Theresa M. Busch

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Research Associate Professor of Radiation Oncology
Associate Director, Division of Oncology Research, Department of Radiation Oncology, University of Pennsylvania
Department: Radiation Oncology

Contact information
Radiation Biology Division
Department of Radiation Oncology
University of Pennsylvania
Smilow Center for Translational Research, Room 8-126
3400 Civic Center Blvd., Bldg. 421
Philadelphia, PA 19104-5156
Office: 215-573-3168
Graduate Group Affiliations
Education:
B.S. (Biophysics)
University of Scranton, 1993.
Ph.D. (Biophysics)
University of New York at Buffalo, Roswell Park Cancer Institute Division, Buffalo, NY, 1998.
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Description of Itmat Expertise

The Busch laboratory is interested in the biological mechanisms of photodynamic therapy (PDT) of solid tumors, PDT effects on tumor oxygenation and blood flow, and methods to augment or abrogate those effects.

Selected Publications

Hana SW, Mesquitab RC, Busch TM, Putt ME: A method for choosing the smoothing parameter in a semi-parametric model for detecting change-points in blood flow. Journal of Applied Statistics 41(1): 26-45, Apr 2014 Notes: Manuscript ID: 830085.

Pietrofesa R, Turowski J, Tyagi S, Dukes F, Arguiri E, Busch TM, Gallagher-Colombo SM, Solomides CC, Cengel KA, Christofidou-Solomidou M: Radiation mitigating properties of the lignan component in flaxseed. BMC Cancer 13(1): 179, Apr 2013.

Edmonds C, Hagan S, Gallagher-Colombo SM, Busch TM, Cengel KA: Photodynamic therapy activated signaling from epidermal growth factor receptor and STAT3: Targeting survival pathways to increase PDT efficacy in ovarian and lung cancer. Cancer Biology & Therapy 13(14): 1463-70, Dec 2012.

Gallagher-Colombo SM, Maas AL, Yuan M, Busch TM: Photodynamic therapy-induced angiogenic signaling: consequences and solutions to improve therapeutic response. Israel Journal of Chemistry 52(8-9): 681-90, Sep 2012.

Maas AL, Carter SL, Wileyto EP, Miller J, Yuan M, Yu G, Durham D, Busch TM: Tumor vascular microenvironment determines responsiveness to photodynamic therapy. Cancer Research 72(8): 2079-88, Apr 2012.

Mesquita RC, Han SW, Miller J, Schenkel SS, Pole A, Esipova TV, Vinogradov SA, Putt ME, Yodh AG, Busch TM: Tumor blood flow differs between mouse strains: consequences for vasoresponse to photodynamic therapy. PloS ONE 7(5): e37322, 2012.

Marotta DE, Cao W, Wileyto EP, Li H, Corbin I, Rickter E, Glickson JD, Chance B, Zheng G, Busch TM: Evaluation of bacteriochlorophyll-reconstituted low-density lipoprotein nanoparticles for photodynamic therapy efficacy in vivo. Nanomedicine 6(3): 475-87, Apr. 2011

Esipova TV, Karagodov A, Miller J, Wilson DF, Busch TM, Vinogradov SA: Two new "protected" oxyphors for biological oximetry: properties and application in tumor imaging. Analytical Chemistry 83(22): 8756-65, Nov 2011.

Grossman CE, Pickup S, Durham A, Wileyto EP, Putt ME, Busch TM: Photodynamic therapy of disseminated non-small cell lung carcinoma in a murine model. Lasers in Surgery & Medicine 43(7): 663-75, Sep 2011.

Ceroni P, Lebedev AY, Marchi E, Yuan M, Esipova TV, Bergamini G, Wilson DF, Busch TM, Vinogradov SA: Evaluation of phototoxicity of dendritic porphyrin-based phosphorescent oxygen probes: an in vitro study. Photochemical Photobiological Sciences 10(6): 1056-65, Jun 2011.

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Last updated: 08/14/2014
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