Institute for Diabetes, Obesity and Metabolism (IDOM).

Selected Publications

Sun Z, Feng D, Fang B, Mullican SE, You SH, Lim HW, Everett LJ, Nabel CS, Li Y, Selvakumaran V, Won KJ, Lazar MA.: Deacetylase-Independent Function of HDAC3 in Transcription and Metabolism Requires Nuclear Receptor Corepressor. Mol Cell. 52(6): 769-82, Dec 2013.

Alenghat T, Osborne LC, Saenz SA, Kobuley D, Ziegler CG, Mullican SE, Choi I, Grunberg S, Sinha R, Wynosky-Dolfi M, Snyder A, Giacomin PR, Joyce KL, Hoang TB, Bewtra M, Brodsky IE, Sonnenberg GF, Bushman FD, Won KJ, Lazar MA, Artis D: Histone deacetylase 3 coordinates commensal-bacteria-dependent intestinal homeostasis. Nature 504(7478): 153-7, Dec 2013.

Mullican SE, Dispirito JR, Lazar MA.: The orphan nuclear receptors at their 25-year reunion. J Mol Endocrinol. Page: [Epub ahead of print] Nov 2013.

Sun Z, Feng D, Fang B, Mullican SE, You SH, Lim HW, Everett LJ, Nabel CS, Li Y, Selvakumaran V, Won KJ, Lazar MA.: Deacetylase-Independent Function of HDAC3 in Transcription and Metabolism Requires Nuclear Receptor Corepressor. Mol Cell. Nov 2013 Notes: 2013 Nov 19. pii: S1097-2765(13)00788-0. doi: 10.1016/j.molcel.2013.10.022. [Epub ahead of print]

Schupp M, Chen F, Briggs ER, Rao S, Pelzmann HJ, Pessentheiner AR, Bogner-Strauss JG, Lazar MA, Baldwin D, Prokesch A.: Metabolite and transcriptome analysis during fasting suggest a role for the p53-Ddit4 axis in major metabolic tissues. BMC Genomics. 2013 Nov 5;14:758. doi: 10.1186/1471-2164-14-758. 14: 758, Nov 2013.

Wang F, Mullican SE, Dispirito JR, Peed LC, Lazar MA.: Lipoatrophy and severe metabolic disturbance in mice with fat-specific deletion of PPARĪ³. Proc Natl Acad Sci U S A. 110(46): 18656-61, Nov 2013.

Schwartz DR, Briggs ER, Qatanani M, Sawaya H, Sebag IA, Picard MH, Scherrer-Crosbie M, Lazar MA.: Human resistin in chemotherapy-induced heart failure in humanized male mice and in women treated for breast cancer. Endocrinology 154(11): 4206-14, Nov 2013.

Gerhart-Hines Z, Feng D, Emmett MJ, Everett LJ, Loro E, Briggs ER, Bugge A, Hou C, Ferrara C, Seale P, Pryma DA, Khurana TS, Lazar MA.: The nuclear receptor Rev-erbĪ± controls circadian thermogenic plasticity. Nature 503(7476): 410-3, Nov 2013.

Ahima RS, Lazar MA.: Physiology. The health risk of obesity--better metrics imperative. Science 341(6148): 856-8, Aug 2013 Notes: doi: 10.1126/science.1241244. No abstract available. [PubMed - in process]

Everett LJ, Lazar MA. : Cell-specific integration of nuclear receptor function at the genome. Wiley Interdiscip Rev Syst Biol Med. Jun 2013 Notes: doi: 10.1002/wsbm.1231. [Epub ahead of print]

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Last updated: 01/29/2014
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