Kaori Ihida-Stansbury

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Research Assistant Professor of Pathology and Laboratory Medicine
Associate Director, The Cardiovascular Medical Research and Education Fund (CMREF) Pulmonary Hypertension Center for Cell study at the University of Pennsylvania
Department: Pathology and Laboratory Medicine

Contact information
Institute for Medicine and Engineering
1010 Vagelos Research Labs
3340 Smith Walk
Philadelphia, PA 19104-6383
Office: 215-898-7554
Fax: 215-573-6815
Lab: 215-746-6098
Education:
BS (Pharmacy)
Nagasaki University, Nagasaki, Japan, 1984.
PhD (Biomedical Science)
Kagoshima University, Kagoshima, Japan, 1993.
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Description of Itmat Expertise

My research interest is to understand how microenvironmental cues regulate stem/progenitor cell differentiation. Currently, my research is focusing on lung vascular SMC differentiation controlled by extracellular matrix properties: stiffness (biophysical property) and TGF-beta signaling (biochemical property). To examine this, I have utilized a decellularized lung scaffolds culture system and determine 3-D matrix signal on cell differentiation. In the long term, I hope that the information gathered using this approach will provide fundamental information necessary to understand the regeneration of the lung and to design more effective therapies.

Selected Publications

Yu, Z., Ricciotti, E., Ihida-Stansbury, K., Stubbe, J., Hawthorne, E.A., Jones, L., Assoian, R., Fitzgerald, G.: Myeloid Cell 5-lipoxygenase activating protein modulates the response to vascular injury. Circ. Res. 112: 432-440, Feb 2013.

Reichert, M., Takano, S., von Burstin, J., Kim, SB., Lee, JS., Ihida-Stansbury, K., Hahn, C., Heeg, S., Schneider, G., Rhim, AD., Stanger, BZ., Rustgi, AK.: The Prrx1 homeodomain transcription factor plays a central role in pancreatic regeneration and carcinogenesis. Genes Dev 27: 288-300, Feb 2013.

Chow,K., Fessel, J., Ihida-Stansbury, K., Schmidt, E., Gaskill, C., Alvarez, D., Graham, B., Harrison, D., Wanger, D., Nozik-Grayck, D., West, J., Klemm, D., Majka, S.: Dysfunctional resident lung mesenchymal stem cells contribute to pulmonary microvascular remodeling. Pulm. Circ. 3(1): 31-49, January 2013.

Zhang, M., Ihida-Stansbury, K., Van Der Spiegel, J., Engheta, N.: Polarization-based non-staining cell detection. Opt. Express 20: 25378-25390, November 2012.

Talati M, Seeley E, Ihida-Stansbury K, Delisser H, McDonald H, Ye F, Zhang X, Shyr Y, Caprioli R, Meyrick B, members of the Pulmonary Hypertension Breakthrough Initiative: Altered Expression of Nuclear and Cytoplasmic Histone H1 in Pulmonary Artery and Pulmonary Artery Smooth Muscle Cells in Patients with IPAH. Pulm. Circ. 2: 340-351, July 2012.

Krymskaya, V.P., Snow, J., Cesarone, G., Khavin, I., Goncharov, D.A., Lim, P., Veasey, S.C., Ihida-Stansbury, K., Jones, P.L., Goncharov, E: mTOR is required for pulmonary arterial vascular smooth muscle cell proliferation under chronic hypoxia. FASEB J 25: 1922-1933, June 2011.

Wang, M., Ihida-Stansbury, K., Kothapalli, D., Tamby M.C., Yu, Z., Chen, L., Grant, G., Cheng, Y.,Lawson, J.A., Assoian, R.K., Jones P.L., Fitzgerald G: Microsomal prostaglandin E2 synthase-1 modulates the response to vascular injury. Circulation 123(6): 631-639, January 2011.

Rehan, VK., Sakurai, R., Corral, J., Krebs, M., Ibe, B., Ihida-Stansbury, K., Torday, J.S.: Antinatal administration of PPAR-gamma agonist RGZ prevents hyperoxia-induced rat lung injury. Am J Physiol Lung Cell Mol Physiol. 299(5): L672-680, November 2010.

K. Ihida-Stansbury, S. Sanyal, C Navarro, P. Janmey, H. Sundararaghavan, J. Burdick, P.L. Jones: Lung vascular smooth muscle cell differentiation controlled by elastic matrix. Mol Biol Cell 21 suppl, December 2010.

K.Ihida-Stansbury, K.C. Kawabata, D.Patel, P Janmey, R Wells, P.L.Jones: Lung SMC differentiation controlled by Prx1-dependent ECM property. Mol. Biol. Cell 20 (suppl), December 2009.

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Last updated: 06/27/2014
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