Marc Yudkoff

faculty photo
William T. Grant Professor in Pediatrics
Department: Pediatrics

Contact information
CHOP
Division of Developmental and Behavioral Pediatrics
34th & CIVIC CENTER
4399
Philadelphia, PA 19104
Office: 2159779779
Education:
M.D. (?)
New York Medical College, 1972.
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Description of Itmat Expertise

Dr. Yudkoff is investigating amino acid metabolism in the brain and whole body, focusing on the development of new treatments for children with inborn errors of nitrogen metabolism such as the urea cycle defects. He also studies the effects on brain amino acid metabolism of the ketogenic diet, a highly effective therapy for children with epilepsy.

Selected Publications

Horyn O, Luhovyy B, Lazarow A, Daikhin Y, Nissim Ilana, Yudkoff M, Nissim I: Biosynthesis of Agmatine In Isolated Mitochondria and Perfused Rat Liver: Studies With 15N-Labeled Arginie. Biochem J. 2005 Notes: In Press.

Nissim I, Luhovyy B, Horyn O, Daikhin Y, Nissim I, Yudkoff M: The role of mitochondrial-bound arginase in the regulation of urea synthesis: Studies with [U-15N4]arginine, isolated mitochondria and perfused rat liver. J Biol Chem 2005 Notes: In Press.

Li C, Buettger C, Kwagh J, Matter A, Daikhin Y, Nissim IB, Collins HW, Yudkoff M, Stanley CA, Matschinsky FM: A signaling role of glutamin in insulin secretion. J. Biol. Chem 279(14): 13393-401, April 2004.

Yudkoff M, Daikhin Y, Nissim I, Lazarow A, Nissim I: Ketogenic diet, brain glutamate metabolism and seizure control. Prostaglandins, Leukotrienes and Essential Fatty Acids 70(3): 277-85, March 2004.

Gyato K, Wray J, Huang ZJ, Yudkoff M, Batshaw ML: Metabolic and neuropsychological phenotype in women heterozygous for ornithine transcarbamylase deficiency. Ann. Neurol 55: 80-86, 2004.

Caldovic L, Morizono H, Daikhin Y, Nissim I, McCarter RJ, Yudkoff M, Tuchman M: Restoration of ureagenesis in N-acetylglutamate. J Pediatr 145: 552-554, 2004.

Yudkoff M, Daikhin Y, Nissim I, Horyn O, Lazarow A, Nissim I: Metabolism of brain amino acids following pentylenetetrazole treatment. Epilepsy Res 53: 151-162, February 2003.

Yudkoff M, Daikhin T, Nissim I, Lazarow A, Horyn O, Nissim I: The ketogenic diet and brain nitrogen metabolism. J. Neurochem 85: 62, 2003.

Nissim I, Horyn O, Luhovyy B, Lazarow A, Kaikhin Y, Nissim I, Yudkoff M: Role fo the glutamate dehydrogenase reaction in furnishing aspartate nitrogen for urea synthesis: studies in perfused rate liver with 15N. Biochem J. 15(376 (Pt 1)): 179-188, 2003.

Nissim I, Horyn O, Luhovyy B, Lazarow A, Daikhin Y, Nissim I, Yudkoff M: Sources of Nitrogen for Hepatic Urea Synthesis: Studies in Perfused Rat Liver with 15N. Biochem J. 2003 Notes: In Press.

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Last updated: 12/12/2013
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