Jeffrey S Barrett

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Adjunct Professor of Pediatrics
Department: Pediatrics

Contact information
The Children's Hospital of Philadelphia
Colket Translational Research Building, Room 4012
3501 Civic Center Boulevard
Philadelphia, PA 19104-4318
Office: (267) 426-5479
Fax: (267) 425-0114
Graduate Group Affiliations
Education:
BS (Chemical Engineering)
Drexel University, 1986.
MS (Pharmacokinetics)
University of Michigan, 1987.
PhD (Pharmacokinetics)
University of Michigan, 1990.
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Description of Itmat Expertise

Dr. Barrett investigates sources of variation in pharmacokinetics and pharmacodynamics, and the development of pharmacometric approaches to advance PK/PD, novel biomarker development and disease progression modeling.

Selected Publications

Barrett JS, Spitsin S , Moorthy G, Barrett KJ, Baker K, Lackner A, Tulic F, Winters A, Evans DL and Douglas SD. : Pharmacologic rationale for the NK1R antagonist, aprepitant as adjunctive therapy in HIV. J Transl Med. 14(1): 148, 2016.

Tebas P, Spitsin S, Barrett JS, Tuluc F, Elci O, Korelitz JJ, Wagner W, Winters A, Kim D, Catalano R, Evans DL, Douglas SD. : Reduction of soluble CD163, substance P, programmed death 1 and inflammatory markers: phase 1B trial of aprepitant in HIV-1-infected adults. AIDS 29(8): 931-9, 2015.

Stockmann C, Barrett JS, Roberts JK, Sherwin CMT. : Use of Modeling and Simulation in the Design and Conduct of Pediatric Clinical Trials and the Optimization of Individualized Dosing Regimens. CPT Pharmacometrics Syst Pharmacol 4(11): 630-40, 2015.

Mascarenhas MR, Mondick JT, Barrett JS, Stallings VA, Wilson MD, Schall JI. : Malabsorption Blood Test: Assessing Fat Absorption in Patients with Cystic Fibrosis and Pancreatic Insufficiency. J Clin Pharmacol. 55(8): 854-65, 2015.

Harskamp-van Ginkel MW, Hill KD, Becker K, Testoni D, Cohen-Wolkowiez M, Gonzalez D, Barrett JS, Benjamin DK Jr, Siegel DA, Banks P, Watt KM: Best Pharmaceuticals for Children Act–Pediatric Trials Network Administrative Core Committee. Drug Dosing in Overweight and Obese Children: A Systematic Review of Current Pharmacokinetic Data and Recommendations for Future Clinical Trials. JAMA Pediatr. 169(7): 678-85, 2015.

Zhang Y, Wei X, Bajaj G, Barrett JS, Meibohm B, Joshi A, Gupta M.: Challenges and considerations for development of therapeutic proteins in pediatric patients. J Clin Pharmacol. 55(Suppl 3): S103-15, 2015.

Van Rongen A, Vaughns JD, Moorthy G, Barrett JS, Knibbe CAJ, van den Anker JN. : Population pharmacokinetics of midazolam and its metabolites in overweight and obese adolescents. Br J Clin Pharmacol 80(5): 1185-96, 2015.

Ng CM, Dombrowsky E, Lin HP, Erlich ME, Moody DE, Barrett JS, Kraft WK. : Population Pharmacokinetic Model of Buprenorphine in Pediatric Patients with Neonatal Abstinence Syndrome. Pharmacotherapy 35(7): 670-80, 2015.

Huang Z, Barrett JS, Barrett K, Barrett R, Ng CM. : Novel Method to Predict Body Weight in Children Based on Age and Morphological Facial Features. J Clin Pharmacol. 55(4): 447-51, 2015.

Barrett JS. : Pediatric models in motion: Requirements for model-based decision support at the bedside British J Clin Pharmacol 79(1): 85-96, 2015.

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Last updated: 04/04/2017
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