Darko Stefanovski

faculty photo
Assistant Professor of Biostatistics, University of Pennsylvania School of Veterinary Medicine
Member, Institute for Diabetes, Obesity, and Metabolism (IDOM), Perelman School of Medicine University of Pennsylvania
Member, Search Committee for Epidemiology Position Department of Clinical Studies New Bolton Center

Contact information
Penn Vet
New Bolton Center
382 West Street Road
Kennett Square, PA 19348
Office: 610-444-5800
Fax: 610-925-6823
Education:
BS (Computer and Information Sciences)
Shepherd College, Shepherdstown, WV, 1999.
M.S. (Bioengineering)
University of Pennsylvania, 2003.
Ph.D. (Physiology and Biophysics)
University of Southern California, Los Angeles, CA, 2009.
Permanent link
 

Description of Itmat Expertise

Obesity,
Diabetes,
Mechanisms of Independent Glucose Disposal,
Insulin Resistance

Description of Research Expertise

Dr. Stefanovski’s research focus is in the field of the biomedical sciences, at the intersection of integrative physiology, statistics and computational biology. For over a decade, he has been involved in research studying obesity and its association with insulin resistance, a state of impaired glucose tolerance, and subsequent pathologies, such as Type 2 Diabetes. Current research indicates that the metabolic syndrome, as a combination of medical disorders, is not only associated with the cardiovascular disease and diabetes, but also with some types of cancer. His diverse background has enabled him to approach the complexity of the metabolic syndrome with a multitude of methodologies, including mathematical modeling, statistical analysis, molecular dynamics, molecular biology, and animal model experiments. His current research involves the study of the effects of rear variants of hepatic glucokinase and its repressor protein GKRP on glucose metabolism and development of novel mathematical model of free fatty acids (FFA) kinetics capable of quantifying whole-body insulin sensitivity of FFA metabolism. Additionally, he is studying the biophysical principles of ions selectivity.

Selected Publications

Johnson Amy L, Johnstone Laura K, Stefanovski Darko: Cerebrospinal fluid Lyme multiplex assay results are not diagnostic in horses with neuroborreliosis. Journal of veterinary internal medicine Feb 2018.

Morgan Jessica, Stefanovski Darko, Lenfest Margret, Chatterjee Sraboni, Orsini James: Novel dry cryotherapy system for cooling the equine digit. Veterinary record open 5(1): e000244, 2018.

Rickels Michael R, Perez Elys M, Peleckis Amy J, Alshehabi Erica, Nguyen Huong-Lan, Stefanovski Darko, Rickels Karl, Teff Karen L: Contribution of parasympathetic muscarinic augmentation of insulin secretion to olanzapine-induced hyperinsulinemia. American journal of physiology. Endocrinology and metabolism Dec 2017.

Shah Faraaz Ali, Singamsetty Srikanth, Guo Lanping, Chuan Byron W, McDonald Sherie, Cooper Bryce A, O'Donnell Brett J, Stefanovski Darko, Wice Burton, Zhang Yingze, O'Donnell Christopher P, McVerry Bryan J: Stimulation of the endogenous incretin glucose-dependent insulinotropic peptide by enteral dextrose improves glucose homeostasis and inflammation in murine endotoxemia. Translational research : the journal of laboratory and clinical medicine 193: 1-12, Nov 2017.

Luethy D, Stefanovski D, Salber R, Sweeney R W: Prediction of Packed Cell Volume after Whole Blood Transfusion in Small Ruminants and South American Camelids: 80 Cases (2006-2016). Journal of veterinary internal medicine 31(6): 1900-1904, Nov 2017.

Schüler Rita, Osterhoff Martin A, Frahnow Turid, Möhlig Matthias, Spranger Joachim, Stefanovski Darko, Bergman Richard N, Xu Li, Seltmann Anne-Cathrin, Kabisch Stefan, Hornemann Silke, Kruse Michael, Pfeiffer Andreas F H: Dietary Fat Intake Modulates Effects of a Frequent ACE Gene Variant on Glucose Tolerance with association to Type 2 Diabetes. Scientific reports 7(1): 9234, Aug 2017.

Stefanovski Darko, Tang George, Wawrowsky Kolja, Boston Raymond C, Lambrecht Nils, Tajbakhsh Jian: Prostate cancer diagnosis using epigenetic biomarkers, 3D high-content imaging and probabilistic cell-by-cell classifiers. Oncotarget 8(34): 57278-57301, Jul 2017.

Morton Gregory J, Muta Kenjiro, Kaiyala Karl J, Rojas Jennifer M, Scarlett Jarrad M, Matsen Miles E, Nelson Jarrell T, Acharya Nikhil K, Piccinini Francesca, Stefanovski Darko, Bergman Richard N, Taborsky Gerald J, Kahn Steven E, Schwartz Michael W: Evidence That the Sympathetic Nervous System Elicits Rapid, Coordinated, and Reciprocal Adjustments of Insulin Secretion and Insulin Sensitivity During Cold Exposure. Diabetes 66(4): 823-834, Apr 2017.

Boyle Ashley G, Stefanovski Darko, Rankin Shelley C: Comparison of nasopharyngeal and guttural pouch specimens to determine the optimal sampling site to detect Streptococcus equi subsp equi carriers by DNA amplification. BMC veterinary research 13(1): 75, Mar 2017.

Zeng W, Alpaugh W, Stefanovski D, Schlingmann K, Dobrinski I, Turner R M: Xenografting of isolated equine (Equus caballus) testis cells results in de novo morphogenesis of seminiferous tubules but not spermatogenesis. Andrology 5(2): 336-346, Mar 2017.

back to top
Last updated: 05/17/2018
The Trustees of the University of Pennsylvania