Albert M. Maguire

faculty photo
Professor of Ophthalmology at the Hospital of the University of Pennsylvania and the Presbyterian Medical Center of Philadelphia
Director, Fellowship Program, Vitreoretinal Surgery, University of Pennsylvania
Department: Ophthalmology

Contact information
Scheie Eye Institute
Department of Ophthalmology
University of Pennsylvania
51 North 39th Street
Philadelphia, PA 19104
Education:
B.A.
Princeton University (magna cum laude), 1982.
M.D.
Harvard University, 1986.
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Description of Research Expertise

Gene therapy for retinal degeneration, gene therapy for ocular neovascularization, Subretinal surgery

Description of Itmat Expertise

gene therapy

retinal diseases

Selected Publications

Ashtari Manzar, Zhang Hui, Cook Philip A, Cyckowski Laura L, Shindler Kenneth S, Marshall Kathleen A, Aravand Puya, Vossough Arastoo, Gee James C, Maguire Albert M, Baker Chris I, Bennett Jean: Plasticity of the human visual system after retinal gene therapy in patients with Leber's congenital amaurosis. Science translational medicine 7(296): 296ra110, Jul 2015.

Morgan Jessica I W, Han Grace, Klinman Eva, Maguire William M, Chung Daniel C, Maguire Albert M, Bennett Jean: High-resolution adaptive optics retinal imaging of cellular structure in choroideremia. Investigative ophthalmology & visual science 55(10): 6381-97, Oct 2014.

Black Aaron, Vasireddy Vidyullatha, Chung Daniel C, Maguire Albert M, Gaddameedi Rajashekhar, Tolmachova Tania, Seabra Miguel, Bennett Jean: Adeno-associated virus 8-mediated gene therapy for choroideremia: preclinical studies in in vitro and in vivo models. The journal of gene medicine 16(5-6): 122-30, May-Jun 2014.

Vasireddy Vidyullatha, Mills Jason A, Gaddameedi Rajashekhar, Basner-Tschakarjan Etiena, Kohnke Monika, Black Aaron D, Alexandrov Krill, Zhou Shangzhen, Maguire Albert M, Chung Daniel C, Mac Helen, Sullivan Lisa, Gadue Paul, Bennicelli Jeannette L, French Deborah L, Bennett Jean: AAV-mediated gene therapy for choroideremia: preclinical studies in personalized models. PloS one 8(5): e61396, 2013.

Vandenberghe Luk H, Bell Peter, Maguire Albert M, Xiao Ru, Hopkins Tim B, Grant Rebecca, Bennett Jean, Wilson James M: AAV9 targets cone photoreceptors in the nonhuman primate retina. PloS one 8(1): e53463, 2013.

Bennett J, Ashtari M, Wellman J, Marshall KA, Cyckowski LL, Chung DC, McCague S, Pierce EA, Chen Y, Bennicelli JL, Zhu X, Ying GS, Sun J, Wright JF, Auricchio A, Simonelli F, Shindler KS, Mingozzi F, High KA, Maguire AM.: AAV2 Gene Therapy Readministration in Three Adults with Congenital Blindness. Sci Transl Med. 4(120): 120ra15, Feb 2012.

Ashtari M, Cyckowski LL, Monroe JF, Marshall KA, Chung DC, Auricchio A, Simonelli F, Leroy BP, Maguire AM, Shindler K, Bennett J.: The human visual cortex responds to gene therapy–mediated recovery of retinal function. J Clin Invest. 121(6): 2160-8, June 2011 Notes: doi: 10.1172/JCI57377. Epub 2011 May 23.

Vandenberghe LH, Bell P, Maguire AM, Cearley CN, Xiao R, Calcedo R, Wang L, Castle MJ, Maguire AC, Grant R, Wolfe JH, Wilson JM, Bennett J.: Dosage thresholds for AAV2 and AAV8 photoreceptor gene therapy in monkey. Sci Transl Med. 3(88): 88ra54, June 2011.

Simonelli F, Maguire AM, Testa F, Pierce EA, Mingozzi F, Bennicelli JL, Rossi S, Marshall K, Banfi S, Surace EM, Sun J, Redmond TM, Zhu X, Shindler KS, Ying GS, Ziviello C, Acerra C, Wright JF, McDonnell JW, High KA, Bennett J, Auricchio A.: Gene therapy for Leber's congenital amaurosis is safe and effective through 1.5 years after vector administration. Mol Ther. 18(3): 643-50, March 2010 Notes: Epub 2009 Dec 1.

Amado D, Mingozzi F, Hui D, Bennicelli JL, Wei Z, Chen Y, Bote E, Grant RL, Golden JA, Narfstrom K, Syed NA, Orlin SE, High KA, Maguire AM, Bennett J.: Safety and efficacy of subretinal readministration of a viral vector in large animals to treat congenital blindness. Sci Transl Med. 2(21): 21ra16, March 2010.

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Last updated: 08/15/2016
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