Mitchell A. Lazar, MD, PhD
Sylvan H. Eisman Professor of Medicine
Department: Medicine
Graduate Group Affiliations
Contact information
12-102 Smilow Center for Translational Research
3400 Civic Center Boulevard / 5160
Philadelphia, PA 19104
3400 Civic Center Boulevard / 5160
Philadelphia, PA 19104
Office: (215) 898-0198
Fax: (215) 898-5408
Fax: (215) 898-5408
Email:
lazar@mail.med.upenn.edu
lazar@mail.med.upenn.edu
Publications
Links
Search PubMed for articles
Lazar Lab
Cell and Molecular Biology Graduate Group
Pharmacological Sciences Graduate Group
Institute for Diabetes, Obesity and Metabolism
Search PubMed for articles
Lazar Lab
Cell and Molecular Biology Graduate Group
Pharmacological Sciences Graduate Group
Institute for Diabetes, Obesity and Metabolism
Education:
S.B. (Chemistry)
Massachusetts Institute of Technology, 1976.
Ph.D. (Neuroscience)
Stanford Univerity, 1981.
M.D.
Stanford Univerity, 1982.
Permanent linkS.B. (Chemistry)
Massachusetts Institute of Technology, 1976.
Ph.D. (Neuroscience)
Stanford Univerity, 1981.
M.D.
Stanford Univerity, 1982.
Description of CVI Expertise
CVI Program Unit(s):Lipid / Atherosclerosis / CAD / ACS / Prevention
CVI Research Description:
We are interested in the transcriptional regulation of metabolism by nuclear receptors, particularly in the context of obesity, insulin resistance, and diabetes. We are studying how nuclear receptor signaling and adipocytokines contribute to atherosclerotic cardiovascular disease, which is the leading cause of death in diabetes.
I am the director of the Institute for Diabetes, Obesity and Metabolism (IDOM).
Selected Publications
Sun Z, Lazar MA.: Dissociating fatty liver and diabetes. Trends Endocrinol Metab Page: [Epub ahead of print] Oct 2012.Yan Q, Carmody RJ, Qu Z, Ruan Q, Jager J, Mullican SE, Lazar MA, Chen YH.: Nuclear factor-κB binding motifs specify Toll-like receptor-induced gene repression through an inducible repressosome. Proc Natl Acad Sci U S A. Page: [Epub ahead of print] Aug 2012.
Feng D, Lazar MA.: Clocks, metabolism, and the epigenome. Mol Cell. 47(2): 158-67, July 2012.
Lazar MA, Birnbaum MJ.: Physiology. De-meaning of metabolism. Science 336(6089): 1651-2, Jun 2012.
Sinha RA, You SH, Zhou J, Siddique MM, Bay BH, Zhu X, Privalsky ML, Cheng SY, Stevens RD, Summers SA, Newgard CB, Lazar MA, Yen PM.: Thyroid hormone stimulates hepatic lipid catabolism via activation of autophagy. J Clin Invest. 122(7): 2428-38, Jun 2012.
Sun Z, Miller RA, Patel RT, Chen J, Dhir R, Wang H, Zhang D, Graham MJ, Unterman TG, Shulman GI, Sztalryd C, Bennett MJ, Ahima RS, Birnbaum MJ, Lazar MA. : Hepatic HDAC3 promotes gluconeogenesis by repressing lipid synthesis and sequestration. Nature Medicine Page: doi: 10.1038/nm.2744. [Epub ahead of print] May 2012.
Bugge A, Feng D, Everett LJ, Briggs E, Mullican SE, Wang F, Jager J, Lazar MA.: Rev-erbα and β coordinately protect the circadian clock and normal metabolic function. Genes & Development 26(7): 657-67, Apr 2012.
Mullican SE, Gaddis CA, Alenghat T, Nair MG, Giacomin PR, Everett LJ, Feng D, Steger DJ, Schug J, Artis D, Lazar MA.: Histone deacetylase 3 is an epigenomic brake in macrophage alternative activation. Genes Dev. 25(23): 2480-8, Dec 2011.
Baker JF, Morales M, Qatanani M, Cucchiara A, Nackos E, Lazar MA, Teff K, VON Feldt JM.: Resistin Levels in Lupus and Associations with Disease-specific Measures, Insulin Resistance, and Coronary Calcification. J Rheumatol. 38(11): 2369-75, Nov 2011.
Singh N, Trivedi CM, Lu M, Mullican SE, Lazar MA, Epstein JA.: Histone deacetylase 3 regulates smooth muscle differentiation in neural crest cells and development of the cardiac outflow tract. Circ Res. 109(11): 1240-9, Nov 2011.