Bart C De Jonghe

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Contact information
University of Pennsylvania
School of Nursing
418 Curie Blvd
140 Fagin Hall
Philadelphia, PA 19146
Graduate Group Affiliations
Education:
B.S. (Pre-Medicine)
The Pennsylvania State University, 2001.
Ph.D. (Nutritional Sciences)
The Pennsylvania State University, 2006.
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Description of Itmat Expertise

Understanding the underlying mechanisms of how chemotherapy generates nausea has been a critical component of my lab. We aspire to improve and build preclinical models of chemotherapy side effects in the hopes of developing agents/regimens which give superior control to existing treatment options.

Selected Publications

De Jonghe Bart C, Hayes Matthew R, Zimmer Derek J, Kanoski Scott E, Grill Harvey J, Bence Kendra K: Food intake reductions and increases in energetic responses by hindbrain leptin and melanotan II are enhanced in mice with POMC-specific PTP1B deficiency. American journal of physiology. Endocrinology and metabolism 303(5): E644-51, Sep 2012.

Tsou Ryan C, Zimmer Derek J, De Jonghe Bart C, Bence Kendra K: Deficiency of PTP1B in leptin receptor-expressing neurons leads to decreased body weight and adiposity in mice. Endocrinology 153(9): 4227-37, Sep 2012.

Kanoski Scott E, Zhao Shiru, Guarnieri Douglas J, DiLeone Ralph J, Yan Jianqun, De Jonghe Bart C, Bence Kendra K, Hayes Matthew R, Grill Harvey J: Endogenous leptin receptor signaling in the medial nucleus tractus solitarius affects meal size and potentiates intestinal satiation signals. American journal of physiology. Endocrinology and metabolism 303(4): E496-503, Aug 2012.

Kanoski Scott E, Rupprecht Laura E, Fortin Samantha M, De Jonghe Bart C, Hayes Matthew R: The role of nausea in food intake and body weight suppression by peripheral GLP-1 receptor agonists, exendin-4 and liraglutide. Neuropharmacology 62(5-6): 1916-27, Apr 2012.

Hayes Matthew R, Kanoski Scott E, De Jonghe Bart C, Leichner Theresa M, Alhadeff Amber L, Fortin Samantha M, Arnold Myrtha, Langhans Wolfgang, Grill Harvey J: The common hepatic branch of the vagus is not required to mediate the glycemic and food intake suppressive effects of glucagon-like-peptide-1. American journal of physiology. Regulatory, integrative and comparative physiology 301(5): R1479-85, Nov 2011.

De Jonghe Bart C, Hayes Matthew R, Bence Kendra K: Melanocortin control of energy balance: evidence from rodent models. Cellular and molecular life sciences : CMLS 68(15): 2569-88, Aug 2011.

De Jonghe Bart C, Hayes Matthew R, Banno Ryoichi, Skibicka Karolina P, Zimmer Derek J, Bowen Kerisha A, Leichner Theresa M, Alhadeff Amber L, Kanoski Scott E, Cyr Nicole E, Nillni Eduardo A, Grill Harvey J, Bence Kendra K: Deficiency of PTP1B in POMC neurons leads to alterations in energy balance and homeostatic response to cold exposure. American journal of physiology. Endocrinology and metabolism 300(6): E1002-11, Jun 2011.

Hayes Matthew R, Leichner Theresa M, Zhao Shiru, Lee Grace S, Chowansky Amy, Zimmer Derek, De Jonghe Bart C, Kanoski Scott E, Grill Harvey J, Bence Kendra K: Intracellular signals mediating the food intake-suppressive effects of hindbrain glucagon-like peptide-1 receptor activation. Cell metabolism 13(3): 320-30, Mar 2011.

Hayes Matthew R, De Jonghe Bart C, Kanoski Scott E: Role of the glucagon-like-peptide-1 receptor in the control of energy balance. Physiology & behavior 100(5): 503-10, Jul 2010.

Banno Ryoichi, Zimmer Derek, De Jonghe Bart C, Atienza Marybless, Rak Kimberly, Yang Wentian, Bence Kendra K: PTP1B and SHP2 in POMC neurons reciprocally regulate energy balance in mice. The Journal of clinical investigation 120(3): 720-34, Mar 2010.

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Last updated: 12/14/2012
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