Albert M. Maguire

faculty photo
Professor of Ophthalmology at the Hospital of the University of Pennsylvania and the Presbyterian Medical Center of Philadelphia
Director, Fellowship Program, Vitreoretinal Surgery, University of Pennsylvania
Department: Ophthalmology

Contact information
Scheie Eye Institute
Department of Ophthalmology
University of Pennsylvania
51 North 39th Street
Philadelphia, PA 19104
Education:
B.A.
Princeton University (magna cum laude), 1982.
M.D.
Harvard University, 1986.
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Description of Research Expertise

Gene therapy for retinal degeneration, gene therapy for ocular neovascularization, Subretinal surgery

Description of Itmat Expertise

gene therapy

retinal diseases

Selected Publications

Ramachandran Pavitra, Lee Vivian, Wei Zhangyong, Song Ji Yun, Casal Giulia, Cronin Therese, Willett Keirnan, Huckfeldt Rachel, Morgan Jessica I W, Aleman Tomas S, Maguire Albert M, Bennett Jean: Evaluation of dose and safety of AAV7m8 and AAV8BP2 in the non-human primate retina. Human gene therapy Oct 2016 Notes: Epub ahead of print.

Bennett Jean, Wellman Jennifer, Marshall Kathleen A, McCague Sarah, Ashtari Manzar, DiStefano-Pappas Julie, Elci Okan U, Chung Daniel C, Sun Junwei, Wright J Fraser, Cross Dominique R, Aravand Puya, Cyckowski Laura L, Bennicelli Jeannette L, Mingozzi Federico, Auricchio Alberto, Pierce Eric A, Ruggiero Jason, Leroy Bart P, Simonelli Francesca, High Katherine A, Maguire Albert M: Safety and durability of effect of contralateral-eye administration of AAV2 gene therapy in patients with childhood-onset blindness caused by RPE65 mutations: a follow-on phase 1 trial. Lancet (London, England) 388(10045): 661-72, Aug 2016.

Bonafede Lucas, Ficicioglu Can H, Serrano Leona, Han Grace, Morgan Jessica I W, Mills Monte D, Forbes Brian J, Davidson Stefanie L, Binenbaum Gil, Kaplan Paige B, Nichols Charles W, Verloo Patrick, Leroy Bart P, Maguire Albert M, Aleman Tomas S: Cobalamin C Deficiency Shows a Rapidly Progressing Maculopathy With Severe Photoreceptor and Ganglion Cell Loss. Investigative ophthalmology & visual science 56(13): 7875-87, Dec 2015.

Ashtari Manzar, Zhang Hui, Cook Philip A, Cyckowski Laura L, Shindler Kenneth S, Marshall Kathleen A, Aravand Puya, Vossough Arastoo, Gee James C, Maguire Albert M, Baker Chris I, Bennett Jean: Plasticity of the human visual system after retinal gene therapy in patients with Leber's congenital amaurosis. Science translational medicine 7(296): 296ra110, Jul 2015.

Morgan Jessica I W, Han Grace, Klinman Eva, Maguire William M, Chung Daniel C, Maguire Albert M, Bennett Jean: High-resolution adaptive optics retinal imaging of cellular structure in choroideremia. Investigative ophthalmology & visual science 55(10): 6381-97, Oct 2014.

Black Aaron, Vasireddy Vidyullatha, Chung Daniel C, Maguire Albert M, Gaddameedi Rajashekhar, Tolmachova Tania, Seabra Miguel, Bennett Jean: Adeno-associated virus 8-mediated gene therapy for choroideremia: preclinical studies in in vitro and in vivo models. The journal of gene medicine 16(5-6): 122-30, May-Jun 2014.

Vasireddy Vidyullatha, Mills Jason A, Gaddameedi Rajashekhar, Basner-Tschakarjan Etiena, Kohnke Monika, Black Aaron D, Alexandrov Krill, Zhou Shangzhen, Maguire Albert M, Chung Daniel C, Mac Helen, Sullivan Lisa, Gadue Paul, Bennicelli Jeannette L, French Deborah L, Bennett Jean: AAV-mediated gene therapy for choroideremia: preclinical studies in personalized models. PloS one 8(5): e61396, 2013.

Vandenberghe Luk H, Bell Peter, Maguire Albert M, Xiao Ru, Hopkins Tim B, Grant Rebecca, Bennett Jean, Wilson James M: AAV9 targets cone photoreceptors in the nonhuman primate retina. PloS one 8(1): e53463, 2013.

Bennett J, Ashtari M, Wellman J, Marshall KA, Cyckowski LL, Chung DC, McCague S, Pierce EA, Chen Y, Bennicelli JL, Zhu X, Ying GS, Sun J, Wright JF, Auricchio A, Simonelli F, Shindler KS, Mingozzi F, High KA, Maguire AM.: AAV2 Gene Therapy Readministration in Three Adults with Congenital Blindness. Sci Transl Med. 4(120): 120ra15, Feb 2012.

Ashtari M, Cyckowski LL, Monroe JF, Marshall KA, Chung DC, Auricchio A, Simonelli F, Leroy BP, Maguire AM, Shindler K, Bennett J.: The human visual cortex responds to gene therapy–mediated recovery of retinal function. J Clin Invest. 121(6): 2160-8, June 2011 Notes: doi: 10.1172/JCI57377. Epub 2011 May 23.

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Last updated: 10/31/2016
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