Marc Yudkoff

faculty photo
William T. Grant Professor in Pediatrics
Department: Pediatrics

Contact information
CHOP
Division of Metabolism
34th & CIVIC CENTER
Philadelphia, PA 19104
Office: 215-590-7474
Fax: 215-590-6804
Education:
BA
University of Chicago, 1967.
M.D. (?)
New York Medical College, 1972.
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Description of Itmat Expertise

Dr. Yudkoff is investigating amino acid metabolism in the brain and whole body, focusing on the development of new treatments for children with inborn errors of nitrogen metabolism such as the urea cycle defects. He also studies the effects on brain amino acid metabolism of the ketogenic diet, a highly effective therapy for children with epilepsy.

Selected Publications

Nissim I, Horyn O, Daikhin Y, Chen P, Li C, Wehrli SL, Nissim I,Yudkoff M : The molecular and metabolic influence of long term agmatine consumption. J Biol Chem. J Biol Chem 289: 9710, 2014.

Rezvani I, Yudkoff M: Urea Cycle and Hyperammonemia (Arginine, Citrulline, Ornithine). Nelson: Textbook of Pediatrics (19th and 20th eds). Kliegman RM, Bonita Sm St Geme J, Schor N, Behrman R. (eds.). 2014.

Summar ML, Häberle J, Yudkoff M: Urea Cycle Disorders. Pediatric Endocrinology and Inborn Errors of Metabolism. Sarafoglou K, Hoffman G, Roth K (eds.). McGraw-Hill, 2014.

Schrier Vergano S, Rao M, McCormack S, Ostrovsky J, Clarke C, Preston J, Bennett MJ, Yudkoff M, Xiao R, Falk MJ : In vivo metabolic flux profiling with stable isotopes discriminates sites and quantifies effects of mitochondrial dysfunction in C. elegans. Mol Genet Metab. 111: 331, 2014.

Clarke C, Xiao R, Place E, Zhang Z, Sondheimer N, Bennett M, Yudkoff M, Falk MJ: Mitochondrial respiratory chain disease discrimination by retrospective cohort analysis of blood metabolites Mol Genet Metab 110: 145, 2013.

Ficicioglu C, Yudkoff M: Urea Cycle: Disease Aspects. Encyclopedia of Biological Chemistry (2nd ed). Elsevier, Page: 494, 2013.

Li C, Liu C, Nissim I, Chen J, Chen P, Doliba N, Zhang T, Nissim I, Daikhin Y, Stokes D, Yudkoff M, Bennett MJ, Stanley CA, Matschinsky FM, Naji A : Regulation of Glucagon Secretion in Normal and Diabetic Human Islets by Gamma-Hydroxybutyrate and Glycine. J Biol Chem. 288: 3938, 2013.

Nissim I, Horyn O, Nissim I, Daikhin Y, Wehrli SL, Yudkoff M, Matschinsky FM: Effects of a Glucokinase Activator on Hepatic Intermediary Metabolism: Study With 13C Isotopomer-Based Metabolomics. Biochem J. 444: 537, 2012.

Bauer DE, Jackson JG, Genda EN, Montoya MM, Yudkoff M, Robinson MB : The glutamate transporter, GLAST, participates in a macromolecular complex that supports glutamate metabolism. Neurochem Int 61: 566, 2012.

Nissim I, Horyn O, Nissim I, Daikhin Y, Wehrli SL, Yudkoff M, Matschinsky FM: Effects of a Glucokinase Activator on Hepatic Intermediary Metabolism: Study With 13C Isotopomer-Based Metabolomics. Biochem J 444: 537, 2012.

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Last updated: 10/20/2014
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