Kathleen M. Loomes

faculty photo
Associate Professor of Pediatrics at the Children's Hospital of Philadelphia
Attending Physician, The Children's Hospital of Philadelphia
Attending Physician, Consultant in Pediatric Gastroenterology, Pennsylvania Hospital, Philadelphia, PA
Attending Physician, Consultant in Pediatric Gastroenterology, Hospital of the University of Pennsylvania
Director of Research Training, The Children's Hospital of Philadelphia, Gastroenterology and Hepatology Fellowship Training Program
Co-Director, Fred and Suzanne Biesecker Pediatric Liver Center, The Children's Hospital of Philadelphia
Department: Pediatrics

Contact information
The Children's Hospital of Philadelphia
Division of Gastroenterology, Hepatology and Nutrition, 7th floor
34th and Civic Center Blvd.
Philadelphia, PA 19104
Office: 267-426-7223
Fax: 267-426-7814
Education:
B.A. (Biology)
Rice University (Cum laude), 1988.
M.D. (Medicine)
University of Texas Southwestern Medical School, 1992.
Permanent link
 

Description of Itmat Expertise

Notch pathway
Liver development
Bile duct development
Role of Notch signaling in bone development and healing
Alagille syndrome
Pediatric liver disease

Selected Publications

Wang KS, Tiao G, Bass LM, Hertel PM, Mogul D, Kerkar N, Clifton M, Azen C, Bull L, Rosenthal P, Stewart D, Superina R, Arnon R, Bozic M, Brandt ML, Dillon PA, Fecteau A, Iyer K, Kamath B, Karpen S, Karrer F, Loomes KM, Mack C, Mattei P, Miethke A, Soltys K, Turmelle YP, West K, Zagory J, Goodhue C, Shneider B, the Childhood Liver Disease Research Network (ChiLDReN): Analysis of surgical interruption of the enterohepatic circulation as a treatment for pediatric cholestasis. Hepatology 2017 Notes: In Press.

Lin H, Zoll B, Russo P, Spinner NB, Loomes KM: A challenging Case of Focal Extrahepatic Duct Obstruction/Hypoplasia in Alagille Syndrome. Journal of Pediatric Gastroenterology and Nutrition Dec 2016 Notes: E-pub ahead of print.

Wang Kasper S, Tiao Greg, Bass Lee M, Hertel Paula M, Mogul Douglas, Kerkar Nanda, Clifton Matthew, Azen Colleen, Bull Laura, Rosenthal Philip, Stewart Dylan, Superina Riccardo, Arnon Ronen, Bozic Molly, Brandt Mary L, Dillon Patrick A, Fecteau Annie, Iyer Kishore, Kamath Binita, Karpen Saul, Karrer Frederick, Loomes Kathleen M, Mack Cara, Mattei Peter, Miethke Alexander, Soltys Kyle, Turmelle Yumirle P, West Karen, Zagory Jessica, Goodhue Cat, Shneider Benjamin L: Analysis of surgical interruption of the enterohepatic circulation as a treatment for pediatric cholestasis. Hepatology (Baltimore, Md.) Dec 2016.

Zamora R, Vodovotz Y, Mi Q, Barclay D, Yin J, Horslen S, Rudnick D, Loomes KM, Squires RH: Data-Driven Modeling for Precision Medicine in Pediatric Acute Liver Failure. Molecular medicine (Cambridge, Mass.) 22, Nov 2016 Notes: Epub ahead of print.

Youngstrom DW, Dishowitz MI, Bales CB, Carr E, Mutyaba PL, Kozloff KM, Shitaye H, Hankenson KD, Loomes KM: Jagged1 expression by osteoblast-lineage cells regulates trabecular bone mass and periosteal expansion in mice. Bone 91: 64-74, October 2016 Notes: doi: 10.1016/j.bone.2016.07.006.

Ng VL, Li R, Loomes KM, Leonis MA, Rudnick DA, Belle SH, Squires RH, for the Pediatric Acute Liver Failure Study Group (PALFSG): Outcomes of Children With and Without Hepatic Encephalopathy from the Pediatric Acute Liver Failure (PALF) Study Group. Journal of Pediatric Gastroenterology and Nutrition 63(3): 357-364, September 2016.

Tsai Ellen A, Gilbert Melissa A, Grochowski Christopher M, Underkoffler Lara A, Meng He, Zhang Xiaojie, Wang Michael M, Shitaye Hailu, Hankenson Kurt D, Piccoli David, Lin Henry, Kamath Binita M, Devoto Marcella, Spinner Nancy B, Loomes Kathleen M: THBS2 Is a Candidate Modifier of Liver Disease Severity in Alagille Syndrome. Cellular and molecular gastroenterology and hepatology 2(5): 663-675.e2, Sep 2016.

Narkewicz MR, Horslen S, Belle SH, Rudnick DA, Ng VL, Rosenthal P, Romero R, Loomes KM, Zhang S, Hardison RM, Squires RH; Pediatric Acute Liver Failure Study Group: Prevalence and Significance of Autoantibodies in Children with Acute Liver Failure. J Pediatr Gastroenterol Nutr August 2016.

Tang V, Cofer ZC, Cui S, Sapp V, Loomes KM, Matthews RP: Loss of a Candidate Biliary Atresia Susceptibility Gene, add3a, Causes Biliary Developmental Defects in Zebrafish. J Pediatr Gastroenterol Nutr August 2016.

January Kathleen, J Conway Laura, Deardorff Matthew, Harrington Ann, Krantz Ian D, Loomes Kathleen, Pipan Mary, Noon Sarah E: Benefits and limitations of a multidisciplinary approach to individualized management of Cornelia de Lange syndrome and related diagnoses. American journal of medical genetics. Part C, Seminars in medical genetics May 2016.

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Last updated: 01/30/2017
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