Kathleen M. Loomes

faculty photo
Associate Professor of Pediatrics at the Children's Hospital of Philadelphia
Attending Physician, Consultant in Pediatric Gastroenterology, Pennsylvania Hospital, Philadelphia, PA
Attending Physician, Consultant in Pediatric Gastroenterology, Hospital of the University of Pennsylvania
Director of Research Training, The Children's Hospital of Philadelphia, Gastroenterology and Hepatology Fellowship Training Program
Department: Pediatrics

Contact information
The Children's Hospital of Philadelphia
Division of Gastroenterology, Hepatology and Nutrition, 7th floor
34th and Civic Center Blvd.
Philadelphia, PA 19104
Office: 267-426-7223
Fax: 267-426-7814
B.A. (Biology)
Rice University (Cum laude), 1988.
M.D. (Medicine)
University of Texas Southwestern Medical School, 1992.
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Description of Itmat Expertise

Notch pathway
Liver development
Bile duct development
Role of Notch signaling in bone development and healing
Alagille syndrome
Pediatric liver disease

Selected Publications

January Kathleen, J Conway Laura, Deardorff Matthew, Harrington Ann, Krantz Ian D, Loomes Kathleen, Pipan Mary, Noon Sarah E: Benefits and limitations of a multidisciplinary approach to individualized management of Cornelia de Lange syndrome and related diagnoses. American journal of medical genetics. Part C, Seminars in medical genetics May 2016.

Rajagopalan Ramakrishnan, Grochowski Christopher M, Gilbert Melissa A, Falsey Alexandra M, Coleman Karlene, Romero Rene, Loomes Kathleen M, Piccoli David A, Devoto Marcella, Spinner Nancy B: Compound heterozygous mutations in NEK8 in siblings with end-stage renal disease with hepatic and cardiac anomalies. American journal of medical genetics. Part A 170(3): 750-3, Mar 2016.

Patel Jyoti K, Loomes Kathleen M, Goldberg David J, Mercer-Rosa Laura, Dodds Kathryn, Rychik Jack: Early Impact of Fontan Operation on Enteric Protein Loss. The Annals of thoracic surgery 101(3): 1025-30, Mar 2016.

Cofer Zenobia C, Cui Shuang, EauClaire Steven F, Kim Cecilia, Tobias John W, Hakonarson Hakon, Loomes Kathleen M, Matthews Randolph P: Methylation Microarray Studies Highlight PDGFA Expression as a Factor in Biliary Atresia. PloS one 11(3): e0151521, 2016.

Kamath BM, Chen Z, Romero R, Fredericks EM, Alonso EM, Arnon R, Heubi J, Hertel PM, Karpen SJ, Loomes KM, Murray KF, Rosenthal P, Schwarz KB, Subbarao G, Teckman JH, Turmelle YP, Wang KS, Sherker AH, Sokol RJ, Magee JC: Quality of Life and Its Determinants in a Multicenter Cohort of Children with Alagille Syndrome. The Journal of Pediatrics 167(2): 390-396.e3, Aug 2015.

Mouzaki M, Bass LM, Sokol RJ, Piccoli DA, Quammie C, Loomes KM, Heubi JE, Hertel PM, Scheenstra R, Furuya K, Kutsch E, Spinner NB, Robbins KN, Venkat V, Rosenthal P, Beyene J, Baker Ar, Kamath BM: Early Life Predictive Markers of Liver Disease Outcome in an International, Multi-Center Cohort of Children with Alagille Syndrome. Liver international: official journal of the International Association for the Study of the Liver Jul 2015.

Tsai EA, Grochowski CM, Falsey AM, Rajagopalan R, Wendel D, Devoto M, Krantz ID, Loomes KM, Spinner NB: Heterozygous Deletion of FOXA2 Segregates with Disease in a Family with Heterotaxy, Panhypopituitarism, and Biliary Atresia. Human Mutation 36(6), June 2015.

Grochowski CM, Rajagopalan R, Falsey AM, Loomes KM, Piccoli DA, Krantz ID, Devoto M, Spinner B: Exome sequencing reveals compound heterozygous mutations in ATP8B1 in a JAG1/NOTCH2 mutation-negative patient with clinically diagnosed Alagille syndrome. American Journal of Medical Genetics 167A(4): 891-3, Mar 2015.

Teckman JH, Rosenthal P, Abel R, Bass LM, Michail S, Murray KF, Rudnick DA, Thomas DW, Spino C, Arnon R, Hertel PM, Heubi J, Kamath BM, Karnsakul W, Loomes KM, Magee JC, Molleston JP, Romero R, Shneider BL, Sherker AH, Sokol RJ: Baseline Analysis of a Young Alpha-1-AT Deficiency Liver Disease Cohort Reveals Frequent Portal Hypertension. Journal of Pediatric Gastroenterology and Nutrition 61(1): 94-101, Feb 2015.

Venkat VL, Shneider BL, Magee JC, Turmelle Y, Arnon R, Bezerra JA, Hertel PM, Karpen SJ, Kerkar N, Loomes KM, Molleston J, Murray KF, Ng VL, Raghunathan T, Rosenthal P, Schwartz K, Sherker AH, Sokol RJ, Teckman J, Wang K, Whitington PF, Heubi JE: Total serum bilirubin predicts fat-soluble vitamin deficiency better than serum bile acids in infants with biliary atresia. Journal of Pediatric Gastroenterology and Nutrition 59(6): 702-7, Dec 2014.

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Last updated: 07/20/2016
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