Darren B. Taichman

faculty photo
Adjunct Associate Professor of Medicine
Consultant in Pulmonary Hypertension, Philadelphia Adult Congenital Heart Center, Children's Hospital of Philadelphia and University of Pennsylvania Health Center
Department: Medicine

Contact information
Executive Deputy Editor
Annals of Internal Medicine
190 N. Independence Mall West
Philadelphia, PA 19106-1572
Office: 215-351-2400
Fax: 215-351-2619
Education:
B.A. (Biology Major; Anthropology and Chemistry Minors)
University of Pennsylvania, 1986.
Ph.D. (Pathology)
University of Pennsylvania, 1992.
M.D. (Medicine)
University of Pennsylvania, 1993.
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Description of Research Expertise

Pulmonary Vascular Disease, Pulmonary Arterial Hypertension, Pulmonary Vascular Development, Endothelial Cell Biology

Description of Itmat Expertise

Dr. Taichman utilizes a database of epidemiological data, linked to a blood repository, for the investigation of protein expression patterns, genetic and other risk factors influencing the development of pulmonary hypertension and response to therapy. Clinical trials involve translational studies of putative biomarkers and mechanistic evaluations integrated into protocols involving traditional clinical end-points. In addition are studies of quality of life in patients with pulmonary arterial hypertension.

Selected Publications

Gabler Nicole B, French Benjamin, Strom Brian L, Palevsky Harold I, Taichman Darren B, Kawut Steven M, Halpern Scott D: Validation of 6-minute walk distance as a surrogate end point in pulmonary arterial hypertension trials. Circulation 126(3): 349-56, Jul 2012.

Carroll Ricki, Antigua Jules, Taichman Darren, Palevsky Harold, Forfia Paul, Kawut Steven, Halpern Scott D: Motivations of patients with pulmonary arterial hypertension to participate in randomized clinical trials. Clinical trials 9(3): 348-57, June 2012.

Krowka Michael J, Miller Dave P, Barst Robyn J, Taichman Darren, Dweik Raed A, Badesch David B, McGoon Michael D: Portopulmonary Hypertension: A Report From the US-Based REVEAL Registry. Chest 141(4): 906-15, Apr 2012.

Gabler Nicole B, French Benjamin, Strom Brian L, Liu Ziyue, Palevsky Harold I, Taichman Darren B, Kawut Steven M, Halpern Scott D: Race and sex differences in response to endothelin receptor antagonists for pulmonary arterial hypertension. Chest 141(1): 20-6, Sep 2011.

Brown Lynette M, Chen Hubert, Halpern Scott, Taichman Darren, McGoon Michael D, Farber Harrison W, Frost Adaani E, Liou Theodore G, Turner Michelle, Feldkircher Kathy, Miller Dave P, Elliott C Gregory: Delay in recognition of pulmonary arterial hypertension: factors identified from the REVEAL Registry. Chest 140(1): 19-26, Jul 2011.

Halpern, S.D., Taichman, D.B.: Misclassification of pulmonary hypertension due to reliance on pulmonary capillary wedge pressure rather than left-ventricular end-diastolic pressure. Chest 136(1): 37-43, 2009.

Roberts, K.E., Fallon, M.B., Krowka, M.J., Brown, R.S., Trotter, J.F., Peter, I., Tighiouart, H., Knowles, J.A., Rabinowitz, D., Benza, R.L, Badesch, D.B., Taichman, D.B., Horn, E.M., Zacks, S., Kaplowitz, N., Kawut, S.M.: Genetic risk factors for portopulmonary hypertension in patients with advanced liver disease. Am J Respir Crit Care Med 179(9): 835-842, 2009.

Peng, T., Zamanian, R., Krowka, M., Benza, R., Roberts, K., Taichman, D., Ryback, D., Trotter, J., Brown, R., Fallon, M., Kawut, S.: Plasma levels of S100A4 in portopulmonary hypertension. Biomarkers 14(3): 156-60, 2009.

Roberts, K.E., Fallon, M.B., Krowka, M.J., Benza, R.L., Knowles, J.A., Badesch, D.B., Brown, R.S., Taichman, D.B., Trotter, J., Zacks, S., Horn, E.M., Kawut, S.M.: Serotonin transporter polymorphisms in patients with portopulmonary hypertension. Chest 135(6): 1470-1475, 2009.

Mikkelsen, M.E., Shull, W.H., Biester, R.C., Taichman, D.B., Lynch, S., Demissie, E., Hansen-Flaschen, J., Christie, J.D.: Cognitive, mood and quality of life impairments in a select population of ARDS survivors. Respirology 14(1): 76-82, 2009.

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Last updated: 07/30/2014
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