Michael C. Phillips

faculty photo
Adjunct Professor of Medicine
Stokes Investigator and Senior Member, Research Institute, The Children’s Hospital of Philadelphia
Department: Medicine

Contact information
CHOP
3615 Civic Center Blvd
Room 1102 ARC
4399
Philadelphia, PA 19104
Office: 215-590-0587
Fax: 215-590-0583
Education:
B.Sc. (Chemistry and Mathematics)
Southampton University, Southampton, England , 1962.
Ph.D. ( )
Southampton University, Southampton, England, 1965.
Permanent link
 

Description of Itmat Expertise

The study of the structure-function relationships of plasma lipoproteins and apolipoproteins, and HDL-mediated cholesterol transport. A range of physical-biochemical methods are employed in conjunction with cell culture systems and, more recently, mouse models to generate mechanistic insights into these systems.

Selected Publications

Tanaka M, Koyama M, Dhanasekaran P, Nguyen D, Nickel M, Lund-Katz S, Saito H, Phillips MC: "Influence of Tertiary Structure Domain Properties on the functionality of Apolipoprotein A-I" Biochemistry 47: 2172-2180, 2008.

Duong PT, Weibel GL, Lund-Katz S, Rothblat GH, Phillips MC: "Characterization and Properties of Pre Beta-HDL Particles Formed by ABCA1-mediated Cellular Lipid Efflux to ApoA-I" J Lipid Res 49: 1006-1014, 2008.

Vedhachalam C, Duong PT, Nickel M, Nguyen D, Dhanasekaran P, Sait H, Rothblat GH, Lund-Katz S, Phillips MC: "Mechanism of ATP-binding Cassette Transporter AI (ABCA1)-mediated Cellular Lipid Efflux to Apolipoprotein A-I and Formation of High Density Lipoprotein Particles" J. Biol. Chem. 282: 25123-25130, 2007.

Vedhachalam C, Gehring AB, Davidson WS, Lund-Katz S, Rotyhblat GH, Phillips MC: "ABCA1-induced Cell Surface Binding Sites for ApoA-I" Arterioscler Thromb Vasc Biol. 27: 1603-1609, 2007.

Duong PT, Collins HL, Nickel M, Lund-Katz S, Rothblat GH, Phillips MC: "Characterization of nascent HDL particles and microparticles formed by ABCA1-mediated efflux of cellular lipids to apoA-I" J Lipid Res 47: 832-843, 2006.

Vedhachalam C, Liu L, Nickel M, Dhanasekaran P, Anantharamaiah GM, Lund-Katz S, Rothblat GH, Phillips MC: "Influence of ApoA-I structure on the ABCA1-mediated efflux of cellular lipids" J Biol Chem 279: 49931-49939, 2004.

Saito H, Dhanasekaran P, Nguyen D, Deridder E, Holvoet P, Lund-Katz S, Phillips MC: "Alpha-helix formation is required for high affinity binding of human apolipoprotein A-I to lipids" J Biol Chem 279: 20974-20981, 2004.

Thuahnai ST, Lund-Katz S, Dhanasekaran P, de la Llera-Moya M, Connelly MA, Williams DL, Rothblat GH, Phillips MC: "Scavenger receptor class B type I-mediated cholesteryl ester-selective uptake and efflux of unesterified cholesterol. Influence of high density lipoprotein size and structure" J Biol Chem 13: 12448-12455, 2004.

Saito H, Dhanasekaran P, Nguyen D, Holvoet P, Lund-Katz S, Phillips MC: "Domain structure and lipid interaction in human apolipoproteins A-I and E, a general model" J Biol Chem 278: 23227-23232, 2003.

Jonas A, Phillips MC: "Lipoprotein Structure" Biochemistry of Lipids, Lipoproteins and Membranes. D.E. Vance and J.E. Vance (eds.). Elsevier, Page: 485-506, 2008.

back to top
Last updated: 10/15/2012
The Trustees of the University of Pennsylvania