Alexis A. Topjian

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Associate Professor of Anesthesiology and Critical Care at the Hospital of the University of Pennsylvania and the Children's Hospital of Philadelphia
Department: Anesthesiology and Critical Care

Contact information
The Children's Hospital of Philadelphia
Department of Anesthesia and Critical Care Medicine
34th Street and Civic Center Boulevard
Philadelphia, PA 19104
Office: 215-590-3915
Fax: 215-590-4327
Education:
B.A. (Biology)
Harvard College, 1996.
M.D. (Medicine)
Columbia College of Physicians & Surgeons, 2001.
M.S.C.E. (Masters in Clinical Epidemiology and Biostatistics)
University of Pennsylvania School of Medicine, 2011.
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Description of Itmat Expertise

Dr. Topjian's research is targeted at improving neurologic and survival outcome following pediatric cardiac arrest. She is investigating induced therapeutic hypothermia to attenuate brain injury in these patients and the role of EEG biomarkers, as well as neuroimaging, for prognostication of brain injury.

Selected Publications

Bhanji F, Topjian AA, Nadkarni VM, Praestgaard AH, Hunt EA, Cheng A, Meaney PA, Berg RA for the American Heart Association’s Get With The Guidelines-Resuscitation Investigators: Survival rates following pediatric in-hospital cardiac arrests during nights and weekends. JAMA Pediatrics Page: e1-e7, November 2016 Notes: Published online November 7, 2016. doi:10.1001/jamapediatrics.2016.2535.

Sutton RM, French B, Meaney PA, Topjian AA, Parshurum C, Edelson DP, Schexnayder S, Abella BS, Merchant RM, Bembea M, Berg RA, Nadkarni VM: Physiologic monitoring of CR quality during adult cardiac arrest: A propensity-matched cohort study. Resuscitation 106: 76-82, September 2016.

Topjian AA, Sanchez SM, Shults J, Berg RA, Dlugos DJ, Abend NS : Early electroencephalographic background features predict outcomes in children resuscitated from cardiac arrest. Pediatric Critical Care Medicine 17(6): 547-557, June 2016.

Williams RR, Topjian AA, Donnelly M, Kessler S, Massy S, Vala L, Parker A, Hewlett J, Ichord R, Lavelle J, Berg RA, Dlugos DJ, Abend NS: Impact of an ICU EEG monitoring pathway on timeliness of therapeutic intervention and electrographic seizure termination. Epilepsia 57(5): 786-795, May 2016.

Morrison LJ, Schmicker RH, Weisfeldt ML, Bigham BL, Berg RA, Topjian AA, Abramson BL, Atkins DL, Egan D, Sopko G, Rac VE; Resuscitation Outcomes Consortium Investigators: Effect of gender on outcome of out of hospital cardiac arrest in the resuscitation outcomes consortium Resuscitation 100: 76-81, March 2016.

Lasa JJ, Rogers RS, Localio R, Shults J, Raymond T, Gaies M, Thiagarajan R, Laussen PC, Kilbaugh TJ, Berg RA, Nadkarni VM, Topjian AA: Extracorporeal-cardiopulmonary resuscitation (E-CPR) during pediatric in-hospital cardiopulmonary arrest is associated with improved survival to discharge: A Report from the American Heart Association’s Get With the Guidelines – Resuscitation Registry (GWTG-R). Circulation 133(2): 165-176, January 2016.

Fernandez SI, Jackson MC, Abend NS, Arya R, Brenton JN, Carpenter JL, Chapman KE, Gaillard WD, Gainza LM, Glauser TA, Goldstein JL, Goodkin HP, Helseth A, Kapur K, McDonough TL, Mikati MA, Peariso K, Riviello J Jr, Tasker RC, Topjian AA, Wainwright MS, Wilfong A, Williams K, Loddenkemper T on behalf of Pediatric Status Epilepticus Research Group (pSERG): Refractory status epilepticus in children with and without prior epilepsy or status epilepticus. Neurology In Press 2016.

Lin J, Banwell BL, Berg RA, Dlugos DJ, Ichord RN, Kilbaugh TJ, Kirsch RE, Kirschen MP, Licht DJ, Massey SL, Naim MY, Rintoul NE, Topjian AA, Abend NS: Electrographic seizures in children and neonates undergoing extracorporeal membrane oxygenation. Pediatric Critical Care Medicine In Press 2016.

Abend NS, Wagenman KL, Blake TP, Schultheis MT, Radcliffe J, Berg RA, Topjian AA, Dlugos DJ: Electrographic status epilepticus and neurobehavioral outcomes in critically ill children. Epilepsy and Behavior 49: 238-244, August 2015.

Donoghue AJ, Abella B, Merchant R, Praestgaard A, Topjian AA, Berg RA, Nadkarni VM for the American Heart Association’s Get With the Guidelines-Resuscitation Investigators: Cardiopulmonary resuscitation for in-hospital events in the emergency department: A comparison of adult and pediatric outcomes and care processes Resuscitation 92: 94-100, July 2015.

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Last updated: 12/02/2016
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