Sissel Lund-Katz

faculty photo
Adjunct Professor of Medicine
Senior Member, Stokes’ Research Institute, The Children’s Hospital of Philadelphia, Philadelphia, PA
Department: Medicine

Contact information
The Children's Hospital of Philadelphia
Joseph Stokes Jr. Research Institute
Abramson Research Center
3615 Civic Center Blvd., Suite 1102E
Philadelphia, PA 19104-4318
Office: (215) 590-0588
Fax: (215) 590-0583
Education:
BS (Chemical Technology)
Oslo Institute of Technology, Oslo, Norway, 1964.
BS (Chemical Engineering)
Gothenburg Technical Institute, Gothenburg, Sweden, 1967.
Ph.D. ( Organic and Biophysical Chemistry)
Bryn Mawr College, Bryn Mawr, PA, 1979.
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Description of Itmat Expertise

The overall objective of my research is to gain a more complete understanding of the structure of apolipoprotein E, especially as it relates to its anti-atherogenic properties, including the ability of the protein to bind to lipids, to heparan and other glycosaminoglycans and to members of the low density lipoprotein receptor (LDLR) family. A range of engineered apoE molecules expressed in E. coli is being used. The focus is on understanding the molecular features that control the binding of apoE and its common isoforms to lipids and to lipoprotein particles of different sizes. In addition, characterizing the lipid efflux and nascent apoE-HDL particle formation that occurs when apoE is a ligand for the ABCA1 transporter in neuronal cells are being investigated.

Selected Publications

Glickson JD, Lund-Katz S, Zhou R, Choi H, Chen IW, Li H, Corbin I, Popov AV, Cao W, Song L, Qi C, Marotta D, Nelson DS, Chen J, Chance B, Zheng G: Lipoprotein nanoplatform for targeted delivery of diagnostic and therapeutic agents. Mol Imaging 7(2): 101-10, March-April 2008.

Sakamoto T, Tanaka M, Vedhachalam C, Nickel M, Nguyen D, Dhanasekaran P, Phillips MC, Lund-Katz S, Saito H: Contributions of the carboxyl-terminal helical segment to the self-association and lipoprotein preferences of human apolipoprotein E3 and E4 isoforms. Biochemistry 47(9): 2968-77, March 2008.

Corbin IR, Li H, Chen J, Lund-Katz S, Zhou R, Glickson JD, Zheng G.: Low-density lipoprotein nanoparticles as magnetic resonance imaging contrast agents Neoplasia 8(6): 488-498, June 2006.

Tanaka M, Vedhachalam C, Sakamoto T, Dhanasekaran P, Phillips MC, Lund-Katz S, Saito H.: Effect of carboxyl-terminal truncation on structure and lipid interaction of human apolipoprotein E4 Biochemistry 45(13): 4240-4247, April 2006.

Futamura M, Dhanasekaran P, Handa T, Phillips MC, Lund-Katz S, Saito H.: Two-step mechanism of binding of apolipoprotein E to heparin: implications for the kinetics of apolipoprotein E-heparan sulfate proteoglycan complex formation on cell surfaces. J Biol Chem 280: 5414-5422, 2005.

Li H, Gray BD, Corbin I, Lebherz C, Choi H, Lund-Katz S, Wilson JM, Glickson JD, Zhou R.: MR and fluorescent imaging of low-density lipoprotein receptors. Acad Radiol 11: 1251-1259, 2004.

Narayanaswami V, Maiorano JN, Dhanasekaran P, Ryan RO, Phillips MC, Lund-Katz S, Davidson WS.: Helix orientation of the functional domains in apolipoprotein e in discoidal high density lipoprotein particles. J Biol Chem 279(14): 14273-14279, 2004.

Saito H, Dhanasekaran P, Baldwin F, Weisgraber KH, Phillips MC, Lund-Katz S.: Effects of polymorphism on the lipid interaction of human apolipoprotein E. J Biol Chem 278(42): 40723-40729, 2003.

H. Saito, P. Dhanasekaran, D. Nguyen, F. Baldwin, K.H. Weisgraber, S. Wehrli, M.C. Phillips, S. Lund-Katz: “Characterization of the Heparin Binding Sites in Human Apolipoprotein E" J. Biol. Chem 278: 14782-14787, 2003.

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Last updated: 12/02/2013
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