Our research interests revolve around understanding neurophysiological correlates of neuropsychiatric diseases, such as autism, schizophrenia and Rett syndrome. We look particularly on how local circuit function is perturbed in rodent models of these diseases, using state-of-the-art in situ imaging methods as well as single cell electrophysiological techniques. The scale of work ranges between the synaptic and local circuits to imaging how multiple brain areas interact in the limbic system and cortex. In collaboration our work spans allele to behavior.
Greg Carlson’s laboratory is working to identify and understand the cortical circuit abnormalities that underlie neuropsychiatric disorders. We believe that we can better understand the normal function of cortical circuitry by understanding the differences in neuronal circuit function that contribute to these disorders. This work will also provide a better foundation for the rational development and preclinical testing of therapies for these diseases. Dr. Carlson’s research primarily deploys in vitro electrophysiology, state-of-the-art voltage-sensitive dye, and other novel imaging methods to probe circuit abnormalities in rodent models of complex neuropsychiatric disorders. Members of his lab are currently working on models of Rett Syndrome, autism, epilepsy and schizophrenia.
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Last updated: 02/23/2012
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