Yejia Zhang

faculty photo
Assistant Professor of Physical Medicine and Rehabilitation at the Veteran's Administration Medical Center
Department: Physical Medicine and Rehabilitation

Contact information
Penn Medicine at Rittenhouse
1800 Lombard Street/1st Floor
Philadelphia, PA 19146
Office: 215-893-2645
Education:
MD
Second Military Medical University, P.R. China, 1989.
PhD (Cell & Molecular Biology)
University of Pennsylvania, 1997.
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Description of Itmat Expertise

The ultimate goal of Dr. Zhang’s research is to develop non-operative treatments for intervertebral disc degeneration and related back pain.

In order to better understand the mechanism of intervertebral disc degeneration and discogenic back pain, tissues from cadaveric donors and patients undergoing spinal surgery were collected and molecular markers such as chemokines (e.g., IL-8) and matrix-degrading enzymes (e.g., ADAM-8) have been examined. Future studies include dissecting the upstream regulators and downstream effectors of these molecules in cultured disc cells and in genetically modified mice.

Selected Publications

Zhang, Y., Lenart, BA, Lee, JK, Chen, D, Shi, P., Ren, J., Muehleman, C., Chen, D., An, HS.: Histological features of endplates of the mammalian spine: from mice to men. Spine 2014

Markova D., Ruel, N., Adams SL., An, HS, Thonar E.,Zack, M., Scanzello C., Anderson, DG., Zhang, Y.: Fibronectin fragments and the cleaving enzyme ADAM-8 in the degenerative human intervertebral disc. Spine 2014.

Zhang,Y., Chee,A., Shi, P., Chen, E-Y., Moss, I., He, T-C., Thonar, E., An, HS. : Allogeneic Articular Chondrocytes Survived and Overexpressed Bone Morphogenetic-7 Gene in the Degenerating Rabbit Intervertebral Disc in Vivo. Am J Phys Med Rehabil 2014.

Wang, B, Jin, H, Zhu, M, Li, J, Zhao, L, Zhang, Y, Tang, D, Xiao, G, Xing, L, Boyce, B, Chen, D. : Chondrocyte β-Catenin Signaling Regulates Postnatal Bone Remodeling through Modulation of Osteoclast Formation. Arthritis & Rheumatism 2014.

Anderson DG, Markova D, An HS, Chee A, Enomoto-Iwamoto M, Markov V, Saitta B, Shi P, Gupta C, Zhang Y: Human Umbilical Cord Blood-derived Mesenchymal Stem Cells in the Cultured Rabbit Intervertebral Disc: A Novel Cell Source for Disc Repair. Am J Phys Med Rehabil 92: 420 - 9, May 2013.

Moss IL, Zhang Y, Shi P, Chee A, Piel, MJ, An HS: Retroperitoneal approach to the intervertebral disc for annular puncture model of intervertebral disc degeneration in the rabbit. Spine J 13(3): 229-34, Mar 2013.

Chee A., Ren,J., Lenart, BA., Chen, E-R., Zhang, Y., An, HS. : Cytotoxicity of Local Anesthetics and Nonionic Contrast Agents on Bovine Intervertebral Disc Cells Cultured in a Three-Dimensional Culture System. Spine J. 2013.

Moss IL, Zhang Y, Shi P, Chee A, Piel, MJ, An HS. : Retroperitoneal approach to the intervertebral disc for annular puncture model of intervertebral disc degeneration in the rabbit. Spine Journal 2013.

Pan TC, Zhang RZ, Markova D, Arita M, Zhang Y, Bogdanovich S, Khurana TS, Bönnemann C, Birk DE and Chu M-L. : Col6a3 Deficiency in Mice Leads to Muscle and Tendon Defects Similar to Human Collagen VI Congenital Muscular Dystrophy. J Biol Chem. 2013.

Shu, B, Li, TF, Li X-F, Tang, D-Z, Zhang, Y, Shi, Q, Wang, Y-J, and Chen D. : Chondrocyte-Specific Inhibition of β-Catenin Signaling Leads to Dysplasia of the Caudal Vertebrae in Mice. Spine 2013.

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Last updated: 05/21/2014
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