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Mitchell A. Lazar, MD, PhD

Willard and Rhoda Ware Professor in Diabetes and Metabolic Diseases
Department: Medicine

Contact information
12-102 Smilow Center for Translational Research
3400 Civic Center Boulevard / 5160
Philadelphia, PA 19104-5160
Office: (215) 898-0198
Fax: (215) 898-5408
Education:
S.B. (Chemistry)
Massachusetts Institute of Technology, 1976.
Ph.D. (Neuroscience)
Stanford Univerity, 1981.
M.D.
Stanford Univerity, 1982.
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Description of CVI Expertise

CVI Program Unit(s):
Lipid / Atherosclerosis / CAD / ACS / Prevention

CVI Research Description:
We are interested in the transcriptional regulation of metabolism by nuclear receptors, particularly in the context of obesity, insulin resistance, and diabetes. We are studying how nuclear receptor signaling and adipocytokines contribute to atherosclerotic cardiovascular disease, which is the leading cause of death in diabetes.

I am the director of the Institute for Diabetes, Obesity and Metabolism (IDOM).

Selected Publications

Armour SM, Remsberg JR, Damle M, Sidoli S, Ho WY, Li Z, Garcia BA, Lazar MA.: An HDAC3-PROX1 corepressor module acts on HNF4α to control hepatic triglycerides. Nat Commun 8(549): 1-11, Sep 2017 Notes: doi: 10.1038/s41467-017-00772-5.

Zhang Y, Papazyan R, Damle M, Fang B, Jager J, Feng D, Peed LC, Guan D, Sun Z, Lazar MA.: The hepatic circadian clock fine-tunes the lipogenic response to feeding through RORα/γ. Genes Dev Jul 2017 Notes: doi: 10.1101/gad.302323.117. [Epub ahead of print]

Emmett MJ, Lim HW, Jager J, Richter HJ, Adlanmerini M, Peed LC, Briggs ER, Steger DJ, Ma T, Sims CA, Baur JA, Pei L, Won KJ, Seale P, Gerhart-Hines Z, Lazar MA.: Histone deacetylase 3 prepares brown adipose tissue for acute thermogenic challenge. Nature 546(7659): 544-548, Jun 2017.

Soccio RE, Li Z, Chen ER, Foong YH, Benson KK, Dispirito JR, Mullican SE, Emmett MJ, Briggs ER, Peed LC, Dzeng RK, Medina CJ, Jolivert JF, Kissig M, Rajapurkar SR, Damle M, Lim HW, Won KJ, Seale P, Steger DJ, Lazar MA.: Targeting PPARγ in the epigenome rescues genetic metabolic defects in mice. J Clin Invest 127(4): 1451-1462, Apr 2017.

Soccio RE, Li Z, Chen ER, Foong YH, Benson K, DiSpirito, Mullican SE, Emmett MJ, Briggs ER, Peed LC, Dzeng RK, Medina-Jimenez C, Kissig M, Rajapurkar SR, Damle M, Lim H-W, Won KJ, Seale P, Steger DJ, Lazar MA: Targeting PPARγ in the epigenome rescues genetic metabolic defects in mice. J Clin Invest 127(2): 1451-1462, Apr 2017.

Lazar MA.: Maturing of the nuclear receptor family. J Clin Invest 127(4): 1123-1125, Apr 2017.

Titchenell PM, Lazar MA, Birnbaum MJ.: Unraveling the Regulation of Hepatic Metabolism by Insulin. Trends Endocrinol Metab S1043-2760(17): 30039-5, Apr 2017.

Hong S, Zhou W, Fang B, Lu W, Loro E, Damle M, Ding G, Jager J, Zhang S, Zhang Y, Feng D, Chu Q, Dill BD, Molina H, Khurana TS, Rabinowitz JD, Lazar MA, Sun Z.: Dissociation of muscle insulin sensitivity from exercise endurance in mice by HDAC3 depletion. Nature Medicine 23(2): 223-234, Feb 2017 Notes: doi: 10.1038/nm.4245. [Epub ahead of print]

Plikus MV, Guerrero-Juarez CF, Ito M, Li YR, Dedhia PH, Zheng Y, Shao M, Gay DL, Ramos R, Hsi TC, Oh JW, Wang X, Ramirez A, Konopelski SE, Elzein A, Wang A, Supapannachart RJ, Lee HL, Lim CH, Nace A, Guo A, Treffeisen E, Andl T, Ramirez RN, Murad R, Offermanns S, Metzger D, Chambon P, Widgerow AD, Tuan TL, Mortazavi A, Gupta RK, Hamilton BA, Millar SE, Seale P, Pear WS, Lazar MA, Cotsarelis G: Regeneration of fat cells from myofibroblasts during wound healing. Science 355(6326): 748-752, Feb 2017.

Papazyan R, Zhang Y, Lazar MA.: Genetic and epigenomic mechanisms of mammalian circadian transcription. Nat Struct Mol Biol. 23(12): 1045-1052, Dec 2016.

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Last updated: 10/09/2017
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