Alexis A. Topjian

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Assistant Professor of Anesthesiology and Critical Care at the Children's Hospital of Philadelphia
Department: Anesthesiology and Critical Care

Contact information
The Children's Hospital of Philadelphia
Department of Anesthesia and Critical Care Medicine
34th Street and Civic Center Boulevard
Philadelphia, PA 19104
Office: 215-590-3915
Fax: 215-590-4327
Education:
B.A. (Biology)
Harvard College, 1996.
M.D. (Medicine)
Columbia College of Physicians & Surgeons, 2001.
M.S.C.E. (Masters in Clinical Epidemiology and Biostatistics)
University of Pennsylvania School of Medicine, 2011.
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Description of Itmat Expertise

Dr. Topjian's research is targeted at improving neurologic and survival outcome following pediatric cardiac arrest. She is investigating induced therapeutic hypothermia to attenuate brain injury in these patients and the role of EEG biomarkers, as well as neuroimaging, for prognostication of brain injury.

Selected Publications

Donoghue AJ, Abella B, Merchant R, Praestgaard A, Topjian AA, Berg RA, Nadkarni VM for the American Heart Association’s Get With the Guidelines-Resuscitation Investigators: Cardiopulmonary resuscitation for in-hospital events in the emergency department: A comparison of adult and pediatric outcomes and care processes Resuscitation 92: 94-100, July 2015.

Topjian AA, Fry M, Jawad AF, Herman ST, Nadkarni VM, Ichord R, Berg RA, Dlugos DJ, Abend NS: Detection of electrographic seizures by critical care providers using color density spectral array after cardiac arrest is feasible. Pediatric Critical Care Medicine 16(5): 461-467, June 2015 Notes: Epub ahead of print.

Moler FW, Silverstein FS, Holubkov R, Slomine BS, Christensen JR, Nadkarni VM, Meert KL, Clark AE, Browning B, Pemberton VL, Page K, Shankaran S, Hutchison JS, Newth CJL, Bennett KS, Berger JT, Topjian AA, Pineda JA, Kock JD, Schleien CL, Dalton HJ, Ofori-Amanfo G, Goodman DM, Fink EL, McQuillen P, Zimmerman JJ. Thomas NJ, van der Jagt EW, Porter MB, Meyer MT, Harrison R, Pham N, Schwartz AD, Nowak JE, Alten J, Wheeler DS, Bhalala US, Lidsky K, Lloyd E, Mathur M, Sgah S, Wu T, Theodorou AA, Sanders RC, Dean JM. For the THAPCA Trial Investigators: Therapeutic hypothermia after out-of-hospital cardiac arrest in children. New England Journal of Medicine 372(20): 1898-1908, May 2015.

Conlon TW, Falkensammer CB, Hammond RS, Nadkarni VM, Berg RA, Topjian AA: Association of left ventricular systolic function and vasopressor support with survival following pediatric out of hospital cardiac arrest. Pediatric Critical Care Medicine 16(2): 146-154, February 2015.

Yang A, Arndt DH, Berg R, Carpenter JL, Chapman KE, Dlugos DJ, Gallentine WB, Giza CC, Goldstein JL, Hahn CD, Lerner JT, Loddenkemper T, Matsumoto JH, Nash KB, Payne ET, Fernandez I, Shults J, Topjian AA, Williams K, Wusthoff CJ, Abend NS: Development and validation of a seizure prediction model in critically ill children. Seizure 25: 104-111, February 2015.

Abend NS, Topjian AA, Williams S: How much does it cost to identify a critically ill child experiencing electrographic seizures? Journal of Clinical Neurophysiology. Epub ahead of print (eds.). January 2015.

Abend NS, Wagenman KL, Blake TP, Schultheis MT, Radcliffe J, Berg RA, Topjian AA, Dlugos DJ: Electrographic status epilepticus and neurobehavioral outcomes in critically ill children. Epilepsy and Behavior Epub ahead print 2015.

Starling RM, Shekdar K, Licht DJ, Nadkarni VM, Berg RA, Topjian AA: Early head computed tomography findings are associated with outcomes after pediatric out-of-hospital cardiac arrest. Pediatric Critical Care Medicine Epub ahead of press 2015.

Topjian AA, Stuart A, Pabalan AA, Clair A, Kilbaugh TJ, Abend NS, Storm PB, Berg RA, Huh JW, Friess SH: Greater fluctuations in serum sodium levels are associated with increased mortality I children with externalized ventriculostomy drains in a pediatric intensive care unit. Pediatric Critical Care Medicine 15(9): 846-855, November 2014.

Kirschen MP, Topjian AA, Hammond R, Illes J, Abend NS: Neuroprognostication after pediatric cardiac arrest. Pediatric Neurology 51(5): 663-668, November 2014.

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Last updated: 07/21/2015
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