Jeffrey S Barrett

faculty photo
Adjunct Professor of Pediatrics
Department: Pediatrics

Contact information
The Children's Hospital of Philadelphia
Colket Translational Research Building, Room 4012
3501 Civic Center Boulevard
Philadelphia, PA 19104-4318
Office: (267) 426-5479
Fax: (267) 425-0114
Graduate Group Affiliations
Education:
BS (Chemical Engineering)
Drexel University, 1986.
MS (Pharmacokinetics)
University of Michigan, 1987.
PhD (Pharmacokinetics)
University of Michigan, 1990.
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Description of Itmat Expertise

Dr. Barrett investigates sources of variation in pharmacokinetics and pharmacodynamics, and the development of pharmacometric approaches to advance PK/PD, novel biomarker development and disease progression modeling.

Selected Publications

Ince I, de Wildt SN, Peeters MYM, Burggraaf K, Jacqz-Aigrain E, Barrett JS, Danhof M, Knibbe CAJ.: Oral bioavailability of the CYP3A substrate midazolam across the human age range from preterm neonates to adults. Abstr 2853 PAGE 22 2013 Notes: [www.page-meeting.org/?abstract=2853]

Bai JP, Barrett JS, Burckart GJ, Meibohm B, Sachs H, Yao L.: Strategic Biomarkers for Drug Development in Treating Rare Diseases and Diseases in Neonates and Infants. AAPS J 15(2): 447-54, 2013.

McCune JS, Baker KS, Blough DK, Gamis A, Bemer MJ, Kelton-Rehkopf MC, Winter L, Barrett JS. : Prescribing patterns and pharmacokinetic-based targeting of intravenous busulfan in pediatric hematopoietic cell transplant recipients. J Clin Pharmacol 53(3): 264-75, 2013.

Della Casa Alberighi O, Barrett JS, Läer S, Meibohm B.: Response to: Physiologically Based Pharmacokinetic (PBPK) Modeling at the Extremes of Age. . Clin Pharmacol and Therapeutics 93(2): 149, 2013.

Stallings VA, Mondick JT, Schall JI, Barrett JS, Wilson M, Mascarenhas MR.: Diagnosing Malabsorption with Systemic Lipid Profiling: Pharmacokinetics of Pentadecanoic Acid and Triheptadecanoic Acid Following Oral Administration in Healthy Subjects and Subjects with Cystic Fibrosis. Int J Clin Pharmacol Therapeut 51(4): 263-73, 2013.

Barrett JS and Zuppa AF.: Basic Principles of Clinical Pharmacology Relevant to Pharmacoepidemiologic Studies Textbook of Pharmacoepidemiology, Second Edition. Strom BL, Kimmel SE, Hennessy S (eds.). Chichester, UK: Wiley, 2013.

Marier JF, Mangum B, Reid B, and Barrett JS.: A Modelling and Simulations Framework to Support Global Regulatory Strategies for Pediatric Drug Development Programs. Therapeutic Innovation and Regulatory Science 47(5): 550-556, 2013.

Barrett JS, McGuire J, Vezina H, Spitsin S, Douglas SD: PET measurement of receptor occupancy as a tool to guide dose selection in neuropharmacology: Are we asking the right questions? J Clin Psychopharmacol 33(6): 725-8, 2013.

Zajicek A, Fossler MJ, Barrett JS, Worthington J, Ternik R, Mclaren D, Charkoftaki G, Lum S, Breitkreutz J, Belthazar M, Mancheros P, Khan M, and Agharkar R.: Pediatric Formulations: Challenges and Potential Solutions. AAPS J 15(4): 1072-81, 2013.

Bajaj G, Dombrowsky E, Yu Q, Agarwal B, Barrett JS.: Considerations for the Prediction of Survival Time in Pancreatic Cancer Based on Registry Data. J Pharmacokinet Pharmacodyn 40: 527-36, 2013.

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Last updated: 12/23/2013
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