Samuel G. Jacobson

faculty photo
Professor of Ophthalmology
Director, Center for Hereditary Retinal Degenerations and Retinal Function Department, Scheie Eye Institute, University of Pennsylvania
Department: Ophthalmology

Contact information
Scheie Eye Institute
51 North 39th Street
2689
Philadelphia, PA 19104
Education:
B.A. (Humanities)
University of Illinois, 1966.
M.D. (Medicine)
University of Illinois, 1970.
Ph.D. (Psychophysics)
University of London, 1977.
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Description of Itmat Expertise

Hereditary retinal degenerations
Age-related macular degeneration

Selected Publications

Zhang Ning, Tsybovsky Yaroslav, Kolesnikov Alexander V, Rozanowska Malgorzata, Swider Malgorzata, Schwartz Sharon B, Stone Edwin M, Palczewska Grazyna, Maeda Akiko, Kefalov Vladimir J, Jacobson Samuel G, Cideciyan Artur V, Palczewski Krzysztof: Protein misfolding and the pathogenesis of ABCA4-associated retinal degenerations. Human molecular genetics 24(11): 3220-37, Jun 2015.

Jacobson Samuel G, Cideciyan Artur V, Roman Alejandro J, Sumaroka Alexander, Schwartz Sharon B, Heon Elise, Hauswirth William W: Improvement and decline in vision with gene therapy in childhood blindness. The New England journal of medicine 372(20): 1920-6, May 2015.

Zelinger Lina, Cideciyan Artur V, Kohl Susanne, Schwartz Sharon B, Rosenmann Ada, Eli Dalia, Sumaroka Alexander, Roman Alejandro J, Luo Xunda, Brown Cassondra, Rosin Boris, Blumenfeld Anat, Wissinger Bernd, Jacobson Samuel G, Banin Eyal, Sharon Dror: Genetics and Disease Expression in the CNGA3 Form of Achromatopsia: Steps on the Path to Gene Therapy. Ophthalmology 122(5): 997-1007, May 2015.

Cideciyan Artur V, Swider Malgorzata, Jacobson Samuel G: Autofluorescence imaging with near-infrared excitation:normalization by reflectance to reduce signal from choroidal fluorophores. Investigative ophthalmology & visual science 56(5): 3393-406, May 2015.

Sadigh Sam, Luo Xunda, Cideciyan Artur V, Sumaroka Alexander, Boxley Stacy L, Hall Laura M, Sheplock Rebecca, Feuer William J, Stambolian Dwight S, Jacobson Samuel G: Drusen and photoreceptor abnormalities in African-Americans with intermediate non-neovascular age-related macular degeneration. Current eye research 40(4): 398-406, Apr 2015.

Li Songhua, Hu Jane, Jin Robin J, Aiyar Ashok, Jacobson Samuel G, Bok Dean, Jin Minghao: Temperature-sensitive retinoid isomerase activity of RPE65 mutants associated with Leber Congenital Amaurosis. Journal of biochemistry Mar 2015.

Beltran William A, Cideciyan Artur V, Lewin Alfred S, Hauswirth William W, Jacobson Samuel G, Aguirre Gustavo D: Gene augmentation for X-linked retinitis pigmentosa caused by mutations in RPGR. Cold Spring Harbor perspectives in medicine 5(2): a017392, Feb 2015.

Cideciyan Artur V, Aguirre Geoffrey K, Jacobson Samuel G, Butt Omar H, Schwartz Sharon B, Swider Malgorzata, Roman Alejandro J, Sadigh Sam, Hauswirth William W: Pseudo-fovea formation after gene therapy for RPE65-LCA. Investigative ophthalmology & visual science 56(1): 526-37, Jan 2015.

Luo Xunda, Cideciyan Artur V, Iannaccone Alessandro, Roman Alejandro J, Ditta Lauren C, Jennings Barbara J, Yatsenko Svetlana A, Sheplock Rebecca, Sumaroka Alexander, Swider Malgorzata, Schwartz Sharon B, Wissinger Bernd, Kohl Susanne, Jacobson Samuel G: Blue cone monochromacy: visual function and efficacy outcome measures for clinical trials. PloS one 10(4): e0125700, 2015.

Ratnapriya Rinki, Zhan Xiaowei, Fariss Robert N, Branham Kari E, Zipprer David, Chakarova Christina F, Sergeev Yuri V, Campos Maria M, Othman Mohammad, Friedman James S, Maminishkis Arvydas, Waseem Naushin H, Brooks Matthew, Rajasimha Harsha K, Edwards Albert O, Lotery Andrew, Klein Barbara E, Truitt Barbara J, Li Bingshan, Schaumberg Debra A, Morgan Denise J, Morrison Margaux A, Souied Eric, Tsironi Evangelia E, Grassmann Felix, Fishman Gerald A, Silvestri Giuliana, Scholl Hendrik P N, Kim Ivana K, Ramke Jacqueline, Tuo Jingsheng, Merriam Joanna E, Merriam John C, Park Kyu Hyung, Olson Lana M, Farrer Lindsay A, Johnson Matthew P, Peachey Neal S, Lathrop Mark, Baron Robert V, Igo Robert P, Klein Ronald, Hagstrom Stephanie A, Kamatani Yoichiro, Martin Tammy M, Jiang Yingda, Conley Yvette, Sahel Jose-Alan, Zack Donald J, Chan Chi-Chao, Pericak-Vance Margaret A, Jacobson Samuel G, Gorin Michael B, Klein Michael L, Allikmets Rando, Iyengar Sudha K, Weber Bernhard H, Haines Jonathan L, Léveillard Thierry, Deangelis Margaret M, Stambolian Dwight, Weeks Daniel E, Bhattacharya Shomi S, Chew Emily Y, Heckenlively John R, Abecasis Gonçalo R, Swaroop Anand: Rare and common variants in extracellular matrix gene Fibrillin 2 (FBN2) are associated with macular degeneration. Human molecular genetics 23(21): 5827-37, Nov 2014.

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Last updated: 01/24/2014
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