Yejia Zhang

faculty photo
Assistant Professor of Physical Medicine and Rehabilitation at the Veteran's Administration Medical Center
Staff Physician, Philadelphia Veterans Affairs Medical Center, Philadelphia, PA.
Department: Physical Medicine and Rehabilitation

Contact information
Penn Medicine at Rittenhouse
1800 Lombard Street/1st Floor
Philadelphia, PA 19146
Office: 215-893-2645
MD (Medicine)
Second Military Medical University, P.R. China, 1989.
PhD (Cell & Molecular Biology)
University of Pennsylvania, 1997.
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Description of Itmat Expertise

The ultimate goal of Dr. Zhang’s research is to develop non-operative treatments for intervertebral disc degeneration and related back pain.

In order to better understand the mechanism of intervertebral disc degeneration and discogenic back pain, tissues from cadaveric donors and patients undergoing spinal surgery were collected and molecular markers such as chemokines (e.g., IL-8) and matrix-degrading enzymes (e.g., ADAM-8) have been examined. Future studies include dissecting the upstream regulators and downstream effectors of these molecules in cultured disc cells and in genetically modified mice.

Selected Publications

Martin, JT, Mauck RL, Wright, AC, Elliott DM, Zhang Y, Vaccaro AR, Albert TJ, Anderson DG, Collins CM, Smith HE. : Population Average T2 MRI Maps Reveal Quantitative Regional Transformations of the Degenerating Intervertebral Disc in a Rabbit Model. J Orthop Res. 33(1): 140-8, Jan 2015

Chandra, A., Lin, T., Zhu, J., Tong, W., Huo, Y., Jia, H., Zhang, Y., Liu, X.S., Cengel, K., Xia, B., and Qin, L.: PTH1-34 blocks radiation-induced osteoblast apoptosis by enhancing DNA repair through canonical Wnt pathway. J. Biol. Chem. Jan 2015.

Zhang Y, Chee A, PhD, Shi P, Adams SL. Markova D, Anderson DG, Smith HE, Deng Y, Plastaras CT, An HS.: Intervertebral Disc Cells Produce Interleukins Found Elevated in Patients with Back Pain. Am J Phys Med Rehabil 2015 Notes: In print.NIHMS#:719503.

Zhang, Y., Lenart, BA, Lee, JK, Chen, D, Shi, P., Ren, J., Muehleman, C., Chen, D., An, HS.: Histological features of endplates of the mammalian spine: from mice to men. Spine 2014

Scanzello C.*, Markova, D.*, Adams SL., Anderson, DG., An HS., Zhang, Y. *These authors contributed equally.: Fibronectin Splice Variation in Human Knee Cartilage, Meniscus and Synovial Membrane: Association with Cartilage Degeneration. J Orthop Res. Nov 2014.

Chandra A, Lin T, Tribble MB, Zhu J, Altman AR, Tseng W-J, Zhang Y, Akintoye SO, Cengel K, Liu XS, Qin L.: PTH1-34 Alleviates Radiotherapy-induced Local Bone Loss by Improving Osteoblast and Osteocyte Survival. Bone 67: 33-40, Oct 2014.

Zhang,Y, Chee, A., Shi, P, Chen, E-Y, Moss, I, He, T-C, Thonar, E, An, HS.: Allogeneic Articular Chondrocyte Transplantation Downregulates Interleukin 8 Gene Expression in the Degenerating Rabbit Intervertebral Disk In Vivo. Am J Phys Med Rehabil. Aug 2014 Notes: NIHMS611149; PMID:25133623.

Markova D., Ruel, N., Adams SL., An, HS, Thonar E.,Zack, M., Scanzello C., Anderson, DG., Zhang, Y.: Fibronectin fragments and the cleaving enzyme ADAM-8 in the degenerative human intervertebral disc. Spine 2014.

Zhang,Y., Chee,A., Shi, P., Chen, E-Y., Moss, I., He, T-C., Thonar, E., An, HS. : Allogeneic Articular Chondrocytes Survived and Overexpressed Bone Morphogenetic-7 Gene in the Degenerating Rabbit Intervertebral Disc in Vivo. Am J Phys Med Rehabil 2014.

Wang, B, Jin, H, Zhu, M, Li, J, Zhao, L, Zhang, Y, Tang, D, Xiao, G, Xing, L, Boyce, B, Chen, D. : Chondrocyte β-Catenin Signaling Regulates Postnatal Bone Remodeling through Modulation of Osteoclast Formation. Arthritis & Rheumatism 2014.

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Last updated: 09/16/2015
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