J. Eric Russell

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Associate Professor of Medicine
Member, Credentials Committee, University of Pennsylvania Health Systems
Department: Medicine

Contact information
310-D Abramson Building
The Children's Hospital of Philadelphia
34th Street and Civic Center Boulevard
Philadelphia, PA 19104
Office: 215-590-3880
Fax: 215-590-2920
Graduate Group Affiliations
Education:
A.B. (Chemistry: magna cum laude)
Harvard University Cambridge, MA, 1980.
M.D. (Medicine)
Stanford University School of Medicine Palo Alto, CA , 1984.
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Description of Research Expertise

RESEARCH INTERESTS

Control and function of human embryonic globin genes.

Key words: Globin, embryonic, sickle cell anemia, thalassemia, mRNA, prothrombin.

Description of Itmat Expertise

Thalassemias, hemoglobinopathies, sickle cell disease, post-transcriptional regulation of adult globin genes, re-activaqtion and function of embryonic globin genes

Selected Publications

Jiang, Y., Xu, X.-S., and Russell, J.E.: The high stability of [beta]-globin mRNA requires site-specific binding of factors that remodel the structure of its 3'UTR. The 8th Cooley's Anemia Symposium, New York Academy of Sciences, March 17-19 2005.

Jiang, Y., Xu, X.-S., and Russell, J.E.: The high stability of human [beta]-globin mRNA is determined by a specific cis-element within its 3'UTR. 28th Annual Meeting of the National Sickle Cell Disease Program, Cincinnati, April 9-13 2005.

He, Z., and Russell, J.E.: Evidence that differential stabilization of [beta]-like globin mRNAs is mediated by specific determinants in their 3'UTRs. 28th Annual Meeting of the National Sickle Cell Disease Program, Cincinnati, April 9-13 2005.

Russell, J.E.: Adaptive post-transcriptional processes mitigate globin chain imbalance in [beta]-thalassemic erythrocytes. 27th Annual Meeting of the National Sickle Cell Disease Program, Los Angeles, April 18-21 2004 Notes: Oral presentation.

He, Z., and Russell, J.E.: Co-expression of human [zeta] globin corrects the sickle phenotype in mouse models of sickle cell disease. 27th Annual Meeting of the National Sickle Cell Disease Program, Los Angeles, April 18-21 2004 Notes: Oral presentation.

Frehm, E.J., Russell, J.E., and Gow, A.J.: Genetic and pharmacologic modulation of nitric oxide-hemoglobin reactivity. Eastern Society for Pediatric Research, Old Greenwich CT, March 26-28 2004 Notes: Oral presentation.

Russell, J.E.: Hemoglobinopathies and thalassemias. Medical Knowledge Self-Assessment Program 13. P.E. Epstein (eds.). Page: 30-32, 2003.

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Last updated: 05/18/2012
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