Alexis A. Topjian

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Associate Professor of Anesthesiology and Critical Care at the Hospital of the University of Pennsylvania and the Children's Hospital of Philadelphia
Department: Anesthesiology and Critical Care

Contact information
The Children's Hospital of Philadelphia
Department of Anesthesia and Critical Care Medicine
34th Street and Civic Center Boulevard
Philadelphia, PA 19104
Office: 215-590-3915
Fax: 215-590-4327
Education:
B.A. (Biology)
Harvard College, 1996.
M.D. (Medicine)
Columbia College of Physicians & Surgeons, 2001.
M.S.C.E. (Masters in Clinical Epidemiology and Biostatistics)
University of Pennsylvania School of Medicine, 2011.
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Description of Itmat Expertise

Dr. Topjian's research is targeted at improving neurologic and survival outcome following pediatric cardiac arrest. She is investigating induced therapeutic hypothermia to attenuate brain injury in these patients and the role of EEG biomarkers, as well as neuroimaging, for prognostication of brain injury.

Selected Publications

Topjian AA, Sanchez SM, Shults J, Berg RA, Dlugos DJ, Abend NS : Early electroencephalographic background features predict outcomes in children resuscitated from cardiac arrest. Pediatric Critical Care Medicine 17(6): 547-557, June 2016.

Williams RR, Topjian AA, Donnelly M, Kessler S, Massy S, Vala L, Parker A, Hewlett J, Ichord R, Lavelle J, Berg RA, Dlugos DJ, Abend NS: Impact of an ICU EEG monitoring pathway on timeliness of therapeutic intervention and electrographic seizure termination. Epilepsia 57(5): 786-795, May 2016.

Morrison LJ, Schmicker RH, Weisfeldt ML, Bigham BL, Berg RA, Topjian AA, Abramson BL, Atkins DL, Egan D, Sopko G, Rac VE; Resuscitation Outcomes Consortium Investigators: Effect of gender on outcome of out of hospital cardiac arrest in the resuscitation outcomes consortium Resuscitation 100: 76-81, March 2016.

Lasa JJ, Rogers RS, Localio R, Shults J, Raymond T, Gaies M, Thiagarajan R, Laussen PC, Kilbaugh TJ, Berg RA, Nadkarni VM, Topjian AA: Extracorporeal-cardiopulmonary resuscitation (E-CPR) during pediatric in-hospital cardiopulmonary arrest is associated with improved survival to discharge: A Report from the American Heart Association’s Get With the Guidelines – Resuscitation Registry (GWTG-R). Circulation 133(2): 165-176, January 2016.

Sutton RM, French B, Meaney PA, Topjian AA, Parshurum C, Edelson DP, Schexnayder S, Abella BS, Merchant RM, Bembea M, Berg RA, Nadkarni VM: Physiologic monitoring of CR quality during adult cardiac arrest: A propensity-matched cohort study. Resuscitation In Press 2016.

Abend NS, Wagenman KL, Blake TP, Schultheis MT, Radcliffe J, Berg RA, Topjian AA, Dlugos DJ: Electrographic status epilepticus and neurobehavioral outcomes in critically ill children. Epilepsy and Behavior 49: 238-244, August 2015.

Donoghue AJ, Abella B, Merchant R, Praestgaard A, Topjian AA, Berg RA, Nadkarni VM for the American Heart Association’s Get With the Guidelines-Resuscitation Investigators: Cardiopulmonary resuscitation for in-hospital events in the emergency department: A comparison of adult and pediatric outcomes and care processes Resuscitation 92: 94-100, July 2015.

Starling RM, Shekdar K, Licht DJ, Nadkarni VM, Berg RA, Topjian AA: Early head computed tomography findings are associated with outcomes after pediatric out-of-hospital cardiac arrest. Pediatric Critical Care Medicine 16(6): 542-548, July 2015.

Topjian AA, Fry M, Jawad AF, Herman ST, Nadkarni VM, Ichord R, Berg RA, Dlugos DJ, Abend NS: Detection of electrographic seizures by critical care providers using color density spectral array after cardiac arrest is feasible. Pediatric Critical Care Medicine 16(5): 461-467, June 2015.

Abend NS, Topjian AA, Williams S: How much does it cost to identify a critically ill child experiencing electrographic seizures? Journal of Clinical Neurophysiology 32(3): 257-264, June 2015.

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Last updated: 06/21/2016
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