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Mitchell A. Lazar, MD, PhD

Willard and Rhoda Ware Professor in Diabetes and Metabolic Diseases
Department: Medicine

Contact information
12-102 Smilow Center for Translational Research
3400 Civic Center Boulevard / 5160
Philadelphia, PA 19104-5160
Office: (215) 898-0198
Fax: (215) 898-5408
Education:
S.B. (Chemistry)
Massachusetts Institute of Technology, 1976.
Ph.D. (Neuroscience)
Stanford Univerity, 1981.
M.D.
Stanford Univerity, 1982.
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Description of CVI Expertise

CVI Program Unit(s):
Lipid / Atherosclerosis / CAD / ACS / Prevention

CVI Research Description:
We are interested in the transcriptional regulation of metabolism by nuclear receptors, particularly in the context of obesity, insulin resistance, and diabetes. We are studying how nuclear receptor signaling and adipocytokines contribute to atherosclerotic cardiovascular disease, which is the leading cause of death in diabetes.

I am the director of the Institute for Diabetes, Obesity and Metabolism (IDOM).

Selected Publications

Zhang Y, Dallner OS, Nakadai T, Fayzikhodjaeva G, Lu YH, Lazar MA, Roeder RG, Friedman JM. : A noncanonical PPARγ/RXRα-binding sequence regulates leptin expression in response to changes in adipose tissue mass. Proc Natl Acad Sci U S A [Epub ahead of print] , Jun 2018 Notes: pii: 201806366. doi: 10.1073/pnas.1806366115.

Lazar MA. : Reversing the curse on PPARγ. J Clin Invest 128(6): 2202-2204, Jun 2018.

Razzoli M, Emmett MJ, Lazar MA, Bartolomucci A. : β-Adrenergic receptors control brown adipose UCP-1 tone and cold response without affecting its circadian rhythmicity. FASEB J. [Epub ahead of print] , May 2018.

Borck PC, Batista TM, Vettorazzi JF, Soares GM, Lubaczeuski C, Guan D, Boschero AC, Vieira E, Lazar MA, Carneiro EM. : Nighttime light exposure enhances Rev-erbα-targeting microRNAs and contributes to hepatic steatosis. Metabolism 85: 250-258, May 2018 Notes: pii: S0026-0495(18)30119-7. doi: 10.1016/j.metabol.2018.05.002.

Hill DA, Lim HW, Kim YH, Ho WY, Foong YH, Nelson VL, Nguyen HCB, Chegireddy K, Kim J, Habertheuer A, Vallabhajosyula P, Kambayashi T, Won KJ, Lazar MA. : Distinct macrophage populations direct inflammatory versus physiological changes in adipose tissue. Proc Natl Acad Sci U S A. 115(22): E5096-E5105, May 2018.

Kim YH, Marhon SA, Zhang Y, Steger DJ, Won KJ, Lazar MA. : Rev-erbα dynamically modulates chromatin looping to control circadian gene transcription. Science 359(6381): 1274-1277, Mar 2018.

Jang JC, Li J, Gambini L, Batugedara HM, Sati S, Lazar MA, Fan L, Pellecchia M, Nair MG : Human resistin protects against endotoxic shock by blocking LPS-TLR4 interaction. Proc Natl Acad Sci U S A 114(48): E10399-E10408, Nov 2017.

Poleshko A, Shah PP, Gupta M, Babu A, Morley MP, Manderfield LJ, Ifkovits JL, Calderon D, Aghajanian H, Sierra-Pagán JE, Sun Z, Wang Q, Li L, Dubois NC, Morrisey EE, Lazar MA, Smith CL, Epstein JA, Jain R. : Genome-Nuclear Lamina Interactions Regulate Cardiac Stem Cell Lineage Restriction. Cell 171(3): 573-587, Oct 2017.

Armour SM, Remsberg JR, Damle M, Sidoli S, Ho WY, Li Z, Garcia BA, Lazar MA.: An HDAC3-PROX1 corepressor module acts on HNF4α to control hepatic triglycerides. Nat Commun 8(549): 1-11, Sep 2017 Notes: doi: 10.1038/s41467-017-00772-5.

Zhang Y, Papazyan R, Damle M, Fang B, Jager J, Feng D, Peed LC, Guan D, Sun Z, Lazar MA.: The hepatic circadian clock fine-tunes the lipogenic response to feeding through RORα/γ. Genes Dev Jul 2017 Notes: doi: 10.1101/gad.302323.117. [Epub ahead of print]

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Last updated: 06/13/2018
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