Kathleen M. Loomes

faculty photo
Professor of Pediatrics at the Children's Hospital of Philadelphia
Attending Physician, The Children's Hospital of Philadelphia
Attending Physician, Consultant in Pediatric Gastroenterology, Pennsylvania Hospital, Philadelphia, PA
Attending Physician, Consultant in Pediatric Gastroenterology, Hospital of the University of Pennsylvania
Director of Research Training, The Children's Hospital of Philadelphia, Gastroenterology and Hepatology Fellowship Training Program
Co-Director, Fred and Suzanne Biesecker Pediatric Liver Center, The Children's Hospital of Philadelphia
Department: Pediatrics

Contact information
The Children's Hospital of Philadelphia
Division of Gastroenterology, Hepatology and Nutrition, 7th floor
34th and Civic Center Blvd.
Philadelphia, PA 19104
Office: 267-426-7223
Fax: 267-426-7814
Education:
B.A. (Biology)
Rice University (Cum laude), 1988.
M.D. (Medicine)
University of Texas Southwestern Medical School, 1992.
Permanent link
 

Description of Itmat Expertise

Notch pathway
Liver development
Bile duct development
Role of Notch signaling in bone development and healing
Alagille syndrome
Pediatric liver disease

Selected Publications

Chapin Catherine A, Burn Thomas, Meijome Tomas, Loomes Kathleen M, Melin-Aldana Hector, Kreiger Portia A, Whitington Peter F, Behrens Edward M, Alonso Estella M: Indeterminate pediatric acute liver failure is uniquely characterized by a CD103+CD8+ T-cell infiltrate. Hepatology Mar 2018 Notes: In Press.

Sorensen LG, Neighbors K, Hardison RM, Loomes KM, Varni JW, Ng VL, Squires RH, Alonso EM for the Pediatric Acute Liver Failure Study Group: Health Related Quality of Life and Neurocognitive Outcomes in the First Year after Pediatric Acute Liver Failure. Journal of Pediatrics 2018 Notes: In Press.

Shneider BL, Spino C, Kamath BM, Magee JC, Bass LM, Setchell KD, Miethke A, Molleston JP, Mack CL, Squires RH, Murray KF, Loomes KM, Rosenthal P, Karpen SJ, Leung DH, Guthery SL, Thomas D, Sherker AH, Sokol RJ, for the Childhood Liver Disease Research Network (ChiLDReN): Placebo-controlled randomized trial of an intestinal bile salt transport inhibitor for pruritus in Alagille syndrome. Hepatology Communications 2018 Notes: In Press.

Narkewicz MR, Horslen S, Hardison RM, Shneider BL, Rodriguez-Baez N, Alonso EM, Ng VL, Leonis MA, Loomes KM, Rudnick DA, Rosenthal P, Romero R, Subbarao GC, Li R, Belle SH, Squires RH.: A Learning Collaborative Approach Increases Specificity of Diagnosis of Acute Liver Failure in Pediatric Patients. Clinical Gastroenterology and Hepatology 2018 Notes: In Press.

Chen Y, Gilbert MA, Grochowski CM, McEldrew DA, Llewellyn J, Waisbourd-Zinman O, Hakonarson H, Bailey-Wilson JE, Russo P, Wells RG, Loomes KM, Spinner NB, Devoto M.: A genome-wide association study identifies a susceptibility locus for biliary atresia on 2p16.1 within the gene EFEMP1. PLOS Genetics 2018 Notes: In Press.

Alonso EM, Ye W, Hawthorne K, Venkat V, Loomes KM, Mack CL, Hertel PM, Karpen SJ, Kerkar N, Molleston JP, Murray KF, Romero R, Rosenthal P, Schwarz KB, Shneider BL, Suchy FJ, Turmelle YP, Wang KS, Whitington PF, Sherker AH, Sokol RJ, Bezerra JA, Magee JC and the ChiLDReN Network: Impact of Steroid Therapy on Early Growth in Infants with Biliary Atresia: The Multi-center START Trial. Journal of Pediatrics 2018 Notes: In Press.

Mitchell E, Loomes KM, Squires RH, Goldberg D: Variability in Acceptance of Organ Offers by Pediatric Liver Transplant Centers and its Impact on Waitlist Mortality. Liver Transplantation 2018 Notes: In Press.

Youngstrom DW, Senos dos Santos R, Zondervan RL, Brodeur JD, Lints AL, Young DR, Mitchell TL, Moore ME, Myers MH, Tseng WJ, Loomes KM, Hankenson KD.: Intraoperative delivery of the Notch ligand Jagged-1 regenerates appendicular and craniofacial bone defects. NPJ Regenerative Medicine 2(32): doi: 10.1038, Dec 2017 Notes: ecollection 2017.

Tsai EA, Gilbert MA, Grochowski CM, Underkoffler LA, Meng H, Zhang X, Wang MM, Shitaye H, Hankenson KD, Piccoli D, Lin H, Kamath BM, Devoto M, Spinner NB, Loomes KM: THBS2 is a Candidate Modifier of Liver Disease Severity in Alagille Syndrome. Cellular and Molecular Gastroenterology and Hepatology Special Edition 2(5): 59-69, July 2017.

Shneider BL, Moore J, Kerkar N, Magee JC, Ye W, Karpen SJ, Kamath BM, Molleston JP, Bezerra JA, Murray KF, Loomes KM, Whitington PF, Rosenthal P, Squires RH, Guthery SL, Arnon R, Schwarz KB, Turmelle YP, Sherker AH, Sokol RJ for the Childhood Liver Disease Research Network: Initial assessment of the infant with neonatal cholestasis - is this biliary atresia? PLOS One 12(5): e017627, May 2017.

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Last updated: 07/17/2018
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