Samuel G. Jacobson

faculty photo
Professor of Ophthalmology
Director, Center for Hereditary Retinal Degenerations and Retinal Function Department, Scheie Eye Institute, University of Pennsylvania
Department: Ophthalmology

Contact information
Scheie Eye Institute
51 North 39th Street
2689
Philadelphia, PA 19104
Education:
B.A. (Humanities)
University of Illinois, 1966.
M.D. (Medicine)
University of Illinois, 1970.
Ph.D. (Psychophysics)
University of London, 1977.
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Description of Itmat Expertise

Hereditary retinal degenerations
Age-related macular degeneration

Selected Publications

Aleman TS, Cideciyan AV, Sumaroka A, Windsor SAM, Herrera W, White A, Kaushal S, Naidu A, Roman, AJ, Schwartz SB, Stone EM, Jacobson SG: Reginal Laminar Architecture in Human Retinitis Pigmentosa Caused by Rhodopsin Gene Mutations. Investigative Ophthalmology & Visual Science 49(4): 1580-1590, April 2008.

Cheng H., Aleman TS., Cideciyan AV., Khanna R., Jacobson SG., Swaroop A.: In vivo function of the orphan nuclear receptor NR2E3 in establishing photoreceptor identity during mammalian retinal development. Human Molecular Genetics 15(17): 2588-602, Sep 1 2006.

Jacobson SG., Cideciyan AV., Sumaroka A., Aleman TS., Schwartz SB., Windsor EA., Roman AJ., Stone EM., MacDonald IM.: Remodeling of the human retina in choroideremia: rab escort protein 1 (REP-1) mutations. Investigative Ophthalmology & Visual Science 47(9): 4113-20, Sep 2006.

Jacobson SG., Boye SL., Aleman TS., Conlon TJ., Zeiss CJ., Roman AJ., Cideciyan AV., Schwartz SB., Komaromy AM., Doobrajh M., Cheung AY., Sumaroka A., Pearce-Kelling SE., Aguirre GD., Kaushal S., Maguire AM., Flotte TR., Hauswirth WW.: Safety in nonhuman primates of ocular AAV2-RPE65, a candidate treatment for blindness in Leber congenital amaurosis. Human Gene Therapy 17(8): 845-58, Aug 2006.

Williams ML, Coleman JE, Haire SE, Aleman TS, Cideciyan AV, Sokal I, Palczewski K, Jacobson SG, Semple-Rowland SL : Lentiviral expression of retinal guanylate cyclase-1 (RetGC1) restores vision in an avian model of childhood blindness. PLoS Med. 3: e201, Jun 2006.

Jacobson SG., Acland GM., Aguirre GD., Aleman TS., Schwartz SB., Cideciyan AV., Zeiss CJ., Komaromy AM., Kaushal S., Roman AJ., Windsor EA., Sumaroka A., Pearce-Kelling SE., Conlon TJ., Chiodo VA., Boye SL., Flotte TR., Maguire AM., Bennett J., Hauswirth WW.: Safety of recombinant adeno-associated virus type 2-RPE65 vector delivered by ocular subretinal injection. Molecular Therapy: the Journal of the American Society of Gene Therapy 13(6): 1074-84, Jun 2006.

Jacobson SG, Acland GM, Aguirre GD, Aleman TS, Schwartz SB, Cideciyan AV, et al., Flotte TR, Maguire AM, Bennett JB, Hauswirth WW : Safety of recombinant adeno-asssociated virus type 2-RPE65 vector delivered by ocular subretinal injection. Mol Ther 13: 1074-84, Jun 2006.

Thompson DA., Janecke AR., Lange J., Feathers KL., Hubner CA., McHenry CL., Stockton DW., Rammesmayer G., Lupski JR., Antinolo G., Ayuso C., Baiget M., Gouras P., Heckenlively JR., den Hollander A., Jacobson SG., Lewis RA., Sieving PA., Wissinger B., Yzer S., Zrenner E., Utermann G., Gal A.: Retinal degeneration associated with RDH12 mutations results from decreased 11-cis retinal synthesis due to disruption of the visual cycle. Human Molecular Genetics 14(24): 3865-75, Dec 15 2005.

Cideciyan AV, Swider M, Aleman TS, Sumaroka A, Schwartz SB, Roman MI, Milam AH, Bennett J, Stone EM, Jacobson SG: ABCA4-associated retinal degenerations spare structure and function of the human parapapillary retina. Invest Ophthalmol Vis Sci 46: 4739-4746, Dec 2005.

Cideciyan AV., Swider M., Aleman TS., Sumaroka A., Schwartz SB., Roman MI., Milam AH., Bennett J., Stone EM., Jacobson SG.: ABCA4-associated retinal degenerations spare structure and function of the human parapapillary retina. Investigative Ophthalmology & Visual Science 46(12): 4739-46, Dec 2005.

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Last updated: 01/24/2014
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