Stephen R. Thom

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Emeritus Professor of Emergency Medicine
Chief of Hyperbaric Medicine, Institute for Environmental Medicine, University of Pennsylvania Philadelphia, PA
Medical Director, Pennstar Flight Program, Hospital of the University of Pennsylvania, Philadelphia, PA
Professor, Emergency Medicine in Pediatrics, Children's Hospital of Philadelphia
Department: Emergency Medicine

Contact information
University of Pennsylvania
Institute for Environmental Medicine
1 John Morgan Building
36th Street and Hamilton Walk
Philadelphia, PA 19104-6068
Graduate Group Affiliations
Education:
B.A. (Biology)
University of Rochester, Rochester, NY, 1975.
Ph.D. (Microbiology)
University of Rochester, Rochester, NY, 1981.
M.D.
University of Rochester, Rochester, NY, 1981.
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Description of Itmat Expertise

Dr. Thom's research interests include the pathophysiology and treatment of carbon monoxide poisoning, pathophysiology of decompression sickness, cytoskeletal control of neutrophil beta-2 integrin adhesion, vasculogenic stem cell mediated neovascularization and the mechanisms of action of hyperbaric oxygen.

Selected Publications

Thom Stephen R, Yang Ming, Bhopale Veena M, Huang Shaohui, Milovanova Tatyana N: Microparticles initiate decompression-induced neutrophil activation and subsequent vascular injuries. Journal of applied physiology (Bethesda, Md. : 1985) Oct 2010.

Thom Stephen R, Bhopale Veena M, Milovanova Tatyana M, Hardy Kevin R, Logue Christopher J, Lambert David S, Troxel Andrea B, Ballard Kerri, Eisinger Dominic: Plasma biomarkers in carbon monoxide poisoning. Clinical toxicology (Philadelphia, Pa.) 48(1): 47-56, Jan 2010.

Thom Stephen R: Oxidative stress is fundamental to hyperbaric oxygen therapy. Journal of applied physiology (Bethesda, Md. : 1985) 106(3): 988-95, Mar 2009.

Milovanova Tatyana N, Bhopale Veena M, Sorokina Elena M, Moore Jonni S, Hunt Thomas K, Hauer-Jensen Martin, Velazquez Omaida C, Thom Stephen R: Hyperbaric oxygen stimulates vasculogenic stem cell growth and differentiation in vivo. Journal of applied physiology (Bethesda, Md. : 1985) 106(2): 711-28, Feb 2009.

Milovanova Tatyana N, Bhopale Veena M, Sorokina Elena M, Moore Jonni S, Hunt Thomas K, Hauer-Jensen Martin, Velazquez Omaida C, Thom Stephen R: Lactate stimulates vasculogenic stem cells via the thioredoxin system and engages an autocrine activation loop involving hypoxia-inducible factor 1. Molecular and cellular biology 28(20): 6248-61, Oct 2008.

Thom Stephen R, Bhopale Veena M, Mancini D Joshua, Milovanova Tatyana N: Actin S-nitrosylation inhibits neutrophil beta2 integrin function. The Journal of biological chemistry 283(16): 10822-34, Apr 2008.

TN Milovanova, JS Moore, TK Hunt, SR Thom: Stem cell mobilization and vasculogenesis stimulated by hyperoxia and lactate. Experimental Biology May 2007.

ST Han, VM Bhopale, SR Thom: Xanthine oxidorecductase and neurological sequelae of carbon monoxide poisoning. Toxicol Lett 170: 115-115, 2007.

KA Gallagher, MD Goldstein, DG Buerk, A Nedeau, M Xaio, H Chen, SR Thom, ZL Liu, OC Valazquez: Diabetic impairments in NO-mediated endothelial progenitor cell mobilization and homing are reversed by hyperoxia and SDF. Clin Invest 117: 1249-1259, 2007.

Thom, S.R., Bhopale, V.M., Velazquez, O.C., Goldstein, L.J., Thom, L.H., and Buerk, D.G. : Stem cell mobilization by hyperbaric oxygen. Experimental Biology April 2006.

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Last updated: 07/07/2011
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