David A Wolk

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Associate Professor of Neurology
Attending Neurologist, Hospital of the University of Pennsylvania
Faculty, Center for Cognitive Neuroscience, University of Pennsylvania
Fellow, Institute on Aging, University of Pennsylvania
Co-Director, Penn Memory Center
Department: Neurology

Contact information
Penn Memory Center
Ralston House
3615 Chestnut Street
Philadelphia, PA 19104
Office: 215 662-7810
Fax: 215 662-7812
Graduate Group Affiliations
BA (Psychology)
Dartmouth College, 1994.
MD (Medicine)
Johns Hopkins University School of Medicine, 1998.
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Description of Research Expertise

Episodic Memory, Event-related Potentials, transcranial direct current stimulation, MRI, Alzheimer's Disease, Dementia, Memory Disorders, Cognitive Neurology, Aging,

Description of Itmat Expertise

My principle interest is in the study of memory in aging and early Alzheimer's Disease, as well as, more generally, biomarkers for preclinical and prodromal disease detection. In particular, our focus has been on trying to discriminate memory changes associated with normal aging versus the earliest signs of Alzheimer's disease using a variety of multimodal approaches, including behavioral measures, structural and functional MRI, and Event-Related Potentials.

Selected Publications

Wolk DA, Dickerson BC : Fractionating verbal episodic memory in Alzheimer's disease. NeuroImage 54(2): 1530-9, Sep 2010.

Wolk DA, Dickerson BC: Apolipoprotein E (APOE) genotype has dissociable effects on memory and attentional-executive network function in Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America 107(22): 10256-61, Jun 2010 Notes: Featured article in Alzheimer Research Forum: ApoE and Brain Networks—The Anatomy of a Risk Factor, May 28, 2010.

Wolk DA, Dunfee KL, Dickerson BC, Aizenstein HJ, Dekosky ST: A medial temporal lobe division of labor: Insights from memory in aging and early Alzheimer disease. Hippocampus 21(5): 461-6, Mar 2010.

Wolk DA, Price JC, Saxton JA, Snitz BE, James JA, Lopez OL, Aizenstein HJ, Cohen AD, Weissfeld LA, Mathis CA, Klunk WE, DeKosky ST: Amyloid imaging in mild cognitive impairment subtypes. Annals of Neurology 65(5): 557-68, May 2009.

Dickerson BC, Wolk DA: MRI cortical thickness biomarker predicts AD-like CSF and cognitive decline in normal adults. Neurology 78(2): 84-90, Dec 2011 Notes: Featured editorial on manuscript: Resnick SM; Scheltens P. MRI-based biomarkers of preclinical AD: An Alzheimer signature. Neurology: 78(2): 80-81. Featured article in Alzheimer Research Forum. Is Structural MRI Closing In on Preclinical AD Biomarker? December 27, 2011.

Pluta J, Yushkevich P, Das S, Wolk D: In vivo Analysis of Hippocampal Subfield Atrophy in Mild Cognitive Impairment via Semi-Automatic Segmentation of T2-Weighted MRI. Journal of Alzheimer's Disease 31(1): 85-99, Jan 2012.

Wolk DA, Price JC, Madeira C, Saxton JA, Snitz BE, Lopez OL, Mathis CA, Klunk WE, Dekosky ST: Amyloid imaging in dementias with atypical presentation. Alzheimer's & Dementia 8(5): 389-98, Jan 2012.

Wolk David A, Mancuso Lauren, Kliot Daria, Arnold Steven E, Dickerson Bradford C: Familiarity-based memory as an early cognitive marker of preclinical and prodromal AD. Neuropsychologia 51(6): 1094-102, Mar 2013.

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Last updated: 05/01/2015
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