Marina Cuchel || Institute for Translational Medicine and Therapeutics || University of Pennsylvania

Marina Cuchel

Research Assistant Professor of Medicine

Member, Institute for Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine

Department: Medicine

Contact information

Institute for Translational Medicine and Therapeutics
8039 Maloney Building
3600 Spruce Street
Email: mcuchel@mail.med.upenn.edu
Philadelphia, PA 19104

Office: (215) 746-2834
Fax: (215) 615-6520

Email:
mcuchel@mail.med.upenn.edu

Education:
M.D. (Medicine, cum laude)
Universita' degli Studi di Milano, 1987.
Specialist (Geriatric Medicine, cum laude)
Universita' degli Studi di Milano , 1991.
Ph.D. (Pathophysiology of Aging)
Universita' degli Studi di Milano, Milan, Italy, 1998.
MS (Translational Research)
University of Pennsylvania School of Medicine, 2008.

Links
Primary Work Website
Institute for Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine

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Description of Research Expertise

Dr. Cuchel is interested in the study of mechanisms regulating the metabolism of lipid and lipoproteins, with particular attention to HDL and reverse cholesterol transport, using two parallel approaches: animal models and well-defined human monogenic disorders. She is also interested in early phase development of novel therapeutic strategies for the treatment of rare genetic disorders of lipid metabolism and for the enhancement of reverse cholesterol transport.

Description of Itmat Expertise

Dr. Cuchel studies mechanisms regulating the metabolism of lipid and lipoproteins, with particular attention to HDL and reverse cholesterol transport. Projects include early phase development of novel therapeutic strategies for the treatment of rare genetic disorders of lipid metabolism and for enhancement of reverse cholesterol transport.

Selected Publications

Cuchel Marina, Meagher Emma A, du Toit Theron Hendrik, Blom Dirk J, Marais A David, Hegele Robert A, Averna Maurizio R, Sirtori Cesare R, Shah Prediman K, Gaudet Daniel, Stefanutti Claudia, Vigna Giovanni B, Du Plessis Anna M E, Propert Kathleen J, Sasiela William J, Bloedon LeAnne T, Rader Daniel J: Efficacy and safety of a microsomal triglyceride transfer protein inhibitor in patients with homozygous familial hypercholesterolaemia: a single-arm, open-label, phase 3 study. Lancet 381(9860): 40-6, Jan 2013.

Cuchel M, Meagher EA, Theron H. du Toit, Blom DJ, Marais AD, Hegele RA, Averna M, Sirtori C, Shah PK, Gaudet D, Stefanutti C, Vigna GB, Du Plessis AME, Bloedon LT, Rader DJ for Phase 3 HoFH Lomitapide Study Investigators: Apheresis Treatment does not Affect the Lipid-Lowering Efficacy of Lomitapide, a Microsomal Triglyceride Transfer Protein Inhibitor, in Patients with Homozygous Familial Hypercholesterolemia. Circulation 126(21 Supplement): A17396, November 2012.

Cuchel M, Meagher E, Theron H Du T, Blom, DJ, Marais AD, Hegele RA, Averna M, Bondioli A, Shah PK, Gaudet D, Stefanutti C, Vigna G, Du Plessis AME, Bloedon LT, Sasiela WJ, Rader DJ. : A Phase 3 Study of Lomitapide, a Microsomal Triglyceride Transfer Protein (MTP) Inhibitor in Patients with Homozygous Familial Hypercholesterolemia. 80th European Atherosclerosis Society Congress (oral presentation) May 2012.

Marina Cuchel, Jeffrey T. Billheimer, John S. Millar, Charles C. Schwartz, Anna C. Raper, Rachel Ochotny, Amanda L. Baer, Ching Su, Bjorn CL Carlsson, Daniel J. Rader: Assessment of Reverse Cholesterol Transport in Vivo in Humans: a Novel Method. Arteriosclerosis, Thrombosis and Vascular Biology, 2012 Scientific Sessions April 2012.

Raper A, Kolansky DM, Cuchel M : Treatment of Familial Hypercholesterolemia: Is There a Need Beyond Statin Therapy? Current Atherosclerosis Reports 14: 11-6, 2012.

Cuchel M, for The Phase 3 HoFH Lomitapide Study Investigators : A phase 3 study of the microsomal triglyceride transfer protein (MTP) inhibitor lomitapide in patients with homozygous familial hypercholesterolemia. European Heart Journal 33(Abstract Supplement): 951, 2012.

Khera Amit V, Cuchel Marina, de la Llera-Moya Margarita, Rodrigues Amrith, Burke Megan F, Jafri Kashif, French Benjamin C, Phillips Julie A, Mucksavage Megan L, Wilensky Robert L, Mohler Emile R, Rothblat George H, Rader Daniel J: Cholesterol efflux capacity, high-density lipoprotein function, and atherosclerosis. The New England Journal of Medicine 364(2): 127-35, Jan 2011.

Zeissig Sebastian, Dougan Stephanie K, Barral Duarte C, Junker Yvonne, Chen Zhangguo, Kaser Arthur, Ho Madelyn, Mandel Hannah, McIntyre Adam, Kennedy Susan M, Painter Gavin F, Veerapen Natacha, Besra Gurdyal S, Cerundolo Vincenzo, Yue Simon, Beladi Sarah, Behar Samuel M, Chen Xiuxu, Gumperz Jenny E, Breckpot Karine, Raper Anna, Baer Amanda, Exley Mark A, Hegele Robert A, Cuchel Marina, Rader Daniel J, Davidson Nicholas O, Blumberg Richard S: Primary deficiency of microsomal triglyceride transfer protein in human abetalipoproteinemia is associated with loss of CD1 function. The Journal of clinical investigation 120(8): 2889-99, Aug 2010.

Cuchel M, Meagher E, Marais AD, Blom DJ, Theron HDT, Shah PK, Hegele RA, Bloeden LT, Sasiela WJ, Rader DJ: Phase 3 study of microsomal trygliceride transfer protein inhibitor (MTP-I) lomitapide in subjects with homozygous familial hypercholesterolemia (HoFH): 56-week results 78th European Atherosclerosis Society Congress (oral presentation) Page: 1413, June 2010.

de la Llera-Moya Margarita, Drazul-Schrader Denise, Asztalos Bela F, Cuchel Marina, Rader Daniel J, Rothblat George H: The Ability to Promote Efflux Via ABCA1 Determines the Capacity of Serum Specimens With Similar High-Density Lipoprotein Cholesterol to Remove Cholesterol From Macrophages. Arteriosclerosis, thrombosis, and vascular biology Jan 2010.