Rexford Sefah Ahima

faculty photo
Professor of Medicine
Director , Penn Diabetes and Endocrinology Research Center Mouse Phenotyping, Physiology and Metabolism Core
Faculty, Institute of Neurological Sciences, University of Pennsylvania
Staff Endocrinologist, Hospital of the University of Pennsylvania
Staff Endocrinologist, Presbyterian Medical Center, Philadelphia, PA
Director, Weight Management and Metabolism Clinic, Presbyterian Medical Center, Philadelphia
Faculty Member, Neuroscience Graduate Group, University of Pennsylvania School of Medicine
Associate Director, Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania
Director, Obesity Unit, Institute for Diabetes, Obesity and metabolism, University of Penn
Member of Diabetes Research Center Executive Committee, Perelman School of Medicine at the University of Pennsylvania
Department: Medicine

Contact information
Department of Medicine
Division of Endocrinology, Diabetes & Metabolism
12-104 Translational Research Center
3400 Civic Center Boulevard, Building 421
Philadelphia, PA 19104-6149
Office: (215) 573-1872
Fax: 215-746-8931
Lab: (215) 573-1874
Education:
B.Sc. (Endocrinology)
University of London, 1981.
M.D.
University of Ghana Medical School, 1986.
Ph.D (Neuroscience)
Tulane University, New Orleans, LA, 1992.
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Description of Research Expertise

Research Interests:
CNS targets of adipokines
Adipokine regulation of glucose and lipid metabolism
Role of lipid droplet proteins in steatosis and glucose metabolism
Role of myokines in glucose and lipid metabolism

Key words:Brain, adipokine, neuroendocrine, insulin, neuropeptide, obesity, diabetes.

Description of Research:
My laboratory is interested in the central and peripheral actions of adipokines. Contrary to the prevailing view of the adipocyte as merely a specialized cell for the storage of excess energy in the form of triglycerides, adipokines secreted by adipose tissue are actively involved in energy homeostasis, and glucose and lipid metabolism. Leptin and adiponectin enhance fat oxidation and insulin sensitivity, whereas resistin induces insulin resistance, steatosis and inflammation. Understanding the biology of adipokines provides valuable insights into the pathogenesis and potential treatment of obesity, diabetes and other metabolic diseases.

Projects:
1. Hypothalamic targets of leptin, adiponectin and resistin
2. Adipokine regulation of glucose and lipid metabolism
3. Role of leptin in neurodegeneration
4. Lipid droplet proteins, steatosis and glucose homeostasis
5. Role of myokines in glucose and lipid metabolism

Laboratory personnel:
Marcus Goncalves- CAMB graduate student
Victor Khor, PhD- Postdoctoral fellow
Emilie Caron, PhD- Postdoctoral fellow
Heong Park, MD- Postdoctoral fellow
Edward Lee, MD, PhD- Postdoctoral fellow (Pathology)
Rotonya Carr, MD- Postdoctoral fellow (Gastroenterology)
Ravindra Dhir, PhD-Senior Lab Manager, Technical Director, Penn DERC Mouse Phenotyping Core
Xiaoyan Yin, MD- Research Specialist, Penn DERC Mouse Phenotyping Core
Regan Roat, BA-Research Specialist, Penn DERC Mouse Phenotyping Core
Vandana Rao- Penn undergraduate
Sheila Bagchi, Penn undergraduate

Description of Other Expertise

Metabolic Phenotyping of mouse models of obesity, diabetes and dyslipidemia:

Monitoring of feeding, energy expenditure, locomotor activity

Description of Itmat Expertise

Neuroendocrinology of obesity

Adipokines

CNS regulation of glucose and lipid metabolism

Myokines and energy and glucose homeostasis
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Last updated: 03/05/2014
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