Elizabeth Olson Hexner

faculty photo
Assistant Professor of Medicine at the Hospital of the University of Pennsylvania
Attending Physician, Hospital of the University of Pennsylvania - Rhoads 7 Liquid Tumor Service
Assistant Director, MTR program, Perelman School of Medicine
Medical Director, Center for Cellular Immunotherapies, Perelman School of Medicine
Department: Medicine

Contact information
Perelman Center for Advanced Medicine
2 West Pavilion
3400 Civic Center Boulevard
Philadelphia, PA 19104
Office: 215.614.1847
Fax: (215) 615-5888
A.B. (French/Comparative Area Studies)
Duke University, 1992.
(Premedical Studies)
Harvard University Extension School, 1994.
M.D. (Medicine)
Columbia College of Physicians and Surgeons, 1999.
M.S.T.R. (Translational Research)
University of Pennsylvania, 2009.
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Description of Research Expertise

Myeloproliferative Disorders
Umbilical Cord Blood Transplantation

Description of Itmat Expertise

Dr. Hexner conducts translational research in experimental transplantation and preclinical early phase studies pertaining to new therapies for myeloproliferative diseases.

Selected Publications

Verstovsek, S., Mesa, R. A., Gotlib, J., Levy, R. S., Gupta, V., DiPersio, J. F., Catalano, J. V., Deininger, M. W., Miller, C. B., Silver, R. T., Talpaz, M., Winton, E. F., Harvey, J. H., Arcasoy, M. O., Hexner, E. O., Lyons, R. M., Raza, A., Vaddi, K., Sun, W., Peng, W., Sandor, V., Kantarjian, H.: Three-year efficacy, overall survival, and safety of ruxolitinib therapy in patients with myelofibrosis from the COMFORT-I study. Haematologica 2015.

Hexner, E. O., Mascarenhas, J., Prchal, J., Roboz, G. J., Baer, M. R., Ritchie, E. K., Leibowitz, D., Demakos, E. P., Miller, C., Siuty, J., Kleczko, J., Price, L., Jeschke, G., Weinberg, R., Basu, T. T., Pahl, H. L., Orazi, A., Najfeld, V., Marchioli, R., Goldberg, J. D., Silverman, L. R., Hoffman, R.: Phase I dose escalation study of lestaurtinib in patients with myelofibrosis. Leuk Lymphoma Page: 1-26, 2015.

Reshef, R., Huffman, A. P., Gao, A., Luskin, M. R., Frey, N. V., Gill, S. I., Hexner, E. O., Kambayashi, T., Loren, A. W., Luger, S. M., Mangan, J. K., Nasta, S. D., Richman, L. P., Sell, M., Stadtmauer, E. A., Vonderheide, R. H., Mick, R., Porter, D. L.: High Graft CD8 Cell Dose Predicts Improved Survival and Enables Better Donor Selection in Allogeneic Stem-Cell Transplantation With Reduced-Intensity Conditioning. J Clin Oncol 33(21): 2392-8, 2015.

Bagley, S. J., Sehgal, A. R., Gill, S., Frey, N. V., Hexner, E. O., Loren, A. W., Mangan, J. K., Porter, D. L., Stadtmauer, E. A., Reshef, R., Luger, S. M.: Acute cholecystitis is a common complication after allogeneic stem cell transplantation and is associated with the use of total parenteral nutrition. Biol Blood Marrow Transplant 21(4): 768-71, 2015.

van Zalen, S., Lombardi, A. A., Jeschke, G. R., Hexner, E. O., Russell, J. E.: AUF-1 and YB-1 independently regulate beta-globin mRNA in developing erythroid cells through interactions with poly(A)-binding protein. Mech Dev 136: 40-52, 2015.

Bolanos-Meade, J., Logan, B. R., Alousi, A. M., Antin, J. H., Barowski, K., Carter, S. L., Goldstein, S. C., Hexner, E. O., Horowitz, M. M., Lee, S. J., Levine, J. E., MacMillan, M. L., Martin, P. J., Mendizabal, A. M., Nakamura, R., Pasquini, M. C., Weisdorf, D. J., Westervelt, P., Ho, V. T.: Phase III clinical trial steroids/mycophenolate mofetil vs steroids/placebo as therapy for acute graft-versus-host disease: BMT CTN 0802. Blood 2014.

Tong, Q., He, S., Xie, F., Mochizuki, K., Liu, Y., Mochizuki, I., Meng, L., Sun, H., Zhang, Y., Guo, Y., Hexner, E., Zhang, Y.: Ezh2 Regulates Transcriptional and Posttranslational Expression of T-bet and Promotes Th1 Cell Responses Mediating Aplastic Anemia in Mice. J Immunol 2014.

Hexner E, Roboz G, Hoffman R, Luger S, Mascarenhas J, Carroll M, Clementi R, Bensen-Kennedy D, and Moliterno A.: Open-label study of oral CEP-701 (lestaurtinib) in patients with polycythaemia vera or essential thrombocythaemia with the JAK2-V617F mutation. Br J Haematol 164: 83–93, 2014.

Reshef, R., Hexner, E. O., Loren, A. W., Frey, N. V., Stadtmauer, E. A., Luger, S. M., Mangan, J. K., Gill, S. I., Vassilev, P., Lafferty, K. A., Smith, J., Van Deerlin, V. M., Mick, R., Porter, D. L.: Early Donor Chimerism Levels Predict Relapse and Survival after Allogeneic Stem Cell Transplantation with Reduced-Intensity Conditioning. Biol Blood Marrow Transplant 2014.

Babushok, D. V., Cardamone, D., Rulander, N., Master, S. R., Hexner, E. O.: A Common, Under-Recognized Cause of Elevated Serum Erythropoietin. Am J Med 2014.

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Last updated: 10/08/2015
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