Elizabeth Olson Hexner

faculty photo
Assistant Professor of Medicine at the Hospital of the University of Pennsylvania
Attending Physician, Hospital of the University of Pennsylvania - Rhoads 7 Liquid Tumor Service
Assistant Director, MTR program, Perelman School of Medicine
Medical Director, Center for Cellular Immunotherapies, Perelman School of Medicine
Department: Medicine

Contact information
Perelman Center for Advanced Medicine
2 West Pavilion
3400 Civic Center Boulevard
Philadelphia, PA 19104
Office: 215.614.1847
Fax: (215) 615-5888
Education:
A.B. (French/Comparative Area Studies)
Duke University, 1992.
(Premedical Studies)
Harvard University Extension School, 1994.
M.D. (Medicine)
Columbia College of Physicians and Surgeons, 1999.
M.S.T.R. (Translational Research)
University of Pennsylvania, 2009.
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Description of Research Expertise

Myeloproliferative Disorders
Umbilical Cord Blood Transplantation

Description of Itmat Expertise

Dr. Hexner conducts translational research in experimental transplantation and preclinical early phase studies pertaining to new therapies for myeloproliferative diseases.

Selected Publications

Hexner E, Luger S, Reshef R, Jeschke G, Mangan J, Frey N, Frank D, Richman L, Vonderheide R, Aqui N, Rosenbach M, Zhang Y, Chew A, Loren A, Stadtmauer E, Levine BL, June C, Emerson S, Porter D: Infusion of CD3/CD28 co-stimulated umbilical cord blood T cells at the time of single umbilical cord blood transplantation may enhance engraftment. American Journal of Hematology 2016 Notes: accepted for publication 1/12/16.

Ganetsky, A., Shah, A., Miano, T. A., Hwang, W. T., He, J., Loren, A. W., Hexner, E. O., Frey, N. V., Porter, D. L., Reshef, R.: Higher tacrolimus concentrations early after transplant reduce the risk of acute GvHD in reduced-intensity allogeneic stem cell transplantation. Bone Marrow Transplant Dec 2015 Notes: doi: 10.1038/bmt.2015.323.

Orlowski R, Huang A, Gohil M, Mangan J, Vignali M, Emerson R, Robins H, Yusko E, Jordan M, Carroll M, Gilliland DG, Hexner E: Integrated Immunological Analysis of the Bone Marrow Tumor Microenvironment in Myeloproliferative Neoplasms to Determine Potential Efficacy of Immune Checkpoint Blockade. Blood 126(2766), December 2015.

Verstovsek, S., Mesa, R. A., Gotlib, J., Levy, R. S., Gupta, V., DiPersio, J. F., Catalano, J. V., Deininger, M. W., Miller, C. B., Silver, R. T., Talpaz, M., Winton, E. F., Harvey, J. H., Arcasoy, M. O., Hexner, E. O., Lyons, R. M., Raza, A., Vaddi, K., Sun, W., Peng, W., Sandor, V., Kantarjian, H.: Three-year efficacy, overall survival, and safety of ruxolitinib therapy in patients with myelofibrosis from the COMFORT-I study. Haematologica 100(9): 1139-45, Sep 2015.

Verstovsek, S., Mesa, R. A., Gotlib, J., Levy, R. S., Gupta, V., Dipersio, J. F., Catalano, J. V., Deininger, M. W., Miller, C. B., Silver, R. T., Talpaz, M., Winton, E. F., Harvey, J. H., Arcasoy, M. O., Hexner, E. O., Lyons, R. M., Paquette, R., Raza, A., Vaddi, K., Erickson-Viitanen, S., Sun, W., Sandor, V., Kantarjian, H. M.: Efficacy, safety and survival with ruxolitinib treatment in patients with myelofibrosis: results of a median 2-year follow-up of COMFORT-I. Haematologica 100(4): 479-88, Apr 2015.

Meng, L., Bai, Z., He, S., Mochizuki, K., Liu, Y., Purushe, J., Sun, H., Wang, J., Yagita, H., Mineishi, S., Fung, H., Yanik, G. A., Caricchio, R., Fan, X., Crisalli, L. M., Hexner, E. O., Reshef, R., Zhang, Y., Zhang, Y.: The Notch Ligand DLL4 Defines a Capability of Human Dendritic Cells in Regulating Th1 and Th17 Differentiation. J Immunol 2015.

Reshef, R., Huffman, A. P., Gao, A., Luskin, M. R., Frey, N. V., Gill, S. I., Hexner, E. O., Kambayashi, T., Loren, A. W., Luger, S. M., Mangan, J. K., Nasta, S. D., Richman, L. P., Sell, M., Stadtmauer, E. A., Vonderheide, R. H., Mick, R., Porter, D. L.: High Graft CD8 Cell Dose Predicts Improved Survival and Enables Better Donor Selection in Allogeneic Stem-Cell Transplantation With Reduced-Intensity Conditioning. J Clin Oncol 33(21): 2392-8, 2015.

Bagley, S. J., Sehgal, A. R., Gill, S., Frey, N. V., Hexner, E. O., Loren, A. W., Mangan, J. K., Porter, D. L., Stadtmauer, E. A., Reshef, R., Luger, S. M.: Acute cholecystitis is a common complication after allogeneic stem cell transplantation and is associated with the use of total parenteral nutrition. Biol Blood Marrow Transplant 21(4): 768-71, 2015.

van Zalen, S., Lombardi, A. A., Jeschke, G. R., Hexner, E. O., Russell, J. E.: AUF-1 and YB-1 independently regulate beta-globin mRNA in developing erythroid cells through interactions with poly(A)-binding protein. Mech Dev 136: 40-52, 2015.

Reilly CR, Babushok D, Bahirwani R, Mondschein J, Hexner E: Clinical Characteristics and Outcomes of Transjugular Intrahepatic Portosystemic Shunt Procedure for Portal Hypertension Secondary to Myeloproliferative Neoplasms. Blood 126(1612), 2015.

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Last updated: 01/27/2016
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