Rahim R. Rizi

faculty photo
Professor of Radiology
Department: Radiology

Contact information
Department of Radiology
1 Silverstein
3400 Spruce Street
Philadelphia, PA 19104-6100
Office: 215-615-2426
Fax: 215-349-5115
Graduate Group Affiliations
Education:
B.S. (Chemistry)
University of Isfahan, Iran, 1976.
M.S. (Physical Chemistry)
Western Illinois University, 1978.
Ph.D. (Physical Chemistry)
University of Iowa , 1983.
M.S. (Computer Science)
University of Pennsylvania , 1987.
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Description of Research Expertise

The primary mission of the Functional and Metabolic Imaging Group (FMIG) is the development and application of novel hyperpolarized MRI techniques to the diagnosis of various pulmonary and metabolic disorders. Hyperpolarization, the process of drastically increasing the population difference between nuclear spin states, provides a platform for imaging lung physiology and metabolic activity with spatial and temporal resolution unattainable with conventional MRI techniques, thus offering the potential for the earlier diagnosis of disease states and the precise monitoring of a patient’s response to medical treatment. This core research theme is executed with an eye toward several ultimate goals: the identification of changes in pulmonary structure and function associated with disease, a more complete understanding of pathogenesis, and the establishment of a more sensitive testing environment to develop treatments for lung disease. To date, significant contributions in these areas include new imagining techniques for the comprehensive description of lung physiology and structure, accurate imaging of the regional pulmonary partial pressure of oxygen in both humans and large and small animals, highly developed imaging of regional ventilation, and a state-of-the-art mechanical ventilation device. Specifically, our research activities at FMIG is divided into four general branches: 1) The development of novel imaging techniques for the quantitative assessment of pulmonary structure and function: 2)The development of novel methods for real-time metabolic imaging: 3)The construction of novel polarization apparatuses: 4) The development and implementation of rapid imaging pulse sequences.

Description of Itmat Expertise

Dr. Rizi investigates non-invasive, regional assessment of lung function which has the potential to markedly enhance early diagnosis and management of disease, to accelerate drug discovery and trials, and to provide fundamental insights into lung disease pathogenesis.

Selected Publications

Pourfathi Mehrdad, Xin Yi, Kadlecek Stephen J, Cereda Maurizio F, Profka Harrilla, Hamedani Hooman, Siddiqui Sarmad M, Ruppert Kai, Drachman Nicholas A, Rajaei Jennia N, Rizi Rahim R: In vivo imaging of the progression of acute lung injury using hyperpolarized [1-(13) C] pyruvate. Magnetic resonance in medicine Jan 2017.

Drachman N, Kadlecek S, Rizi R.R.: Analyzing Reaction Dynamics With Hyperpolarized 13C-NMR. Proc. Intl. Soc. Mag. Reson. Med. 24, Honolulu, Hawaii. ID. 7437 2017.

Hamedani H, Pourfathi M, Xin Y, Kadlecek S, Cereda M, Profka H, Duncan I, Siddiqui S, Drachman N, Ruppert K, Rizi R.R.: A Multi-Variate Regional Study of Acute Lung Injury Using Hyperpolarized [1-13C] Pyruvate. Proc. Intl. Soc. Mag. Reson. Med. 24, Honolulu, Hawaii. ID. 7276 2017.

Drachman N, Siddiqui S, Pourfathi M, Kadlecek S, Rizi R.R.: Assessment of Lung Injury by MR Quantification of the Bicarbonate-­to­-Pyruvate Ratio in the Heart. Proc. Am. Thorac. Soc. Int. Conf. Washington, D.C. ID. 11235 2017.

Pourfathi M, Xin Y, Kadlecek S, Cereda M, Profka H, Hamedani H, Duncan I, Siddiqui S, Drachman N, Rizi R.R.: Combination of Pulmonary Lactate-­to­-Pyruvate and Compliance to Characterize the Severity and Progression of Acute Lung Injury Using Hyperpolarized [1­13C] Pyruvate MRI. Proc. Am. Thorac. Soc. Int. Conf. Washington, D.C. ID. 10987 2017.

Siddiqui S, Pourfathi M, Habertheuer A, Xin Y, Hamedani H, Profka H, Naji A, Vallabhajosyula P, Rizi R.R.: Metabolic and Structural Imaging of Syngeneic and Allogeneic Rat Lung Transplantation. Proc. Am. Thorac. Soc. Int. Conf. Washington, D.C. ID. 10851 2017.

Siddiqui S, Pourfathi M, Drachman N, Kadlecek S, Xin Y, Profka H, Rizi R.R. : CT and Hyperpolarized Carbon­13 MR­-based Multimodal Biomaker for Pulmonary Fibrosis in a Bleomycin Induced Lung Injury Model. Proc. Am. Thorac. Soc. Int. Conf. Washington, D.C. ID. 10796 2017.

Xin Y, Cereda M, Hamedani H, Siddiqui S, Pourfathi M, Itkin-Ofer M, Turner S, Meeder N, Kadlecek S, Clapp J, Hughes L, Roberts A, Bey Q, Rodriguez A, Drachman N, Duncan I, Profka H, Tustison N, Gee J, Kavanagh B.P. Rizi R.R.: Parametric Response Maps to Measure the Effects of Prone Position in Pigs with Experimental Lung Injury. Proc. Am. Thorac. Soc. Int. Conf. Washington, D.C. ID. 10570 2017.

Cereda M, Xin Y, Hamedani H, Bellani G, Kadlecek S, Itkin-Ofer M, Clapp J, Guerra L, Meeder N, Turner S, Hughes L, Duncan I, Pourfathi M, Siddiqui S, Drachman N, Roberts A, Bey Q, Rodriguez A, Tustison N, Gee J, Kavanagh B.P., Rizi R.R.: Imaging Prediction of ARDS Outcome. Proc. Am. Thorac. Soc. Int. Conf. Washington, D.C. ID. 10433 2017.

Pourfathi M, Xin Y, Kadlecek S, Cereda M, Profka H, Hamedani H, Siddiqui S, Duncan I, Drachman N, Rizi R.R.: Investigating the Effects of Protective and Non-­protective Ventilation After Acute Lung Injury Using Hyperpolarized [1­13C] Pyruvate. Proc. Am. Thorac. Soc. Int. Conf. Washington, D.C. ID. 6921 2017.

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Last updated: 02/16/2017
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