Louis J. Soslowsky

faculty photo
Fairhill Professor
Director of Orthopaedic Research, University of Pennsylvania
Member, Institute for Medicine and Engineering, University of Pennsylvania
Director of Basic Science Research, Shoulder and Elbow Service, University of Pennsylvania
Vice Chair for Research, Department of Orthopaedic Surgery, University of Pennsylvania (reappointed 2009)
Professor, Department of Bioengineering, University of Pennsylvania
Fellow, Institute of Aging, University of Pennsylvania
Founding Director, Penn Center for Musculoskeletal Disorders, University of Pennsylvania (Type 1 center designation in 2008)
Member, Institute for Translational Medicine and Therapeutics
Executive Committee, University of Pennsylvania, Department of Bioengineering
Search Committee, University of Pennsylvania, Institute for Regenerative Medicine
Member, University of Pennsylvania, Animal Program Advisory Committee (APAC), Vice Provost for Research
Associate Dean for Research Integration, University of Pennsylvania, Perelman School of Medicine
Department: Orthopaedic Surgery

Contact information
McKay Orthopaedic Research Laboratory
424 Stemmler Hall
3450 Hamilton Walk
Philadelphia, PA 19104-6081
Office: 215-898-8653
Fax: 215-573-2133
Education:
Diploma
East Brunswick High School , 1982.
B.S. (Engineering Mechanics)
Columbia University, 1986.
M.S. (Engineering Mechanics)
Columbia University, 1987.
M.Phil
Columbia University, 1989.
Ph.D. (Engineering Mech./Biomechanics, Mentor: Van C. Mow)
Columbia University, 1991.
Cert. (Academic Medicine Leadership Program)
Wharton School of the University of Pennsylvania , 2008.
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Description of Research Expertise

orthopaedic research, orthopaedic biomechanics and tissue engineering, tendons and ligaments, shoulder and elbow

Description of Itmat Expertise

Dr. Soslowsky's research program involves orthopaedic biomechanics and functional tissue engineering with an emphasis on tendon and ligament injury, repair, and regeneration.

Selected Publications

Tucker, J.J, Gordon, J.A., Zanes, R.C., Zuskov, A., Vinciguerra, J.D., Bloebaum, R.D., Soslowsky, L.J.: P(2) porous titanium implants improve tendon healing in an acute rat supraspinatus repair model. J Shoulder Elbow Surg 26(3): 529-35, 2017.

Freedman, B.R., Gordon, J.A., Bhatt, P.B., Pardes, A.M., Thomas, S.J.,2, Sarver, J.J., Riggin, C.N., Tucker, J.J., Williams, A.W., Zanes, R.C., Hast, M.W., Farber, D.C., Silbernagel, K.G., Soslowsky, L.J. : Nonsurgical treatment and early return to activity leads to improved Achilles tendon fatigue mechanics and functional outcomes during early healing in an animal model. J Ortho Res 34(12): 2172-80, Dec 2016.

Huegel, J., Kim, D.H., Cirone, J.M., Pardes, A.M., Morris, T.R., Nuss, C.A., Mauck, R.L., Soslowsky, L.J., Kuntz, A.F.: Autologous tendon-derived cell-seeded nanofibrous scaffolds improve rotator cuff repair in an age-dependent fashion. J Orthop Res Aug 2016 Notes: Epub ahead of print.

Tucker, J.J., Cirone, J.M., Morris, T.R., Nuss, C.A., Huegel, J., Waldorff, E.I., Zhang, N., Ryaby, J.T., Soslowsky, L.J.: Pulsed electromagnetic field therapy improves tendon-to-bone healing in a rat rotator cuff repair model. J Orthop Res Jun 2016.

Zhang, K., Asai, S., Hast, M.W., Liu, M., Usami, Y., Iwamoto, M., Soslowsky, L.J., Enomoto-Iwamoto, M.: Tendon mineralization is progressive and associated with deterioration of tendon biomechanical properties, and requires BMP-Smad signaling in the mouse Achilles tendon injury model. Matrix Bio 52-54: 315-24, May-Jul 2016.

Marinovich, R., Soenjaya, Y., Wallace, G.Q., Zuskov, A., Dunkman, A., Foster, B.L., Ao, M., Bartman, K., Lam, V., Rizkalla, A., Beier, F., Somerman, M.J., Holdsworth, D.W., Soslowsky, L.J., Lagugné-Labarthet, F., Goldberg, H.A.: The role of bone sialoprotein in the tendon-bone insertion. Matrix biology 53-54: 325-38, 2016.

Pardes, A.M., Freedman, B.R., Soslowsky, L.J.: Ground reaction forces are more sensitive gait measures than temporal parameters in rodents following rotator cuff injury. J Biomech 49(3): 376-81, 2016.

Zgheib, C., Hodges, M., Hu J., Beason, D.P., Soslowsky, L.J., Liechty, K.W., Xu,J.: Mechanisms of mesenchymal stem cell correction of the impaired biomechanical properties of diabetic skin: The role of miR-29a. Wound Repair Regen 24(2): 237-46, 2016.

Connizzo, B.K., Adams, SM, Adams, T., Birk, D.E., Soslowsky, L.J: Collagen V Expression is Crucial in Regional Development of the Supraspinatus Tendon. J Orthop Res 2016.

Connizzo, B.K., Adams, S.M., Adams, T.H., Jawad, A.F., Birk, D.E., Soslowsky, L.J.: Multiscale Regression Modeling in Mouse Supraspinatus Tendons Reveals That Dynamic Processes Act as Mediators in Structure-Function Relationships. J of Biomechanics 49(9), 2016.

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Last updated: 06/07/2017
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