Sylvia E. Rosas
Assistant Professor of Medicine
Senior Fellow, Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia, PA , University of Pennsylvania
Attending Physician, Philadelphia Veterans Administration Medical Center
Member, PENN Cardiovascular Institute
Member, Institute for Translational Medicine and Therapeutics
Department: Medicine
Contact information
Room 113
1 Founders Pavilion/HUP
3400 Spruce Street
Philadelphia, PA 19104
1 Founders Pavilion/HUP
3400 Spruce Street
Philadelphia, PA 19104
Office: 215-615-3446
Fax: 215-615-3447
Fax: 215-615-3447
Email:
sylvia.rosas@uphs.upenn.edu
sylvia.rosas@uphs.upenn.edu
Publications
Education:
M.D.
Colegio Mayor de Nuestra Senora del Rosario, Bogota, Colombia, 1990.
(Business Administration)
Wharton Management Program, University of Pennsylvania, 2002.
M.S.C.E. (Clinical Epidemiology and Biostatistics Program)
University of Pennsylvania, 2003.
Permanent linkM.D.
Colegio Mayor de Nuestra Senora del Rosario, Bogota, Colombia, 1990.
(Business Administration)
Wharton Management Program, University of Pennsylvania, 2002.
M.S.C.E. (Clinical Epidemiology and Biostatistics Program)
University of Pennsylvania, 2003.
Description of Research Expertise
epidemiological studiescardiovascular disease
non-invasive studies
chronic kidney disease
novel cardiovascular risk factors
coronary calcifications
minority health
Description of Itmat Expertise
Dr. Rosas's primary research focus is on cardiovascular disease in patients with chronic kidney disease including the role of novel risk factors in the development and progression of atherosclerosis. Oxidative stress, inflammation, mineral and lipid metabolism are of particular interest. She studies the impact of vascular calcification in morbidity and mortality in chronic kidney disease. She is currently performing a randomized control trial to assess the differential effect of different types of activated vitamin D in progression of coronary calcification.She is an ancillary Principal Investigator to the Chronic Renal Insufficiency Cohort (CRIC, a multicenter study of 3600 participants with CKD sponsored by NIH. She is evaluating how novel and traditional cardiovascular risk factors affect atherosclerosis measured by carotid intima-media thickness and plaque.
Selected Publications
Rassi AN, Cavender MA, Fonarow GC, Cannon CP, Hernandez AF, Peterson ED, Peacock WF, Laskey WK, Rosas SE, Zhao X, Schwamm LH, Bhatt DL. : Temporal Trends and Predictors in the Use of Aldosterone Antagonists Post-Acute Myocardial Infarction. Journal of the American College of Cardiology 61(1): 35-40, Jan 2013.Liu KD, Yang W, Anderson AH, Feldman HI, Demirjian S, Hamano T, He J, Lash J, Lustigova E, Rosas SE, Simonson MS, Tao K, Hsu CY; on behalf of the Chronic Renal Insufficiency Cohort (CRIC) study investigators.: Urine neutrophil gelatinase-associated lipocalin (NGAL) level and risk of progressive chronic kidney disease: results from the CRIC study. Kidney International 2013.
Jane F Ferguson, Gregory J Matthews, Raymond R Townsend, Dominic S Raj, Peter A.Kanetsky, Matthew Budoff, Michael J Fischer, Sylvia E Rosas, Radhika Kanthety, Mahboob Rahman, Stephen R Master, Atif Qasim, Mingyao Li, Nehal N. Mehta, Haiqing Shen, Braxton D Mitchell, Jeffrey R O’Connell, Alan R Shuldiner, Weang Kee Ho1, Robin Young, Asif Rasheed, John Danesh, Jiang He, John W Kusek, Akinlolu O Ojo, John Flack, Alan S Go, Crystal A Gadegbeku, Jackson T Wright, Danish Saleheen,Harold I Feldman, Daniel J Rader, Andrea S Foulkes, Muredach P Reilly and the Chronic Renal Insufficiency Cohort (CRIC) Study Investigators: Candidate Gene Association Study of Coronary Artery Calcification in Chronic Kidney Disease: Findings from the Chronic Renal Insufficiency Cohort Study. Journal of the American College of Cardiology 2013.
B Mohamed, W Yang, H Litt and SE Rosas: Valvular Calcification, Inflammation and Mortality in Dialysis Patients Journal of Heart Valve Disease 2013.
Rosas SE, Feldman HI: Synthetic Vascular Hemodialysis Access vs Native Arteriovenous Fistula: A Cost-Utility Analysis. Annals of Surgery 255(1): 181-6, Jan 2012
Khan AM, Yang W, Chirinos J, Litt H,Rosas SE: FGF-23 and the progression of coronary arterial calcification in patients new to dialysis Clinical Journal of the American Society of Nephrology 7(12): 2017-22, December 2012.
Adeseun GA, Xie D, Wang X, Joffe MM, Mohler III ER, Townsend RR, Budoff M, Rosas SE. : Carotid Plaque, Carotid Intima-Media Thickness, and Coronary Calcification Equally Discriminate Prevalent Cardiovascular Disease in Kidney Disease American Journal of Nephrology 36(4): 342-347, December 2012.
Park M, Hsu CY, Li Y, Mishra RK, Keane M, Rosas SE, Dries D, Xie D, Chen J, He J, Anderson A, Go AS, Shlipak MG; Chronic Renal Insufficiency Cohort (CRIC) Study Group: Associations between Kidney Function and Subclinical Cardiac Abnormalities in CKD. Journal of the American Society of Nephrology 23(10): 1725-34, October 2012.
Vasaiwala S, Cannon CP, Fonarow GC, Peacock WF, Laskey W, Schwamm LH, Liang L, Hernandez AF, Peterson ED, Rosas SE, Bhatt DL; Get With The Guidelines Steering Committee and Investigators: Quality of Care and Outcomes Among Patients With Acute Myocardial Infarction by Level of Kidney Function at Admission: Report From the Get With The Guidelines Coronary Artery Disease Program Clinical Cardiology 35: 541-7, September 2012.
Wahl P, Xie H, Scialla J, Anderson CA, Bellovich K, Brecklin C, Chen J, Feldman H, Gutierrez OM, Lash J, Leonard MB, Negrea L, Rosas SE, Anderson AH, Townsend RR, Wolf M, Isakova T. : Earlier onset and greater severity of disordered mineral metabolism in diabetic patients with chronic kidney disease. Diabetes Care 35(5): 994-1001, May 2012.